All Stories

  1. Advances in biomarker discovery for canine cognitive dysfunction: a comprehensive structured narrative review and future perspectives
  2. An Efficient Method for Neuron‐Like Differentiation of SH ‐ SY5Y Neuroblastoma Cells Using Retinoic Acid and Laminin‐Rich Extracellular Matrix
  3. Cognition in later life: The role of structural support and life satisfaction in the Brazilian Longitudinal Study of Aging (ELSI-Brazil).
  4. From companionship to science: the importance of dogs in advancing translational research on Alzheimer's disease – a scoping review
  5. Ruthenium( ii )/diphosphine/naphthoquinone complexes: synthesis, characterization, anticancer activity and molecular docking studies
  6. Cellular responses to DisBa-01, an ɑvβ3 integrin inhibitor, alone and in combination with doxorubicin in three-dimensional breast cancer models
  7. Antagonistic effect of a nitric oxide donor agents based on ruthenium complex combined with cisplatin on lung tumor cell lines
  8. Feasibility and pilot testing of a non‐randomized teacher training program to improve knowledge and attitudes toward aging and dementia in public schools in Brazil: The ARISE program
  9. Tumoural Hypoxic Extracellular Vesicles Foster a Protective Microenvironment in Triple‐Negative Breast Cancer
  10. Interplay between depressive symptoms and Alzheimer’s disease dementia: unraveling the potential roles of ADAM10 and Negr1
  11. Higher soluble ADAM10 plasma levels are associated with decreased cognitive performance in older adults carrying APOEε4
  12. The heart-mind connection: exploring the association between cardiovascular health and cognitive performance in older women
  13. Exploring the connection between dementia and cardiovascular risk with a focus on ADAM10
  14. Frequency of care mediates the effect of older adults’ cognitive performance on the perceived strain of their informal caregivers in a middle-income country
  15. Factors influencing the cognitive performance in cognitively unimpaired older adults and people living with Alzheimer’s disease: Insights from a middle-income Latin American country
  16. Ruthenium(II)-mercapto complexes induce cell damage via apoptosis pathway on ovarian cancer cells
  17. An efficient method for neuron-like differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and laminin-rich extracellular matrix
  18. Enhanced Cytotoxicity of [10]-Gingerol-Coumarin-Triazole Hybrid as a Theranostic Agent for Triple Negative Breast Cancer
  19. Palladium(II) and platinum(II) thiophene-based thiosemicarbazones: Synthesis, properties, and anticancer studies
  20. Classification of Apolipoprotein E ϵ4 Allele Carriers in Cognitively Healthy Older Adults and Alzheimer’s Disease Patients Using Event-Related Potentials and Event-Related Spectral Perturbation
  21. Label-free ADAM10 capacitive assay for the early diagnosis of Alzheimer’s disease
  22. Tumoral hypoxic extracellular vesicles create a protective microenvironment for triple-negative breast cancer
  23. ADAM10 isoforms: Optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer’s disease
  24. Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease
  25. Present and Future of Blood-Based Biomarkers of Alzheimer’s Disease: Beyond the Classics
  26. Electrochemical magneto-immunoassay for detection of ADAM10 Alzheimer's biomarker using gold nanoparticles as label
  27. The effect of light irradiation on a nitro-ruthenium porphyrin complex in the induced death of lung cancer cells in two- and three-dimensional cultures: Insights into the effect of nitric oxide
  28. Pd(ii)/diphosphine/curcumin complexes as potential anticancer agents
  29. Plasma ADAM10 Levels and Their Association with Alzheimer’s Disease Diagnosis in Older Adults with Fewer Years of Formal Education
  30. Empathy as a crucial skill in disrupting disparities in global brain health
  31. The Brain Health Diplomat's Toolkit: supporting brain health diplomacy leaders in Latin America and the Caribbean
  32. Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study
  33. ADAM10 as a biomarker for Alzheimer's disease: A systematic review
  34. Cytotoxic activity of Ru(II)/DPEPhos/N,S-mercapto complexes (DPEPhos   -[(2-diphenylphosphino)phenyl]ether)
  35. Nanoencapsulation of Ruthenium Complex Ru(ThySMet): A Strategy to Improve Selective Cytotoxicity Against Breast Tumor Cells in 2D and 3D Culture Models
  36. Protecting cognitive function in older adults with age-related hearing loss: Insights from The Irish Longitudinal Study on Ageing (TILDA) and the role of hearing aids
  37. New ruthenium(ii) complexes with cyclic thio- and semicarbazone: evaluation of cytotoxicity and effects on cell migration and apoptosis of lung cancer cells
  38. Cytotoxic Activity of Ru(II)/DPEPhos/N,S-Mercapto Complexes (DPEPhos = Bis-[(2-Diphenylphosphino)Phenyl]Ether)
  39. New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway
  40. Developments in scalable strategies for detecting early markers of cognitive decline
  41. Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands
  42. Dynamics of Formation of Binuclear Metal Complexes: A New Cu(I) Compound with N ‐(2‐thiophenecarbonyl)‐ N’ ‐(3‐Cl, 4‐F‐phenyl)thiourea as Ligand
  43. Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19
  44. Diabetes predicts cognitive decline in the Irish population
  45. Biomarkers for Different Types of Dementia with a Therapeutic Focus
  46. Apolipoprotein E ε4 allele impairs cortical activity in healthy aging and Alzheimer’s disease
  47. Ruthenium(ii)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers
  48. Handicap auditivo e fragilidade em idosos da comunidade
  49. Cytotoxic and Antiparasitic Activities of Diphosphine-Metal Complexes of Group 10 Containing Acylthiourea as Ligands
  50. Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells
  51. Phenylalanine and COVID-19: Tracking disease severity markers
  52. Plasma 25-hydroxyvitamin D levels, quality of life, inflammation and depression in older adults: Are they related?
  53. Comorbidities predict 30-day hospital mortality of older adults with COVID-19
  54. Recent progresses on p-tau as a blood-based Alzheimer’s disease biomarker
  55. Associations between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity
  56. Poluição do ar e sua relação com a epilepsia
  57. Is there any relation between the elevations in liver transaminases and the severity of COVID-19?
  58. IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19
  59. Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review
  60. [6]-Gingerol-Derived Semi-Synthetic Compound SSi6 Inhibits Tumor Growth and Metastatic Dissemination in Triple-Negative Breast Cancer Xenograft Models
  61. Scavenging capacity and cytotoxicity of new Ru(II)-diphosphine/α-amino acid complexes
  62. [10]-Gingerol-Loaded Nanoemulsion and its Biological Effects on Triple-Negative Breast Cancer Cells
  63. Are body fat and inflammatory markers independently associated with age-related muscle changes?
  64. ADAM10 as a biomarker of mild cognitive impairment but not of cognitive frailty
  65. ADAM10 as a complimentary biomarker for mild Alzheimer's disease
  66. A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated factors
  67. Preparation and characterization of [6]-gingerol/β-cyclodextrin inclusion complexes
  68. Levels of ADAM10 predict worse in cognition
  69. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  70. A novel ruthenium(ii) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells
  71. Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug
  72. ADAM10 as a biomarker for Alzheimer’s disease
  73. Cytotoxicity of ruthenium-N,N-disubstituted-N′-acylthioureas complexes
  74. Ruthenium(II) Phosphine/Mercapto Complexes: Their in Vitro Cytotoxicity Evaluation and Actions as Inhibitors of Topoisomerase and Proteasome Acting as Possible Triggers of Cell Death Induction
  75. A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers
  76. ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study
  77. Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment
  78. Lycium barbarum polysaccharide fraction associated with photobiomodulation protects from epithelium thickness and collagen fragmentation in a model of cutaneous photodamage
  79. ADAM10 Plasma Levels Predict Worsening in Cognition of Older Adults: A 3-Year Follow-Up Study
  80. [10]-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models
  81. Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands
  82. Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin
  83. Structure Elucidation and Absolute Configuration Determination of Nortriterpenoids from Picramnia glazioviana
  84. Blood-based Biomarkers of Alzheimer’s Disease: The Long and Winding Road
  85. Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid
  86. Selective Coordination Mode of Acylthiourea Ligands in Half-Sandwich Ru(II) Complexes and Their Cytotoxic Evaluation
  87. Early Diagnosis of Alzheimer’s Disease in Blood Using a Disposable Electrochemical Microfluidic Platform
  88. Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
  89. Historic concepts of dementia and Alzheimer's disease: From ancient times to the present
  90. SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells
  91. Acetylation of cedrelone increases its cytotoxic activity and reverts the malignant phenotype of breast cancer cells in 3D culture
  92. Cytotoxic and apoptotic effects of ternary silver(i) complexes bearing 2-formylpyridine thiosemicarbazones and 1,10-phenanthroline
  93. Factors associated with depressive symptoms in older adults in context of social vulnerability
  94. Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer
  95. Ru(ii)/diclofenac-based complexes: DNA, BSA interaction and their anticancer evaluation against lung and breast tumor cells
  96. Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB
  97. Silver(i) complexes of 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazones and triphenylphosphine: structural, cytotoxicity, and apoptotic studies
  98. Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by thetrans-[Ru(PPh3)2(N,N-dimethyl-N-thiophenylthioureato-k2...
  99. Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis
  100. Alphavbeta3 integrin blocking inhibits apoptosis and induces autophagy in murine breast tumor cells
  101. Metastasis and cachexia: alongside in clinics, but not so in animal models
  102. Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
  103. [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDAMB- 231 Breast Tumor Cells
  104. Evaluation of the cytotoxicity on breast cancer cell of extracts and compounds isolated from Hyptis pectinata (L.) poit
  105. ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
  106. Metastasis inhibition in breast cancer by targeting cancer cell extravasation
  107. Ru(II)/N-N/PPh3 complexes as potential anticancer agents against MDA-MB-231 cancer cells (N-N = diimine or diamine)
  108. Label-free evaluation of small-molecule–protein interaction using magnetic capture and electrochemical detection
  109. Sarcopenia, frailty and their prevention by exercise
  110. Transport of the Ruthenium Complex [Ru(GA)(dppe)2]PF6 into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors
  111. Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding
  112. Anti-Proliferative and Anti-Migration Activity of Arene–Ruthenium(II) Complexes with Azole Therapeutic Agents
  113. Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors
  114. Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults
  115. Hydrolysis reaction promotes changes in coordination mode of Ru(II)/acylthiourea organometallic complexes with cytotoxicity against human lung tumor cell lines
  116. The trans -[Ru(PPh 3 ) 2 ( N , N -dimethyl- N ′-thiophenylthioureato-k 2 O,S)(bipy)]PF 6 complex has pro-apoptotic effects on triple negative breast cancer cells and presents low toxicity in vivo
  117. Autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells
  118. Translation, Adaptation and Validation of Rapid Geriatric Assessment to the Brazilian Context
  119. Photobiomodulation of a flowable matrix in a human skin ex vivo model demonstrates energy-based enhancement of engraftment integration and remodeling
  120. A bibliometric analysis in oncology and nanomedicine areas
  121. Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
  122. Fully disposable microfluidic electrochemical device for detection of estrogen receptor alpha breast cancer biomarker
  123. microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer’s Disease
  124. Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis
  125. Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells
  126. A Review of Ruthenium Complexes Activities on Breast Cancer Cells
  127. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo
  128. Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity of lapachol
  129. GERONTOLOGY AS A CAREER: EVIDENCE FROM COGNITIVE IMPROVEMENT IN A COGNITIVE TRAINING GROUP
  130. [10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture
  131. Abstract B40: [10]-gingerol as a pro-apoptotic molecule in triple negative breast cancer
  132. Heteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N′-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies
  133. Copper(I)–Phosphine Polypyridyl Complexes: Synthesis, Characterization, DNA/HSA Binding Study, and Antiproliferative Activity
  134. Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor
  135. Half sandwich Ru(ii)-acylthiourea complexes: DNA/HSA-binding, anti-migration and cell death in a human breast tumor cell line
  136. BACE1 levels are increased in plasma of Alzheimer's disease patients compared with matched cognitively healthy controls
  137. Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis
  138. Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole
  139. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging
  140. Antioxidant potential of the fruit from Lycium barbarum
  141. Cytotoxicity of Ru(II) piano–stool complexes with chloroquine and chelating ligands against breast and lung tumor cells: Interactions with DNA and BSA
  142. Chiral Platinum(II) Complexes Featuring Phosphine and Chloroquine Ligands as Cytotoxic and Monofunctional DNA-Binding Agents
  143. Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease
  144. Characterization of metabolic profile of intact non-tumor and tumor breast cells by high-resolution magic angle spinning nuclear magnetic resonance spectroscopy
  145. Molecular Design, Synthesis and Evaluation of 2,3-Diarylquinoxalines as Estrogen Receptor Ligands
  146. Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells
  147. Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells
  148. O5-04-03: Regular multimodal aerobic exercise reduces pro-inflammatory cytokines and improves BDNF peripheral levels and executive functions in elderly MCI individuals with different BDNF Val66Met genotypes
  149. ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects
  150. Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats
  151. Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes
  152. Physical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levels
  153. Copper (II) and 2,2′-Bipyridine Complexation Improves Chemopreventive Effects of Naringenin against Breast Tumor Cells
  154. ADAM10 AS A CANDIDATE BIOMARKER FOR ALZHEIMER'S DISEASE
  155. On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas
  156. A review of the anticancer effects of a ginger component
  157. Effects of Blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats
  158. Cedrelone kills breast tumor cells in vitro
  159. Abstract B10: Effects of limonoid cedrelone on MDA-MB-231 breast tumor cells in vitro
  160. Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease
  161. ADAM9 silencing inhibits breast tumor cell invasion in vitro
  162. Correlation Between Mini-Mental State Examination and Platelet ADAM10 Expression in Alzheimer's Disease
  163. ADAM10 as a Biomarker for Alzheimer's Disease: A Study with Brazilian Elderly
  164. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines
  165. Platelet ADAM10 levels in elderly with mild Alzheimer's disease
  166. Relationship between mini-mental state exam and platelet ADAM10 levels in mild Alzheimer's disease
  167. An Elderly's profile with Alzheimer's disease treated by the exceptional medicine program of São Carlos City (São Paulo, Brazil)
  168. Family functioning and social support for elderly people with cognitive impairments, living in impoverished environments
  169. Familiar functionality in cognitively impaired elderly in a long-term care institution
  170. Rat skin wound healing induced by alternagin-C, a disintegrin-like, Cys-rich protein from Bothrops alternatus venom
  171. The specificity of frutalin lectin using biomembrane models
  172. Camptosemin, a tetrameric lectin of Camptosema ellipticum: structural and functional analysis
  173. Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions
  174. Integrating MR techniques to study Alzheimer's disease
  175. The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups
  176. Effects of alternagin-C from Bothrops alternatus on gene expression and activity of metalloproteinases in regenerating skeletal muscle
  177. Hemostatic effects of recombinant DisBa-01, a disintegrin from Bothrops alternatus
  178. Endocytosis of pulchellin and its recombinant B-chain into K-562 cells: Binding and uptake studies
  179. A novel αvβ3-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis
  180. Modulation of in vitro and in vivo angiogenesis by alternagin-C, a disintegrin-like protein from Bothrops alternatus snake venom and by a peptide derived from its sequence
  181. L'imagerie par bioluminescence pour visualiser la progression tumorale et la métastase chez le petit animal
  182. Alternagin-C, a disintegrin-like protein from the venom of Bothrops alternatus, modulates alpha2ß1 integrin-mediated cell adhesion, migration and proliferation
  183. Alternagin-C, a Disintegrin-like Protein, Induces Vascular Endothelial Cell Growth Factor (VEGF) Expression and Endothelial Cell Proliferation in Vitro
  184. BaG, a new dimeric metalloproteinase/disintegrin from the Bothrops alternatus snake venom that interacts with α5β1 integrin
  185. Characterization and partial purification of a lectin from the hemolymph of the white shrimp Litopenaeus schmitti