All Stories

  1. Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: A Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders

    Article • Journal of Clinical Medicine, May 2023, MDPI AG

    Paula Ludovico

  2. Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Professor Ulla B Vogel, Paula Ludovico

  3. Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review

    Article • Cancers, February 2023, MDPI AG

    Paula Ludovico

  4. Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

    Article • Nutrients, October 2022, MDPI AG

    Paula Ludovico

  5. Innovative, integrative, and interactive in‐class activity on metabolic regulation: Evaluating educational impacts

    Article • Biochemistry and Molecular Biology Education, August 2021, Wiley

    Paula Ludovico

  6. Functional Genetic Variants in ATG10 Are Associated with Acute Myeloid Leukemia

    Article • Cancers, March 2021, MDPI AG

    Paula Ludovico

  7. Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts

    Article • Cancers, March 2021, MDPI AG

    Paula Ludovico

  8. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen

  9. The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2020, Elsevier

    Paula Ludovico

  10. Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment

    Article • Bioorganic Chemistry, July 2020, Elsevier

    Paula Ludovico

  11. Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line

    Article • Anti-Cancer Drugs, June 2020, Wolters Kluwer Health

    Paula Ludovico

  12. Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

    Article • Biology, March 2020, MDPI AG

    Paula Ludovico

  13. Transcriptomic and chemogenomic analyses unveil the essential role of Com2-regulon in response and tolerance of Saccharomyces cerevisiae to stress induced by sulfur dioxide

    Article • Microbial Cell, November 2019, Shared Science Publishers OG

    Paula Ludovico

  14. Targeting Metabolic Reprogramming in Acute Myeloid Leukemia

    Article • Cells, August 2019, MDPI AG

    Paula Ludovico

  15. α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

    Article • Aging Cell, April 2019, Wiley

    Ana Rita Guedes, Paula Ludovico

  16. Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis

    Article • Aging, December 2018, Impact Journals, LLC

    Paula Ludovico

  17. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

    Article • Cell Death and Differentiation, November 2018, Springer Science + Business Media

    Paula Ludovico

  18. Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment

    Article • European Journal of Medicinal Chemistry, September 2018, Elsevier

    Dr. Fatima Baltazar, Paula Ludovico

  19. Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells

    Article • Journal of Cellular and Molecular Medicine, August 2018, Wiley

    Paula Ludovico

  20. From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells

    Article • Oxidative Medicine and Cellular Longevity, June 2018, Hindawi Publishing Corporation

    Paula Ludovico

  21. Linking cellular proteostasis to yeast longevity

    Article • FEMS Yeast Research, April 2018, Oxford University Press (OUP)

    Paula Ludovico

  22. pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity

    Article • Microbial Cell, March 2018, Shared Science Publishers OG

    Paula Ludovico

  23. New perspectives from South-Y-East, not all about death A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017

    Article • Microbial Cell, February 2018, Shared Science Publishers OG

    Paula Ludovico

  24. Guidelines and recommendations on yeast cell death nomenclature

    Article • Microbial Cell, January 2018, Shared Science Publishers OG

    Paula Ludovico, Maria João Sousa

  25. The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A

    Article • PeerJ, November 2017, PeerJ

    Paula Ludovico

  26. Chronic stress triggers Tau pathology through autophagy inhibition and induction of stress granules

    Article • European Neuropsychopharmacology, October 2017, Elsevier

    Paula Ludovico

  27. Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy

    Article • Acta Biomaterialia, June 2017, Elsevier

    Paula Ludovico

  28. Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

    Article • Molecular Psychiatry, May 2017, Springer Science + Business Media

    Paula Ludovico

  29. Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Paula Ludovico

  30. Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy

    Article • Mechanisms of Ageing and Development, January 2017, Elsevier

    Paula Ludovico

  31. Yeast on the corner of life and death decisions

    Article • Mechanisms of Ageing and Development, January 2017, Elsevier

    Paula Ludovico

  32. The “stressed” autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system

    Article • European Neuropsychopharmacology, October 2016, Elsevier

    Paula Ludovico

  33. Mitochondrial proteomics of the acetic acid - induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii - derived hybrid strain

    Article • Microbial Cell, February 2016, Shared Science Publishers OG

    Paula Ludovico

  34. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang

  35. AMPK in Pathogens

    Article • January 2016, Springer Science + Business Media

    Paula Ludovico

  36. IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages

    Article • Frontiers in Immunology, September 2015, Frontiers

    Paula Ludovico

  37. Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies

    Article • Biomolecules, May 2015, MDPI AG

    Paula Ludovico

  38. Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches

    Article • Oncotarget, December 2014, Impact Journals, LLC

    Paula Ludovico

  39. Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen

    Article • PLoS Neglected Tropical Diseases, August 2014, PLOS

    Paula Ludovico

  40. Bioresorbable ureteral stents from natural origin polymers

    Article • Journal of Biomedical Materials Research Part B Applied Biomaterials, June 2014, Wiley

    Dr Ricardo A Pires, Professor Rui L. Reis, Paula Ludovico

  41. Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing

    Article • Microbial Cell, April 2014, Shared Science Publishers OG

    Paula Ludovico

  42. Microbial Programmed Necrosis: The Cost of Conflicts Between Stress and Metabolism

    Article • January 2014, Springer Science + Business Media

    Paula Ludovico

  43. P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation

    Article • PLoS ONE, September 2013, PLOS

    Paula Ludovico

  44. Reactive oxygen species, ageing and the hormesis police

    Article • FEMS Yeast Research, September 2013, Oxford University Press (OUP)

    Paula Ludovico

  45. Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid

    Article • PLoS ONE, August 2013, PLOS

    Paula Ludovico

  46. Yeast between life and death: a summary of the Ninth International Meeting on Yeast Apoptosis in Rome, Italy, 17–20 September 2012

    Article • Cell Death and Differentiation, June 2013, Springer Science + Business Media

    Paula Ludovico

  47. DNA replication stress-induced loss of reproductive capacity inS. cerevisiaeand its inhibition by caloric restriction

    Article • Cell Cycle, April 2013, Taylor & Francis

    Paula Ludovico

  48. Yeast Stress, Aging, and Death

    Article • Oxidative Medicine and Cellular Longevity, January 2013, Hindawi Publishing Corporation

    Professor Cristina Giannattasio, Paula Ludovico

  49. The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii

    Article • PLoS ONE, December 2012, PLOS

    Maria João Sousa, Paula Ludovico

  50. SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

    Article • Autophagy, October 2012, Taylor & Francis

    Professor Tiago F Outeiro, Paula Ludovico

  51. Functionality of the Paracoccidioides Mating α-Pheromone-Receptor System

    Article • PLoS ONE, October 2012, PLOS

    Paula Ludovico

  52. Morphological heterogeneity ofParacoccidioides brasiliensis: relevance of the Rho-like GTPasePbCDC42

    Article • Medical Mycology, October 2012, Oxford University Press (OUP)

    Paula Ludovico

  53. An alternative respiratory pathway on Candida krusei: implications on susceptibility profile and oxidative stress

    Article • FEMS Yeast Research, March 2012, Oxford University Press (OUP)

    Paula Ludovico

  54. Cellular Models of Aging

    Article • Oxidative Medicine and Cellular Longevity, January 2012, Hindawi Publishing Corporation

    Paula Ludovico

  55. Yeast as a platform to uncover ceramide-induced ancient cell death routines

    Article • Cell Cycle, January 2012, Taylor & Francis

    Paula Ludovico

  56. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2011, Elsevier

    Paula Ludovico

  57. The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation

    Article • PLoS ONE, November 2011, PLOS

    Paula Ludovico

  58. Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?

    Article • Biochemical Society Transactions, September 2011, Portland Press Ltd.

    Paula Ludovico

  59. The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma

    Article • Genes & Immunity, August 2011, Springer Science + Business Media

    Paula Ludovico

  60. The bacterial exotoxin AIP56 induces fish macrophage and neutrophil apoptosis using mechanisms of the extrinsic and intrinsic pathways

    Article • Fish & Shellfish Immunology, January 2011, Elsevier

    Paula Ludovico

  61. The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance

    Article • Fungal Genetics and Biology, December 2010, Elsevier

    Paula Ludovico

  62. Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

    Article • Aging, October 2010, Impact Journals, LLC

    Paula Ludovico

  63. Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae

    Article • Applied and Environmental Microbiology, October 2010, ASM Journals

    Paula Ludovico

  64. Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity

    Article • Proceedings of the National Academy of Sciences, August 2010, Proceedings of the National Academy of Sciences

    Paula Ludovico

  65. Overeating yeast display fatty acid-induced necrotic cell death

    Article • Cell Cycle, August 2010, Taylor & Francis

    Paula Ludovico

  66. Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis

    Article • Fungal Genetics and Biology, December 2009, Elsevier

    Paula Ludovico

  67. Expressing and functional analysis of mammalian apoptotic regulators in yeast

    Article • Cell Death and Differentiation, November 2009, Springer Science + Business Media

    Paula Ludovico

  68. Metal stress induces programmed cell death in aquatic fungi

    Article • Aquatic Toxicology, May 2009, Elsevier

    Paula Ludovico

  69. Neurodevelopmental delay in theCln3Δex7/8mouse model for Batten disease

    Article • Genes Brain & Behavior, April 2009, Wiley

    Paula Ludovico

  70. Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway

    Article • PROTEOMICS, February 2009, Wiley

    Paula Ludovico

  71. Joined in death: highlights of the Sixth International Meeting on Yeast Apoptosis in Leuven, Belgium, 30 April-4 May 2008

    Article • Yeast, December 2008, Wiley

    Paula Ludovico

  72. Drug-induced apoptosis in yeast

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2008, Elsevier

    Paula Ludovico

  73. Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis

    Article • Molecular Biology of the Cell, March 2008, American Society for Cell Biology (ASCB)

    Paula Ludovico

  74. Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis

    Article • Fungal Genetics and Biology, December 2007, Elsevier

    Paula Ludovico

  75. NO-mediated apoptosis in yeast

    Article • Journal of Cell Science, September 2007, The Company of Biologists

    Paula Ludovico

  76. Nitric Oxide Signaling Is Disrupted in the Yeast Model for Batten Disease

    Article • Molecular Biology of the Cell, July 2007, American Society for Cell Biology (ASCB)

    Paula Ludovico

  77. An atypical active cell death process underlies the fungicidal activity of ciclopirox olamine against the yeastSaccharomyces cerevisiae

    Article • FEMS Yeast Research, May 2007, Oxford University Press (OUP)

    Paula Ludovico

  78. Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span

    Article • Mechanisms of Ageing and Development, May 2007, Elsevier

    Paula Ludovico

  79. Genome size and ploidy of Paracoccidioides brasiliensis reveals a haploid DNA content: Flow cytometry and GP43 sequence analysis

    Article • Fungal Genetics and Biology, January 2007, Elsevier

    Paula Ludovico

  80. Multiplex PCR identification of eight clinically relevantCandidaspecies

    Article • Medical Mycology, January 2007, Oxford University Press (OUP)

    Paula Ludovico

  81. A twenty-year survey of dermatophytoses in Braga, Portugal

    Article • International Journal of Dermatology, July 2006, Wiley

    Paula Ludovico

  82. Hyperosmotic stress induces metacaspase- and mitochondria-dependent apoptosis inSaccharomyces cerevisiae

    Article • Molecular Microbiology, September 2005, Wiley

    Professor José M. Peinado, Paula Ludovico

  83. Yeast Programmed Cell Death: An Intricate Puzzle

    Article • IUBMB Life, March 2005, Wiley

    Paula Ludovico

  84. An AIF orthologue regulates apoptosis in yeast

    Article • The Journal of Cell Biology, September 2004, Rockefeller University Press

    Paula Ludovico

  85. Article • FEMS Yeast Research, June 2003, Oxford University Press (OUP)

    Paula Ludovico

  86. Energy conversion coupled to cyanide-resistant respiration in the yeasts and

    Article • FEMS Yeast Research, April 2003, Oxford University Press (OUP)

    Paula Ludovico

  87. Acetic acid induces a programmed cell death process in the food spoilage yeast

    Article • FEMS Yeast Research, March 2003, Elsevier

    Paula Ludovico

  88. The Spoilage Yeast Zygosaccharomyces bailii Forms Mitotic Spores: a Screening Method for Haploidization

    Article • Applied and Environmental Microbiology, January 2003, ASM Journals

    Maria João Sousa, Paula Ludovico

  89. CytochromecRelease and Mitochondria Involvement in Programmed Cell Death Induced by Acetic Acid inSaccharomyces cerevisiae

    Article • Molecular Biology of the Cell, August 2002, American Society for Cell Biology (ASCB)

    Paula Ludovico

  90. Assessment of mitochondrial membrane potential in yeast cell populations by flow cytometry

    Article • Microbiology, December 2001, Society for General Microbiology

    Paula Ludovico

  91. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid

    Article • Microbiology, September 2001, Society for General Microbiology

    Maria João Sousa, Paula Ludovico

  92. Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic Glucose Catabolism

    Article • Springer Science + Business Media

    Paula Ludovico