All Stories

  1. Mapping the lipidome in mitochondria‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease
  2. Neuro–glia communication and glycolysis
  3. Current Advances in Mitochondrial Targeted Interventions in Alzheimer’s Disease
  4. Therapeutic potential of glutaminyl cyclases: Current status and emerging trends
  5. Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
  6. Retinal imaging in animal models: Searching for biomarkers of neurodegeneration
  7. Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria
  8. A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
  9. WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose
  10. Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
  11. Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
  12. Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria
  13. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system
  14. Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats
  15. Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update
  16. Oxygen Sensing and Signaling in Alzheimer’s Disease: A Breathtaking Story!
  17. Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease
  18. Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease
  19. WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration
  20. IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis
  21. Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease
  22. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  23. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
  24. Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort
  25. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
  26. Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease
  27. Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors
  28. Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
  29. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
  30. Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones
  31. Cognitive Impairment in Obesity and Diabetes
  32. An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease
  33. Retinal thickness of the triple‐transgenic mice model of Alzheimer\’s disease at the age of one month
  34. Is Alzheimer’s disease an inflammasomopathy?
  35. Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area
  36. Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study
  37. Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease
  38. Post-translational modifications in brain health and disease
  39. Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies
  40. Diabesity and brain disturbances: A metabolic perspective
  41. A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss
  42. The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel
  43. Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease
  44. Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer’s disease?
  45. O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease
  46. Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
  47. Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease
  48. Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology
  49. The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
  50. Sweet Mitochondria: A Shortcut to Alzheimer’s Disease
  51. Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing
  52. Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects
  53. Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
  54. Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid
  55. Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements
  56. Diabesity and Brain Energy Metabolism: The Case of Alzheimer’s Disease
  57. Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!
  58. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology
  59. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
  60. Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
  61. Mini-Symposium: Energy Demand and Energy Supply in Alzheimer's Disease - Introduction
  62. Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine
  63. Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease
  64. Erratum
  65. Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells
  66. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  67. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling
  68. Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria
  69. Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions
  70. Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells
  71. Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers
  72. Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers
  73. The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
  74. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients
  75. Endoplasmic reticulum stress
  76. Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu
  77. Type 2 Diabetes Aggravates Alzheimer's Disease-Associated Vascular Alterations of the Aorta in Mice
  78. Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats
  79. Exercise-Induced Protection Against Aging and Neurodegenerative Diseases
  80. Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
  81. Autophagy in Alzheimer’s disease: A Cleaning Service Out-of-order?
  82. Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease
  83. Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes
  84. Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
  85. The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
  86. Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells
  87. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia
  88. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats
  89. Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status
  90. Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
  91. Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes
  92. Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
  93. Metformin and male reproduction: effects on Sertoli cell metabolism
  94. Alzheimer's Disease: An Overview☆
  95. Alzheimer's Disease
  96. Increased Susceptibility to Amyloid-β Toxicity in Rat Brain Microvascular Endothelial Cells under Hyperglycemic Conditions
  97. The Janus Face of Insulin in Brain
  98. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?
  99. Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes
  100. Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells
  101. High-sugar diets, type 2 diabetes and Alzheimerʼs disease
  102. Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease
  103. Mitochondrial-Targeted Protective Properties of Isolated Diterpenoids fromSideritisspp. in Response to the Deleterious Changes Induced by H2O2
  104. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links
  105. Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies
  106. Molecular mechanisms beyond glucose transport in diabetes-related male infertility
  107. Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
  108. Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease
  109. Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
  110. UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats
  111. Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease
  112. Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance
  113. Mechanism of inhibition of mitochondrial ATP synthase by 17β−Estradiol
  114. The impairment of insulin signaling in Alzheimer's disease
  115. Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile
  116. Alzheimer disease as a vascular disorder: Where do mitochondria fit?
  117. Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
  118. Impact of Diabetes in Blood-Testis and Blood-Brain Barriers: Resemblances and Differences
  119. Hormonal control of Sertoli cell metabolism regulates spermatogenesis
  120. Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin
  121. Oxidative Damage to RNA in Aging and Neurodegenerative Disorders
  122. Guidelines for the use and interpretation of assays for monitoring autophagy
  123. Association of Mitochondrial Signaling in Alzheimer’s Disease and Hypoxia
  124. Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
  125. The role of iron as a mediator of oxidative stress in Alzheimer disease
  126. Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
  127. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover
  128. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
  129. Mitochondrial Importance in Alzheimer’s, Huntington’s and Parkinson’s Diseases
  130. Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
  131. Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α
  132. Insulin in Central Nervous System: More than Just a Peripheral Hormone
  133. New Insights into the Mechanisms of Mitochondrial Preconditioning-Triggered Neuroprotection
  134. Oxidative Stress and Balance in Neurodegenerative Diseases
  135. Neurofilamentopathy in Neurodegenerative Diseases
  136. Mitophagy in Neurodegeneration: An Opportunity for Therapy?
  137. Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
  138. SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
  139. Mitochondria as Potential Targets in Antidiabetic Therapy
  140. Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen
  141. Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
  142. Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
  143. Autophagy in Alzheimer’s disease
  144. Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?
  145. A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
  146. Mitochondria: The Missing Link Between Preconditioning and Neuroprotection
  147. Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
  148. Mitochondrial preconditioning: a potential neuroprotective strategy
  149. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
  150. Mitochondria: A therapeutic target in neurodegeneration
  151. Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?
  152. Natural Oxidant Balance in Parkinson Disease
  153. Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes
  154. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
  155. Doxorubicin: The Good, the Bad and the Ugly Effect
  156. An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease
  157. RNA oxidation in Alzheimer disease and related neurodegenerative disorders
  158. Altered redox balance in disease: Can we change the new equilibria?
  159. Alzheimer’s Disease: An Overview
  160. Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease
  161. Food Deprivation Promotes Oxidative Imbalance in Rat Brain
  162. Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
  163. Oxidative Stress Signaling in Alzheimers Disease
  164. Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview
  165. Antioxidant Therapy in Alzheimers Disease: Theory and Practice
  166. Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage
  167. Metformin Protects the Brain Against the Oxidative Imbalance Promoted by Type 2 Diabetes
  168. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
  169. Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
  170. Nucleic acid oxidation in Alzheimer disease
  171. Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease
  172. Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases
  173. Oxidative RNA Damage and Neurodegeneration
  174. Metformin promotes isolated rat liver mitochondria impairment
  175. Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction
  176. Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets
  177. Errata
  178. Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
  179. Vascular oxidative stress in Alzheimer disease
  180. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
  181. Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
  182. Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
  183. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
  184. Indices of Metabolic Dysfunction and Oxidative Stress
  185. Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
  186. The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics
  187. The Key Role of Oxidative Stress in Alzheimer's Disease
  188. Foreword: Mitochondria in Alzheimer disease
  189. Involvement of Oxidative Stress in Alzheimer Disease
  190. Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy?
  191. Therapeutic options in Alzheimer’s disease
  192. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
  193. Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream
  194. Insulin Attenuates Diabetes-Related Mitochondrial Alterations: A Comparative Study
  195. Presenilin mutation: A deadly first hit in Alzheimer disease
  196. Tamoxifen and Estradiol Interact with the Flavin Mononucleotide Site of Complex I Leading to Mitochondrial Failure
  197. CoQ10 therapy attenuates amyloid β-peptide toxicity in brain mitochondria isolated from aged diabetic rats
  198. Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology
  199. Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease
  200. Alzheimer's disease: an intracellular movement disorder?
  201. Redox metals and oxidative abnormalities in human prion diseases
  202. Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
  203. Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies
  204. Oxidative Stress and Neurodegeneration
  205. Therapeutic Opportunities in Alzheimer Disease: One for all or all for One?
  206. Chronological primacy of oxidative stress in Alzheimer disease
  207. Tau phosphorylation in Alzheimer's disease: pathogen or protector?
  208. A Second Look into the Oxidant Mechanisms in Alzheimers Disease
  209. Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats
  210. Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron
  211. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
  212. Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen
  213. Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease
  214. Biphasic expression of lipin suggests dual roles in adipocyte development
  215. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
  216. Neurofilament proteins in neurodegenerative diseases
  217. Therapeutic potential of oxidant mechanisms in Alzheimer’s disease
  218. Hydroxytamoxifen protects against oxidative stress in brain mitochondria
  219. Effect of Streptozotocin-Induced Diabetes on Rat Brain Mitochondria
  220. Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-  Exposure
  221. Effect of amyloid ?-peptide on permeability transition pore: A comparative study
  222. Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria
  223. Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress