All Stories

  1. Therapeutic Trials in Alzheimer’s Disease: Where Are We Now?
  2. Fueling Alzheimer’s Disease: Where Does Immunometabolism Stand?
  3. MitoTempo protects against nε-carboxymethyl lysine-induced mitochondrial dyshomeostasis and neuronal cells injury
  4. Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease
  5. Corrigendum: Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
  6. Mapping the lipidome in mitochondria‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease
  7. Neuro–glia communication and glycolysis
  8. Current Advances in Mitochondrial Targeted Interventions in Alzheimer’s Disease
  9. Therapeutic potential of glutaminyl cyclases: Current status and emerging trends
  10. Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
  11. Retinal imaging in animal models: Searching for biomarkers of neurodegeneration
  12. Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria
  13. A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
  14. Disrupted cellular quality control mechanisms in aging
  15. WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose
  16. Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
  17. Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
  18. Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria
  19. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system
  20. Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats
  21. Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update
  22. Oxygen Sensing and Signaling in Alzheimer’s Disease: A Breathtaking Story!
  23. Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease
  24. Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease
  25. WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration
  26. IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis
  27. Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease
  28. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  29. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
  30. Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort
  31. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
  32. Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease
  33. Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors
  34. Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
  35. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
  36. Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones
  37. Cognitive Impairment in Obesity and Diabetes
  38. An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease
  39. Retinal thickness of the triple‐transgenic mice model of Alzheimer\’s disease at the age of one month
  40. Is Alzheimer’s disease an inflammasomopathy?
  41. Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area
  42. Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study
  43. Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease
  44. Post-translational modifications in brain health and disease
  45. Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies
  46. Diabesity and brain disturbances: A metabolic perspective
  47. A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss
  48. The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel
  49. Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease
  50. Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer’s disease?
  51. O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease
  52. Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
  53. Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease
  54. Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology
  55. The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
  56. Sweet Mitochondria: A Shortcut to Alzheimer’s Disease
  57. Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing
  58. Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects
  59. Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
  60. Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid
  61. Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements
  62. Diabesity and Brain Energy Metabolism: The Case of Alzheimer’s Disease
  63. Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!
  64. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology
  65. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
  66. Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
  67. Mini-Symposium: Energy Demand and Energy Supply in Alzheimer's Disease - Introduction
  68. Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine
  69. Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease
  70. Erratum
  71. Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells
  72. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  73. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling
  74. Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria
  75. Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions
  76. Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells
  77. Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers
  78. Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers
  79. The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
  80. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients
  81. Endoplasmic reticulum stress
  82. Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu
  83. Type 2 Diabetes Aggravates Alzheimer's Disease-Associated Vascular Alterations of the Aorta in Mice
  84. Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats
  85. Exercise-Induced Protection Against Aging and Neurodegenerative Diseases
  86. Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
  87. Autophagy in Alzheimer’s disease: A Cleaning Service Out-of-order?
  88. Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease
  89. Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes
  90. Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
  91. The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
  92. Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells
  93. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia
  94. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats
  95. Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status
  96. Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
  97. Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes
  98. Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
  99. Metformin and male reproduction: effects on Sertoli cell metabolism
  100. Alzheimer's Disease: An Overview☆
  101. Alzheimer's Disease
  102. Increased Susceptibility to Amyloid-β Toxicity in Rat Brain Microvascular Endothelial Cells under Hyperglycemic Conditions
  103. The Janus Face of Insulin in Brain
  104. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?
  105. Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes
  106. Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells
  107. High-sugar diets, type 2 diabetes and Alzheimerʼs disease
  108. Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease
  109. Mitochondrial-Targeted Protective Properties of Isolated Diterpenoids fromSideritisspp. in Response to the Deleterious Changes Induced by H2O2
  110. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links
  111. Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies
  112. Molecular mechanisms beyond glucose transport in diabetes-related male infertility
  113. Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
  114. Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease
  115. Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
  116. UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats
  117. Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease
  118. Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance
  119. Mechanism of inhibition of mitochondrial ATP synthase by 17β−Estradiol
  120. The impairment of insulin signaling in Alzheimer's disease
  121. Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile
  122. Alzheimer disease as a vascular disorder: Where do mitochondria fit?
  123. Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
  124. Impact of Diabetes in Blood-Testis and Blood-Brain Barriers: Resemblances and Differences
  125. Hormonal control of Sertoli cell metabolism regulates spermatogenesis
  126. Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin
  127. Oxidative Damage to RNA in Aging and Neurodegenerative Disorders
  128. Guidelines for the use and interpretation of assays for monitoring autophagy
  129. Association of Mitochondrial Signaling in Alzheimer’s Disease and Hypoxia
  130. Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
  131. The role of iron as a mediator of oxidative stress in Alzheimer disease
  132. Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
  133. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover
  134. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
  135. Mitochondrial Importance in Alzheimer’s, Huntington’s and Parkinson’s Diseases
  136. Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
  137. Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α
  138. Insulin in Central Nervous System: More than Just a Peripheral Hormone
  139. New Insights into the Mechanisms of Mitochondrial Preconditioning-Triggered Neuroprotection
  140. Oxidative Stress and Balance in Neurodegenerative Diseases
  141. Neurofilamentopathy in Neurodegenerative Diseases
  142. Mitophagy in Neurodegeneration: An Opportunity for Therapy?
  143. Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
  144. SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
  145. Mitochondria as Potential Targets in Antidiabetic Therapy
  146. Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen
  147. Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
  148. Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
  149. Autophagy in Alzheimer’s disease
  150. Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?
  151. A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
  152. Mitochondria: The Missing Link Between Preconditioning and Neuroprotection
  153. Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
  154. Mitochondrial preconditioning: a potential neuroprotective strategy
  155. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
  156. Mitochondria: A therapeutic target in neurodegeneration
  157. Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?
  158. Natural Oxidant Balance in Parkinson Disease
  159. Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes
  160. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
  161. Doxorubicin: The Good, the Bad and the Ugly Effect
  162. An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease
  163. RNA oxidation in Alzheimer disease and related neurodegenerative disorders
  164. Altered redox balance in disease: Can we change the new equilibria?
  165. Alzheimer’s Disease: An Overview
  166. Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease
  167. Food Deprivation Promotes Oxidative Imbalance in Rat Brain
  168. Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
  169. Oxidative Stress Signaling in Alzheimers Disease
  170. Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview
  171. Antioxidant Therapy in Alzheimers Disease: Theory and Practice
  172. Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage
  173. Metformin Protects the Brain Against the Oxidative Imbalance Promoted by Type 2 Diabetes
  174. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
  175. Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
  176. Nucleic acid oxidation in Alzheimer disease
  177. Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease
  178. Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases
  179. Oxidative RNA Damage and Neurodegeneration
  180. Metformin promotes isolated rat liver mitochondria impairment
  181. Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction
  182. Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets
  183. Errata
  184. Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
  185. Vascular oxidative stress in Alzheimer disease
  186. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
  187. Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
  188. Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
  189. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
  190. Indices of Metabolic Dysfunction and Oxidative Stress
  191. Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
  192. The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics
  193. The Key Role of Oxidative Stress in Alzheimer's Disease
  194. Foreword: Mitochondria in Alzheimer disease
  195. Involvement of Oxidative Stress in Alzheimer Disease
  196. Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy?
  197. Therapeutic options in Alzheimer’s disease
  198. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
  199. Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream
  200. Insulin Attenuates Diabetes-Related Mitochondrial Alterations: A Comparative Study
  201. Presenilin mutation: A deadly first hit in Alzheimer disease
  202. Tamoxifen and Estradiol Interact with the Flavin Mononucleotide Site of Complex I Leading to Mitochondrial Failure
  203. CoQ10 therapy attenuates amyloid β-peptide toxicity in brain mitochondria isolated from aged diabetic rats
  204. Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology
  205. Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease
  206. Alzheimer's disease: an intracellular movement disorder?
  207. Redox metals and oxidative abnormalities in human prion diseases
  208. Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
  209. Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies
  210. Oxidative Stress and Neurodegeneration
  211. Therapeutic Opportunities in Alzheimer Disease: One for all or all for One?
  212. Chronological primacy of oxidative stress in Alzheimer disease
  213. Tau phosphorylation in Alzheimer's disease: pathogen or protector?
  214. A Second Look into the Oxidant Mechanisms in Alzheimers Disease
  215. Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats
  216. Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron
  217. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
  218. Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen
  219. Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease
  220. Biphasic expression of lipin suggests dual roles in adipocyte development
  221. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
  222. Neurofilament proteins in neurodegenerative diseases
  223. Therapeutic potential of oxidant mechanisms in Alzheimer’s disease
  224. Hydroxytamoxifen protects against oxidative stress in brain mitochondria
  225. Effect of Streptozotocin-Induced Diabetes on Rat Brain Mitochondria
  226. Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-  Exposure
  227. Effect of amyloid ?-peptide on permeability transition pore: A comparative study
  228. Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria
  229. Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress