All Stories

  1. Synergistic anti-tumor activity of ciclopirox olamine and metformin in triple-negative breast cancer

    Article • Genes & Diseases, January 2025, Elsevier

    Shile Huang

  2. Inhibition of Chk1 with Prexasertib Enhances the Anticancer Activity of Ciclopirox in Non-Small Cell Lung Cancer Cells

    Article • Cells, October 2024, MDPI AG

    Shile Huang

  3. PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

    Article • Cells, September 2024, MDPI AG

    Shile Huang

  4. Biological Functions and Potential Therapeutic Significance of O-GlcNAcylation in Hepatic Cellular Stress and Liver Diseases

    Article • Cells, May 2024, MDPI AG

    Shile Huang

  5. TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism

    Article • International Journal of Molecular Sciences, April 2024, MDPI AG

    Shile Huang

  6. A Comprehensive View on the Protein Functions of Porcine Epidemic Diarrhea Virus

    Article • Genes, January 2024, MDPI AG

    Shile Huang

  7. Autophagy and Apoptosis in Rabies Virus Replication

    Article • Cells, January 2024, MDPI AG

    Shile Huang

  8. ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus

    Article • PLoS Pathogens, January 2024, PLOS

    Shile Huang

  9. TRIM28 promotes porcine epidemic diarrhea virus replication by mitophagy-mediated inhibition of the JAK-STAT1 pathway

    Article • International Journal of Biological Macromolecules, January 2024, Elsevier

    Shile Huang

  10. TRIM25 Suppresses Rabies Virus Fixed HEP-Flury Strain Production by Activating RIG-1-Mediated Type I Interferons

    Article • Genes, July 2023, MDPI AG

    Shile Huang

  11. TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination

    Article • International Journal of Molecular Sciences, June 2023, MDPI AG

    Shile Huang

  12. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

    Article • Cells, June 2023, MDPI AG

    Shile Huang

  13. MIR155HG Plays a Bivalent Role in Regulating Innate Antiviral Immunity by Encoding Long Noncoding RNA-155 and microRNA-155-5p

    Article • mBio, December 2022, ASM Journals

    Shile Huang, Kul Raj Rai

  14. Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling

    Article • Neuropharmacology, November 2022, Elsevier

    Shile Huang

  15. Resveratrol induces autophagy impeding BAFF-stimulated B-cell proliferation and survival by inhibiting the Akt/mTOR pathway

    Article • Biochemical Pharmacology, August 2022, Elsevier

    Shile Huang

  16. NOX2-derived hydrogen peroxide impedes the AMPK/Akt-mTOR signaling pathway contributing to cell death in neuronal cells

    Article • Cellular Signalling, June 2022, Elsevier

    Shile Huang

  17. Tracing brain genotoxic stress in Parkinson’s disease with a novel single-cell genetic sensor

    Article • Science Advances, April 2022, American Association for the Advancement of Science

    Shile Huang

  18. Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity

    Article • Frontiers in Immunology, September 2021, Frontiers

    Shile Huang, Kul Raj Rai

  19. Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway

    Article • International Immunopharmacology, July 2021, Elsevier

    Shile Huang

  20. Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells

    Article • Cells, June 2021, MDPI AG

    Shile Huang

  21. Cadmium Impairs Autophagy Leading to Apoptosis by Ca2+-Dependent Activation of JNK Signaling Pathway in Neuronal Cells

    Article • Neurochemical Research, May 2021, Springer Science + Business Media

    Shile Huang

  22. RDUR, a lncRNA, Promotes Innate Antiviral Responses and Provides Feedback Control of NF-κB Activation

    Article • Frontiers in Immunology, May 2021, Frontiers

    Shile Huang, Kul Raj Rai

  23. Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer

    Article • Frontiers in Oncology, April 2021, Frontiers

    Shile Huang

  24. Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents

    Article • Signal Transduction and Targeted Therapy, March 2021, Springer Science + Business Media

    Shile Huang

  25. Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication

    Article • Virologica Sinica, March 2021, Elsevier

    Shile Huang

  26. Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth

    Article • Scientific Reports, March 2021, Springer Science + Business Media

    Shile Huang

  27. Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling

    Article • Journal of Virology, February 2021, ASM Journals

    Shile Huang

  28. Reposition of the Fungicide Ciclopirox for Cancer Treatment

    Article • Recent Patents on Anti-Cancer Drug Discovery, February 2021, Bentham Science Publishers

    Shile Huang

  29. Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

    Article • Cell Reports, January 2021, Elsevier

    Shile Huang

  30. mTOR Signaling in Metabolism and Cancer

    Article • Cells, October 2020, MDPI AG

    Shile Huang

  31. Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

    Article • Neuropharmacology, September 2020, Elsevier

    Shile Huang

  32. Rhabdovirus Infection Is Dependent on Serine/Threonine Kinase AP2-Associated Kinase 1

    Article • Life, August 2020, MDPI AG

    Shile Huang

  33. Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis

    Article • Journal of Ginseng Research, July 2020, Elsevier

    Shile Huang

  34. Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways

    Article • Oncogene, June 2020, Springer Science + Business Media

    Shile Huang

  35. Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

    Article • Cell Calcium, May 2020, Elsevier

    Shile Huang

  36. Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells

    Article • The International Journal of Biochemistry & Cell Biology, April 2020, Elsevier

    Shile Huang

  37. Artesunate enhances the immune response of rabies vaccine as an adjuvant

    Article • Vaccine, December 2019, Elsevier

    Shile Huang

  38. Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

    Article • Cells, September 2019, MDPI AG

    Shile Huang

  39. Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells

    Article • The International Journal of Biochemistry & Cell Biology, September 2019, Elsevier

    Shile Huang

  40. Maduramicin induces apoptosis through ROS-PP5-JNK pathway in skeletal myoblast cells and muscle tissue

    Article • Toxicology, August 2019, Elsevier

    Shile Huang

  41. Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

    Article • Cells, July 2019, MDPI AG

    Shile Huang

  42. Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation

    Article • Journal of Cellular and Molecular Medicine, July 2019, Wiley

    Shile Huang

  43. ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells

    Article • Signal Transduction and Targeted Therapy, June 2019, Springer Science + Business Media

    Shile Huang

  44. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway

    Article • Molecular Cancer, April 2019, Springer Science + Business Media

    Shile Huang

  45. Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

    Article • BMC Cancer, March 2019, Springer Science + Business Media

    Shile Huang

  46. Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells

    Article • Cellular Signalling, March 2019, Elsevier

    Shile Huang

  47. The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression

    Article • Cell Death and Differentiation, January 2019, Springer Science + Business Media

    Shile Huang

  48. BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells

    Article • Cellular Signalling, January 2019, Elsevier

    Shile Huang

  49. Corrigendum to “Maduramicin-activated protein phosphatase 2A results in extracellular signal-regulated kinase 1/2 inhibition, leading to cytotoxicity in myocardial H9c2 cells” [Toxicol. Lett. 284 (2018) 96–102]

    Article • Toxicology Letters, January 2019, Elsevier

    Shile Huang

  50. Maduramicin induces cardiac muscle cell death by the ROS‐dependent PTEN/Akt–Erk1/2 signaling pathway

    Article • Journal of Cellular Physiology, December 2018, Wiley

    Shile Huang

  51. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis

    Article • Neoplasia, November 2018, Elsevier

    Shile Huang

  52. Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

    Article • Anti-Cancer Agents in Medicinal Chemistry, August 2018, Bentham Science Publishers

    Shile Huang

  53. Resveratrol inhibits Erk1/2-mediated adhesion of cancer cells via activating PP2A-PTEN signaling network

    Article • Journal of Cellular Physiology, August 2018, Wiley

    Shile Huang

  54. Host Immune Response to Influenza A Virus Infection

    Article • Frontiers in Immunology, March 2018, Frontiers

    Shile Huang

  55. Maduramicin-activated protein phosphatase 2A results in extracellular signal-regulated kinase 1/2 inhibition, leading to cytotoxicity in myocardial H9c2 cells

    Article • Toxicology Letters, March 2018, Elsevier

    Shile Huang

  56. Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation

    Article • Genes & Cancer, February 2018, Impact Journals, LLC

    Shile Huang

  57. Maduramicin induces apoptosis and necrosis, and blocks autophagic flux in myocardial H9c2 cells

    Article • Journal of Applied Toxicology, October 2017, Wiley

    Shile Huang

  58. SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling

    Article • British Journal of Cancer, September 2017, Springer Science + Business Media

    Shile Huang

  59. Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A

    Article • Genes & Cancer, May 2017, Impact Journals, LLC

    Shile Huang

  60. Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells

    Article • Journal of Cellular Physiology, May 2017, Wiley

    Shile Huang

  61. Human T-cell lymphotropic virus type 1 and its oncogenesis

    Article • Acta Pharmacologica Sinica, April 2017, Nature

    Shile Huang

  62. Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+-CaMKII-Dependent Akt/mTOR Pathway

    Article • Journal of Cellular Physiology, February 2017, Wiley

    Shile Huang

  63. Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway

    Article • Journal of Neurochemistry, February 2017, Wiley

    Shile Huang

  64. Understanding of leukemic stem cells and their clinical implications

    Article • Molecular Cancer, January 2017, Springer Science + Business Media

    Shile Huang

  65. An insight of rapamycin against cadmium’s neurotoxicity

    Article • Oncotarget, January 2017, Impact Journals, LLC

    Shile Huang

  66. Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway

    Article • Bone Marrow Transplantation, November 2016, Wiley

    Shile Huang

  67. Repositioning the Old Fungicide Ciclopirox for New Medical Uses

    Article • Current Pharmaceutical Design, September 2016, Bentham Science Publishers

    Shile Huang

  68. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK

    Article • Biochemical Pharmacology, September 2016, Elsevier

    Shile Huang

  69. IL-2, IL-4, IFN-γ or TNF-α enhances BAFF-stimulated cell viability and survival by activating Erk1/2 and S6K1 pathways in neoplastic B-lymphoid cells

    Article • Cytokine, August 2016, Elsevier

    Shile Huang

  70. Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

    Article • Neuropharmacology, June 2016, Elsevier

    Shile Huang

  71. Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Shile Huang

  72. eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Shile Huang

  73. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl

  74. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling

    Article • Research in Veterinary Science, February 2016, Elsevier

    Shile Huang

  75. Correction: Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection

    Article • PLoS Pathogens, January 2016, PLOS

    Shile Huang

  76. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla

  77. PP2A Level in Colorectal Cancer Cells Predicts the Response of p38 Targeted Therapy

    Article • EBioMedicine, December 2015, Elsevier

    Shile Huang

  78. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity

    Article • Nucleic Acids Research, October 2015, Oxford University Press (OUP)

    Shile Huang

  79. Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Shile Huang

  80. Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways

    Article • Neuropharmacology, October 2015, Elsevier

    Shile Huang

  81. Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5

    Article • Journal of Neurochemistry, September 2015, Wiley

    Shile Huang

  82. Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

    Article • Cellular and Molecular Life Sciences, June 2015, Springer Science + Business Media

    Shile Huang

  83. A deut of mTORC1/2 for cell adhesion

    Article • Cell Cycle, April 2015, Taylor & Francis

    Shile Huang

  84. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons

    Article • Veterinary Microbiology, February 2015, Elsevier

    Shile Huang

  85. Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis

    Article • Journal of Vascular Research, January 2015, Karger Publishers

    Shile Huang

  86. Maduramicin Inhibits Proliferation and Induces Apoptosis in Myoblast Cells

    Article • PLOS One, December 2014, PLOS

    Shile Huang

  87. Fusarochromanone Induces G1 Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells

    Article • PLOS One, November 2014, PLOS

    Shile Huang

  88. A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis

    Article • PLOS One, October 2014, PLOS

    Shile Huang

  89. Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

    Article • Toxicological Sciences, October 2014, Oxford University Press (OUP)

    Shile Huang

  90. N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain

    Article • Neuropathology and Applied Neurobiology, September 2014, Wiley

    Shile Huang

  91. Biological activities of fusarochromanone: a potent anti-cancer agent

    Article • BMC Research Notes, September 2014, Springer Science + Business Media

    Shile Huang

  92. Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

    Article • Cellular Signalling, August 2014, Elsevier

    Shile Huang

  93. A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA

    Article • Oncogene, May 2014, Springer Science + Business Media

    Shile Huang

  94. Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression

    Article • Journal of Virology, May 2014, ASM Journals

    Shile Huang

  95. PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

    Article • Asian Pacific Journal of Cancer Prevention, March 2014, Asian Pacific Organization for Cancer Prevention

    Shile Huang

  96. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection

    Article • PLoS Pathogens, January 2014, PLOS

    Shile Huang

  97. BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells

    Article • Biochemical Pharmacology, January 2014, Elsevier

    Shile Huang

  98. Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin

    Article • PLOS One, November 2013, PLOS

    Shile Huang

  99. Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network

    Article • Journal of Neurochemistry, October 2013, Wiley

    Shile Huang

  100. Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells

    Article • Carcinogenesis, August 2013, Oxford University Press (OUP)

    Shile Huang

  101. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation byAblOncogenes

    Article • Cancer Research, July 2013, American Association for Cancer Research (AACR)

    Shile Huang

  102. Editorial (Hot Topic: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products)

    Article • Anti-Cancer Agents in Medicinal Chemistry, July 2013, Bentham Science Publishers

    Shile Huang

  103. Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer

    Article • Anti-Cancer Agents in Medicinal Chemistry, July 2013, Bentham Science Publishers

    Shile Huang

  104. Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling

    Article • Anti-Cancer Agents in Medicinal Chemistry, July 2013, Bentham Science Publishers

    Shile Huang

  105. Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats

    Article • Reproductive Toxicology, June 2013, Elsevier

    Shile Huang

  106. Current development of the second generation of mTOR inhibitors as anticancer agents

    Article • Chinese Journal of Cancer, May 2013, Editorial Office of Chinese Journal of Cancer

    Shile Huang

  107. Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway

    Article • Chemico-Biological Interactions, April 2013, Elsevier

    Shile Huang

  108. α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

    Article • Proceedings of the National Academy of Sciences, September 2012, Proceedings of the National Academy of Sciences

    Shile Huang

  109. Human Albumin Prevents 6-Hydroxydopamine-Induced Loss of Tyrosine Hydroxylase in In Vitro and In Vivo

    Article • PLOS One, July 2012, PLOS

    Shile Huang

  110. The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis

    Article • Anti-Cancer Agents in Medicinal Chemistry, May 2012, Bentham Science Publishers

    Shile Huang

  111. Cryptotanshinone Activates p38/JNK and Inhibits Erk1/2 Leading to Caspase-Independent Cell Death in Tumor Cells

    Article • Cancer Prevention Research, May 2012, American Association for Cancer Research (AACR)

    Shile Huang

  112. A new clue to explain resistance to mTOR inhibitors

    Article • Cell Cycle, March 2012, Taylor & Francis

    Shile Huang

  113. Rapamycin Inhibits Lymphatic Endothelial Cell Tube Formation by Downregulating Vascular Endothelial Growth Factor Receptor 3 Protein Expression

    Article • Neoplasia, March 2012, Elsevier

    Shile Huang

  114. Transport of Influenza Virus Neuraminidase (NA) to Host Cell Surface Is Regulated by ARHGAP21 and Cdc42 Proteins

    Article • Journal of Biological Chemistry, March 2012, Elsevier

    Shile Huang

  115. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells

    Article • Carcinogenesis, January 2012, Oxford University Press (OUP)

    Shile Huang

  116. Cryptotanshinone Inhibits Lymphatic Endothelial Cell Tube Formation by Suppressing VEGFR-3/ERK and Small GTPase Pathways

    Article • Cancer Prevention Research, December 2011, American Association for Cancer Research (AACR)

    Shile Huang

  117. CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death

    Article • Journal of Neurochemistry, October 2011, Wiley

    Shile Huang

  118. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound

    Article • Biochemical and Biophysical Research Communications, October 2011, Elsevier

    Shile Huang

  119. Pharmacological and clinical properties of curcumin

    Article • Botanics Targets and Therapy, June 2011, Taylor & Francis

    Shile Huang

  120. Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

    Article • PLOS One, April 2011, PLOS

    Shile Huang

  121. The Targets of Curcumin

    Article • Current Drug Targets, March 2011, Bentham Science Publishers

    Shile Huang

  122. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

    Article • Free Radical Biology and Medicine, March 2011, Elsevier

    Shile Huang

  123. Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

    Article • Current Protein and Peptide Science, February 2011, Bentham Science Publishers

    Shile Huang

  124. Editorial [Hot Topic: Novel Protein & Peptide Science (Guest Editor: Shile Huang)]

    Article • Current Protein and Peptide Science, February 2011, Bentham Science Publishers

    Shile Huang

  125. The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway

    Article • Oncogene, January 2011, Springer Science + Business Media

    Shile Huang

  126. Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

    Article • Journal of Biological Chemistry, December 2010, Elsevier

    Shile Huang

  127. Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity

    Article • Cancer Chemotherapy and Pharmacology, September 2010, Springer Science + Business Media

    Shile Huang

  128. Updates of mTOR Inhibitors

    Article • Anti-Cancer Agents in Medicinal Chemistry, September 2010, Bentham Science Publishers

    Shile Huang

  129. The Complexes of Mammalian Target of Rapamycin

    Article • Current Protein and Peptide Science, September 2010, Bentham Science Publishers

    Shile Huang

  130. Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation

    Article • Cancer Prevention Research, August 2010, American Association for Cancer Research (AACR)

    Shile Huang

  131. Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway

    Article • PLOS One, May 2010, PLOS

    Shile Huang

  132. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

    Article • Laboratory Investigation, May 2010, Elsevier

    Shile Huang

  133. The antitumor activity of the fungicide ciclopirox

    Article • International Journal of Cancer, March 2010, Wiley

    Shile Huang

  134. mTOR Signaling in Cancer Cell Motility and Tumor Metastasis

    Article • Critical Reviews in Eukaryotic Gene Expression, January 2010, Begell House

    Shile Huang

  135. Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

    Article • The International Journal of Biochemistry & Cell Biology, June 2009, Elsevier

    Shile Huang

  136. Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

    Article • Cancer Research, January 2009, American Association for Cancer Research (AACR)

    Shile Huang

  137. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

    Article • Free Radical Biology and Medicine, October 2008, Elsevier

    Shile Huang

  138. Curcumin Inhibition of Integrin (α6β4)-Dependent Breast Cancer Cell Motility and Invasion

    Article • Cancer Prevention Research, October 2008, American Association for Cancer Research (AACR)

    Shile Huang

  139. Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

    Article • Oncogene, May 2008, Springer Science + Business Media

    Shile Huang

  140. MAPK and mTOR pathways are involved in cadmium‐induced neuronal apoptosis

    Article • Journal of Neurochemistry, November 2007, Wiley

    Shile Huang

  141. Negative Regulation of ASK1 by p21Cip1 Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo

    Article • Molecular and Cellular Biology, February 2007, ASM Journals

    Shile Huang

  142. Predicted mechanisms of resistance to mTOR inhibitors

    Article • British Journal of Cancer, September 2006, Springer Science + Business Media

    Shile Huang

  143. Curcumin inhibits the mammalian target of rapamycin‐mediated signaling pathways in cancer cells

    Article • International Journal of Cancer, June 2006, Wiley

    Shile Huang

  144. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

    Article • Oncogene, May 2006, Springer Science + Business Media

    Shile Huang

  145. Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity

    Article • Journal of Biological Chemistry, August 2004, Elsevier

    Shile Huang

  146. mTOR as a Target for Cancer Therapy

    Article • January 2004, Springer Science + Business Media

    Shile Huang

  147. Targeting mTOR signaling for cancer therapy

    Article • Current Opinion in Pharmacology, August 2003, Elsevier

    Shile Huang

  148. Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1

    Article • Molecular Cell, June 2003, Elsevier

    Shile Huang

  149. Rapamycins: Mechanisms of Action and Cellular Resistance

    Article • Cancer Biology & Therapy, May 2003, Taylor & Francis

    Shile Huang

  150. Mechanisms of resistance to rapamycins

    Article • Drug Resistance Updates, December 2001, Elsevier

    Shile Huang

  151. Article • Cancer and Metastasis Reviews, January 2001, Springer Science + Business Media

    Shile Huang

  152. Nitric oxide-mediated cGMP synthesis in Helix neural ganglia

    Article • Brain Research, January 1998, Elsevier

    Shile Huang