All Stories

  1. Functionalized Lipid Nanoparticles for Targeted RNA Delivery in Immune and Inflammatory Diseases
  2. Insights into the membrane repair mechanism by the coiled-coil-mediated oligomerization of TRIM72
  3. Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
  4. Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
  5. Activatable PROTAC nanoassembly for photodynamic PTP1B proteolysis enhances glioblastoma immunotherapy
  6. Revisiting the structure of UBR box from human UBR6
  7. Author Correction: NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  8. Deciphering ligand and metal ion dependent intricate folding landscape of Vc2 c-di-GMP riboswitch aptamer
  9. NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  10. Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
  11. NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  12. Deciphering the role of the hendecad-repeat coiled-coil domain of TRIM72 in membrane curvature recognition
  13. SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
  14. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  15. Quo Vadis Experimental Structural Biology?
  16. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  17. Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates
  18. Structural insights into ClpP protease side exit pore‐opening by a pH drop coupled with substrate hydrolysis
  19. LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
  20. Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway
  21. Crystal structure of yeast Gid10 in complex with Pro/N-degron
  22. Dynamics and Entropy of Cyclohexane Rings Control pH-Responsive Reactivity
  23. Opening the side exit pores of ClpP by lowering the pH of proteolytic chamber coupled with substrate hydrolysis
  24. Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction
  25. Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes
  26. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
  27. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  28. Structural basis for the N‐degron specificity of ClpS1 from Arabidopsis thaliana
  29. Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis
  30. TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages
  31. Enhancing Protein Crystallization under a Magnetic Field
  32. Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway
  33. Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway
  34. Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant
  35. A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser
  36. Structural and Mechanistic Insights into Caffeine Degradation by the Bacterial N-Demethylase Complex
  37. Structural studies of a novel ubiquitin-modifying enzyme, SdeA, using various tools
  38. Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
  39. MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity
  40. eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle
  41. A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
  42. pH-dependent regulation of SQSTM1/p62 during autophagy
  43. Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
  44. The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation
  45. Structural insight into degradation mechanism of N-end rule substrates by p62/SQSTM1 selective autophagy adaptor
  46. Structural and Biochemical Study of the Mono ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila
  47. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
  48. Unveiling the pathway to Z-DNA in the protein-induced B–Z transition
  49. Structural Studies of Peptide Binding Interaction of HCV IRES Domain IV
  50. A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ
  51. An assessment tool for determination of coiled-coil orientation
  52. ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils
  53. Structural Characterization of RNA Recognition Motif-2 Domain of SART3
  54. The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane
  55. Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway
  56. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism
  57. Structural Characterization of pre-miRNA 155
  58. A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain
  59. Structure biology of selective autophagy receptors
  60. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  61. Structural stability of CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  62. Mitochondrial ATP synthase activity is impaired by suppressed O -GlcNAcylation in Alzheimer's disease
  63. mTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment
  64. A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation
  65. Swapping of interaction partners with ATG5 for autophagosome maturation
  66. PEA-15 facilitates EGFR dephosphorylation
  67. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners
  68. eIF4AIII enhances translation of nuclear cap-binding complex–bound mRNAs by promoting disruption of secondary structures in 5′UTR
  69. Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase
  70. Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 fromSaccharomyces cerevisiae
  71. Insights into the Molecular Evolution of HslU ATPase through Biochemical and Mutational Analyses
  72. Expansion of the clinicopathological and mutational spectrum of Perry syndrome
  73. In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe
  74. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
  75. Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma brucei
  76. Change in single cystathionine β-synthase domain-containing protein from a bent to flat conformation upon adenosine monophosphate binding
  77. Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice
  78. Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8
  79. Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases
  80. Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana
  81. Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20
  82. Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism
  83. Structure of the autophagic E2 enzyme Atg10
  84. Crystal structure ofPyrococcus furiosusPF2050, a member of the DUF2666 protein family
  85. Correction
  86. Structural insights into the conformational diversity of ClpP from Bacillus subtilis
  87. Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
  88. Single Cystathionine  -Synthase Domain-Containing Proteins Modulate Development by Regulating the Thioredoxin System in Arabidopsis
  89. Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome
  90. Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  91. Crystal structures of two CBSX proteins fromArabidopsis thaliana
  92. Structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) fromHaloferax volcanii
  93. Corrigendum to “Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii” [Biochem. Biophys. Res. Commun. 405 (2011) 112–117]
  94. Crystal Structure of a Coiled-Coil Domain from Human ROCK I
  95. Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii
  96. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
  97. Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing
  98. Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins
  99. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
  100. A simple technique to convert sitting-drop vapor diffusion into hanging-drop vapor diffusion by solidifying the reservoir solution with agarose
  101. Biochemical and structural characterization of 5′-methylthioadenosine nucleosidases from Arabidopsis thaliana
  102. Conformational Change of ClpP from Bacillus subtilis Characterized by Electron Microscopic study
  103. Crystal structure of PRY-SPRY domain of human TRIM72
  104. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy
  105. Real-time imaging of NF-AT nucleocytoplasmic shuttling with a photoswitchable fluorescence protein in live cells
  106. A preliminary crystallographic study of CDCP2 fromArabidopsis thaliana
  107. Structural and biochemical characterization of ClpP fromBacillus subtilis
  108. Structural comparison of 5′-methylthioadenosine nucleosidases fromArabidopsis thaliana
  109. Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine β-synthase domain-containing protein, CDCP2, fromArabidopsis thaliana
  110. A Role for a Menthone Reductase in Resistance against Microbial Pathogens in Plants
  111. A degradation signal recognition in prokaryotes
  112. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy
  113. Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay
  114. The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding
  115. Structural Basis of SspB-tail Recognition by the Zinc Binding Domain of ClpX
  116. Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S
  117. STAM–AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH
  118. Crystal structure of 5′-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-Å resolution
  119. Crystal Structure of the FERM Domain of Focal Adhesion Kinase
  120. Characterization of the HslU chaperone affinity for HslV protease
  121. Crystal Structure of the Bowman–Birk Inhibitor from Barley Seeds in Ternary Complex with Porcine Trypsin
  122. Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair
  123. Proteomics-based Target Identification: BENGAMIDES AS A NEW CLASS OF METHIONINE AMINOPEPTIDASE INHIBITORS
  124. Structural Basis of Degradation Signal Recognition by SspB, a Specificity-Enhancing Factor for the ClpXP Proteolytic Machine
  125. Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
  126. Homotetrameric Structure of the SNAP-23 N-terminal Coiled-coil Domain
  127. SAP couples Fyn to SLAM immune receptors
  128. Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV
  129. Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)
  130. Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor
  131. Crystal Structure of Klebsiella aerogenesUreE, a Nickel-binding Metallochaperone for Urease Activation
  132. The Quaternary Arrangement of HslU and HslV in a Cocrystal: A Response to Wang, Yale
  133. Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography
  134. Mutational studies on HslU and its docking mode with HslV
  135. Docking of components in a bacterial complex
  136. Nucleoside diphosphate kinase from the hyperthermophilic archaeonMethanococcus jannaschii: overexpression, crystallization and preliminary X-ray crystallographic analysis
  137. Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family
  138. Crystallization and preliminary X-ray crystallographic analysis ofEscherichia coliCyaY, a structural homologue of human frataxin
  139. Crystallization and preliminary X-ray diffraction analysis ofSaccharomyces cerevisiaeYgr203p, a homologue of Acr2 arsenate reductase
  140. Crystallization and preliminary X-ray crystallographic analysis of human nucleoside diphosphate kinase A
  141. Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications
  142. Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae
  143. Crystal structure of a 16 kda double-headed bowman-birk trypsin inhibitor from barley seeds at 1.9 Å resolution
  144. Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction
  145. Crystallization and preliminary X-ray analysis of a complex between the Bowman–Birk trypsin inhibitor from barley and porcine pancreatic trypsin
  146. Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin in complex with chymotrypsin
  147. Crystallization and preliminary X-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage T4
  148. Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex
  149. A thermostable xylose isomerase fromThermus caldophilus: biochemical characterization, crystallization and preliminary X-ray analysis
  150. Preliminary X-ray crystallographic analysis of Bowman–Birk trypsin inhibitor from barley seeds
  151. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator
  152. Crystal structure of carboxylesterase from Pseudomonas fluorescens, an α/β hydrolase with broad substrate specificity
  153. The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor
  154. Crystal structure analyses of uncomplexed ecotin in two crystal forms: Implications for its function and stability
  155. Crystal structure of the complex of porcine pancreatic trypsin with Kunitz-type soybean trypsin inhibitor
  156. Refined Structure of the Chitinase from Barley Seeds at 2.0 Å Resolution
  157. Crystal structure of Bacillus licheniformis α-Amylase at 1.7resolution
  158. Crystal structure of an uncleaved α 1 -antitrypsin reveals the conformation of its inhibitory reactive loop
  159. Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase fromThermus aquaticus
  160. Crystallization, molecular replacement solution, and refinement of tetrameric β-amylase from sweet potato
  161. Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds
  162. Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds