All Stories

  1. Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus

    Article • Science Translational Medicine, May 2025, American Association for the Advancement of Science

    Dr Francesca Finetti

  2. IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B

    Article • Cell Death and Disease, May 2025, Springer Science + Business Media

    Dr Francesca Finetti

  3. Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles

    Article • Proceedings of the National Academy of Sciences, February 2025, Proceedings of the National Academy of Sciences

    Michael Dustin, Dr Francesca Finetti

  4. An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation

    Article • Scientific Reports, December 2024, Springer Science + Business Media

    Dr Francesca Finetti

  5. Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

    Article • Cell Death and Disease, February 2024, Springer Science + Business Media

    Dr Francesca Finetti

  6. Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics

    Article • Journal of Cell Science, December 2023, The Company of Biologists

    Dr Francesca Finetti

  7. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

    Article • Journal of Experimental Medicine, November 2022, Rockefeller University Press

    Dr Francesca Finetti

  8. IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Dr Francesca Finetti

  9. The Bardet–Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

    Article • Journal of Cell Science, August 2021, The Company of Biologists

    Dr Francesca Finetti

  10. A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

    Article • Cell Death and Differentiation, July 2021, Springer Science + Business Media

    Dr Francesca Finetti

  11. Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment

    Article • Blood, April 2021, American Society of Hematology

    Dr Francesca Finetti

  12. The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells

    Article • Frontiers in Cell and Developmental Biology, March 2021, Frontiers

    Dr Francesca Finetti

  13. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl

  14. Editorial: Dissecting the Intraflagellar Transport System in Physiology and Disease: Cilia-Related and -Unrelated Roles

    Article • Frontiers in Cell and Developmental Biology, November 2020, Frontiers

    Dr Francesca Finetti

  15. Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC

    Article • Frontiers in Cell and Developmental Biology, March 2020, Frontiers

    Dr Francesca Finetti

  16. Optimization of Organotypic Cultures of Mouse Spleen for Staining and Functional Assays

    Article • Frontiers in Immunology, March 2020, Frontiers

    Dr Francesca Finetti

  17. Emerging Roles of the Intraflagellar Transport System in the Orchestration of Cellular Degradation Pathways

    Article • Frontiers in Cell and Developmental Biology, November 2019, Frontiers

    Dr Francesca Finetti

  18. The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases

    Article • Cell Death and Differentiation, May 2019, Springer Science + Business Media

    Dr Francesca Finetti

  19. A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells

    Article • Frontiers in Immunology, May 2019, Frontiers

    Dr Francesca Finetti

  20. p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

    Article • Haematologica, February 2019, Ferrata Storti Foundation (Haematologica)

    Dr Francesca Finetti

  21. The immunological synapse as a pharmacological target

    Article • Pharmacological Research, June 2018, Elsevier

    Dr Francesca Finetti

  22. Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes

    Article • Frontiers in Immunology, May 2018, Frontiers

    Dr Francesca Finetti

  23. Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange

    Article • F1000Research, October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  24. Faculty of 1000 evaluation for Ciliary extracellular vesicles: txt msg organelles.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  25. Faculty of 1000 evaluation for Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  26. Faculty of 1000 evaluation for Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  27. Faculty of 1000 evaluation for The immune synapse clears and excludes molecules above a size threshold.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  28. Faculty of 1000 evaluation for Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  29. Faculty of 1000 evaluation for Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  30. Faculty of 1000 evaluation for Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  31. Faculty of 1000 evaluation for HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  32. Faculty of 1000 evaluation for B-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  33. Faculty of 1000 evaluation for HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  34. Faculty of 1000 evaluation for Imaging of Cell-Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  35. Faculty of 1000 evaluation for Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  36. Faculty of 1000 evaluation for Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.

    Article • October 2017, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  37. Faculty of 1000 evaluation for Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation.

    Article • October 2016, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  38. Faculty of 1000 evaluation for Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.

    Article • June 2016, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  39. Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set

    Article • Frontiers in Immunology, February 2016, Frontiers

    Dr Francesca Finetti

  40. Faculty of 1000 evaluation for Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion.

    Article • October 2015, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  41. The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse

    Article • Journal of Cell Science, June 2015, The Company of Biologists

    Dr Francesca Finetti

  42. The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis

    Article • Cell Death and Differentiation, March 2015, Nature

    Dr Francesca Finetti

  43. Faculty of 1000 evaluation for Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

    Article • February 2015, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  44. Regulation of Vesicular Traffic at the T Cell Immune Synapse: Lessons from the Primary Cilium

    Article • Traffic, January 2015, Wiley

    Dr Francesca Finetti

  45. Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system

    Article • Journal of Cell Science, February 2014, The Company of Biologists

    Dr Francesca Finetti

  46. Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc

    Article • Cell Death and Disease, February 2014, Nature

    Dr Francesca Finetti

  47. Faculty of 1000 evaluation for Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.

    Article • November 2013, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  48. Faculty of 1000 evaluation for T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.

    Article • January 2013, Faculty of 1000, Ltd.

    Dr Francesca Finetti

  49. Compartmentalization of signaling by vesicular trafficking: a shared building design for the immune synapse and the primary cilium

    Article • Immunological Reviews, December 2012, Wiley

    Dr Francesca Finetti

  50. The Shc Family Protein Adaptor, Rai, Negatively Regulates T Cell Antigen Receptor Signaling by Inhibiting ZAP-70 Recruitment and Activation

    Article • PLOS One, December 2011, PLOS

    Dr Francesca Finetti

  51. The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development

    Article • Journal of Allergy and Clinical Immunology, June 2011, Elsevier

    Dr Francesca Finetti

  52. TheBordetella pertussisadenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse

    Article • Journal of Cell Biology, May 2011, Rockefeller University Press

    Dr Francesca Finetti

  53. TheBordetella pertussisadenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse

    Article • Journal of Experimental Medicine, May 2011, Rockefeller University Press

    Dr Francesca Finetti

  54. Intraflagellar transport: a new player at the immune synapse

    Article • Trends in Immunology, April 2011, Elsevier

    Dr Francesca Finetti

  55. Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia

    Article • Blood, January 2010, American Society of Hematology

    Dr Francesca Finetti

  56. Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters

    Article • Immunological Reviews, November 2009, Wiley

    Dr Francesca Finetti

  57. Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

    Article • Nature Cell Biology, October 2009, Springer Science + Business Media

    Dr Giuseppe Perinetti, Dr Francesca Finetti

  58. The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects inCol6a1−/−myopathic mice

    Article • British Journal of Pharmacology, July 2009, Wiley

    Dr Francesca Finetti

  59. The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity

    Article • Blood, May 2008, American Society of Hematology

    Dr Francesca Finetti

  60. p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis

    Article • Cell Death and Differentiation, June 2006, Nature

    Dr Francesca Finetti

  61. Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein

    Article • Biochemical and Biophysical Research Communications, October 2003, Elsevier

    Dr Francesca Finetti