All Stories

  1. The anatomical compartment defines distinct immune remodeling within human visceral adipose tissue during aging
  2. Functionalized Lipid Nanoparticles for Targeted RNA Delivery in Immune and Inflammatory Diseases
  3. Insights into the membrane repair mechanism by the coiled-coil-mediated oligomerization of TRIM72
  4. Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
  5. Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
  6. Activatable PROTAC nanoassembly for photodynamic PTP1B proteolysis enhances glioblastoma immunotherapy
  7. Revisiting the structure of UBR box from human UBR6
  8. Author Correction: NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  9. Deciphering ligand and metal ion dependent intricate folding landscape of Vc2 c-di-GMP riboswitch aptamer
  10. NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  11. Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
  12. NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
  13. Deciphering the role of the hendecad-repeat coiled-coil domain of TRIM72 in membrane curvature recognition
  14. SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
  15. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  16. Quo Vadis Experimental Structural Biology?
  17. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  18. Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates
  19. Structural insights into ClpP protease side exit pore‐opening by a pH drop coupled with substrate hydrolysis
  20. LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
  21. Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway
  22. Crystal structure of yeast Gid10 in complex with Pro/N-degron
  23. Dynamics and Entropy of Cyclohexane Rings Control pH-Responsive Reactivity
  24. Opening the side exit pores of ClpP by lowering the pH of proteolytic chamber coupled with substrate hydrolysis
  25. Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction
  26. Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes
  27. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
  28. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  29. Structural basis for the N‐degron specificity of ClpS1 from Arabidopsis thaliana
  30. Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis
  31. TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages
  32. Enhancing Protein Crystallization under a Magnetic Field
  33. Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway
  34. Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway
  35. Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant
  36. A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser
  37. Structural and Mechanistic Insights into Caffeine Degradation by the Bacterial N-Demethylase Complex
  38. Structural studies of a novel ubiquitin-modifying enzyme, SdeA, using various tools
  39. Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
  40. MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity
  41. eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle
  42. A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
  43. pH-dependent regulation of SQSTM1/p62 during autophagy
  44. Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
  45. The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation
  46. Structural insight into degradation mechanism of N-end rule substrates by p62/SQSTM1 selective autophagy adaptor
  47. Structural and Biochemical Study of the Mono ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila
  48. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
  49. Unveiling the pathway to Z-DNA in the protein-induced B–Z transition
  50. Structural Studies of Peptide Binding Interaction of HCV IRES Domain IV
  51. A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ
  52. An assessment tool for determination of coiled-coil orientation
  53. ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils
  54. Structural Characterization of RNA Recognition Motif-2 Domain of SART3
  55. The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane
  56. Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway
  57. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism
  58. Structural Characterization of pre-miRNA 155
  59. A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain
  60. Structure biology of selective autophagy receptors
  61. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  62. Structural stability of CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  63. Mitochondrial ATP synthase activity is impaired by suppressed O -GlcNAcylation in Alzheimer's disease
  64. mTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment
  65. A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation
  66. Swapping of interaction partners with ATG5 for autophagosome maturation
  67. PEA-15 facilitates EGFR dephosphorylation
  68. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners
  69. eIF4AIII enhances translation of nuclear cap-binding complex–bound mRNAs by promoting disruption of secondary structures in 5′UTR
  70. Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase
  71. Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 fromSaccharomyces cerevisiae
  72. Insights into the Molecular Evolution of HslU ATPase through Biochemical and Mutational Analyses
  73. Expansion of the clinicopathological and mutational spectrum of Perry syndrome
  74. In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe
  75. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
  76. Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma brucei
  77. Change in single cystathionine β-synthase domain-containing protein from a bent to flat conformation upon adenosine monophosphate binding
  78. Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice
  79. Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8
  80. Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases
  81. Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana
  82. Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20
  83. Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism
  84. Structure of the autophagic E2 enzyme Atg10
  85. Crystal structure ofPyrococcus furiosusPF2050, a member of the DUF2666 protein family
  86. Correction
  87. Structural insights into the conformational diversity of ClpP from Bacillus subtilis
  88. Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
  89. Single Cystathionine  -Synthase Domain-Containing Proteins Modulate Development by Regulating the Thioredoxin System in Arabidopsis
  90. Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome
  91. Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  92. Crystal structures of two CBSX proteins fromArabidopsis thaliana
  93. Structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) fromHaloferax volcanii
  94. Corrigendum to “Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii” [Biochem. Biophys. Res. Commun. 405 (2011) 112–117]
  95. Crystal Structure of a Coiled-Coil Domain from Human ROCK I
  96. Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii
  97. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
  98. Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing
  99. Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins
  100. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
  101. A simple technique to convert sitting-drop vapor diffusion into hanging-drop vapor diffusion by solidifying the reservoir solution with agarose
  102. Biochemical and structural characterization of 5′-methylthioadenosine nucleosidases from Arabidopsis thaliana
  103. Conformational Change of ClpP from Bacillus subtilis Characterized by Electron Microscopic study
  104. Crystal structure of PRY-SPRY domain of human TRIM72
  105. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy
  106. Real-time imaging of NF-AT nucleocytoplasmic shuttling with a photoswitchable fluorescence protein in live cells
  107. A preliminary crystallographic study of CDCP2 fromArabidopsis thaliana
  108. Structural and biochemical characterization of ClpP fromBacillus subtilis
  109. Structural comparison of 5′-methylthioadenosine nucleosidases fromArabidopsis thaliana
  110. Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine β-synthase domain-containing protein, CDCP2, fromArabidopsis thaliana
  111. A Role for a Menthone Reductase in Resistance against Microbial Pathogens in Plants
  112. A degradation signal recognition in prokaryotes
  113. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy
  114. Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay
  115. The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding
  116. Structural Basis of SspB-tail Recognition by the Zinc Binding Domain of ClpX
  117. Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S
  118. STAM–AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH
  119. Crystal structure of 5′-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-Å resolution
  120. Crystal Structure of the FERM Domain of Focal Adhesion Kinase
  121. Characterization of the HslU chaperone affinity for HslV protease
  122. Crystal Structure of the Bowman–Birk Inhibitor from Barley Seeds in Ternary Complex with Porcine Trypsin
  123. Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair
  124. Proteomics-based Target Identification: BENGAMIDES AS A NEW CLASS OF METHIONINE AMINOPEPTIDASE INHIBITORS
  125. Structural Basis of Degradation Signal Recognition by SspB, a Specificity-Enhancing Factor for the ClpXP Proteolytic Machine
  126. Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
  127. Homotetrameric Structure of the SNAP-23 N-terminal Coiled-coil Domain
  128. SAP couples Fyn to SLAM immune receptors
  129. Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV
  130. Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)
  131. Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor
  132. Crystal Structure of Klebsiella aerogenesUreE, a Nickel-binding Metallochaperone for Urease Activation
  133. The Quaternary Arrangement of HslU and HslV in a Cocrystal: A Response to Wang, Yale
  134. Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography
  135. Mutational studies on HslU and its docking mode with HslV
  136. Docking of components in a bacterial complex
  137. Nucleoside diphosphate kinase from the hyperthermophilic archaeonMethanococcus jannaschii: overexpression, crystallization and preliminary X-ray crystallographic analysis
  138. Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family
  139. Crystallization and preliminary X-ray crystallographic analysis ofEscherichia coliCyaY, a structural homologue of human frataxin
  140. Crystallization and preliminary X-ray diffraction analysis ofSaccharomyces cerevisiaeYgr203p, a homologue of Acr2 arsenate reductase
  141. Crystallization and preliminary X-ray crystallographic analysis of human nucleoside diphosphate kinase A
  142. Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications
  143. Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae
  144. Crystal structure of a 16 kda double-headed bowman-birk trypsin inhibitor from barley seeds at 1.9 Å resolution
  145. Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction
  146. Crystallization and preliminary X-ray analysis of a complex between the Bowman–Birk trypsin inhibitor from barley and porcine pancreatic trypsin
  147. Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin in complex with chymotrypsin
  148. Crystallization and preliminary X-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage T4
  149. Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex
  150. A thermostable xylose isomerase fromThermus caldophilus: biochemical characterization, crystallization and preliminary X-ray analysis
  151. Preliminary X-ray crystallographic analysis of Bowman–Birk trypsin inhibitor from barley seeds
  152. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator
  153. Crystal structure of carboxylesterase from Pseudomonas fluorescens, an α/β hydrolase with broad substrate specificity
  154. The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor
  155. Crystal structure analyses of uncomplexed ecotin in two crystal forms: Implications for its function and stability
  156. Crystal structure of the complex of porcine pancreatic trypsin with Kunitz-type soybean trypsin inhibitor
  157. Refined Structure of the Chitinase from Barley Seeds at 2.0 Å Resolution
  158. Crystal structure of Bacillus licheniformis α-Amylase at 1.7resolution
  159. Crystal structure of an uncleaved α 1 -antitrypsin reveals the conformation of its inhibitory reactive loop
  160. Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase fromThermus aquaticus
  161. Crystallization, molecular replacement solution, and refinement of tetrameric β-amylase from sweet potato
  162. Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds
  163. Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds