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  1. Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

    Article • European Journal of Biochemistry, September 2021, Wiley

    Shuo-Chien Ling

  2. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

    Article • Journal of Cell Biology, August 2021, Rockefeller University Press

    Shuo-Chien Ling

  3. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Article • eLife, March 2021, eLife

    Shuo-Chien Ling

  4. Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction

    Article • Proceedings of the National Academy of Sciences, October 2020, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  5. Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis

    Article • Acta Neuropathologica Communications, September 2020, Springer Science + Business Media

    Shuo-Chien Ling

  6. The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43

    Article • Neurobiology of Aging, August 2020, Elsevier

    Shuo-Chien Ling

  7. FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits

    Article • Human Molecular Genetics, September 2019, Oxford University Press (OUP)

    Shuo-Chien Ling

  8. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

    Article • Acta Neuropathologica, July 2019, Springer Science + Business Media

    Shuo-Chien Ling, Dr Christopher M Morris

  9. Elevated FUS levels by overriding its autoregulation produce gain-of-toxicity properties that disrupt protein and RNA homeostasis

    Article • Autophagy, June 2019, Taylor & Francis

    Jolie Ho, Shuo-Chien Ling

  10. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Article • eLife, February 2019, eLife

    Shuo-Chien Ling

  11. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

    Article • Autophagy, January 2019, Taylor & Francis

    Jolie Ho, Dr Yee Kit Tai, Shuo-Chien Ling

  12. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

    Article • Neuron, November 2018, Elsevier

    Shuo-Chien Ling

  13. Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination

    Article • Proceedings of the National Academy of Sciences, October 2018, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  14. Ooplasmic flow cooperates with transport and anchorage in Drosophila oocyte posterior determination

    Article • Journal of Cell Biology, July 2018, Rockefeller University Press

    Shuo-Chien Ling

  15. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients

    Article • Acta Neuropathologica, May 2018, Springer Science + Business Media

    Shuo-Chien Ling

  16. Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions

    Article • Neural Plasticity, January 2018, Hindawi Publishing Corporation

    Shuo-Chien Ling

  17. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

    Article • Acta Neuropathologica, March 2017, Springer Science + Business Media

    Shuo-Chien Ling

  18. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis

    Article • Free Radical Biology and Medicine, August 2016, Elsevier

    Shuo-Chien Ling

  19. FUS-linked essential tremor associated with motor dysfunction in Drosophila

    Article • Human Genetics, July 2016, Springer Science + Business Media

    Shuo-Chien Ling

  20. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    Article • Neuron, May 2016, Elsevier

    Shuo-Chien Ling

  21. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla

  22. Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

    Article • Proceedings of the National Academy of Sciences, November 2015, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  23. Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

    Article • Acta Neuropathologica Communications, June 2015, Springer Science + Business Media

    Shuo-Chien Ling

  24. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

    Article • Nature Communications, January 2015, Springer Science + Business Media

    Shuo-Chien Ling

  25. Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy

    Article • Neuron, April 2014, Elsevier

    Shuo-Chien Ling

  26. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  27. Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

    Article • Neuron, August 2013, Elsevier

    Shuo-Chien Ling

  28. Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

    Article • Journal of Biological Chemistry, August 2013, Elsevier

    Shuo-Chien Ling

  29. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  30. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

    Article • Nature Neuroscience, September 2012, Springer Science + Business Media

    Shuo-Chien Ling

  31. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

    Article • Nature Neuroscience, February 2011, Springer Science + Business Media

    Shuo-Chien Ling

  32. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

    Article • Proceedings of the National Academy of Sciences, July 2010, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  33. Microtubule binding by dynactin is required for microtubule organization but not cargo transport

    Article • Journal of Cell Biology, February 2007, Rockefeller University Press

    Shuo-Chien Ling

  34. Proteomic Characterization of Messenger Ribonucleoprotein Complexes Bound to Nontranslated or Translated Poly(A) mRNAs in the Rat Cerebral Cortex

    Article • Journal of Biological Chemistry, February 2005, Elsevier

    Shuo-Chien Ling

  35. Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein

    Article • Proceedings of the National Academy of Sciences, December 2004, Proceedings of the National Academy of Sciences

    Shuo-Chien Ling

  36. A Receptor for Activated C Kinase Is Part of Messenger Ribonucleoprotein Complexes Associated with PolyA-mRNAs in Neurons

    Article • Journal of Neuroscience, October 2002, Society for Neuroscience

    Shuo-Chien Ling

  37. Characterization of Granular Particles Isolated from Postsynaptic Densities

    Article • Journal of Neurochemistry, October 1998, Wiley

    Shuo-Chien Ling