All Stories

  1. Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages

    Article • Journal of Biological Chemistry, October 2023, Elsevier

    Dr Takeshi Noda

  2. Opposing roles of RUBCN isoforms in autophagy and memory B cell generation

    Article • Science Signaling, September 2023, American Association for the Advancement of Science

    Dr Takeshi Noda

  3. Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts

    Article • Cell Structure and Function, January 2023, Japan Society for Cell Biology

    Dr Takeshi Noda

  4. VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells

    Article • Autophagy Reports, October 2022, Taylor & Francis

    Dr Takeshi Noda

  5. VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes

    Article • mBio, August 2022, ASM Journals

    Dr Takeshi Noda

  6. Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast

    Article • FEBS Open Bio, September 2021, Wiley

    Dr Takeshi Noda

  7. A CRISPR/Cas9‐based method for seamless N‐terminal protein tagging in Saccharomyces cerevisiae

    Article • Yeast, September 2021, Wiley

    Dr Takeshi Noda

  8. Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations

    Article • Antioxidants, July 2021, MDPI AG

    Dr Takeshi Noda

  9. Vacuolar protein Tag1 and Atg1–Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae

    Article • Journal of Cell Science, February 2021, The Company of Biologists

    Dr Takeshi Noda

  10. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen

  11. Autophagosome formation in relation to the endoplasmic reticulum

    Article • Journal of Biomedical Science, October 2020, Springer Science + Business Media

    Dr Takeshi Noda

  12. STEEP mediates STING ER exit and activation of signaling

    Article • Nature Immunology, July 2020, Springer Science + Business Media

    Dr Takeshi Noda

  13. ERdj8 governs the size of autophagosomes during the formation process

    Article • The Journal of Cell Biology, June 2020, Rockefeller University Press

    Dr Takeshi Noda

  14. Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan

    Article • PLoS ONE, March 2020, PLOS

    Dr Takeshi Noda

  15. Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells

    Article • Frontiers in Microbiology, February 2020, Frontiers

    Dr Takeshi Noda

  16. Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

    Article • mBio, October 2019, ASM Journals

    Dr Takeshi Noda

  17. Osteoblastic lysosome plays a central role in mineralization

    Article • Science Advances, July 2019, American Association for the Advancement of Science

    Dr Takeshi Noda

  18. Induction of selective autophagy in cells replicating hepatitis C virus genome

    Article • Journal of General Virology, December 2018, Society for General Microbiology

    Dr Takeshi Noda

  19. Glutamine activates cell growth and suppresses autophagy

    Article • PLoS Genetics, April 2018, PLOS

    Dr Takeshi Noda

  20. Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress

    Article • Molecular Biology of the Cell, December 2017, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda, Dr Akira Matsuura

  21. mTORC1 is activated by Rheb at the Golgi-lysosome contact site

    Article • Journal of Cell Science, December 2017, The Company of Biologists

    Dr Takeshi Noda

  22. The enigma of Atg9 vesicles in autophagy

    Article • Biochemical Society Transactions, November 2017, Portland Press Ltd.

    Dr Takeshi Noda

  23. Regulation of Autophagy through TORC1 and mTORC1

    Article • Biomolecules, July 2017, MDPI AG

    Dr Takeshi Noda

  24. Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

    Article • PLoS Pathogens, July 2017, PLOS

    Dr Takeshi Noda

  25. Quantitative Assay of Macroautophagy Using Pho8△60 Assay and GFP-Cleavage Assay in Yeast

    Article • January 2017, Elsevier

    Dr Takeshi Noda

  26. Study on Autophagy by Professor Ohsumi: Nobel Prize Originated from the Frontier

    Article • TRENDS IN THE SCIENCES, January 2017, Japan Science Support Foundation

    Dr Takeshi Noda

  27. Fatty acid desaturase is required for Atg9 delivery during autophagy

    Article • Biology Open, November 2016, The Company of Biologists

    Dr Takeshi Noda

  28. Atg9A trafficking through the recycling endosomes is required for autophagosome formation

    Article • Journal of Cell Science, September 2016, The Company of Biologists

    Dr Takeshi Noda

  29. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang

  30. mTORC1 and PI3Phosphatase

    Article • FEBS Letters, December 2015, Wiley

    Dr Takeshi Noda

  31. Dynamic relocation of the TORC1-Gtr1/2-Ego1/2/3 complex is regulated by Gtr1 and Gtr2

    Article • Molecular Biology of the Cell, November 2015, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda, Dr Akira Matsuura

  32. Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

    Article • Autophagy, June 2014, Taylor & Francis

    Dr Takeshi Noda

  33. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

    Article • The Journal of Cell Biology, October 2013, Rockefeller University Press

    Dr Takeshi Noda

  34. Porphyromonas gingivalispromotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation

    Article • Cellular Microbiology, September 2013, Wiley

    Dr Takeshi Noda

  35. TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy

    Article • Journal of Cell Science, August 2013, The Company of Biologists

    Dr Takeshi Noda

  36. Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

    Article • The EMBO Journal, August 2013, Wiley

    Dr Takeshi Noda

  37. Autophagosomes form at ER–mitochondria contact sites

    Article • Nature, March 2013, Nature

    Dr Takeshi Noda

  38. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke

  39. Morphological Analysis of Autophagy

    Article • January 2012, Springer Science + Business Media

    Dr Takeshi Noda

  40. Three-Axis Model for Atg Recruitment in Autophagy against Salmonella

    Article • International Journal of Cell Biology, January 2012, Hindawi Publishing Corporation

    Dr Takeshi Noda

  41. Dysfunction of Autophagy Participates in Vacuole Formation and Cell Death in Cells Replicating Hepatitis C Virus

    Article • Journal of Virology, October 2011, ASM Journals

    Dr Takeshi Noda

  42. The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

    Article • Molecular Biology of the Cell, April 2011, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  43. Atg14L recruits PtdIns 3-kinase to the ER for autophagosome formation

    Article • Autophagy, April 2011, Taylor & Francis

    Dr Takeshi Noda

  44. Chemical modulators of autophagy as biological probes and potential therapeutics

    Article • Nature Methods, January 2011, Nature

    Dr Takeshi Noda

  45. Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

    Article • Molecular Biology of the Cell, October 2010, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  46. Regulation of membrane biogenesis in autophagy via PI3P dynamics

    Article • Seminars in Cell and Developmental Biology, September 2010, Elsevier

    Dr Takeshi Noda

  47. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

    Article • The Journal of Cell Biology, August 2010, Rockefeller University Press

    Dr Takeshi Noda

  48. Between canonical and antibacterial autophagy: Rab7 is required for GAS-containing autophagosome-like vacuole formation

    Article • Autophagy, April 2010, Taylor & Francis

    Dr Takeshi Noda

  49. Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

    Article • Traffic, March 2010, Wiley

    Dr Takeshi Noda

  50. Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation

    Article • Autophagy, February 2010, Taylor & Francis

    Dr Takeshi Noda

  51. Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

    Article • Molecular Biology of the Cell, January 2010, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  52. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Dr Takeshi Noda, Osamu Takeuchi

  53. An Initial Step of GAS-Containing Autophagosome-Like Vacuoles Formation Requires Rab7

    Article • PLoS Pathogens, November 2009, PLOS

    Dr Takeshi Noda

  54. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

    Article • Nature, November 2009, Nature

    Dr Takeshi Noda

  55. Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy: ANALYSIS OF THE ORGANIZATION OF THE Atg16L1 COMPLEX IN FIBROBLASTS

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Takeshi Noda

  56. Molecular basis of canonical and bactericidal autophagy

    Article • International Immunology, September 2009, Oxford University Press (OUP)

    Dr Takeshi Noda

  57. Binding Rubicon to cross the Rubicon

    Article • Autophagy, August 2009, Taylor & Francis

    Dr Takeshi Noda

  58. The late stages of autophagy: how does the end begin?

    Article • Cell Death and Differentiation, May 2009, Nature

    Dr Takeshi Noda

  59. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

    Article • Nature, March 2009, Nature

    Dr Takeshi Noda

  60. Atg4BC74Ahampers autophagosome closure: A useful protein for inhibiting autophagy

    Article • Autophagy, January 2009, Taylor & Francis

    Dr Takeshi Noda

  61. Chapter 1 Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3

    Article • January 2009, Elsevier

    Dr Takeshi Noda

  62. An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

    Article • Molecular Biology of the Cell, November 2008, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  63. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

    Article • Nature, October 2008, Nature

    Dr Takeshi Noda, Osamu Takeuchi

  64. Toward unraveling membrane biogenesis in mammalian autophagy

    Article • Current Opinion in Cell Biology, August 2008, Elsevier

    Dr Takeshi Noda

  65. Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

    Article • Genes to Cells, June 2008, Wiley

    Dr Takeshi Noda

  66. The Ubi brothers reunited

    Article • Autophagy, May 2008, Taylor & Francis

    Dr Takeshi Noda

  67. The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

    Article • Molecular Biology of the Cell, March 2008, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  68. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Article • Autophagy, February 2008, Taylor & Francis

    Professor Gianluca Tettamanti, Dr Takeshi Noda

  69. Chapter 2 Viability Assays to Monitor Yeast Autophagy

    Article • January 2008, Elsevier

    Dr Takeshi Noda

  70. Chapter 3 The Quantitative Pho8Δ60 Assay of Nonspecific Autophagy

    Article • January 2008, Elsevier

    Dr Takeshi Noda

  71. Chapter 1 Biochemical Methods to Monitor Autophagy‐Related Processes in Yeast

    Article • January 2008, Elsevier

    Dr Takeshi Noda

  72. Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

    Article • Cell Structure and Function, January 2008, Japan Society for Cell Biology

    Dr Takeshi Noda

  73. Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

    Article • Autophagy, September 2007, Taylor & Francis

    Dr Takeshi Noda

  74. Starvation Triggers the Delivery of the Endoplasmic Reticulum to the Vacuole via Autophagy in Yeast

    Article • Traffic, January 2005, Wiley

    Dr Takeshi Noda

  75. Processing of ATG8s, Ubiquitin-Like Proteins, and Their Deconjugation by ATG4s Are Essential for Plant Autophagy

    Article • The Plant Cell, November 2004, American Society of Plant Biologists (ASPB)

    Dr Takeshi Noda

  76. Interrelationships among Atg proteins during autophagy inSaccharomyces cerevisiae

    Article • Yeast, September 2004, Wiley

    Dr Takeshi Noda

  77. In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Takeshi Noda

  78. Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain

    Article • The EMBO Journal, July 2003, Wiley

    Dr Takeshi Noda

  79. The Early Secretory Pathway Contributes to Autophagy in Yeast

    Article • Cell Structure and Function, January 2003, Japan Society for Cell Biology

    Dr Takeshi Noda

  80. Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene

    Article • PLANT PHYSIOLOGY, July 2002, American Society of Plant Biologists (ASPB)

    Dr Takeshi Noda

  81. Yeast autophagosomes: de novo formation of a membrane structure

    Article • Trends in Cell Biology, May 2002, Elsevier

    Dr Takeshi Noda

  82. Autophagosome Requires Specific Early Sec Proteins for Its Formation and NSF/SNARE for Vacuolar Fusion

    Article • Molecular Biology of the Cell, November 2001, American Society for Cell Biology (ASCB)

    Dr Takeshi Noda

  83. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

    Article • The EMBO Journal, November 2001, Wiley

    Dr Takeshi Noda

  84. Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure

    Article • Journal of Biological Chemistry, May 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Takeshi Noda

  85. Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

    Article • The Journal of Cell Biology, January 2001, Rockefeller University Press

    Dr Takeshi Noda

  86. A ubiquitin-like system mediates protein lipidation

    Article • Nature, November 2000, Nature

    Dr Takeshi Noda

  87. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

    Article • The EMBO Journal, November 2000, Wiley

    Dr Takeshi Noda

  88. The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

    Article • The Journal of Cell Biology, October 2000, Rockefeller University Press

    Dr Takeshi Noda

  89. A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Takeshi Noda

  90. Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy Pathways

    Article • The Journal of Cell Biology, February 2000, Rockefeller University Press

    Dr Takeshi Noda

  91. Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

    Article • The Journal of Cell Biology, October 1999, Rockefeller University Press

    Dr Takeshi Noda

  92. Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast

    Article • The EMBO Journal, October 1999, Wiley

    Dr Takeshi Noda, Dr Akira Matsuura

  93. Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway

    Article • The EMBO Journal, July 1999, Wiley

    Dr Takeshi Noda

  94. A protein conjugation system essential for autophagy

    Article • Nature, September 1998, Nature

    Dr Takeshi Noda

  95. Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

    Article • Journal of Biological Chemistry, February 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Takeshi Noda

  96. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae

    Article • Gene, June 1997, Elsevier

    Dr Takeshi Noda, Dr Akira Matsuura

  97. Mutational Analysis of Csc1/Vps4p: Involvement of Endosome in Regulation of Autophagy in Yeast.

    Article • Cell Structure and Function, January 1997, Japan Society for Cell Biology

    Dr Takeshi Noda

  98. Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

    Article • Proceedings of the National Academy of Sciences, October 1996, Proceedings of the National Academy of Sciences

    Dr Takeshi Noda

  99. Novel System for Monitoring Autophagy in the Yeast Saccharomyces cerevisiae

    Article • Biochemical and Biophysical Research Communications, May 1995, Elsevier

    Dr Takeshi Noda, Dr Akira Matsuura

  100. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction

    Article • The Journal of Cell Biology, October 1992, Rockefeller University Press

    Dr Takeshi Noda