All Stories

  1. Vitamin E components give a multitude of oxidation products.
  2. Celebrating the 10th anniversary of the creation of the European Network for Oxysterol Research (ENOR)
  3. Cholesterol is a lipid producing signaling molecules controlling Aging
  4. Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles
  5. Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: A systematic review and meta-analysis of preclinical models
  6. Sterol metabolism and cancer
  7. European network for oxysterol research (ENOR): 10 th anniversary
  8. Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models
  9. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  10. Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia
  11. The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets
  12. Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
  13. The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets
  14. Oxysterols and sterols: From lipidomics to food sciences
  15. A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues
  16. Oxysterols: An expanding family of structurally diversified bioactive steroids
  17. The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells
  18. Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis
  19. Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis
  20. HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris
  21. Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite
  22. The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer
  23. Extracellular vesicles: lipids as key components of their biogenesis and functions
  24. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers
  25. Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment
  26. Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation
  27. Meet Our Editorial Board Member
  28. Dendrogenin A (DDA) is a cholesterol metabolite with potent anticancer properties
  29. Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death
  30. Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
  31. Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry
  32. Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS
  33. Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study
  34. From tamoxifen to dendrogenin A: The discovery of a mammalian tumor suppressor and cholesterol metabolite
  35. When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1
  36. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  37. dendrogenin A: a good cholesterol metabolite against cancer
  38. Cholesterol metabolites exported from human brain
  39. One step synthesis of 6-oxo-cholestan-3β,5α-diol
  40. The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells
  41. Cholesterol and Cancer, in the Balance
  42. Emerging concepts on the role of exosomes in lipid metabolic diseases
  43. Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies
  44. Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission
  45. 5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells
  46. Oxysterols and related sterols: Implications in pharmacology and pathophysiology
  47. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
  48. Improved realism of hybrid mouse models may not be sufficient to generate reference dosimetric data
  49. Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer
  50. Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A
  51. Cholesterol epoxide hydrolase and cancer
  52. Cholesterol metabolism and cancer: the good, the bad and the ugly
  53. Cholesterol metabolism and resistance to tamoxifen
  54. MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy
  55. Guidelines for the use and interpretation of assays for monitoring autophagy
  56. Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor
  57. Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles
  58. Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands
  59. Exosomes as intercellular signalosomes and pharmacological effectors
  60. Four decades of discovery in breast cancer research and treatment an interview with V. Craig Jordan
  61. Auraptene Is an Inhibitor of Cholesterol Esterification and a Modulator of Estrogen Receptors
  62. Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
  63. Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: From molecular modeling to in vivo evaluation
  64. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins
  65. Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting
  66. Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases
  67. Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism
  68. Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion
  69. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism
  70. Insights into the Cholecystokinin 2 Receptor Binding Site and Processes of Activation
  71. The Prototypical Inhibitor of Cholesterol Esterification, Sah 58-035 [3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], Is an Agonist of Estrogen Receptors
  72. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways
  73. Synthesis and Biological Properties of New Stilbene Derivatives of Resveratrol as New Selective Aryl Hydrocarbon Modulators
  74. Molecular Characterization of the Microsomal Tamoxifen Binding Site
  75. Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells
  76. High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor
  77. Identification of Tyrosine 189 and Asparagine 358 of the Cholecystokinin 2 Receptor in Direct Interaction with the Crucial C-Terminal Amide of Cholecystokinin by Molecular Modeling, Site-Directed Mutagenesis, and Structure/Affinity Studies
  78. Contrasting Effects of Prenyltransferase Inhibitors on Estrogen-Dependent Cell Cycle Progression and Estrogen Receptor-Mediated Transcriptional Activity in MCF-7 Cells
  79. Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells
  80. Identification of Two Tamoxifen Target Proteins by Photolabeling with 4-(2-Morpholinoethoxy)benzophenone
  81. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor
  82. Different populations of progesterone receptor–steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity
  83. Characterization of the Membranous Antiestrogen Binding Protein: I Partial purification of the protein in its active state
  84. Characterization of the Membranous Antiestrogen Binding Protein: II Purification to homogeneity
  85. Characterization of a benzyl-phenoxy-ethanamine binding protein in Trypanosoma equiperdum and the possible relation between binding affinity and trypanocidal activity
  86. Cytosolic Type II Estrogen Binding Site in Rat Uterus: Specific Photolabeling with Estrone
  87. The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not
  88. Further evidence for a biological role of anti-estrogen-binding sites in mediating the growth inhibitory action of diphenylmethane derivatives