All Stories

  1. A Potential Role of Natural Bioactive Compounds Found in Food in the Prevention of Idiopathic Parkinson’s Disease

    Article • Nutrients, October 2025, MDPI AG

    Juan Segura-Aguilar

  2. On the Role of Iron in Idiopathic Parkinson’s Disease

    Article • Biomedicines, November 2023, MDPI AG

    Juan Segura-Aguilar

  3. Why are neuromelanin-containing dopaminergic neurons lost in idiopathic Parkinson’s disease?

    Article • Cellular and Molecular Life Sciences, September 2023, Springer Science + Business Media

    Juan Segura-Aguilar

  4. Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease

    Article • Neural Regeneration Research, July 2023, Medknow

    Juan Segura-Aguilar

  5. A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies

    Article • Antioxidants, March 2023, MDPI AG

    Juan Segura-Aguilar

  6. Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase

    Article • Antioxidants, January 2022, MDPI AG

    Juan Segura-Aguilar

  7. Generation of nonviral integration-free human iPS cell line KISCOi001-A from normal human fibroblasts, under defined xeno-free and feeder-free conditions

    Article • Stem Cell Research, March 2021, Elsevier

    Juan Segura-Aguilar

  8. Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes

    Article • Neurotoxicity Research, February 2021, Springer Science + Business Media

    Juan Segura-Aguilar

  9. State and perspectives on flavonoid neuroprotection against aminochrome-induced neurotoxicity

    Article • Neural Regeneration Research, January 2021, Medknow

    Juan Segura-Aguilar

  10. The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity

    Article • Neurotoxicity Research, June 2020, Springer Science + Business Media

    Juan Segura-Aguilar

  11. The importance of choosing a preclinical model that reflects what happens in Parkinson's disease

    Article • Neurochemistry International, June 2019, Elsevier

    Juan Segura-Aguilar

  12. DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells

    Article • Neurotoxicity Research, September 2018, Springer Science + Business Media

    Juan Segura-Aguilar

  13. Can we conclude a potential therapeutic action for Parkinson’s disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?

    Article • Cell Death and Disease, July 2018, Springer Science + Business Media

    Juan Segura-Aguilar

  14. P1‐159: RARE VARIANTS IN PLCG2, ABI3, AND TREM2 GENES ARE ASSOCIATED WITH ALZHEIMER'S DISEASE IN AN ARGENTINIAN SAMPLE: IS IT A EUROPEAN HERITAGE?

    Article • Alzheimer s & Dementia, July 2018, Wiley

    Juan Segura-Aguilar

  15. Comment on: “Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease”

    Article • CNS Drugs, June 2018, Springer Science + Business Media

    Juan Segura-Aguilar

  16. Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures

    Article • NeuroToxicology, May 2018, Elsevier

    Juan Segura-Aguilar

  17. Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease

    Article • Frontiers in Neuroscience, March 2018, Frontiers

    Juan Segura-Aguilar

  18. Neurotoxins as Preclinical Models for Parkinson’s Disease

    Article • Neurotoxicity Research, January 2018, Springer Science + Business Media

    Juan Segura-Aguilar

  19. KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity

    Article • Neurotoxicity Research, January 2018, Springer Science + Business Media

    Juan Segura-Aguilar

  20. The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-Induced Mitochondrial Damage

    Article • ACS Chemical Neuroscience, August 2017, American Chemical Society (ACS)

    Juan Segura-Aguilar

  21. Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

    Article • Progress in Neurobiology, August 2017, Elsevier

    Juan Segura-Aguilar

  22. Aminochrome induces microglia and astrocyte activation

    Article • Toxicology in Vitro, August 2017, Elsevier

    Juan Segura-Aguilar

  23. Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome)

    Article • Neurotoxicity Research, July 2017, Springer Science + Business Media

    Juan Segura-Aguilar

  24. Aminochrome as preclinical model for Parkinson's disease

    Article • Oncotarget, June 2017, Impact Journals, LLC

    Juan Segura-Aguilar

  25. Commentary: Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?

    Article • Frontiers in Neuroanatomy, May 2017, Frontiers

    Juan Segura-Aguilar

  26. DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers

    Article • Neurotoxicity Research, May 2017, Springer Science + Business Media

    Juan Segura-Aguilar

  27. New preclinical model are required to discover neuroprotective compound in Parkinson’s disease

    Article • Pharmacological Research, May 2017, Elsevier

    Juan Segura-Aguilar

  28. On the Role of Mining Exposure in Epigenetic Effects in Parkinson’s Disease

    Article • Neurotoxicity Research, April 2017, Springer Science + Business Media

    Juan Segura-Aguilar

  29. On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo

    Article • Neurotoxicity Research, March 2017, Springer Science + Business Media

    Juan Segura-Aguilar

  30. Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson’s Disease?

    Article • ACS Chemical Neuroscience, March 2017, American Chemical Society (ACS)

    Juan Segura-Aguilar

  31. Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite)

    Article • Anais da Academia Brasileira de Ciências, March 2017, FapUNIFESP (SciELO)

    Juan Segura-Aguilar

  32. On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease

    Article • Neural Regeneration Research, January 2017, Medknow

    Juan Segura-Aguilar

  33. Corrigendum: Commentary: Evaluation of Models of Parkinson's Disease

    Article • Frontiers in Neuroscience, July 2016, Frontiers

    Juan Segura-Aguilar

  34. DT-diaphorase protects astrocytes from aminochrome-induced toxicity

    Article • NeuroToxicology, July 2016, Elsevier

    Juan Segura-Aguilar

  35. Commentary: A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease

    Article • Frontiers in Pharmacology, June 2016, Frontiers

    Juan Segura-Aguilar

  36. Commentary: Evaluation of Models of Parkinson's Disease

    Article • Frontiers in Neuroscience, April 2016, Frontiers

    Juan Segura-Aguilar

  37. Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease

    Article • Cellular and Molecular Life Sciences, March 2016, Springer Science + Business Media

    Juan Segura-Aguilar

  38. Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases

    Article • Neurotoxicity Research, March 2016, Springer Science + Business Media

    Juan Segura-Aguilar

  39. Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson’s Disease

    Article • Current Medicinal Chemistry, February 2016, Bentham Science Publishers

    Juan Segura-Aguilar

  40. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl

  41. The need of a new and more physiological preclinical model for Parkinson’s disease

    Article • Cellular and Molecular Life Sciences, January 2016, Springer Science + Business Media

    Juan Segura-Aguilar

  42. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla

  43. Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

    Article • Neurotoxicity Research, September 2015, Springer Science + Business Media

    Juan Segura-Aguilar

  44. Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update

    Article • Neurotoxicity Research, January 2015, Springer Science + Business Media

    Juan Segura-Aguilar

  45. DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

    Article • Toxicological Sciences, January 2015, Oxford University Press (OUP)

    Juan Segura-Aguilar

  46. A new mechanism for protection of dopaminergic neurons mediated by astrocytes

    Article • Neural Regeneration Research, January 2015, Medknow

    Juan Segura-Aguilar

  47. Molecular and Neurochemical Mechanisms Dopamine Oxidation To O-Quinones in Parkinson’s Disease Pathogenesis

    Article • January 2015, Springer Science + Business Media

    Juan Segura-Aguilar

  48. Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

    Article • Neurotoxicity Research, November 2014, Springer Science + Business Media

    Juan Segura-Aguilar

  49. Protective and toxic roles of dopamine in Parkinson's disease

    Article • Journal of Neurochemistry, March 2014, Wiley

    Juan Segura-Aguilar

  50. Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

    Article • Autophagy, January 2014, Taylor & Francis

    Juan Segura-Aguilar

  51. Advances in Stem Cell Research for Parkinson Disease

    Article • January 2014, Springer Science + Business Media

    Juan Segura-Aguilar

  52. Dopamine and L-dopa as Selective Endogenous Neurotoxins

    Article • January 2014, Springer Science + Business Media

    Juan Segura-Aguilar

  53. Mechanisms of Dopamine Oxidation and Parkinson’s Disease

    Article • January 2014, Springer Science + Business Media

    Juan Segura-Aguilar

  54. RCSN Cell System for Identifying Dopaminergic Neurotoxicity

    Article • January 2014, Springer Science + Business Media

    Juan Segura-Aguilar

  55. One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity

    Article • Neurotoxicity Research, February 2013, Springer Science + Business Media

    Juan Segura-Aguilar

  56. Frequency of the D620N Mutation in VPS35 in Parkinson Disease

    Article • Archives of Neurology, October 2012, American Medical Association (AMA)

    Juan Segura-Aguilar

  57. Erratum to: Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

    Article • Neurotoxicity Research, August 2012, Springer Science + Business Media

    Juan Segura-Aguilar

  58. Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2012, Elsevier

    Juan Segura-Aguilar

  59. Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

    Article • Neurotoxicity Research, April 2012, Springer Science + Business Media

    Juan Segura-Aguilar

  60. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Professor Godefridus J Peters, Professor Brigitte Galliot, Professor Luca Scorrano

  61. Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

    Article • Human Molecular Genetics, February 2012, Oxford University Press (OUP)

    Juan Segura-Aguilar

  62. The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

    Article • BioMetals, February 2012, Springer Science + Business Media

    Juan Segura-Aguilar

  63. Dopamine Oxidation and Autophagy

    Article • Parkinson s Disease, January 2012, Wiley

    Juan Segura-Aguilar

  64. The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease

    Article • January 2012, Springer Science + Business Media

    Juan Segura-Aguilar

  65. Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome

    Article • Neurotoxicity Research, December 2011, Springer Science + Business Media

    Juan Segura-Aguilar

  66. Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

    Article • Parkinsonism & Related Disorders, September 2011, Elsevier

    Professor Carles Vilarino-Guell, Juan Segura-Aguilar

  67. ChemInform Abstract: The Role of Metal Ions in Dopaminergic Neuron Degeneration in Parkinsonism and Parkinson′s Disease

    Article • ChemInform, July 2011, Wiley

    Juan Segura-Aguilar

  68. The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease

    Article • Monatshefte für Chemie - Chemical Monthly, March 2011, Springer Science + Business Media

    Juan Segura-Aguilar

  69. Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line

    Article • Toxicological Sciences, March 2011, Oxford University Press (OUP)

    Juan Segura-Aguilar

  70. Catecholaminergic Cell Lines for the Study of Dopamine Metabolism and Neurotoxicity

    Article • January 2011, Springer Science + Business Media

    Juan Segura-Aguilar

  71. Association of Parkinson disease to PARK16 in a Chilean sample

    Article • Parkinsonism & Related Disorders, January 2011, Elsevier

    Juan Segura-Aguilar

  72. Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity

    Article • Chemical Research in Toxicology, July 2010, American Chemical Society (ACS)

    Juan Segura-Aguilar

  73. Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

    Article • Neurotoxicity Research, February 2010, Springer Science + Business Media

    Juan Segura-Aguilar

  74. Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

    Article • Neurotoxicity Research, January 2010, Springer Science + Business Media

    Juan Segura-Aguilar

  75. Diagnóstico genético disponible para la enfermedad de huntington en chile

    Article • Revista médica de Chile, August 2009, SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)

    Juan Segura-Aguilar

  76. IV Neurotoxicity Society Meeting: Neurochemical Mechanisms of Neurodegenerative Disorders

    Article • Neurotoxicity Research, June 2009, Springer Science + Business Media

    Juan Segura-Aguilar

  77. Molecular and Neurochemical Mechanisms in PD Pathogenesis

    Article • Neurotoxicity Research, May 2009, Springer Science + Business Media

    Juan Segura-Aguilar

  78. Copper·Dopamine Complex Induces Mitochondrial Autophagy Preceding Caspase-independent Apoptotic Cell Death

    Article • Journal of Biological Chemistry, March 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Juan Segura-Aguilar

  79. Chapter 4 Molecular Aspects of Neurotoxins in Dopaminergic Neurons

    Article • January 2009, Elsevier

    Juan Segura-Aguilar

  80. The catecholaminergic RCSN-3 cell line: A model to study dopamine metabolism

    Article • Neurotoxicity Research, September 2008, Springer Science + Business Media

    Juan Segura-Aguilar

  81. Copper Neurotoxicity in Rat Substantia Nigra and Striatum Is Dependent on DT-Diaphorase Inhibition

    Article • Chemical Research in Toxicology, June 2008, American Chemical Society (ACS)

    Juan Segura-Aguilar

  82. Erratum

    Article • Drug Development and Industrial Pharmacy, January 2008, Taylor & Francis

    Juan Segura-Aguilar

  83. Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

    Article • Experimental Neurology, January 2008, Elsevier

    Juan Segura-Aguilar

  84. Botulinum neurotoxin: Evolution from poison, to research tool - onto medicinal therapeutic and future pharmaceutical panacea

    Article • Neurotoxicity Research, December 2007, Springer Science + Business Media

    Juan Segura-Aguilar

  85. Lrrk2 mutations in South America: A study of Chilean Parkinson's disease

    Article • Neuroscience Letters, July 2007, Elsevier

    Juan Segura-Aguilar

  86. Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson’s disease

    Article • Neurotoxicity Research, June 2007, Springer Science + Business Media

    Juan Segura-Aguilar

  87. Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component

    Article • Neuroscience Letters, May 2007, Elsevier

    Juan Segura-Aguilar

  88. Inhibition of VMAT-2 and DT-Diaphorase Induce Cell Death in a Substantia Nigra-Derived Cell LineAn Experimental Cell Model for Dopamine Toxicity Studies

    Article • Chemical Research in Toxicology, May 2007, American Chemical Society (ACS)

    Juan Segura-Aguilar

  89. Neurotoxins and neurotoxicity mechanisms. an overview

    Article • Neurotoxicity Research, September 2006, Springer Science + Business Media

    Juan Segura-Aguilar

  90. Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

    Article • Journal of Neuroscience Research, January 2006, Wiley

    Juan Segura-Aguilar

  91. Dopamine-Dependent Iron Toxicity in Cells Derived from Rat Hypothalamus

    Article • Chemical Research in Toxicology, March 2005, American Chemical Society (ACS)

    Juan Segura-Aguilar

  92. Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

    Article • Journal of Neurochemistry, February 2005, Wiley

    Juan Segura-Aguilar

  93. Cell Lines as In Vitro Models for Drug Screening and Toxicity Studies

    Article • Drug Development and Industrial Pharmacy, January 2005, Taylor & Francis

    Juan Segura-Aguilar

  94. On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation

    Article • Neurobiology of Disease, July 2004, Elsevier

    Juan Segura-Aguilar

  95. Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor

    Article • Pharmacology Biochemistry and Behavior, February 2004, Elsevier

    Juan Segura-Aguilar

  96. Neurotoxins and neurotoxic species implicated in neurodegeneration

    Article • Neurotoxicity Research, January 2004, Springer Science + Business Media

    Juan Segura-Aguilar

  97. Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats

    Article • Neurotoxicity Research, January 2003, Springer Science + Business Media

    Juan Segura-Aguilar

  98. Inhibition of DT-Diaphorase potentiates thein vivo neurotoxic effect of intranigral injection of salsolinol in rats

    Article • Neurotoxicity Research, January 2003, Springer Science + Business Media

    Juan Segura-Aguilar

  99. MPP+-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity

    Article • Neurotoxicity Research, January 2003, Springer Science + Business Media

    Juan Segura-Aguilar

  100. Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. A review

    Article • Neurotoxicity Research, January 2003, Springer Science + Business Media

    Juan Segura-Aguilar

  101. Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra

    Article • Pharmacology Biochemistry and Behavior, November 2002, Elsevier

    Juan Segura-Aguilar

  102. Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

    Article • Journal of Neuroscience Research, March 2002, Wiley

    Juan Segura-Aguilar

  103. Neurotoxicological and neuroprotective elements in Parkinson’s disease

    Article • Neurotoxicity Research, January 2002, Springer Science + Business Media

    Juan Segura-Aguilar

  104. Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour

    Article • Neurotoxicity Research, January 2002, Springer Science + Business Media

    Juan Segura-Aguilar

  105. Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture

    Article • Neurotoxicity Research, January 2002, Springer Science + Business Media

    Juan Segura-Aguilar

  106. Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

    Article • Journal of Neurochemistry, December 2001, Wiley

    Juan Segura-Aguilar

  107. Possible Role of Salsolinol Quinone Methide in the Decrease of RCSN-3 Cell Survival

    Article • Biochemical and Biophysical Research Communications, May 2001, Elsevier

    Juan Segura-Aguilar

  108. THE PRICE OF DEVELOPMENT IN CHILE

    Article • Neuroreport, March 2001, Wolters Kluwer Health

    Juan Segura-Aguilar

  109. The possible role of one-electron reduction of aminochrome in the neurodegenerative process of the dopaminergic system

    Article • Neurotoxicity Research, March 2001, Springer Science + Business Media

    Juan Segura-Aguilar

  110. Glutathione Transferase M2-2 Catalyzes Conjugation of Dopamine and Dopa o-Quinones

    Article • Biochemical and Biophysical Research Communications, July 2000, Elsevier

    Juan Segura-Aguilar

  111. Reduction of Brain Antioxidant Defense Upon Treatment with Butylated Hydroxyanisole (BHA) and Sudan III in Syrian Golden Hamster

    Article • Neurochemical Research, March 2000, Springer Science + Business Media

    Juan Segura-Aguilar

  112. Regioselectivity and Reversibility of the Glutathione Conjugation of Quercetin Quinone Methide

    Article • Chemical Research in Toxicology, March 2000, American Chemical Society (ACS)

    Juan Segura-Aguilar

  113. Article • Molecular and Cellular Biochemistry, January 2000, Springer Science + Business Media

    Juan Segura-Aguilar

  114. Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

    Article • Cancer Letters, November 1999, Elsevier

    Juan Segura-Aguilar

  115. Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers

    Article • Pharmaceutical Research, May 1999, Springer Science + Business Media

    Juan Segura-Aguilar

  116. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

    Article • Free Radical Biology and Medicine, January 1999, Elsevier

    Juan Segura-Aguilar

  117. DT-diaphorase catalyzes N-denitration and redox cycling of tetryl

    Article • FEBS Letters, October 1998, Wiley

    Juan Segura-Aguilar

  118. Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 1998, Elsevier

    Juan Segura-Aguilar

  119. Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

    Article • FEBS Letters, May 1998, Wiley

    Juan Segura-Aguilar

  120. Nitrobenzimidazoles as Substrates for DT-Diaphorase and Redox Cycling Compounds: Their Enzymatic Reactions and Cytotoxicity

    Article • Archives of Biochemistry and Biophysics, October 1997, Elsevier

    Juan Segura-Aguilar

  121. Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

    Article • Biochemical Journal, May 1997, Portland Press Ltd.

    Juan Segura-Aguilar

  122. Effects of Four Organohalogen Environmental Contaminants on Cytochrome P450 Forms That Catalyze 4- and 2-Hydroxylation of Estradiol in the Rat Liver

    Article • Biochemical and Molecular Medicine, April 1997, Elsevier

    Juan Segura-Aguilar

  123. Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome

    Article • Journal of Biological Chemistry, February 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Juan Segura-Aguilar

  124. The two-electron quinone reductase DT-diaphorase generates and maintains the antioxidant (reduced) form of coenzyme Q in membranes

    Article • Molecular Aspects of Medicine, January 1997, Elsevier

    Juan Segura-Aguilar

  125. DT-Diaphorase Maintains the Reduced State of Ubiquinones in Lipid Vesicles thereby Promoting their Antioxidant Function

    Article • Free Radical Biology and Medicine, January 1997, Elsevier

    Juan Segura-Aguilar

  126. Peroxidase Activity of Liver Microsomal Vitamin D 25-Hydroxylase and Cytochrome P450 1A2 Catalyzes 25-Hydroxylation of Vitamin D3and Oxidation of Dopamine to Aminochrome

    Article • Biochemical and Molecular Medicine, June 1996, Elsevier

    Juan Segura-Aguilar

  127. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems.

    Article • Proceedings of the National Academy of Sciences, March 1996, Proceedings of the National Academy of Sciences

    Juan Segura-Aguilar

  128. Effects of Superoxide Dismutase and Catalase during Reduction of Adrenochrome by DT-Diaphorase and NADPH-Cytochrome P450 Reductase

    Article • Biochemical and Molecular Medicine, October 1995, Elsevier

    Juan Segura-Aguilar

  129. Studies on the mode of action of the herbicidal effect of 2,4,5-trichlorophenoxyacetic acid on germinating Norway spruce

    Article • Environmental and Experimental Botany, July 1995, Elsevier

    Juan Segura-Aguilar

  130. Superoxide Dismutase and Catalase Enhance Autoxidation during One-Electron Reduction of Aminochrome by NADPH-Cytochrome P-450 Reductase

    Article • Biochemical and Molecular Medicine, February 1995, Elsevier

    Juan Segura-Aguilar

  131. Superoxide dismutase and catalase prevent the formation of reactive oxygen species during reduction of cyclized dopa ortho-quinone by DT-diaphorase

    Article • Chemico-Biological Interactions, November 1994, Elsevier

    Juan Segura-Aguilar

  132. The protective effect of superoxide dismutase and catalase against formation of reactive oxygen species during reduction of cyclized norepinephrine ortho-quinone of DT-diaphorase

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 1994, Elsevier

    Juan Segura-Aguilar

  133. Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours

    Article • Carcinogenesis, January 1994, Oxford University Press (OUP)

    Juan Segura-Aguilar

  134. A new direct method for determining superoxide dismutase activity by measuring hydrogen peroxide formation

    Article • Chemico-Biological Interactions, January 1993, Elsevier

    Juan Segura-Aguilar

  135. The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination

    Article • PLANT PHYSIOLOGY, December 1992, American Society of Plant Biologists (ASPB)

    Juan Segura-Aguilar

  136. The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)

    Article • Leukemia Research, June 1992, Elsevier

    Juan Segura-Aguilar

  137. Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, March 1992, Elsevier

    Juan Segura-Aguilar

  138. Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

    Article • Neurochemical Research, February 1991, Springer Science + Business Media

    Juan Segura-Aguilar

  139. Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

    Article • Neurotoxicology and Teratology, November 1990, Elsevier

    Juan Segura-Aguilar

  140. The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters

    Article • Carcinogenesis, January 1990, Oxford University Press (OUP)

    Juan Segura-Aguilar

  141. On the mechanism of the Mn3+-induced neurotoxicity of dopamine: Prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

    Article • Chemico-Biological Interactions, January 1989, Elsevier

    Juan Segura-Aguilar

  142. DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

    Article • Free Radical Biology and Medicine, January 1988, Elsevier

    Juan Segura-Aguilar

  143. Effect of superoxide dismutase on the autoxidation of various hydroquinones—A possible role of superoxide dismutase as a superoxide: Semiquinone oxidoreductase

    Article • Free Radical Biology and Medicine, January 1988, Elsevier

    Juan Segura-Aguilar

  144. DT-diaphorase-catalyzed two electron reduction of quinone epoxides

    Article • Free Radical Biology and Medicine, January 1987, Elsevier

    Juan Segura-Aguilar

  145. Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

    Article • Archives of Biochemistry and Biophysics, November 1986, Elsevier

    Juan Segura-Aguilar