All Stories

  1. Viral microRNA inhibition enhances antiviral immunity by modulating corneal inflammatory and resolution pathways in HSV-1 induced keratitis
  2. Molecular Pathways Driving Corneal Neovascularization in Herpes Simplex Keratitis
  3. The PI3K/Akt Pathway in Herpesvirus Biology: A Double-Edged Sword in Host–Virus Interactions
  4. A CDK-4EBP1 signaling axis drives HSV-1 replication and underscores a druggable pathway for potent antiviral intervention
  5. Host-Directed Novel Mechanistic Insights of Doxorubicin Reveal its Efficacy Against Drug-Resistant HSV-1 underscoring risks with Oncolytic Virotherapy
  6. Herpesvirus Simplex Virus‐1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment
  7. Different forms of the Akt protein control how the immune system responds to HSV-1 infection
  8. HPSE-mediated proinflammatory signaling contributes to neurobehavioral deficits following intranasal HSV-1 infection
  9. Heparanase, a host gene that potently restricts retrovirus transcription
  10. Herpesvirus Infections of the Corneal Endothelium
  11. Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate
  12. Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion
  13. Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology
  14. OPTN-TBK1 axis and a role for PLK1 in HSV-1 infection
  15. The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
  16. Tolerability, pharmacokinetics, and anti-herpetic activity of orally administered BX795
  17. Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction
  18. Neutrophil Extracellular Traps and Their Possible Implications in Ocular Herpes Infection
  19. Archaic connectivity between the sulfated heparan sulfate and the herpesviruses – An evolutionary potential for cross-species interactions
  20. Putative targeting by BX795 causes decrease in protein kinase C protein levels and inhibition of HSV1 infection
  21. Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation
  22. Postinfection Metabolic Reprogramming of the Murine Trigeminal Ganglion Limits Herpes Simplex Virus-1 Replication
  23. Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells
  24. Immune Response to SARS-CoV-2 Vaccines
  25. Optineurin in ocular herpes infection
  26. CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in Human Corneal Epithelial Cells
  27. Plasma Membrane-Derived Liposomes Exhibit Robust Antiviral Activity against HSV-1
  28. OPTN (optineurin)-mediated selective autophagy prevents neurodegeneration due to herpesvirus infection
  29. Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection
  30. Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection
  31. BX795-Organic Acid Coevaporates: Evaluation of Solid-State Characteristics, In Vitro Cytocompatibility and In Vitro Activity against HSV-1 and HSV-2
  32. mTORC2 confers neuroprotection and potentiates immunity during virus infection
  33. Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy
  34. Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection
  35. OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
  36. Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress
  37. Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages
  38. Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry
  39. The 3- O -sulfation of heparan sulfate modulates protein binding and lyase degradation
  40. Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing
  41. In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection
  42. Vaccines and Therapies in Development for SARS-CoV-2 Infections
  43. Heparanase, cell signaling, and viral infections
  44. Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections
  45. Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery
  46. Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea
  47. Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells
  48. An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye
  49. Emerging Roles of Heparanase in Viral Pathogenesis
  50. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1
  51. Effects of histatin-1 peptide on human corneal epithelial cells
  52. Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells
  53. Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections
  54. Could Zinc Oxide Tetrapod Nanoparticles Be Used as an Effective Immunotherapy Against HSV-2?
  55. Liposome-Mediated Herpes Simplex Virus Uptake Is Glycoprotein-D Receptor-Independent but Requires Heparan Sulfate
  56. Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes
  57. Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms
  58. Extended Release of an Anti–Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection
  59. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  60. Cell Entry Mechanisms of HSV: What we have Learned in Recent Years
  61. Long-Term Outcomes and Prognostic Factors of Trabeculectomy following Intraocular Bevacizumab Injection for Neovascular Glaucoma
  62. Basal Autophagy Is Required for Herpes simplex Virus-2 Infection
  63. Heparanase is a host enzyme required for herpes simplex virus-1 release from cells
  64. Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models
  65. Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection
  66. A Role for 3-O-Sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells
  67. Semaphorin 7a in Herpetic Neurotrophic Keratitis
  68. Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies
  69. Corneal lymphangiogenesis in herpetic stromal keratitis
  70. Characterization of a Proteolytically Stable D-Peptide That Suppresses Herpes Simplex Virus 1 Infection: Implications for the Development of Entry-Based Antiviral Therapy
  71. Comprehensive Analysis of Herpes Simplex Virus 1 (HSV-1) Entry Mediated by Zebrafish 3-O-Sulfotransferase Isoforms: Implications for the Development of a Zebrafish Model of HSV-1 Infection
  72. Zebrafish 3-O-Sulfotransferase-4 Generated Heparan Sulfate Mediates HSV-1 Entry and Spread
  73. Zebrafish: Modeling for Herpes Simplex Virus Infections
  74. Inhibition of Myosin Light Chain Kinase Can be Targeted for the Development of New Therapies against Herpes Simplex Virus Type-1 Infection
  75. An Investigative Peptide–Acyclovir Combination to Control Herpes Simplex Virus Type 1 Ocular Infection
  76. Exploiting Herpes Simplex Virus Entry for Novel Therapeutics
  77. Authors' Response
  78. Role of heparan sulfate in ocular diseases
  79. Recent advances in vaccine development for herpes simplex virus types I and II
  80. Zebrafish encoded 3-O-sulfotransferase-2 generated heparan sulfate serves as a receptor during HSV-1 entry and spread
  81. Glycoprotein targeted therapeutics: a new era of anti‐herpes simplex virus‐1 therapeutics
  82. Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry
  83. Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection
  84. Tin Oxide Nanowires Suppress Herpes Simplex Virus-1 Entry and Cell-to-Cell Membrane Fusion
  85. Contortrostatin, a Homodimeric Disintegrin Isolated from Snake Venom Inhibits Herpes Simplex Virus Entry and Cell Fusion
  86. Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update
  87. Role of heparan sulfate in sexually transmitted infections
  88. Unraveling the Cell Entry Mechanisms of HSV: Therapeutic Potential?
  89. A 3-O-Sulfated Heparan Sulfate Binding Peptide Preferentially Targets Herpes Simplex Virus 2-Infected Cells
  90. Increased axonal expression of nectin-1 in multiple sclerosis plaques
  91. Early Events in Herpes Simplex Virus Lifecycle with Implications for an Infection of Lifetime
  92. Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells
  93. Virostatic potential of micro–nano filopodia-like ZnO structures against herpes simplex virus-1
  94. Herpes simplex virus infects most cell types in vitro: clues to its success
  95. An Important Role for Syndecan-1 in Herpes Simplex Virus Type-1 Induced Cell-to-Cell Fusion and Virus Spread
  96. Anti-heparan Sulfate Peptides That Block Herpes Simplex Virus Infection in Vivo
  97. Chronic Progressive Deficits in Neuron Size, Density and Number in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus
  98. Corneal Latency and Transmission of Herpes Simplex Virus-1
  99. Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection
  100. The role of herpesviruses in ocular infections
  101. Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry
  102. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type‐1 infection
  103. Mediators and Mechanisms of Herpes Simplex Virus Entry into Ocular Cells
  104. Expanding the role of 3-O sulfated heparan sulfate in herpes simplex virus type-1 entry
  105. A role for heparan sulfate in viral surfing
  106. An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate
  107. Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
  108. Viral entry mechanisms: simplicity drives complexity
  109. Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures
  110. INTRAVITREAL ALEMTUZUMAB PENETRATES FULL-THICKNESS RETINA IN RABBIT EYES
  111. A Novel Function of Heparan Sulfate in the Regulation of Cell-Cell Fusion
  112. A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion
  113. Expression of Herpes Virus Entry Mediator (HVEM) in the Cornea and Trigeminal Ganglia of Normal and HSV-1 Infected Mice
  114. Role of Nectin-1, HVEM, and PILR-α in HSV-2 Entry into Human Retinal Pigment Epithelial Cells
  115. The importance of heparan sulfate in herpesvirus infection
  116. Role for nectin‐1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells
  117. Antiviral Activity of Phytochemicals: A Comprehensive Review
  118. HVEM and Nectin-1 Are the Major Mediators of Herpes Simplex Virus 1 (HSV-1) Entry into Human Conjunctival Epithelium
  119. Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread
  120. Using a 3-O-Sulfated Heparin Octasaccharide To Inhibit the Entry of Herpes Simplex Virus Type 1
  121. Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the developing human and murine brain
  122. RITUXIMAB PENETRATES FULL-THICKNESS RETINA IN CONTRAST TO TISSUE PLASMINOGEN ACTIVATOR CONTROL
  123. Role of 3‐O‐sulfated heparan sulfate in virus‐induced polykaryocyte formation
  124. Herpes simplex virus type 2 entry into cultured human corneal fibroblasts is mediated by herpesvirus entry mediator
  125. Viral Inhibition Studies on Sulfated Lignin, a Chemically Modified Biopolymer and a Potential Mimic of Heparan Sulfate
  126. Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells
  127. Herpes simplex virus type 1 infection induces oxidative stress and the release of bioactive lipid peroxidation by-products in mouse P19N neural cell cultures
  128. A novel role for phagocytosis-like uptake in herpes simplex virus entry
  129. Role for 3-O-Sulfated Heparan Sulfate as the Receptor for Herpes Simplex Virus Type 1 Entry into Primary Human Corneal Fibroblasts
  130. Expression of Nectin-1 in Normal and Herpes Simplex Virus Type 1-Infected Murine Brain
  131. A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread
  132. A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread
  133. A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells
  134. Spinoculation of heparan sulfate deficient cells enhances HSV-1 entry, but does not abolish the need for essential glycoproteins in viral fusion
  135. Structural Characterization of a Serendipitously Discovered Bioactive Macromolecule, Lignin Sulfate
  136. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1
  137. Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase
  138. A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1
  139. Herpes simplex virus entry receptor nectin-1 is widely expressed in the murine eye
  140. Mutations in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs Alter Functional Interactions with the Entry/Fusion Receptors HVEM, Nectin-2, and 3-O-Sulfated Heparan Sulfate but Not with Nectin-1
  141. Cellular expression of gH confers resistance to herpes simplex virus type-1 entry
  142. Heparan Sulfate 3-O-Sulfotransferase Isoform 5 Generates Both an Antithrombin-binding Site and an Entry Receptor for Herpes Simplex Virus, Type 1
  143. Portable sulphotransferase domain determines sequence specificity of heparan sulphate 3-O-sulphotransferases
  144. Transcription from the Gene Encoding the Herpesvirus Entry Receptor Nectin-1 (HveC) in Nervous Tissue of Adult Mouse
  145. Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry
  146. Striking Similarity of Murine Nectin-1α to Human Nectin-1α (HveC) in Sequence and Activity as a Glycoprotein D Receptor for Alphaherpesvirus Entry
  147. A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
  148. Flagellar Motor-switch Binding Face of CheY and the Biochemical Basis of Suppression by CheY Mutants That Compensate for Motor-switch Defects in Escherichia coli
  149. Mutations Leading to Altered CheA Binding Cluster on a Face of CheY