All Stories

  1. Yeast mycobiome of fruit and vegetable biowastes revealed by culture-dependent and metabarcoding approaches: Screening for the production of succinic acid and single cell oils

    Article • Food Bioscience, December 2024, Elsevier

    Maria João Sousa

  2. Combining Fluconazole with Benzo[a]phenoxazine Derivatives as a Promising Strategy Against Fluconazole-Resistant Candida Species

    Article • Molecules, November 2024, MDPI AG

    Maria João Sousa

  3. Anticancer Activity of Benzo[a]phenoxazine Compounds Promoting Lysosomal Dysfunction

    Article • Cells, August 2024, MDPI AG

    Maria João Sousa

  4. The fungicide cymoxanil impairs respiration in Saccharomyces cerevisiae via cytochrome c oxidase inhibition

    Article • FEBS Letters, May 2024, Wiley

    Maria João Sousa

  5. Current and novel approaches in yeast cell death research

    Article • Cell Death and Differentiation, May 2024, Springer Science + Business Media

    Maria João Sousa

  6. Novel yeast-based biosensor for environmental monitoring of tebuconazole

    Article • Applied Microbiology and Biotechnology, January 2024, Springer Science + Business Media

    Maria João Sousa

  7. Bridging the gap: linking Torulaspora delbrueckii genotypes to fermentation phenotypes and wine aroma

    Article • FEMS Yeast Research, January 2024, Oxford University Press (OUP)

    Maria João Sousa

  8. Evolution and functional diversification of yeast sugar transporters

    Article • Essays in Biochemistry, September 2023, Portland Press Ltd.

    Maria João Sousa

  9. Novel Benzo[a]phenoxazinium Chlorides Functionalized with Sulfonamide Groups as NIR Fluorescent Probes for Vacuole, Endoplasmic Reticulum, and Plasma Membrane Staining

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Maria João Sousa

  10. Contributions of Adaptive Laboratory Evolution towards the Enhancement of the Biotechnological Potential of Non-Conventional Yeast Species

    Article • Journal of Fungi, January 2023, MDPI AG

    Maria João Sousa

  11. Evaluation of Antifungal Activity and Potential Application as Fluorescent Probes of Indolenine and Benzo[e]Indole‐Based Squarylium Dyes

    Article • Photochemistry and Photobiology, January 2023, Wiley

    Maria João Sousa

  12. Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[a]phenoxazine Derivative

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Maria João Sousa, Dr. Fatima Baltazar

  13. Impact of ergosterol content on acetic and lactic acids toxicity to Saccharomyces cerevisiae

    Article • Yeast, November 2022, Wiley

    Maria João Sousa

  14. Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications

    Article • Cells, July 2022, MDPI AG

    Maria João Sousa

  15. Torulaspora delbrueckii Phenotypic and Metabolic Profiling towards Its Biotechnological Exploitation

    Article • Journal of Fungi, May 2022, MDPI AG

    Maria João Sousa

  16. Squaraine Dyes Derived from Indolenine and Benzo[e]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents

    Article • Photochemistry and Photobiology, April 2022, Wiley

    Maria João Sousa

  17. Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax

    Article • APOPTOSIS, April 2022, Springer Science + Business Media

    Maria João Sousa

  18. A glimpse at an early stage of microbe domestication revealed in the variable genome of Torulaspora delbrueckii, an emergent industrial yeast

    Article • Molecular Ecology, March 2022, Wiley

    Maria João Sousa

  19. KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications

    Article • Cells, January 2022, MDPI AG

    Maria João Sousa

  20. Saccharomyces cerevisiae Cells Lacking the Zinc Vacuolar Transporter Zrt3 Display Improved Ethanol Productivity in Lignocellulosic Hydrolysates

    Article • Journal of Fungi, January 2022, MDPI AG

    Maria João Sousa

  21. Whole-Genome Sequencing and Annotation of the Yeast Clavispora santaluciae Reveals Important Insights about Its Adaptation to the Vineyard Environment

    Article • Journal of Fungi, January 2022, MDPI AG

    Maria João Sousa

  22. Novel Nile Blue Analogue Stains Yeast Vacuolar Membrane, Endoplasmic Reticulum, and Lipid Droplets, Inducing Cell Death through Vacuole Membrane Permeabilization

    Article • Journal of Fungi, November 2021, MDPI AG

    Maria João Sousa

  23. Biotechnological Importance of Torulaspora delbrueckii: From the Obscurity to the Spotlight

    Article • Journal of Fungi, August 2021, MDPI AG

    Maria João Sousa

  24. The Plasma Membrane at the Cornerstone Between Flexibility and Adaptability: Implications for Saccharomyces cerevisiae as a Cell Factory

    Article • Frontiers in Microbiology, August 2021, Frontiers

    Maria João Sousa

  25. Development of an automated yeast-based spectrophotometric method for toxicity screening: Application to ionic liquids, GUMBOS, and deep eutectic solvents

    Article • Chemosphere, August 2021, Elsevier

    Maria João Sousa

  26. Regulation of Cell Death Induced by Acetic Acid in Yeasts

    Article • Frontiers in Cell and Developmental Biology, June 2021, Frontiers

    Maria João Sousa

  27. Identification of novel pentose transporters in Kluyveromyces marxianus using a new screening platform

    Article • FEMS Yeast Research, April 2021, Oxford University Press (OUP)

    Maria João Sousa

  28. Improvement of Torulaspora delbrueckii Genome Annotation: Towards the Exploitation of Genomic Features of a Biotechnologically Relevant Yeast

    Article • Journal of Fungi, April 2021, MDPI AG

    Maria João Sousa

  29. N-(5-Amino-9H-benzo[a]phenoxazin-9-ylidene)propan-1-aminium chlorides as antifungal agents and NIR fluorescent probes

    Article • New Journal of Chemistry, January 2021, Royal Society of Chemistry

    Maria João Sousa

  30. Evaluation of Fluorescent Staining Capacity of Two New Nile Blue Analogues

    Article • November 2020, MDPI AG

    Maria João Sousa

  31. Two Symmetrical Squarylium Cyanine Dyes: Synthesis, Photophysics and Antifungal Activity in Saccharomyces cerevisiae

    Article • November 2020, MDPI AG

    Maria João Sousa

  32. Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process

    Article • Oxidative Medicine and Cellular Longevity, October 2020, Hindawi Publishing Corporation

    Maria João Sousa

  33. Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes

    Article • Bioorganic Chemistry, May 2020, Elsevier

    Maria João Sousa

  34. New NIR dyes based on quinolizino[1,9-hi]phenoxazin-6-iminium chlorides: synthesis, photophysics and antifungal activity

    Article • Dyes and Pigments, February 2020, Elsevier

    Maria João Sousa

  35. Hexose transport in Torulaspora delbrueckii: identification of Igt1, a new dual-affinity transporter

    Article • FEMS Yeast Research, January 2020, Oxford University Press (OUP)

    Maria João Sousa

  36. Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

    Article • Medicinal Chemistry, May 2019, Bentham Science Publishers

    Maria João Sousa

  37. Contacts in Death: The Role of the ER-Mitochondria Axis in Acetic Acid-Induced Apoptosis in Yeast

    Article • Journal of Molecular Biology, November 2018, Elsevier

    Maria João Sousa

  38. New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship

    Article • Molecules, October 2018, MDPI AG

    Maria João Sousa

  39. Proteasome inhibition prevents cell death induced by the chemotherapeutic agent cisplatin downstream of DNA damage

    Article • DNA Repair, October 2018, Elsevier

    Maria João Sousa

  40. The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis

    Article • Cells, February 2018, MDPI AG

    Maria João Sousa

  41. Guidelines and recommendations on yeast cell death nomenclature

    Article • Microbial Cell, January 2018, Shared Science Publishers OG

    Paula Ludovico, Maria João Sousa, Michael Chang

  42. Integrating transcriptomics and metabolomics for the analysis of the aroma profiles of Saccharomyces cerevisiae strains from diverse origins

    Article • BMC Genomics, June 2017, Springer Science + Business Media

    Maria João Sousa

  43. VDAC regulates AAC-mediated apoptosis and cytochrome c release in yeast

    Article • Microbial Cell, October 2016, Shared Science Publishers OG

    Maria João Sousa

  44. Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents

    Article • Tetrahedron Letters, August 2016, Elsevier

    Maria João Sousa

  45. Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Maria João Sousa

  46. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl, Dr Marc Etienne Poirot

  47. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla, Dave Bridges

  48. Dietary Restriction and Nutrient Balance in Aging

    Article • Oxidative Medicine and Cellular Longevity, January 2016, Hindawi Publishing Corporation

    Maria João Sousa

  49. Regulation of Bax/mitochondria interaction by AKT

    Article • FEBS Letters, December 2015, Wiley

    Maria João Sousa

  50. Benzo[a]phenoxazinium chlorides functionalized with chloride atoms and/or ester groups

    Article • October 2015, MDPI AG

    Maria João Sousa

  51. Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

    Article • Oncotarget, September 2015, Impact Journals, LLC

    Maria João Sousa

  52. Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium

    Article • Oncotarget, December 2014, Impact Journals, LLC

    Maria João Sousa

  53. Evaluation of Newly Synthesised Benzo[a]Phenoxazinium Chlorides as Fluorescent Probes Using Saccharomyces Cerevisiae as Model Organism

    Article • November 2014, MDPI AG

    Maria João Sousa

  54. Antiproliferative Activity of 2,3,6,7-Tetrahydro-1H-Benzo[a]Quinolizino[1,9-hi]Phenoxazin-14(5H)-Iminium Chloride Derivatives

    Article • November 2014, MDPI AG

    Maria João Sousa

  55. Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae

    Article • Microbial Cell, September 2014, Shared Science Publishers OG

    Maria João Sousa

  56. The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids

    Article • FEMS Yeast Research, August 2014, Oxford University Press (OUP)

    Maria João Sousa

  57. Mentha piperitaessential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

    Article • FEMS Yeast Research, August 2014, Oxford University Press (OUP)

    Maria João Sousa

  58. The Genome Sequence of the Highly Acetic Acid-Tolerant Zygosaccharomyces bailii-Derived Interspecies Hybrid Strain ISA1307, Isolated From a Sparkling Wine Plant

    Article • DNA Research, January 2014, Oxford University Press (OUP)

    Maria João Sousa

  59. The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids

    Article • FEMS Yeast Research, October 2013, Oxford University Press (OUP)

    Maria João Sousa

  60. C2-Phytoceramide Perturbs Lipid Rafts and Cell Integrity in Saccharomyces cerevisiae in a Sterol-Dependent Manner

    Article • PLOS One, September 2013, PLOS

    Maria João Sousa

  61. Ammonium-Dependent Shortening of CLS in Yeast Cells Starved for Essential Amino Acids Is Determined by the Specific Amino Acid Deprived, through Different Signaling Pathways

    Article • Oxidative Medicine and Cellular Longevity, January 2013, Hindawi Publishing Corporation

    Maria João Sousa

  62. Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae

    Article • BMC Genomics, January 2013, Springer Science + Business Media

    Maria João Sousa

  63. The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii

    Article • PLOS One, December 2012, PLOS

    Maria João Sousa, Paula Ludovico

  64. The protective role of yeast Cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p)

    Article • FEBS Letters, December 2012, Wiley

    Maria João Sousa

  65. Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism

    Article • PLOS One, November 2012, PLOS

    Maria João Sousa

  66. The Emerging Role of the Yeast Torulaspora delbrueckii in Bread and Wine Production: Using Genetic Manipulation to Study Molecular Basis of Physiological Responses

    Article • August 2012, IntechOpen

    Maria João Sousa

  67. Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan

    Article • PLOS One, May 2012, PLOS

    Maria João Sousa

  68. Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity

    Article • Oxidative Medicine and Cellular Longevity, January 2012, Hindawi Publishing Corporation

    Maria João Sousa

  69. Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

    Article • Biochemical Society Transactions, October 2011, Portland Press Ltd.

    Maria João Sousa

  70. The impact of acetate metabolism on yeast fermentative performance and wine quality: reduction of volatile acidity of grape musts and wines

    Article • Applied Microbiology and Biotechnology, October 2010, Springer Science + Business Media

    Maria João Sousa

  71. Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier

    Article • Molecular Microbiology, March 2010, Wiley

    Maria João Sousa

  72. Small heat-shock protein Hsp12 contributes to yeast tolerance to freezing stress

    Article • Microbiology, April 2009, Society for General Microbiology

    Maria João Sousa

  73. Improved gene disruption method for Torulaspora delbrueckii

    Article • FEMS Yeast Research, February 2009, Oxford University Press (OUP)

    Maria João Sousa

  74. Mitochondria-dependent apoptosis in yeast

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2008, Elsevier

    Maria João Sousa

  75. Synthesis of naphtho[2,3-a]phenoxazinium chlorides: Structure–activity relationships of these heterocycles and benzo[a]phenoxazinium chlorides as new antimicrobials

    Article • Bioorganic & Medicinal Chemistry, March 2008, Elsevier

    Maria João Sousa

  76. Ethanol tolerance of sugar transport, and the rectification of stuck wine fermentations

    Article • Microbiology, February 2008, Society for General Microbiology

    Maria João Sousa

  77. ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis

    Article • Molecular Microbiology, November 2007, Wiley

    Maria João Sousa

  78. Synthesis, characterisation and antimicrobial activity of new benzo[a]phenoxazine based fluorophores

    Article • Tetrahedron Letters, November 2007, Elsevier

    Maria João Sousa

  79. Sugar utilization patterns and respiro-fermentative metabolism in the baker's yeast Torulaspora delbrueckii

    Article • Microbiology, March 2007, Society for General Microbiology

    Maria João Sousa

  80. YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity

    Article • FEBS Letters, November 2006, Wiley

    Maria João Sousa

  81. Isolation and characterization of theLGT1gene encoding a low-affinity glucose transporter fromTorulaspora delbrueckii

    Article • Yeast, February 2005, Wiley

    Maria João Sousa

  82. Freeze tolerance of the yeastTorulaspora delbrueckii: cellular and biochemical basis

    Article • FEMS Microbiology Letters, November 2004, Oxford University Press (OUP)

    Maria João Sousa

  83. Isolation of an acetyl-CoA synthetase gene(ZbACS2) fromZygosaccharomyces bailii

    Article • Yeast, March 2004, Wiley

    Maria João Sousa

  84. Cloning and characterization of the gene encoding a high-affinity maltose transporter from

    Article • FEMS Yeast Research, January 2004, Oxford University Press (OUP)

    Maria João Sousa

  85. Activity of Essential Oils from Mediterranean Lamiaceae Species against Food Spoilage Yeasts

    Article • Journal of Food Protection, April 2003, International Association for Food Protection

    Maria João Sousa

  86. The Spoilage Yeast Zygosaccharomyces bailii Forms Mitotic Spores: a Screening Method for Haploidization

    Article • Applied and Environmental Microbiology, January 2003, ASM Journals

    Maria João Sousa, Paula Ludovico

  87. Zygosaccharomyces bailii: A Yeast With a Peculiar Pattern for the Regulation of Acetic Acid Metabolism in the Presence of Glucose

    Article • January 2003, Springer Science + Business Media

    Maria João Sousa

  88. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid

    Article • Microbiology, September 2001, Society for General Microbiology

    Maria João Sousa, Paula Ludovico

  89. Construction of a genomic library of the food spoilage yeast and isolation of the ?-isopropylmalate dehydrogenase gene ()

    Article • FEMS Yeast Research, April 2001, Elsevier

    Maria João Sousa

  90. Yeasts as a model for assessing the toxicity of the fungicides Penconazol, Cymoxanil and Dichlofluanid

    Article • Chemosphere, November 2000, Elsevier

    Maria João Sousa

  91. Rapid detection of efflux pumps and their relation with drug resistance in yeast cells

    Article • Cytometry Part A, January 2000, Wiley

    Maria João Sousa

  92. Mechanisms underlying the transport and intracellular metabolism of acetic acid in the presence of glucose in the yeast Zygosaccharomyces bailii

    Article • Microbiology, March 1998, Society for General Microbiology

    Maria João Sousa

  93. Transport of acetic acid in Zygosaccharomyces bailii: effects of ethanol and their implications on the resistance of the yeast to acidic environments.

    Article • Applied and Environmental Microbiology, January 1996, ASM Journals

    Maria João Sousa

  94. Effects of ethanol and acetic acid on the transport of malic acid and glucose in the yeast Schizosaccharomyces pombe: implications in wine deacidification

    Article • FEMS Microbiology Letters, February 1995, Oxford University Press (OUP)

    Maria João Sousa

  95. Must deacidification with an induced flocculant yeast strain of Schizosaccharomyces pombe

    Article • Applied Microbiology and Biotechnology, May 1993, Springer Science + Business Media

    Maria João Sousa

  96. Transport of malic acid in the yeastSchizosaccharomyces pombe: Evidence for proton-dicarboxylate symport

    Article • Yeast, December 1992, Wiley

    Maria João Sousa

  97. Differences in the flocculation mechanism ofKluyveromyces marxianus andSaccharomyces cerevisiae

    Article • Biotechnology Letters, March 1992, Springer Science + Business Media

    Maria João Sousa

  98. Malo‐alcoholic fermentation: the influence of operating conditions on the kinetics of deacidification

    Article • Journal of Wine Research, January 1991, Taylor & Francis

    Maria João Sousa