All Stories

  1. The Co-Administration of Fluoroquinolones Strongly Increases the Anticancer Efficacy of Carboplatin Treatment—Novel Insights for Breast Cancer Chemotherapy from the Canine Mammary Tumor Model

    Article • Biology, April 2026, MDPI AG

    Professor Tullio Florio

  2. Simple and Rapid Model to Generate Differentiated Endometrial Floating Organoids

    Article • BIO-PROTOCOL, January 2026, Bio-Protocol, LLC

    Professor Tullio Florio

  3. Drug enteric metabolism in gut microbiota-brain crosstalk

    Article • Life Sciences, December 2025, Elsevier

    Professor Tullio Florio

  4. Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets

    Article • Molecular Therapy — Nucleic Acids, December 2025, Elsevier

    Professor Tullio Florio

  5. Chronic administration of metformin exerts cytostatic and cytotoxic effects via the PP2A-GSK3β-MCL-1 pathway by inhibiting the tmCLIC1 membrane protein in glioblastoma-initiating cells

    Article • Journal of Experimental & Clinical Cancer Research, November 2025, Springer Science + Business Media

    Professor Tullio Florio

  6. A floating endometrial organoid model recapitulates epithelial-stromal cell interactions in vitro

    Article • Experimental Cell Research, September 2025, Elsevier

    Professor Tullio Florio

  7. Abstract 5584: The critical role of CLIC1 in mediating metformin's antitumoral effects on glioblastoma

    Article • Cancer Research, April 2025, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  8. Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Professor Tullio Florio

  9. The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells

    Article • Cancer Cell International, December 2024, Springer Science + Business Media

    Professor Tullio Florio

  10. Ruta graveolens, but Not Rutin, Inhibits Survival, Migration, Invasion, and Vasculogenic Mimicry of Glioblastoma Cells

    Article • International Journal of Molecular Sciences, November 2024, MDPI AG

    Professor Tullio Florio

  11. Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets

    Article • Expert Opinion on Therapeutic Targets, November 2024, Taylor & Francis

    Professor Tullio Florio

  12. Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

    Article • Cell Communication and Signaling, September 2024, Springer Science + Business Media

    Professor Tullio Florio

  13. Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors

    Article • Scientific Reports, August 2024, Springer Science + Business Media

    Professor Tullio Florio

  14. Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation

    Article • Frontiers in Molecular Biosciences, July 2024, Frontiers

    Professor Tullio Florio

  15. Abstract 147: Identification of cell sub-populations in Neuroblastoma cell lines with single-cell-sequencing analysis

    Article • Cancer Research, March 2024, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  16. Development of Biotinylated Liposomes Encapsulating Metformin for Therapeutic Targeting of Inflammation-Based Diseases

    Article • Pharmaceutics, February 2024, MDPI AG

    Professor Tullio Florio

  17. Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas

    Article • Life, November 2023, MDPI AG

    Professor Tullio Florio

  18. Metformin potentiates immunosuppressant activity and adipogenic differentiation of human umbilical cord-mesenchymal stem cells

    Article • International Immunopharmacology, November 2023, Elsevier

    Professor Tullio Florio

  19. Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2023, Elsevier

    Professor Tullio Florio

  20. Editorial: “Small molecules targeting transmembrane receptors and ion channels in drug discovery”

    Article • Frontiers in Molecular Biosciences, May 2023, Frontiers

    Professor Tullio Florio

  21. Patient's dermal fibroblasts as disease markers for visceral myopathy

    Article • Biomaterials Advances, May 2023, Elsevier

    Professor Tullio Florio

  22. Proteasome inhibitors in medullary thyroid carcinoma: time to restart with clinical trials?

    Article • Frontiers in Endocrinology, April 2023, Frontiers

    Professor Tullio Florio

  23. Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity

    Article • Neuro-Oncology, April 2023, Oxford University Press (OUP)

    Professor Tullio Florio

  24. Abstract 4788: Oxidative stress promotes colorectal cancer aggressiveness through transmembrane chloride intracellular channel 1 (tmCLIC1) antioxidant activity

    Article • Cancer Research, April 2023, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  25. The Impact of Experimental Conditions on Cell Mechanics as Measured with Nanoindentation

    Article • Nanomaterials, March 2023, MDPI AG

    Professor Tullio Florio

  26. Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

    Article • Cells, December 2022, MDPI AG

    Professor Tullio Florio

  27. Immunotherapy of Neuroendocrine Neoplasms: Any Role for the Chimeric Antigen Receptor T Cells?

    Article • Cancers, August 2022, MDPI AG

    Professor Tullio Florio

  28. Cellular Mechanosensitivity: Validation of an Adaptable 3D-Printed Device for Microindentation

    Article • Nanomaterials, August 2022, MDPI AG

    Professor Tullio Florio

  29. Immune Checkpoint Blockade in Lung Carcinoids with Aggressive Behaviour: One More Arrow in Our Quiver?

    Article • Journal of Clinical Medicine, February 2022, MDPI AG

    Professor Tullio Florio

  30. Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

    Article • Journal of Experimental & Clinical Cancer Research, February 2022, Springer Science + Business Media

    Professor Tullio Florio

  31. N6-Isopentenyladenosine Hinders the Vasculogenic Mimicry in Human Glioblastoma Cells through Src-120 Catenin Pathway Modulation and RhoA Activity Inhibition

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Professor Tullio Florio

  32. Structure and Properties of Electrochemically Synthesized Silver Nanoparticles in Aqueous Solution by High-Resolution Techniques

    Article • Molecules, August 2021, MDPI AG

    Professor Tullio Florio

  33. Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting

    Article • Pharmaceutics, July 2021, MDPI AG

    Professor Tullio Florio

  34. Efficacy of a Three Drug-Based Therapy for Neuroblastoma in Mice

    Article • International Journal of Molecular Sciences, June 2021, MDPI AG

    Professor Tullio Florio

  35. Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management

    Article • Frontiers in Endocrinology, June 2021, Frontiers

    Professor Tullio Florio

  36. An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Professor Tullio Florio

  37. Immune Checkpoint Inhibitors: New Weapons Against Medullary Thyroid Cancer?

    Article • Frontiers in Endocrinology, April 2021, Frontiers

    Professor Tullio Florio

  38. Octreotide and Pasireotide Combination Treatment in Somatotroph Tumor Cells: Predominant Role of SST2 in Mediating Ligand Effects

    Article • Cancers, April 2021, MDPI AG

    Professor Tullio Florio

  39. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl, Professor Nektarios Tavernarakis

  40. Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks

    Article • Journal of Clinical Medicine, December 2020, MDPI AG

    Professor Tullio Florio

  41. Exosomes and Extracellular Vesicles as Emerging Theranostic Platforms in Cancer Research

    Article • Cells, December 2020, MDPI AG

    Professor Tullio Florio

  42. Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization

    Article • Bioorganic Chemistry, December 2020, Elsevier

    Professor Tullio Florio

  43. Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment

    Article • Molecules, November 2020, MDPI AG

    Professor Tullio Florio

  44. Extracellular Vesicles Loaded miRNAs as Potential Modulators Shared Between Glioblastoma, and Parkinson’s and Alzheimer’s Diseases

    Article • Frontiers in Cellular Neuroscience, November 2020, Frontiers

    Professor Tullio Florio

  45. MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment

    Article • Biomedicines, November 2020, MDPI AG

    Professor Tullio Florio

  46. Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

    Article • Stem Cells Translational Medicine, June 2020, Oxford University Press (OUP)

    Professor Tullio Florio

  47. Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells

    Article • Frontiers in Endocrinology, February 2020, Frontiers

    Professor Tullio Florio

  48. Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells

    Article • Cells, November 2019, MDPI AG

    Professor Tullio Florio

  49. Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms

    Article • International Journal of Molecular Sciences, August 2019, MDPI AG

    Professor Tullio Florio

  50. Abstract 2549: Allostatic conditions in human glioblastoma stem cells are maintained with the contribution of CLIC1 membrane protein functional expression

    Article • Cancer Research, July 2019, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  51. Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells

    Article • Cancers, May 2019, MDPI AG

    Professor Tullio Florio

  52. Proteases Upregulation in Sporadic Alzheimer’s Disease Brain

    Article • Journal of Alzheimer’s Disease, April 2019, IOS Press

    Professor Tullio Florio

  53. Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity

    Article • Frontiers in Oncology, March 2019, Frontiers

    Professor Tullio Florio

  54. Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

    Article • International Journal of Molecular Sciences, February 2019, MDPI AG

    Professor Tullio Florio

  55. Large expert-curated database for benchmarking document

    Article • Database, January 2019, Oxford University Press (OUP)

    Dr Daniel Prieto, Associate Professor James A.L. Brown, Professor Amanda G Thrift, Docent Kutty Selva Nandakumar, Professor Miguel Viveiros, MD Diego A. Valera-Cornejo, Dr Soroush Safaei, Dr Carmen San Martín, Piero Carninci, Dr Florian Rehfeldt, Dr Yoichi Watanabe, Kazuki Ide, Mr Alvin Wong, PD Dr. Adrian Meule, Dr Maurizio Petrelli, Dr Christine McGarrigle, Dr Tristan Reddan, Dr Nicola Roberts, Professor Stefan Lorkowski, Dr Cyrille Goarant, Dr Emma C Hobbs, Dr. Saurab Sharma, Ph.D., Dr Farid Rahimi, Prof. Iseult Lynch, Mirella Walker, Dr Luca Galluzzi, Sophie Ohlsson, Professor Tullio Florio, Dr Rabea A Gadelkareem, Dr Azubuike Christian Ukubuiwe, Prof Gajendra PS Raghava, Prof Jun Shen, Lubna Razak, ABHISHEKA BANSAL, Craig Billington, Dr Alejandro Lazo-Langner, Joan Albiol, MOURAD TAYEBI, Chuang Ma, Christine Toelzer , Dr. Kathrin Karsay, Professor Andrew M Beale, Professor Hugh James Byrne, Dr Ugo Marzocchi, Ana Nordberg, Martin Bartas, Natalia Echeverría, Dr Patricia M Graves, Dr Elvis A F Martis, Dr marco cascella, Dr. Giuseppe Lanza, Dr Michael Boah

  56. Mutual Influence of ROS, pH, and CLIC1 Membrane Protein in the Regulation of G1–S Phase Progression in Human Glioblastoma Stem Cells

    Article • Molecular Cancer Therapeutics, November 2018, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  57. Emerging multitarget tyrosine kinase inhibitors in the treatment of neuroendocrine neoplasms

    Article • Endocrine Related Cancer, September 2018, Bioscientifica

    Professor Tullio Florio

  58. Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

    Article • Frontiers in Pharmacology, August 2018, Frontiers

    Professor Tullio Florio

  59. Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

    Article • Molecular Neurobiology, July 2018, Springer Science + Business Media

    Professor Tullio Florio

  60. Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects

    Article • Scientific Reports, March 2018, Springer Science + Business Media

    Professor Tullio Florio

  61. In Silico Identification and Experimental Validation of Novel Anti-Alzheimer’s Multitargeted Ligands from a Marine Source Featuring a “2-Aminoimidazole plus Aromatic Group” Scaffold

    Article • ACS Chemical Neuroscience, February 2018, American Chemical Society (ACS)

    Professor Tullio Florio

  62. Sprouty2 enhances the tumorigenic potential of glioblastoma cells

    Article • Neuro-Oncology, February 2018, Oxford University Press (OUP)

    Professor Tullio Florio

  63. Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

    Article • Cell Death and Disease, February 2018, Springer Science + Business Media

    Dr. Katia Cortese, Professor Tullio Florio

  64. In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity

    Article • Experimental Cell Research, February 2018, Elsevier

    Professor Tullio Florio

  65. Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas

    Article • BIO-PROTOCOL, January 2018, Bio-Protocol, LLC

    Professor Tullio Florio

  66. Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer’s Disease and Cancer

    Article • Journal of Alzheimer’s Disease, November 2017, IOS Press

    Professor Tullio Florio

  67. Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors

    Article • Frontiers in Cellular Neuroscience, October 2017, Frontiers

    Professor Tullio Florio

  68. Abstract 304: CLIC1 membrane insertion is a pivotal regulator of glioblastoma stem cell G1-S transition by promoting an increase of chloride permeability

    Article • Cancer Research, July 2017, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  69. The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

    Article • Stem Cell Research & Therapy, May 2017, Springer Science + Business Media

    Prof Luciano Mutti, Professor Tullio Florio

  70. Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

    Article • Neurotoxicity Research, May 2017, Springer Science + Business Media

    Professor Tullio Florio

  71. Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?

    Article • Oncotarget, April 2017, Impact Journals, LLC

    Professor Tullio Florio

  72. Does pasireotide directly modulate skeletal muscle metabolism?

    Article • Endocrine, April 2017, Springer Science + Business Media

    Professor Tullio Florio

  73. A novel splice variant of the protein tyrosine phosphatasePTPRJthat encodes for a soluble protein involved in angiogenesis

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Professor Tullio Florio

  74. The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Professor Tullio Florio

  75. Subventricular zone microenvironment protects glioblastoma cells from radiotherapy cytotoxicity: role of the chemokine CXCL12

    Article • Translational Cancer Research, November 2016, AME Publishing Company

    Professor Tullio Florio

  76. Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

    Article • Pharmacological Research, November 2016, Elsevier

    Professor Tullio Florio

  77. Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells

    Article • Frontiers in Molecular Neuroscience, October 2016, Frontiers

    Professor Tullio Florio

  78. A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

    Article • The International Journal of Biochemistry & Cell Biology, October 2016, Elsevier

    Professor Tullio Florio

  79. Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma

    Article • Expert Opinion on Drug Discovery, September 2016, Taylor & Francis

    Professor Tullio Florio

  80. FGFR4 Polymorphism as Molecular Determinant of the Efficacy of mTOR Inhibitors In GH-Secreting Pituitary Adenomas

    Article • Endocrinology, September 2016, Endocrine Society

    Professor Tullio Florio

  81. Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells

    Article • Cell Cycle, August 2016, Taylor & Francis

    Professor Tullio Florio

  82. Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas

    Article • Molecular Neurobiology, August 2016, Springer Science + Business Media

    Professor Tullio Florio

  83. Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors

    Article • Endocrine, August 2016, Springer Science + Business Media

    Professor Tullio Florio

  84. Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Professor Tullio Florio

  85. Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies

    Article • Current Drug Targets, April 2016, Bentham Science Publishers

    Professor Tullio Florio

  86. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Professor Tullio Florio

  87. Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

    Article • Drug Discovery Today, January 2016, Elsevier

    Professor Tullio Florio

  88. PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs

    Article • PPAR Research, January 2016, Hindawi Publishing Corporation

    Professor Tullio Florio

  89. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA

    Article • Scientific Reports, December 2015, Springer Science + Business Media

    Professor Tullio Florio

  90. The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma

    Article • Cell Cycle, November 2015, Taylor & Francis

    Professor Tullio Florio

  91. Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 2015, Elsevier

    Professor Tullio Florio

  92. In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

    Article • BMC Cancer, April 2015, Springer Science + Business Media

    Professor Tullio Florio

  93. Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation

    Article • PLOS One, March 2015, PLOS

    Professor Tullio Florio

  94. Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

    Article • Molecular Neurobiology, November 2014, Springer Science + Business Media

    Professor Tullio Florio

  95. Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

    Article • Oncotarget, October 2014, Impact Journals, LLC

    Professor Tullio Florio

  96. Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures

    Article • July 2014, Bioscientifica

    Dr Alexandru SAVEANU, Professor Tullio Florio

  97. Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA

    Article • Cancer Cell International, July 2014, Springer Science + Business Media

    Professor Tullio Florio

  98. Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma

    Article • Journal of Cellular Physiology, June 2014, Wiley

    Professor Tullio Florio

  99. CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment

    Article • Frontiers in Cellular Neuroscience, May 2014, Frontiers

    Professor Tullio Florio

  100. Antitumoral effects of metformin on cancer stem cells: identification of novel molecular targets

    Article • Endocrine Abstracts, April 2014, Bioscientifica

    Professor Tullio Florio

  101. Neuroendocrine tumors: insights into innovative therapeutic options and rational development of targeted therapies

    Article • Drug Discovery Today, April 2014, Elsevier

    Dr Alexandru SAVEANU, Professor Tullio Florio

  102. Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System

    Article • International Journal of Endocrinology, January 2014, Hindawi Publishing Corporation

    Professor Tullio Florio

  103. New Molecules and Old Drugs as Emerging Approaches to Selectively Target Human Glioblastoma Cancer Stem Cells

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Tullio Florio

  104. Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

    Article • Toxicology, December 2013, Elsevier

    Pietro Fiaschi, Professor Tullio Florio

  105. Minimalist Hybrid Ligand/Receptor-Based Pharmacophore Model for CXCR4 Applied to a Small-Library of Marine Natural Products Led to the Identification of Phidianidine A as a New CXCR4 Ligand Exhibiting Antagonist Activity

    Article • ACS Chemical Biology, October 2013, American Chemical Society (ACS)

    Professor Tullio Florio

  106. A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 2013, Elsevier

    Professor Tullio Florio

  107. Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm

    Article • International Journal of Peptides, February 2013, Hindawi Publishing Corporation

    Professor Tullio Florio

  108. Adult Pituitary Stem Cells

    Article • February 2013, Springer Science + Business Media

    Professor Tullio Florio

  109. Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures

    Article • Cell Cycle, February 2013, Taylor & Francis

    Professor Tullio Florio

  110. Neuroblastoma: Inhibition by Alu-Like RNA

    Article • January 2013, Springer Science + Business Media

    Professor Tullio Florio

  111. Metformin selectively affects human glioblastoma tumor-initiating cell viability

    Article • Cell Cycle, December 2012, Taylor & Francis

    Professor Tullio Florio

  112. Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

    Article • The International Journal of Biochemistry & Cell Biology, November 2012, Elsevier

    Professor Tullio Florio

  113. The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells

    Article • Drug Discovery Today, October 2012, Elsevier

    Professor Tullio Florio

  114. Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity

    Article • Journal of Neurochemistry, September 2012, Wiley

    Professor Tullio Florio

  115. A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties

    Article • International Journal of Molecular Sciences, September 2012, MDPI AG

    Professor Tullio Florio

  116. Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment

    Article • Neurotoxicity Research, August 2012, Springer Science + Business Media

    Professor Tullio Florio

  117. EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms

    Article • Oncogene, July 2012, Springer Science + Business Media

    Professor Tullio Florio

  118. Role of Prion Protein Aggregation in Neurotoxicity

    Article • International Journal of Molecular Sciences, July 2012, MDPI AG

    Professor Tullio Florio

  119. Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure

    Article • PLOS One, July 2012, PLOS

    Professor Tullio Florio

  120. NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2012, Elsevier

    Professor Tullio Florio

  121. In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

    Article • BMC Neuroscience, April 2012, Springer Science + Business Media

    Professor Tullio Florio

  122. Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma

    Article • British Journal of Pharmacology, April 2012, Wiley

    Professor Tullio Florio

  123. Isolation of stem-like cells from spontaneous feline mammary carcinomas: Phenotypic characterization and tumorigenic potential

    Article • Experimental Cell Research, April 2012, Elsevier

    Professor Tullio Florio

  124. Abstract 10: Oncogenic variant EGFRvIII defines a hierarchy in glioblastoma and expression is restricted by epigenetic mechanisms despite the presence of gene amplification

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  125. CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis

    Article • BMC Veterinary Research, March 2012, Springer Science + Business Media

    Professor Tullio Florio

  126. Amyloid-β Protein Precursor Regulates Phosphorylation and Cellular Compartmentalization of Microtubule Associated Protein Tau

    Article • Journal of Alzheimer’s Disease, March 2012, IOS Press

    Professor Tullio Florio

  127. Goat anti‐human GM‐CSF recognizes canine GM‐CSF

    Article • Veterinary Clinical Pathology, March 2012, Wiley

    Professor Tullio Florio

  128. Balance between somatostatin and D2 receptor expression drives TSH‐secreting adenoma response to somatostatin analogues and dopastatins

    Article • Clinical Endocrinology, February 2012, Wiley

    Dr Alexandru SAVEANU, Professor Tullio Florio

  129. Recombinant Human Prion Protein Fragment 90–231, a Useful Model to Study Prion Neurotoxicity

    Article • OMICS A Journal of Integrative Biology, February 2012, Mary Ann Liebert Inc

    Professor Tullio Florio

  130. An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples

    Article • Disease Models & Mechanisms, January 2012, The Company of Biologists

    Professor Tullio Florio

  131. Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

    Article • Journal of Toxicology, January 2012, Hindawi Publishing Corporation

    Professor Tullio Florio

  132. Persistent increase of d-aspartate in d-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay

    Article • Neurobiology of Aging, November 2011, Elsevier

    Professor Tullio Florio

  133. Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets

    Article • Biochemical Pharmacology, November 2011, Elsevier

    Professor Tullio Florio

  134. The pathological prion protein forms ionic conductance in lipid bilayer

    Article • Neurochemistry International, August 2011, Elsevier

    Maurizio Pocchiari, Professor Tullio Florio

  135. Combined chemotherapy with cytotoxic and targeted compounds for the management of human malignant pleural mesothelioma

    Article • Trends in Pharmacological Sciences, August 2011, Elsevier

    Professor Tullio Florio

  136. The Chemokine SDF1/CXCL12: A Novel Autocrine/Paracrine Factor Involved In Pituitary Adenoma Development

    Article • The Open Neuroendocrinology Journal, May 2011, Bentham Science Publishers

    Professor Tullio Florio

  137. Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature

    Article • Journal of Neuroimmunology, May 2011, Elsevier

    Professor Tullio Florio

  138. An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease

    Article • Haematologica, April 2011, Ferrata Storti Foundation (Haematologica)

    Professor Tullio Florio, Daniela de Totero

  139. Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

    Article • Cell Death and Disease, March 2011, Springer Science + Business Media

    Professor Tullio Florio

  140. High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

    Article • The International Journal of Biochemistry & Cell Biology, March 2011, Elsevier

    Professor Tullio Florio

  141. 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

    Article • Neurobiology of Disease, February 2011, Elsevier

    Professor Tullio Florio

  142. Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved

    Article • Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, January 2011, PAGEPress Publications

    Professor Tullio Florio

  143. Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)

    Article • Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, January 2011, PAGEPress Publications

    Professor Tullio Florio

  144. Adult Pituitary Stem Cells: From Pituitary Plasticity to Adenoma Development

    Article • Neuroendocrinology, January 2011, Karger Publishers

    Professor Tullio Florio

  145. Chemokines and chemokine receptors: New actors in neuroendocrine regulations

    Article • Frontiers in Neuroendocrinology, January 2011, Elsevier

    Professor Tullio Florio

  146. Glioblastoma Cancer Stem Cells: Response to Epidermal Growth Factor Receptor Kinase Inhibitors

    Article • January 2011, Springer Science + Business Media

    Professor Tullio Florio

  147. In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5

    Article • Pituitary, November 2010, Springer Science + Business Media

    Dr Alexandru SAVEANU, Professor Tullio Florio

  148. Somatostatin and somatostatin receptors 1, 2 and 5 selective agonists inhibit C6 glioma cell growth in vitro and in vivo: Analysis of activated intracellular pathways

    Article • Regulatory Peptides, September 2010, Elsevier

    Professor Tullio Florio

  149. An Alu‐like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells

    Article • The FASEB Journal, June 2010, Wiley

    Professor Tullio Florio

  150. Efficacy of Novel Acridine Derivatives in the Inhibition of hPrP90-231 Prion Protein Fragment Toxicity

    Article • Neurotoxicity Research, April 2010, Springer Science + Business Media

    Professor Tullio Florio

  151. Gefitinib Targets EGFR Dimerization and ERK1/2 Phosphorylation to Inhibit Pleural Mesothelioma Cell Proliferation

    Article • Current Cancer Drug Targets, March 2010, Bentham Science Publishers

    Prof Luciano Mutti, Professor Tullio Florio

  152. The Somatostatin Analogue Octreotide Confers Sensitivity to Rapamycin Treatment on Pituitary Tumor Cells

    Article • Cancer Research, January 2010, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  153. Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target

    Article • Journal of Oncology, January 2010, Hindawi Publishing Corporation

    Professor Tullio Florio

  154. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice

    Article • AJP Endocrinology and Metabolism, November 2009, American Physiological Society

    Professor Tullio Florio

  155. Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors

    Article • Journal of Biological Chemistry, March 2009, Elsevier

    Professor Tullio Florio

  156. Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

    Article • Neurotoxicity Research, February 2009, Springer Science + Business Media

    Professor Tullio Florio

  157. The Eighth Fibronectin Type III Domain of Protein Tyrosine Phosphatase Receptor J Influences the Formation of Protein Complexes and Cell Localization

    Article • The Journal of Biochemistry, January 2009, Oxford University Press (OUP)

    Professor Tullio Florio

  158. Chemokines and pituitary functions

    Article • Frontiers in Neuroscience, January 2009, Frontiers

    Professor Tullio Florio

  159. Somatostatin Receptors 1, 2, and 5 Cooperate in the Somatostatin Inhibition of C6 Glioma Cell Proliferationin Vitrovia a Phosphotyrosine Phosphatase-η-Dependent Inhibition of Extracellularly Regulated Kinase-1/2

    Article • Endocrinology, September 2008, Endocrine Society

    Professor Tullio Florio

  160. Somatostatin inhibits colon cancer cell growth through cyclooxygenase‐2 downregulation

    Article • British Journal of Pharmacology, September 2008, Wiley

    Professor Tullio Florio

  161. Overexpression of Stromal Cell–Derived Factor 1 and Its Receptor CXCR4 Induces Autocrine/Paracrine Cell Proliferation in Human Pituitary Adenomas

    Article • Clinical Cancer Research, August 2008, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  162. Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study

    Article • June 2008

    Dr Alexandru SAVEANU, Professor Tullio Florio

  163. Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases

    Article • Molecular and Cellular Endocrinology, May 2008, Elsevier

    Professor Tullio Florio

  164. Chemokines, their Receptors and Significance in Brain Function

    Article • January 2008, Elsevier

    Professor Tullio Florio

  165. Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors

    Article • Frontiers in Bioscience, January 2008, Frontiers in Bioscience

    Professor Tullio Florio

  166. 17β-Estradiol Promotes Breast Cancer Cell Proliferation-Inducing Stromal Cell-Derived Factor-1-Mediated Epidermal Growth Factor Receptor Transactivation: Reversal by Gefitinib Pretreatment

    Article • Molecular Pharmacology, October 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Tullio Florio

  167. Protective Effects of Some Creatine Derivatives in Brain Tissue Anoxia

    Article • Neurochemical Research, October 2007, Springer Science + Business Media

    Professor Tullio Florio

  168. Intracellular accumulation of a mild‐denatured monomer of the human PrP fragment 90–231, as possible mechanism of its neurotoxic effects

    Article • Journal of Neurochemistry, September 2007, Wiley

    Professor Tullio Florio

  169. Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants

    Article • Journal of Neurochemistry, August 2007, Wiley

    Professor Tullio Florio

  170. ERK1/2 and p38 MAP kinases control prion protein fragment 90–231‐induced astrocyte proliferation and microglia activation

    Article • Glia, August 2007, Wiley

    Professor Tullio Florio

  171. Amyloid Precursor Protein and Presenilin Involvement in Cell Signaling

    Article • Neurodegenerative Diseases, June 2007, Karger Publishers

    Professor Tullio Florio

  172. Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor GRB2 and Modulate ERK 1,2 Signaling

    Article • Journal of Biological Chemistry, May 2007, Elsevier

    Professor Tullio Florio

  173. Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function

    Article • March 2007, Bioscientifica

    Professor Tullio Florio

  174. Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tract

    Article • Amino Acids, February 2007, Springer Science + Business Media

    Professor Tullio Florio

  175. Amino‐Terminally Truncated Prion Protein PrP90‐231 Induces Microglial Activation in Vitro

    Article • Annals of the New York Academy of Sciences, January 2007, Wiley

    Professor Tullio Florio

  176. Amyloid Precursor Protein and Presenilin 1 Interaction Studied by FRET in Human H4 Cells

    Article • Annals of the New York Academy of Sciences, January 2007, Wiley

    Professor Tullio Florio

  177. An Intracellular Multi-Effector Complex Mediates Somatostatin Receptor 1 Activation of Phospho-Tyrosine Phosphatase η

    Article • Molecular Endocrinology, January 2007, Endocrine Society

    Professor Tullio Florio

  178. CXCR4 and SDF1 expression in human meningiomas: A proliferative role in tumoral meningothelial cells in vitro1

    Article • Neuro-Oncology, January 2007, Oxford University Press (OUP)

    Professor Tullio Florio

  179. Amyloid Precursor Protein Modulates ERK‐1 and ‐2 Signaling

    Article • Annals of the New York Academy of Sciences, December 2006, Wiley

    Professor Tullio Florio

  180. CXC Receptor and Chemokine Expression in Human Meningioma

    Article • Annals of the New York Academy of Sciences, December 2006, Wiley

    Professor Tullio Florio

  181. Characterization of the Proapoptotic Intracellular Mechanisms Induced by a Toxic Conformer of the Recombinant Human Prion Protein Fragment 90-231

    Article • Annals of the New York Academy of Sciences, December 2006, Wiley

    Professor Tullio Florio

  182. SDF‐1 Controls Pituitary Cell Proliferation through the Activation of ERK1/2 and the Ca2+‐Dependent, Cytosolic Tyrosine Kinase Pyk2

    Article • Annals of the New York Academy of Sciences, December 2006, Wiley

    Professor Tullio Florio

  183. The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds

    Article • Neuroscience, November 2006, Elsevier

    Professor Tullio Florio, Alessandro Parodi

  184. Expression of CXC chemokine receptors 1–5 and their ligands in human glioma tissues: Role of CXCR4 and SDF1 in glioma cell proliferation and migration

    Article • Neurochemistry International, October 2006, Elsevier

    Professor Tullio Florio

  185. P4-151

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Professor Tullio Florio

  186. P1-420

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Professor Tullio Florio

  187. P1-422

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Professor Tullio Florio

  188. Conformation Dependent Pro-Apoptotic Activity of the Recombinant Human Prion Protein Fragment 90-231

    Article • International Journal of Immunopathology and Pharmacology, April 2006, SAGE Publications

    Professor Tullio Florio

  189. Octreotide, a Somatostatin Analogue, Mediates Its Antiproliferative Action in Pituitary Tumor Cells by Altering Phosphatidylinositol 3-Kinase Signaling and Inducing Zac1 Expression

    Article • Cancer Research, February 2006, American Association for Cancer Research (AACR)

    Professor Tullio Florio

  190. Chemokine Stromal Cell-Derived Factor 1α Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals

    Article • Molecular Pharmacology, October 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Tullio Florio

  191. Stromal cell-derived factor-1α (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation

    Article • Experimental Cell Research, August 2005, Elsevier

    Professor Tullio Florio

  192. The rat tyrosine phosphatase η increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue

    Article • Oncogene, February 2005, Springer Science + Business Media

    Professor Tullio Florio

  193. Somatostatin Receptor Subtype-Dependent Regulation of Nitric Oxide Release: Involvement of Different Intracellular Pathways

    Article • Molecular Endocrinology, January 2005, Endocrine Society

    Professor Tullio Florio

  194. Identification of a Conserved N-Capping Box Important for the Structural Autonomy of the Prion α3-Helix: The Disease Associated D202N Mutation Destabilizes the Helical Conformation

    Article • International Journal of Immunopathology and Pharmacology, January 2005, SAGE Publications

    Professor Tullio Florio

  195. The Phosphotyrosine Phosphatase η Mediates Somatostatin Inhibition of Glioma Proliferation via the Dephosphorylation of ERK1/2

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Professor Tullio Florio

  196. P3-380 Neurotoxicity of the recombinant prion protein fragment 90–231 in SH-SY5Y cells is dependent on its conversion in β-structured-isoform

    Article • Neurobiology of Aging, July 2004, Elsevier

    Professor Tullio Florio

  197. The Expression of the Phosphotyrosine Phosphatase DEP-1/PTPη Dictates the Responsivity of Glioma Cells to Somatostatin Inhibition of Cell Proliferation

    Article • Journal of Biological Chemistry, July 2004, Elsevier

    Professor Tullio Florio

  198. Expression of Somatostatin Receptor mRNA in Human Meningiomas and their Implication in in vitro Antiproliferative Activity

    Article • Journal of Neuro-Oncology, January 2004, Springer Science + Business Media

    Professor Tullio Florio

  199. Prion Protein Fragment 106–126 Induces a p38 MAP Kinase—Dependent Apoptosis in SH‐SY5Y Neuroblastoma Cells Independently from the Amyloid Fibril Formation

    Article • Annals of the New York Academy of Sciences, December 2003, Wiley

    Professor Tullio Florio

  200. The Tyrosine Phosphatase Shp-2 Mediates Intracellular Signaling Initiated by Ret Mutants

    Article • Endocrinology, October 2003, Endocrine Society

    Professor Tullio Florio

  201. Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases

    Article • Neurochemistry International, July 2003, Elsevier

    Professor Tullio Florio

  202. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH‐secreting pituitary adenoma cells in vitro

    Article • Clinical Endocrinology, June 2003, Wiley

    Professor Tullio Florio

  203. Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation

    Article • Toxicology Letters, April 2003, Elsevier

    Professor Tullio Florio

  204. Somatostatin Inhibits Tumor Angiogenesis and Growth via Somatostatin Receptor-3-Mediated Regulation of Endothelial Nitric Oxide Synthase and Mitogen-Activated Protein Kinase Activities

    Article • Endocrinology, April 2003, Endocrine Society

    Dr Ulrich Pfeffer, Professor Tullio Florio

  205. Contribution of two conserved glycine residues to fibrillogenesis of the 106–126 prion protein fragment. Evidence that a soluble variant of the 106–126 peptide is neurotoxic

    Article • Journal of Neurochemistry, March 2003, Wiley

    Professor Tullio Florio

  206. Basic Fibroblast Growth Factor Activates Endothelial Nitric-Oxide Synthase in CHO-K1 Cells via the Activation of Ceramide Synthesis

    Article • Molecular Pharmacology, February 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Tullio Florio

  207. In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone‐secreting human pituitary adenomas

    Article • Clinical Endocrinology, September 2002, Wiley

    Professor Tullio Florio

  208. Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein

    Article • Neurochemistry International, July 2002, Elsevier

    Professor Tullio Florio

  209. p38 MAP Kinase Mediates the Cell Death Induced by PrP106–126 in the SH-SY5Y Neuroblastoma Cells

    Article • Neurobiology of Disease, February 2002, Elsevier

    Professor Tullio Florio

  210. Inhibition of nuclear factor-κB activation induces apoptosis in cerebellar granule cells

    Article • Journal of Neuroscience Research, December 2001, Wiley

    Professor Tullio Florio

  211. Inhibition of nuclear factor‐κB activation induces apoptosis in cerebellar granule cells

    Article • Journal of Neuroscience Research, November 2001, Wiley

    Professor Tullio Florio

  212. The Activation of the Phosphotyrosine Phosphatase   (r-PTP ) Is Responsible for the Somatostatin Inhibition of PC Cl3 Thyroid Cell Proliferation

    Article • Molecular Endocrinology, October 2001, Endocrine Society

    Professor Tullio Florio

  213. Chemokines and Their Receptors in the Central Nervous System

    Article • Frontiers in Neuroendocrinology, July 2001, Elsevier

    Professor Tullio Florio

  214. Stromal cell‐derived factor‐1α induces astrocyte proliferation through the activation of extracellular signal‐regulated kinases 1/2 pathway

    Article • Journal of Neurochemistry, June 2001, Wiley

    Professor Tullio Florio

  215. Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor‐mediated mechanisms

    Article • Drug Development Research, January 2001, Wiley

    Professor Tullio Florio

  216. Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2

    Article • Journal of Physiology-Paris, October 2000, Elsevier

    Professor Tullio Florio

  217. Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

    Article • Neurobiology of Disease, August 2000, Elsevier

    Professor Tullio Florio

  218. Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106–126

    Article • International Journal of Developmental Neuroscience, May 2000, Wiley

    Professor Tullio Florio

  219. Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia

    Article • Glia, February 2000, Wiley

    Professor Tullio Florio

  220. Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia

    Article • Glia, February 2000, Wiley

    Professor Tullio Florio

  221. A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+

    Article • Journal of Molecular Endocrinology, December 1999, Bioscientifica

    Professor Tullio Florio

  222. Glial and Neuronal Cells Express Functional Chemokine Receptor CXCR4 and Its Natural Ligand Stromal Cell‐Derived Factor 1

    Article • Journal of Neurochemistry, December 1999, Wiley

    Professor Tullio Florio

  223. Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

    Article • European Journal of Endocrinology, October 1999, Oxford University Press (OUP)

    Professor Tullio Florio

  224. Expression of Chemokine Receptors in the Rat Braina

    Article • Annals of the New York Academy of Sciences, June 1999, Wiley

    Professor Tullio Florio

  225. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: Involvement of A2 purinergic receptor subtypes

    Article • Life Sciences, March 1999, Elsevier

    Professor Tullio Florio

  226. Somatostatin Activation of Mitogen-Activated Protein Kinase via Somatostatin Receptor 1 (SSTR1)

    Article • Molecular Endocrinology, January 1999, Endocrine Society

    Professor Tullio Florio

  227. Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line

    Article • Journal of Neuroscience Research, November 1998, Wiley

    Professor Tullio Florio

  228. Intracellular Signalling Mediating HIV-1 gp120 Neurotoxicity

    Article • Cellular Signalling, February 1998, Elsevier

    Professor Tullio Florio

  229. TGF-?1 prevents gp120-induced impairment of Ca2+ homeostasis and rescues cortical neurons from apoptotic death

    Article • Journal of Neuroscience Research, September 1997, Wiley

    Professor Tullio Florio

  230. Oncogene Transformation of PC Cl3 Clonal Thyroid Cell Line Induces an Autonomous Pattern of Proliferation That Correlates with a Loss of Basal and Stimulated Phosphotyrosine Phosphatase Activity

    Article • Endocrinology, September 1997, Endocrine Society

    Professor Tullio Florio

  231. Somatostatin Inhibits Interleukin 6 Release from Rat Cortical Type I Astrocytes via the Inhibition of Adenylyl Cyclase

    Article • Biochemical and Biophysical Research Communications, June 1997, Elsevier

    Professor Tullio Florio

  232. Intracellular Calcium Rise through L-Type Calcium Channels, as Molecular Mechanism for Prion Protein Fragment 106-126-Induced Astroglial Proliferation

    Article • Biochemical and Biophysical Research Communications, November 1996, Elsevier

    Professor Tullio Florio

  233. Cyclic 3,5 adenoise monophosphate and cyclosporin A inhibit cellular proliferation and serine/threonine protein phosphatase activity in pituitary cells

    Article • Endocrinology, October 1996, Endocrine Society

    Professor Tullio Florio

  234. Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors

    Article • Journal of Molecular Endocrinology, October 1996, Bioscientifica

    Professor Tullio Florio

  235. INTRACELLULAR TRANSDUCING MECHANISMS COUPLED TO BRAIN SOMATOSTATIN RECEPTORS

    Article • Pharmacological Research, June 1996, Elsevier

    Professor Tullio Florio

  236. A PRION PROTEIN FRAGMENT MODIFIES PLASMA MEMBRANE VISCOSITY AND INTRACELLULAR. CALCIUM LEVEL

    Article • Journal of Neuropathology & Experimental Neurology, May 1995, Oxford University Press (OUP)

    Professor Tullio Florio

  237. α1B, But Not α1A, Adrenoceptor Activates Calcium Influx through the Stimulation of a Tyrosine Kinase/Phosphotyrosine Phosphatase Pathway, Following Noradrenaline-Induced Emptying of IP3 Sensitive Calcium Stores, in PC C13 Rat Thyroid Cell Line

    Article • Biochemical and Biophysical Research Communications, April 1995, Elsevier

    Professor Tullio Florio

  238. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells

    Article • Molecular Endocrinology, October 1994, Endocrine Society

    Professor Tullio Florio

  239. The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin- sensitive pathways

    Article • Endocrinology, March 1994, Endocrine Society

    Professor Tullio Florio

  240. Effect of acetyl-?-carnitine treatment on brain adenylate cyclase activity in young and aged rats

    Article • European Neuropsychopharmacology, June 1993, Elsevier

    Professor Tullio Florio

  241. Modulation by GTP of Basal and Agonist‐Stimulated Striatal Adenylate Cyclase Activity Following Chronic Blockade of D1 and D2 Dopamine Receptors: Involvement of G Proteins in the Development of Receptor Supersensitivity

    Article • Journal of Neurochemistry, November 1992, Wiley

    Professor Tullio Florio

  242. Dopamine and somatostatin inhibition of prolactin secretion from MMQ pituitary cells: role of adenosine triphosphate-sensitive potassium channels

    Article • Endocrinology, October 1992, Endocrine Society

    Professor Tullio Florio

  243. Somatostatin receptor gene expression and related transducing mechanisms in MMQ cells, a prolactin secreting cell line

    Article • Pharmacological Research, September 1992, Elsevier

    Professor Tullio Florio

  244. Molecular mechanisms mediating the effects of l-α-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats

    Article • Pharmacology Biochemistry and Behavior, September 1992, Elsevier

    Professor Tullio Florio

  245. G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells

    Article • Science, May 1992, American Association for the Advancement of Science

    Professor Tullio Florio

  246. Interleukin 6 modulation of second messenger systems in anterior pituitary cells

    Article • Life Sciences, January 1992, Elsevier

    Professor Tullio Florio

  247. Age-related alterations of somatostatin gene expression in different rat brain areas

    Article • Brain Research, August 1991, Elsevier

    Professor Tullio Florio

  248. Dihydropyridine Modulation of Voltage‐Activated Calcium Channels in PC12 Cells: Effect of Pertussis Toxin Pretreatment

    Article • Journal of Neurochemistry, March 1991, Wiley

    Professor Tullio Florio

  249. Cytosolic calcium rise induced by maitotoxin in PC12 cells: Effect of omega-conotoxin (GVIA)

    Article • Pharmacological Research, October 1990, Elsevier

    Professor Tullio Florio

  250. Interleukin 1 beta modulation of TRH stimulated prolactin secretion and inositol phosphate production

    Article • Pharmacological Research, October 1990, Elsevier

    Professor Tullio Florio

  251. Interaction between immune and neuroendocrine systems: interleukin 1 beta inhibition of prolactin release and intracellular transducing mechanisms

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Tullio Florio

  252. Purinergic modulation of adenylate cyclase activity and prolactin secretion in rat adenohypophysis

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Tullio Florio

  253. Interleukin‐1 Modulation of Anterior Pituitary Function.

    Article • Annals of the New York Academy of Sciences, June 1990, Wiley

    Professor Tullio Florio

  254. Fipexide improvement of cognitive functions in rat: Behavioural and neurochemical studies

    Article • Pharmacological Research, March 1990, Elsevier

    Professor Tullio Florio

  255. Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release

    Article • Pharmacological Research, November 1989, Elsevier

    Professor Tullio Florio

  256. Dihydropiridine inhibition of k+ and maitotoxin stimulated calcium fluxes in pc12 cells: effect of pertussis toxin

    Article • Pharmacological Research, November 1989, Elsevier

    Professor Tullio Florio

  257. Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism

    Article • Biochemical and Biophysical Research Communications, November 1989, Elsevier

    Professor Tullio Florio

  258. Interleukin I modulation of anterior pituitary function: Effect on hormone release and second messenger systems

    Article • Pharmacological Research, November 1989, Elsevier

    Professor Tullio Florio

  259. Somatostatin inhibition of adenylate cyclase activity in different brain areas

    Article • Brain Research, July 1989, Elsevier

    Professor Tullio Florio

  260. Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels

    Article • Pharmacological Research Communications, December 1988, Elsevier

    Professor Tullio Florio

  261. Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay

    Article • Pharmacological Research Communications, December 1988, Elsevier

    Professor Tullio Florio

  262. A pertussis toxin sensitive G protein mediates dihydropyridine inhibition of maitotoxin stimulated calcium flux in 235-1 pituitary clone

    Article • Pharmacological Research Communications, September 1988, Elsevier

    Professor Tullio Florio

  263. Dihydroergotoxin interaction with central dopaminergic neurotransmission

    Article • Pharmacological Research Communications, September 1988, Elsevier

    Professor Tullio Florio

  264. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells

    Article • Biochemical and Biophysical Research Communications, September 1988, Elsevier

    Professor Tullio Florio

  265. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells

    Article • Biochemical and Biophysical Research Communications, September 1988, Elsevier

    Professor Tullio Florio

  266. Gonadectomy affects prolactin secretion from male and female rat lactotropes: A reverse hemolytic plaque assay study

    Article • Pharmacological Research Communications, September 1988, Elsevier

    Professor Tullio Florio

  267. Somatostatin and SMS 201-995 reverse the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin

    Article • European Journal of Pharmacology, July 1988, Elsevier

    Professor Tullio Florio

  268. Depletion of brain somatostatin (SRIF) by cysteamine (CSH) induces impairment of cognitive functions in rat: Reversal by administration of exogenous SRIF or its analogue SMS 201-995

    Article • Pharmacological Research Communications, March 1988, Elsevier

    Professor Tullio Florio

  269. Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line

    Article • Biochemical and Biophysical Research Communications, February 1988, Elsevier

    Professor Tullio Florio

  270. Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats

    Article • Brain Research, January 1988, Elsevier

    Professor Tullio Florio

  271. Calmodulin modulates prolactin secretion in vitro: Studies with calmodulin containing liposomes

    Article • Life Sciences, November 1987, Elsevier

    Professor Tullio Florio

  272. Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro

    Article • Springer Science + Business Media

    Professor Tullio Florio