All Stories

  1. Glutamine sensing licenses cholesterol synthesis

    Article • The EMBO Journal, October 2024, Springer Science + Business Media

    Professor Luca Scorrano

  2. The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

    Article • Seminars in Cell and Developmental Biology, September 2024, Elsevier

    Professor Luca Scorrano

  3. Sweetening mitochondria: Hexokinase shields mitochondria from fission when glucose is low

    Article • Molecular Cell, July 2024, Elsevier

    Professor Luca Scorrano

  4. A RalA between high-fat diet and mitochondrial shape

    Article • Nature Metabolism, January 2024, Springer Science + Business Media

    Professor Luca Scorrano

  5. Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies

    Article • Cell Death and Differentiation, January 2024, Springer Science + Business Media

    Professor Luca Scorrano

  6. Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

    Article • Cell Death and Disease, January 2024, Springer Science + Business Media

    Professor Luca Scorrano

  7. Targeting mitochondrial shape: at the heart of cardioprotection

    Article • Basic Research in Cardiology, November 2023, Springer Science + Business Media

    Professor Luca Scorrano

  8. The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation

    Article • Cardiovascular Research, October 2023, Oxford University Press (OUP)

    Professor Luca Scorrano

  9. Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

    Article • Cell Death and Disease, August 2023, Springer Science + Business Media

    Professor Luca Scorrano

  10. IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells

    Article • Frontiers in Immunology, July 2023, Frontiers

    Professor Luca Scorrano

  11. Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress

    Article • Redox Biology, July 2023, Elsevier

    Professor Luca Scorrano

  12. Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

    Article • Science, June 2023, American Association for the Advancement of Science

    Professor Luca Scorrano

  13. LDLs take a shortcut to mitochondria

    Article • Nature Cell Biology, June 2023, Springer Science + Business Media

    Professor Luca Scorrano

  14. Mind the GAP(43) for mitochondria transfer to glioblastomas

    Article • Nature Cancer, May 2023, Springer Science + Business Media

    Professor Luca Scorrano

  15. Apoptotic cell death in disease—Current understanding of the NCCD 2023

    Article • Cell Death and Differentiation, April 2023, Springer Science + Business Media

    Professor Luca Scorrano

  16. Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line

    Article • Cell Death and Disease, April 2023, Springer Science + Business Media

    Noriko Gotoh, Professor Luca Scorrano

  17. High-Throughput Microscopy Analysis of Mitochondrial Membrane Potential in 2D and 3D Models

    Article • Cells, April 2023, MDPI AG

    Professor Luca Scorrano

  18. Mitochondrial cristae: lung cancer metabolism architects

    Article • Life Metabolism, April 2023, Oxford University Press (OUP)

    Professor Luca Scorrano

  19. A Novel Benchtop Device for Efficient and Simple Purification of Cytokines, Growth Factors and Stem Cells from Adipose Tissue

    Article • Biomedicines, March 2023, MDPI AG

    Professor Luca Scorrano

  20. Determinants and outcomes of mitochondrial dynamics

    Article • Molecular Cell, March 2023, Elsevier

    Professor Luca Scorrano

  21. Dysfunctional mitochondria accumulate in a skeletal muscle knockout model of Smn1, the causal gene of spinal muscular atrophy

    Article • Cell Death and Disease, February 2023, Springer Science + Business Media

    Professor Luca Scorrano

  22. Activation of Ca2+phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Professor Luca Scorrano

  23. OPA1 drives macrophage metabolism and functional commitment via p65 signaling

    Article • Cell Death and Differentiation, October 2022, Springer Science + Business Media

    Professor Luca Scorrano

  24. Mitochondrial dynamics: roles in exercise physiology and muscle mass regulation

    Article • Current Opinion in Physiology, June 2022, Elsevier

    Professor Luca Scorrano

  25. Shaping fuel utilization by mitochondria

    Article • Current Biology, June 2022, Elsevier

    Professor Luca Scorrano

  26. Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

    Article • Cell Death and Disease, May 2022, Springer Science + Business Media

    Professor Luca Scorrano

  27. Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

    Article • Genome Biology, April 2022, Springer Science + Business Media

    Professor Luca Scorrano

  28. Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

    Article • Cell Death and Disease, April 2022, Springer Science + Business Media

    Professor Luca Scorrano

  29. Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

    Article • Journal of Experimental & Clinical Cancer Research, March 2022, Springer Science + Business Media

    Professor Luca Scorrano

  30. Author Correction: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

    Article • Nature Metabolism, February 2022, Springer Science + Business Media

    Professor Luca Scorrano

  31. Transient Exposure of Endothelial Cells to Doxorubicin Leads to Long-Lasting Vascular Endothelial Growth Factor Receptor 2 Downregulation

    Article • Cells, January 2022, MDPI AG

    Professor Luca Scorrano

  32. Transgene expression in mice of the Opa1 mitochondrial transmembrane protein through bicontinuous cubic lipoplexes containing gemini imidazolium surfactants

    Article • Journal of Nanobiotechnology, December 2021, Springer Science + Business Media

    Professor Luca Scorrano

  33. The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

    Article • Nature Metabolism, December 2021, Springer Science + Business Media

    Professor Luca Scorrano

  34. Beware of regional heterogeneity when assessing the role of schools in the SARS-CoV-2 second wave in Italy—Authors´ reply.

    Article • The Lancet Regional Health - Europe, September 2021, Elsevier

    Professor Luca Scorrano

  35. Autophagy in major human diseases

    Article • The EMBO Journal, August 2021, Springer Science + Business Media

    Professor Luca Scorrano

  36. Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy

    Article • Cell Death and Differentiation, August 2021, Springer Science + Business Media

    Professor Luca Scorrano

  37. Revisiting the evidence for physical distancing, face masks, and eye protection

    Article • The Lancet, August 2021, Elsevier

    Professor Luca Scorrano

  38. A cross-sectional and prospective cohort study of the role of schools in the SARS-CoV-2 second wave in Italy

    Article • The Lancet Regional Health - Europe, June 2021, Elsevier

    Professor Luca Scorrano

  39. Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

    Article • Redox Biology, May 2021, Elsevier

    Professor Luca Scorrano

  40. Dietary spermidine improves cognitive function

    Article • Cell Reports, April 2021, Elsevier

    Professor Luca Scorrano

  41. Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism

    Article • Cell Death and Differentiation, March 2021, Springer Science + Business Media

    Professor Luca Scorrano

  42. Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

    Article • Cell Reports, March 2021, Elsevier

    Professor Luca Scorrano

  43. No evidence of association between schools and SARS-CoV-2 second wave in Italy

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Professor Luca Scorrano

  44. OPA1, a new mitochondrial target in cancer therapy

    Article • Aging, November 2020, Impact Journals, LLC

    Professor Luca Scorrano

  45. Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

    Article • Nature Communications, August 2020, Springer Science + Business Media

    Professor Luca Scorrano

  46. Opa1 Overexpression Protects from Early-Onset Mpv17−/−-Related Mouse Kidney Disease

    Article • Molecular Therapy, August 2020, Elsevier

    Professor Luca Scorrano

  47. P73 C-terminus is dispensable for multiciliogenesis

    Article • Cell Cycle, June 2020, Taylor & Francis

    Professor Luca Scorrano

  48. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

    Article • Cell Metabolism, May 2020, Elsevier

    Professor Luca Scorrano

  49. Opa1overexpression protects from early onsetMpv17-/--related mouse kidney disease

    Article • March 2020, Cold Spring Harbor Laboratory Press

    Professor Luca Scorrano

  50. The cell biology of mitochondrial membrane dynamics

    Article • Nature Reviews Molecular Cell Biology, February 2020, Springer Science + Business Media

    Professor Luca Scorrano

  51. MCUB Hearts Mitochondria in Sickness, Less in Health

    Article • Circulation, November 2019, Wolters Kluwer Health

    Professor Luca Scorrano

  52. Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

    Article • Cell Reports, August 2019, Elsevier

    Professor Luca Scorrano

  53. Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles

    Article • Cells, June 2019, MDPI AG

    Professor Luca Scorrano

  54. DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Professor Luca Scorrano

  55. Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics

    Article • Redox Biology, June 2019, Elsevier

    Professor Luca Scorrano

  56. Too close not to encyst: Polycystic kidney disease and interorganellar contact sites

    Article • Science Signaling, May 2019, American Association for the Advancement of Science

    Professor Luca Scorrano

  57. PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

    Article • Frontiers in Physiology, May 2019, Frontiers

    Professor Luca Scorrano

  58. Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

    Article • Autophagy, April 2019, Taylor & Francis

    Professor Luca Scorrano

  59. Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

    Article • Life Science Alliance, April 2019, Life Science Alliance, LLC

    Professor Luca Scorrano

  60. Coming together to define membrane contact sites

    Article • Nature Communications, March 2019, Springer Science + Business Media

    Professor Luca Scorrano

  61. Finding a new balance to cure Charcot-Marie-Tooth 2A

    Article • Journal of Clinical Investigation, March 2019, American Society for Clinical Investigation

    Professor Luca Scorrano

  62. Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle

    Article • Cell Reports, March 2019, Elsevier

    Professor Luca Scorrano

  63. Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network

    Article • Nucleic Acids Research, January 2019, Oxford University Press (OUP)

    Professor Luca Scorrano

  64. Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

    Article • Aging Cell, December 2018, Wiley

    Professor Luca Scorrano

  65. Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy

    Article • Pharmacological Research, December 2018, Elsevier

    Professor Luca Scorrano

  66. Shipping Calpastatin to the Rescue: Prevention of Neuromuscular Degeneration through Mitofusin 2

    Article • Cell Metabolism, October 2018, Elsevier

    Professor Luca Scorrano

  67. Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis

    Article • Frontiers in Molecular Neuroscience, September 2018, Frontiers

    Professor Luca Scorrano

  68. The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Professor Luca Scorrano

  69. Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

    Article • Cell Reports, August 2018, Elsevier

    Professor Luca Scorrano

  70. Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

    Article • Nature Communications, July 2018, Springer Science + Business Media

    Jean-Marc NUOFFER, Professor Luca Scorrano

  71. Leducq Network

    Article • Circulation Research, July 2018, Wolters Kluwer Health

    Professor Luca Scorrano

  72. An ode to mitochondria biologists, new and old

    Article • Biochemical and Biophysical Research Communications, May 2018, Elsevier

    Professor Luca Scorrano

  73. Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids

    Article • Cell Metabolism, April 2018, Elsevier

    Professor Luca Scorrano

  74. Lipid utilization in skeletal muscle cells is modulated in vitro and in vivo by specific miRNAs

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Professor Luca Scorrano

  75. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

    Article • Genome Biology, March 2018, Springer Science + Business Media

    Professor Luca Scorrano

  76. Flaming Mitochondria: The Anti-inflammatory Drug Leflunomide Boosts Mitofusins

    Article • Cell Chemical Biology, March 2018, Elsevier

    Professor Luca Scorrano

  77. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Article • Cell Death and Differentiation, January 2018, Nature

    Abhishek Garg, Professor David M. Pereira, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Professor Luca Scorrano

  78. The INs and OUTs of mitofusins

    Article • Journal of Cell Biology, January 2018, Rockefeller University Press

    Professor Luca Scorrano

  79. Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease

    Article • Cell Reports, January 2018, Elsevier

    Professor Luca Scorrano

  80. Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events

    Article • Scientific Reports, December 2017, Springer Science + Business Media

    Professor Luca Scorrano

  81. SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition

    Article • Cell Death and Differentiation, December 2017, Springer Science + Business Media

    Professor Luca Scorrano

  82. RevAMPing Mitochondrial Shape to Live Longer

    Article • Cell Metabolism, December 2017, Elsevier

    Professor Luca Scorrano

  83. Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission

    Article • Cell Death and Disease, October 2017, Springer Science + Business Media

    Professor Luca Scorrano

  84. Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Professor Luca Scorrano

  85. The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

    Article • Scientific Reports, July 2017, Springer Science + Business Media

    Professor Luca Scorrano

  86. Molecular definitions of autophagy and related processes

    Article • The EMBO Journal, June 2017, EMBO

    Professor Nektarios Tavernarakis, Professor Luca Scorrano

  87. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence

    Article • Cell Metabolism, June 2017, Elsevier

    Stefano Ciciliot, Professor Luca Scorrano

  88. Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors

    Article • Oncotarget, April 2017, Impact Journals, LLC

    Professor Luca Scorrano

  89. Judging a tumor cell by its cover: a matter of mitochondrial contact sites

    Article • The EMBO Journal, March 2017, Springer Science + Business Media

    Professor Luca Scorrano

  90. Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  91. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 2017, Elsevier

    Professor Luca Scorrano

  92. Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

    Article • Cell Reports, December 2016, Elsevier

    Professor Luca Scorrano

  93. Cardioprotection and lifespan extension by the natural polyamine spermidine

    Article • Nature Reports Stem Cells, November 2016, Springer Science + Business Media

    Professor Luca Scorrano

  94. The organelle replication connection

    Article • Nature, October 2016, Springer Science + Business Media

    Professor Luca Scorrano

  95. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

    Article • Proceedings of the National Academy of Sciences, September 2016, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  96. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 2016, Elsevier

    Professor Luca Scorrano

  97. Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor‐dependent apoptosis

    Article • The EMBO Journal, July 2016, Springer Science + Business Media

    Professor Luca Scorrano

  98. Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

    Article • Scientific Reports, June 2016, Nature

    Dr MIGUEL SANCHEZ-ALVAREZ, Professor Luca Scorrano

  99. Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Professor Luca Scorrano

  100. Mitochondrial Cristae: Where Beauty Meets Functionality

    Article • Trends in Biochemical Sciences, March 2016, Elsevier

    Professor Luca Scorrano

  101. Mitofusins, from Mitochondria to Metabolism

    Article • Molecular Cell, March 2016, Elsevier

    Professor Luca Scorrano

  102. scorrano

    Article • Annual Review of Physiology, February 2016, Annual Reviews

    Professor Luca Scorrano, Dr Lena Pernas

  103. Early effects of the antineoplastic agent salinomycin on mitochondrial function

    Article • Cell Death and Disease, October 2015, Springer Science + Business Media

    Professor Luca Scorrano

  104. Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure

    Article • Journal of Biological Chemistry, October 2015, Elsevier

    Professor Luca Scorrano

  105. The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

    Article • Cell Metabolism, June 2015, Elsevier

    Professor Luca Scorrano

  106. Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

    Article • Cell Metabolism, June 2015, Elsevier

    Professor Luca Scorrano

  107. Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology

    Article • Thrombosis and Haemostasis, May 2015, Schattauer GmbH

    Dr Sang-Bing Ong, Professor Luca Scorrano

  108. Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

    Article • Cell Death and Differentiation, April 2015, Springer Science + Business Media

    Professor Luca Scorrano

  109. Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

    Article • Molecular Cell, April 2015, Elsevier

    Professor Luca Scorrano

  110. Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration

    Article • PLOS One, March 2015, PLOS

    Valdemar Máximo, Paula Soares, Professor Luca Scorrano

  111. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

    Article • Cell Metabolism, February 2015, Elsevier

    Professor Luca Scorrano

  112. The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

    Article • Cell Death and Differentiation, December 2014, Springer Science + Business Media

    Professor Luca Scorrano

  113. Mitochondria: from cell death executioners to regulators of cell differentiation

    Article • Trends in Cell Biology, December 2014, Elsevier

    Professor Luca Scorrano

  114. At the right distance: ER-mitochondria juxtaposition in cell life and death

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 2014, Elsevier

    Professor Luca Scorrano

  115. Correction: Corrigendum: Mitofusin 2 tethers endoplasmic reticulum to mitochondria

    Article • Nature, September 2014, Springer Science + Business Media

    Professor Luca Scorrano

  116. O ROM(e)O1, ROM(e)O1, Wherefore Art Thou ROM(e)O1?

    Article • Science Signaling, January 2014, American Association for the Advancement of Science

    Professor Luca Scorrano

  117. Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion

    Article • Journal of Cell Biology, January 2014, Rockefeller University Press

    Professor Luca Scorrano

  118. Mitochondrial Apoptosis Regulation by Bcl-2 Family Members

    Article • January 2014, Elsevier

    Professor Luca Scorrano

  119. When numbers matters: mitochondrial DNA and gliomagenesis

    Article • Cell Death and Differentiation, November 2013, Springer Science + Business Media

    Professor Luca Scorrano

  120. Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

    Article • Science, November 2013, American Association for the Advancement of Science

    Professor Luca Scorrano

  121. Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

    Article • Diabetes, September 2013, American Diabetes Association

    Dr. Carsten Merkwirth, Professor Luca Scorrano

  122. Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

    Article • Cell, September 2013, Elsevier

    Professor Luca Scorrano

  123. Keeping mitochondria in shape: a matter of life and death

    Article • European Journal of Clinical Investigation, July 2013, Wiley

    Professor Luca Scorrano

  124. D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries

    Article • Molecular and Cellular Neuroscience, July 2013, Elsevier

    Professor Luca Scorrano

  125. Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

    Article • Neurobiology of Disease, July 2013, Elsevier

    Professor Luca Scorrano

  126. OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

    Article • The EMBO Journal, May 2013, Wiley

    Professor Luca Scorrano

  127. Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

    Article • PLOS One, February 2013, PLOS

    Professor Luca Scorrano

  128. Mitochondrial dynamics and physiology

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 2013, Elsevier

    Professor Luca Scorrano

  129. Mitochondrial morphology in mitophagy and macroautophagy

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 2013, Elsevier

    Professor Luca Scorrano

  130. Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease

    Article • The EMBO Journal, October 2012, Wiley

    Professor Luca Scorrano

  131. The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, October 2012, Elsevier

    Professor Luca Scorrano

  132. Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency

    Article • Cell Death and Differentiation, August 2012, Springer Science + Business Media

    Professor Luca Scorrano

  133. Optic Atrophy 1-Dependent Mitochondrial Remodeling Controls Steroidogenesis in Trophoblasts

    Article • Current Biology, July 2012, Elsevier

    Anna I Bakardjiev, Professor Luca Scorrano

  134. Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation

    Article • Human Molecular Genetics, June 2012, Oxford University Press (OUP)

    Professor Luca Scorrano

  135. The Pathophysiology of LETM1

    Article • Journal of General Physiology, May 2012, Rockefeller University Press

    Professor Luca Scorrano

  136. In Epilepsy, BAD Is Not Really Bad

    Article • Neuron, May 2012, Elsevier

    Professor Luca Scorrano

  137. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Professor Godefridus J Peters, Professor Brigitte Galliot, Professor Luca Scorrano

  138. Shaping the role of mitochondria in the pathogenesis of Huntington's disease

    Article • The EMBO Journal, March 2012, Wiley

    Professor Luca Scorrano

  139. Mitochondrial Dynamics in Cancer and Neurodegenerative and Neuroinflammatory Diseases

    Article • International Journal of Cell Biology, January 2012, Hindawi Publishing Corporation

    Professor Luca Scorrano

  140. Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration

    Article • Acta Neuropathologica, December 2011, Springer Science + Business Media

    Professor Luca Scorrano

  141. Apaf1 plays a pro-survival role by regulating centrosome morphology and function

    Article • Journal of Cell Science, October 2011, The Company of Biologists

    Professor Luca Scorrano

  142. Phagocytosis: Coupling of Mitochondrial Uncoupling and Engulfment

    Article • Current Biology, October 2011, Elsevier

    Professor Luca Scorrano

  143. Mitochondrial elongation during autophagy

    Article • Autophagy, October 2011, Taylor & Francis

    Professor Luca Scorrano

  144. Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy

    Article • Cell Cycle, August 2011, Taylor & Francis

    Professor Luca Scorrano

  145. Tonight, the same old, deadly programme: BH3-only proteins, mitochondria and yeast

    Article • The EMBO Journal, July 2011, Wiley

    Professor Luca Scorrano

  146. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

    Article • Nature, April 2011, Nature

    Professor Luca Scorrano

  147. Traveling Bax and Forth from Mitochondria to Control Apoptosis

    Article • Cell, April 2011, Elsevier

    Professor Luca Scorrano

  148. Mitofusin 2 Regulates STIM1 Migration from the Ca2+ Store to the Plasma Membrane in Cells with Depolarized Mitochondria

    Article • Journal of Biological Chemistry, April 2011, Elsevier

    Professor Luca Scorrano

  149. Prohibitin(g) Cancer: Aurilide and Killing by Opa1-Dependent Cristae Remodeling

    Article • Chemistry & Biology, January 2011, Elsevier

    Professor Luca Scorrano

  150. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

    Article • EMBO Molecular Medicine, November 2010, EMBO

    Professor Luca Scorrano

  151. Trichoplein/mitostatin regulates endoplasmic reticulum–mitochondria juxtaposition

    Article • EMBO Reports, October 2010, EMBO

    Professor Luca Scorrano

  152. Two Close, Too Close

    Article • Circulation Research, September 2010, Wolters Kluwer Health

    Professor Luca Scorrano

  153. Mitochondrial shape changes: orchestrating cell pathophysiology

    Article • EMBO Reports, August 2010, Springer Science + Business Media

    Professor Luca Scorrano

  154. An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

    Article • The EMBO Journal, August 2010, Wiley

    Professor Luca Scorrano

  155. Editorial

    Article • Seminars in Cell and Developmental Biology, August 2010, Elsevier

    Professor Luca Scorrano

  156. A BID on mitochondria with MTCH2

    Article • BDJ, July 2010, Nature

    Professor Luca Scorrano

  157. Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin

    Article • Cell Death and Differentiation, May 2010, Springer Science + Business Media

    Professor Luca Scorrano

  158. Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

    Article • Cell Death and Differentiation, May 2010, Springer Science + Business Media

    Professor Luca Scorrano

  159. Endosome–mitochondria juxtaposition during apoptosis induced by H. pylori VacA

    Article • Cell Death and Differentiation, April 2010, Springer Science + Business Media

    Professor Luca Scorrano

  160. Mitochondrial fission and remodelling contributes to muscle atrophy

    Article • The EMBO Journal, April 2010, Springer Science + Business Media

    Professor Luca Scorrano

  161. The Interplay between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis

    Article • January 2010, Springer Science + Business Media

    Professor Luca Scorrano

  162. OPA1 and Its Clinical Implications

    Article • December 2009, Wiley

    Professor Luca Scorrano

  163. Cristae Remodeling and Mitochondrial Fragmentation: A Checkpoint for Cytochrome c Release and Apoptosis?

    Article • November 2009, Springer Science + Business Media

    Professor Luca Scorrano

  164. Opening the doors to cytochrome c: Changes in mitochondrial shape and apoptosis

    Article • The International Journal of Biochemistry & Cell Biology, October 2009, Elsevier

    Professor Luca Scorrano

  165. The changing shape of mitochondrial apoptosis

    Article • Trends in Endocrinology and Metabolism, August 2009, Elsevier

    Professor Luca Scorrano

  166. Reactive oxygen species are NOXious for neurons

    Article • Nature Neuroscience, July 2009, Springer Science + Business Media

    Professor Luca Scorrano

  167. When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum

    Article • The EMBO Journal, June 2009, Wiley

    Professor Luca Scorrano

  168. The SUMO arena goes mitochondrial with MAPL

    Article • EMBO Reports, June 2009, Springer Science + Business Media

    Professor Luca Scorrano

  169. Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

    Article • Mitochondrion, June 2009, Elsevier

    Professor Luca Scorrano

  170. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

    Article • EMBO Molecular Medicine, May 2009, Springer Science + Business Media

    Professor Luca Scorrano

  171. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    Article • Cell Death and Differentiation, April 2009, Springer Science + Business Media

    MD, PhD Klas Blomgren, Professor Luca Scorrano

  172. The Mitochondrial Pathway: Focus on Shape Changes

    Article • January 2009, Springer Science + Business Media

    Professor Luca Scorrano

  173. Mitofusin 2 tethers endoplasmic reticulum to mitochondria

    Article • Nature, December 2008, Nature

    Professor Luca Scorrano

  174. Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?: Figure 1.

    Article • Journal of Cell Biology, November 2008, Rockefeller University Press

    Professor Luca Scorrano

  175. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer

    Article • Oncogene, October 2008, Springer Science + Business Media

    Professor Luca Scorrano

  176. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  177. A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function

    Article • Human Molecular Genetics, August 2008, Oxford University Press (OUP)

    Prof Corrado Angelini, Professor Luca Scorrano

  178. S9.7 Dominant optic atrophy caused by a novel OPA1 mutation: Disruption of the mitochondrial network with preserved bioenergetics

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2008, Elsevier

    Prof Corrado Angelini, Professor Luca Scorrano

  179. High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2008, Elsevier

    Professor Luca Scorrano

  180. Multiple Functions of Mitochondria-Shaping Proteins

    Article • May 2008, Wiley

    Professor Luca Scorrano

  181. Mitofusin 2: A Mitochondria-Shaping Protein with Signaling Roles Beyond Fusion

    Article • Antioxidants & Redox Signaling, March 2008, Mary Ann Liebert Inc

    Professor Luca Scorrano

  182. LETM1, deleted in Wolf Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability

    Article • Human Molecular Genetics, October 2007, Oxford University Press (OUP)

    Professor Luca Scorrano

  183. Targeting Cell Death

    Article • Clinical Pharmacology & Therapeutics, October 2007, Wiley

    Professor Luca Scorrano

  184. A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis

    Article • Cell Death and Differentiation, April 2007, Springer Science + Business Media

    Professor Luca Scorrano

  185. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

    Article • Nature Protocols, February 2007, Nature

    Professor Luca Scorrano

  186. Measuring Mitochondrial Shape Changes and Their Consequences on Mitochondrial Involvement During Apoptosis

    Article • January 2007, Springer Science + Business Media

    Professor Luca Scorrano

  187. Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

    Article • Journal of Experimental Medicine, December 2006, Rockefeller University Press

    Professor Luca Scorrano

  188. The Mitochondrial Fission Protein hFis1 Requires the Endoplasmic Reticulum Gateway to Induce Apoptosis

    Article • Molecular Biology of the Cell, November 2006, American Society for Cell Biology (ASCB)

    Professor Luca Scorrano

  189. The many shapes of mitochondrial death

    Article • Oncogene, August 2006, Nature

    Professor Luca Scorrano

  190. (De)constructing Mitochondria: What For?

    Article • Physiology, August 2006, American Physiological Society

    Professor Luca Scorrano

  191. To fuse and to protect. A novel role for CED-9 in mitochondrial morphology reveals an ancient function

    Article • Cell Death and Differentiation, July 2006, Springer Science + Business Media

    Professor Luca Scorrano

  192. Laying the foundations of programmed cell death

    Article • Cell Death and Differentiation, July 2006, Springer Science + Business Media

    Professor Luca Scorrano

  193. Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

    Article • Cell, July 2006, Elsevier

    Professor Luca Scorrano

  194. OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

    Article • Cell, July 2006, Elsevier

    Professor Luca Scorrano

  195. Mitochondrial dynamics in cell life and death

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, May 2006, Elsevier

    Professor Luca Scorrano

  196. The relationship between mitochondrial shape and function and the cytoskeleton

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, May 2006, Elsevier

    Professor Luca Scorrano

  197. Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin‐mediated photodynamic therapy

    Article • The FASEB Journal, February 2006, Wiley

    Professor Luca Scorrano

  198. Proteins That Fuse and Fragment Mitochondria in Apoptosis: Con-Fissing a Deadly Con-Fusion?

    Article • Journal of Bioenergetics and Biomembranes, June 2005, Springer Science + Business Media

    Professor Luca Scorrano

  199. Stanley J. Korsmeyer (1950–2005)

    Article • Journal of Bioenergetics and Biomembranes, June 2005, Springer Science + Business Media

    Professor Luca Scorrano

  200. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

    Article • Proceedings of the National Academy of Sciences, December 2004, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  201. OPA1 requires mitofusin 1 to promote mitochondrial fusion

    Article • Proceedings of the National Academy of Sciences, October 2004, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  202. Arachidonic Acid Released by Phospholipase A2 Activation Triggers Ca2+-dependent Apoptosis through the Mitochondrial Pathway

    Article • Journal of Biological Chemistry, June 2004, Elsevier

    Professor Luca Scorrano

  203. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis

    Article • The EMBO Journal, March 2004, Springer Science + Business Media

    Professor Luca Scorrano

  204. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

    Article • Journal of Clinical Investigation, December 2003, American Society for Clinical Investigation

    Professor Luca Scorrano

  205. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members

    Article • Biochemical Pharmacology, October 2003, Elsevier

    Professor Luca Scorrano

  206. Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis

    Article • Cell Death and Differentiation, August 2003, Springer Science + Business Media

    Professor Luca Scorrano

  207. Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene

    Article • Proceedings of the National Academy of Sciences, August 2003, Proceedings of the National Academy of Sciences

    Dr Peter Christian Kloehn, Professor Luca Scorrano

  208. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

    Article • Nature, August 2003, Springer Science + Business Media

    Professor Luca Scorrano

  209. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

    Article • Biochemical and Biophysical Research Communications, May 2003, Elsevier

    Professor Luca Scorrano

  210. Cell death induced by granzyme C

    Article • Blood, April 2003, American Society of Hematology

    Professor Luca Scorrano

  211. BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

    Article • Science, April 2003, American Association for the Advancement of Science

    Professor Luca Scorrano

  212. Mitochondria Are Direct Targets of the Lipoxygenase Inhibitor MK886

    Article • Journal of Biological Chemistry, August 2002, Elsevier

    Professor Luca Scorrano

  213. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth

    Article • Cancer Cell, July 2002, Elsevier

    Professor Luca Scorrano

  214. A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

    Article • Developmental Cell, January 2002, Elsevier

    Professor Luca Scorrano

  215. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK

    Article • Proceedings of the National Academy of Sciences, December 2001, Proceedings of the National Academy of Sciences

    Professor Luca Scorrano

  216. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

    Article • Nature Immunology, May 2001, Springer Science + Business Media

    Professor Luca Scorrano

  217. Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

    Article • Journal of Biological Chemistry, April 2001, Elsevier

    Professor Luca Scorrano

  218. The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

    Article • Journal of Biological Chemistry, April 2001, Elsevier

    Professor Luca Scorrano

  219. A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c

    Article • The EMBO Journal, February 2001, Springer Science + Business Media

    Professor Luca Scorrano

  220. Interactions of Chloromethyltetramethylrosamine (Mitotracker Orangetm) with Isolated Mitochondria and Intact Cells

    Article • Annals of the New York Academy of Sciences, November 1999, Wiley

    Professor Luca Scorrano

  221. Erratum

    Article • FEBS Journal, October 1999, Wiley

    Professor Luca Scorrano

  222. Mitochondria and cell death

    Article • FEBS Journal, September 1999, Wiley

    Professor Luca Scorrano

  223. Chloromethyltetramethylrosamine (Mitotracker OrangeTM) Induces the Mitochondrial Permeability Transition and Inhibits Respiratory Complex I

    Article • Journal of Biological Chemistry, August 1999, Elsevier

    Professor Luca Scorrano

  224. Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

    Article • Journal of Biological Chemistry, August 1999, Elsevier

    Professor Luca Scorrano

  225. Chemical modification of the mitochondrial permeability transition pore by specific amino acid reagents

    Article • Drug Development Research, January 1999, Wiley

    Professor Luca Scorrano

  226. Perspectives on the mitochondrial permeability transition

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, June 1998, Elsevier

    Professor Luca Scorrano

  227. On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

    Article • Journal of Biological Chemistry, May 1997, Elsevier

    Professor Luca Scorrano

  228. Article • Molecular and Cellular Biochemistry, January 1997, Springer Science + Business Media

    Professor Luca Scorrano