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  1. Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

    Article • Cells, March 2023, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

  2. Mathematical Models of Death Signaling Networks

    Article • Entropy, October 2022, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

  3. Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux

    Article • Cancer and Metastasis Reviews, April 2022, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  4. AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWo

    Article • Frontiers in Bioscience-Landmark, April 2022, IMR Press

    Executive Director, The Hormel Institute Robert Clarke

  5. Comparative assessment and novel strategy on methods for imputing proteomics data

    Article • Scientific Reports, January 2022, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  6. swCAM: estimation of subtype-specific expressions in individual samples with unsupervised sample-wise deconvolution

    Article • Bioinformatics, December 2021, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  7. A Bayesian approach for accurate de novo transcriptome assembly

    Article • Scientific Reports, September 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  8. ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements

    Article • PLoS Computational Biology, July 2021, PLOS

    Executive Director, The Hormel Institute Robert Clarke

  9. Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor

    Article • Nutrients, May 2021, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

  10. ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

    Article • BMC Bioinformatics, April 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  11. Data-driven detection of subtype-specific differentially expressed genes

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  12. Identifying intracellular signaling modules and exploring pathways associated with breast cancer recurrence

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  13. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen

  14. Experimental models of endocrine responsive breast cancer: strengths, limitations, and use

    Article • January 2021, OAE Publishing

    Executive Director, The Hormel Institute Robert Clarke

  15. Author Correction: BICORN: An R package for integrative inference of de novo cis-regulatory modules

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  16. IntAPT: integrated assembly of phenotype-specific transcripts from multiple RNA-seq profiles

    Article • Bioinformatics, October 2020, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  17. IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

    Article • Neoplasia, October 2020, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  18. Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer

    Article • Nature Communications, September 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  19. Maternal obesity increases offspring’s mammary cancer recurrence and impairs tumor immune response

    Article • Endocrine Related Cancer, September 2020, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  20. Preface

    Article • Cancer and Metastasis Reviews, August 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  21. A systems biology approach to discovering pathway signaling dysregulation in metastasis

    Article • Cancer and Metastasis Reviews, August 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  22. BICORN: An R package for integrative inference of de novo cis-regulatory modules

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  23. debCAM: a bioconductor R package for fully unsupervised deconvolution of complex tissues

    Article • Bioinformatics, March 2020, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  24. RNA interference screening methods to identify proliferation determinants and mechanisms of resistance to immune attack

    Article • January 2020, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  25. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer

    Article • Frontiers in Oncology, August 2019, Frontiers

    Executive Director, The Hormel Institute Robert Clarke

  26. Systems biology: perspectives on multiscale modeling in research on endocrine-related cancers

    Article • Endocrine Related Cancer, June 2019, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  27. Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) Protein

    Article • Molecular Cancer Research, April 2019, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  28. Effects of Jaeumkanghwa-tang on tamoxifen responsiveness in preclinical ER+ breast cancer model

    Article • Endocrine Related Cancer, March 2019, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  29. Microbiome signatures in prostate cancer

    Article • Carcinogenesis, February 2019, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  30. SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Executive Director, The Hormel Institute Robert Clarke

  31. Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

    Article • Cancers, January 2019, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

  32. Introduction: The Unfolded Protein Response

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  33. Role of Protein Translation in Unfolded Protein Response

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  34. Roles of Spliced and Unspliced XBP1 in Breast Cancer

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  35. The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  36. Dielectrophoretic properties distinguish responses to estrogen and fulvestrant in breast cancer cells

    Article • Sensors and Actuators B Chemical, December 2018, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  37. Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes

    Article • Cell Death Discovery, October 2018, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  38. CRNET: an efficient sampling approach to infer functional regulatory networks by integrating large-scale ChIP-seq and time-course RNA-seq data

    Article • Bioinformatics, December 2017, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  39. SparseIso: a novel Bayesian approach to identify alternatively spliced isoforms from RNA-seq data

    Article • Bioinformatics, September 2017, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  40. Breast cancer cell obatoclax response characterization using passivated-electrode insulator-based dielectrophoresis

    Article • Electrophoresis, July 2017, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  41. EGR1 regulates cellular metabolism and survival in endocrine resistant breast cancer

    Article • Oncotarget, May 2017, Impact Journals, LLC

    Executive Director, The Hormel Institute Robert Clarke

  42. Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats

    Article • Clinical Cancer Research, January 2017, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  43. CyNetSVM: A Cytoscape App for Cancer Biomarker Identification Using Network Constrained Support Vector Machines

    Article • PLoS ONE, January 2017, PLOS

    Executive Director, The Hormel Institute Robert Clarke

  44. Autophagy, Inflammation, and Breast Cancer Risk

    Article • January 2017, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  45. RNA Interference Screening to Identify Proliferation Determinants in Breast Cancer Cells

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Executive Director, The Hormel Institute Robert Clarke

  46. Introduction: Cancer Gene Networks

    Article • November 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  47. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

    Article • Cancer Research, October 2016, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  48. Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants

    Article • Computers in Biology and Medicine, October 2016, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  49. PSSV: a novel pattern-based probabilistic approach for somatic structural variation identification

    Article • Bioinformatics, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  50. DM-BLD: differential methylation detection using a hierarchical Bayesian model exploiting local dependency

    Article • Bioinformatics, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  51. Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model

    Article • JNCI Journal of the National Cancer Institute, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  52. Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk

    Article • Endocrine Related Cancer, August 2016, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  53. G-DOC Plus – an integrative bioinformatics platform for precision medicine

    Article • BMC Bioinformatics, April 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  54. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa

  55. Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  56. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang

  57. ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles

    Article • Nucleic Acids Research, December 2015, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  58. Endocrine resistance in breast cancer – An overview and update

    Article • Molecular and Cellular Endocrinology, December 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  59. A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Executive Director, The Hormel Institute Robert Clarke

  60. BACOM2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor

    Article • Scientific Reports, September 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  61. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling

    Article • Breast Cancer Research and Treatment, August 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  62. Role of GRP78 in promoting therapeutic-resistant breast cancer

    Article • Future Medicinal Chemistry, August 2015, Future Science

    Executive Director, The Hormel Institute Robert Clarke

  63. Overcoming cancer resistance

    Article • Future Medicinal Chemistry, August 2015, Future Science

    Executive Director, The Hormel Institute Robert Clarke

  64. Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation

    Article • Oncogene, July 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  65. Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers

    Article • Frontiers in Oncology, June 2015, Frontiers

    Executive Director, The Hormel Institute Robert Clarke

  66. BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency

    Article • BMC Genomics, June 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  67. Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

    Article • Molecular & Cellular Oncology, April 2015, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  68. Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells

    Article • CPT Pharmacometrics & Systems Pharmacology, April 2015, Wiley

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

  69. Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate

    Article • Cancer Research, March 2015, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  70. BMRF-Net: a software tool for identification of protein interaction subnetworks by a bagging Markov random field-based method: Fig. 1.

    Article • Bioinformatics, March 2015, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  71. Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement

    Article • Breast Cancer Research and Treatment, February 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  72. Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research

    Article • The FASEB Journal, February 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien, Executive Director, The Hormel Institute Robert Clarke

  73. Application of Metabolomics in Drug Resistant Breast Cancer Research

    Article • Metabolites, February 2015, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

  74. Molecular mechanisms of tamoxifen-associated endometrial cancer (Review)

    Article • Oncology Letters, February 2015, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

  75. The Changing Spectrum of Biomedical and Clinical Research

    Article • January 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  76. Blockage of Lysosomal Degradation Is Detrimental to Cancer Cell Survival

    Article • January 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  77. Aromatase inhibitor plus ovarian suppression as adjuvant therapy in premenopausal women with breast cancer

    Article • Cancer Biology & Therapy, December 2014, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  78. Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α

    Article • Molecular Endocrinology, December 2014, Endocrine Society

    Executive Director, The Hormel Institute Robert Clarke

  79. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance

    Article • Carcinogenesis, November 2014, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  80. When is a vesicle not just a vesicle: mitochondrial spheroids and mitochondrial autophagosomes

    Article • Cell & Bioscience, November 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  81. Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics

    Article • PLoS ONE, November 2014, PLOS

    Executive Director, The Hormel Institute Robert Clarke

  82. NF-κB Signaling Is Required for XBP1 (Unspliced and Spliced)-Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer

    Article • Molecular and Cellular Biology, November 2014, ASM Journals

    Executive Director, The Hormel Institute Robert Clarke

  83. Integration of Network Biology and Imaging to Study Cancer Phenotypes and Responses

    Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, November 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  84. ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway

    Article • Oncogene, October 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  85. Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer

    Article • Receptors & Clinical Investigation, October 2014, Smart Science and Technology, LLC

    Executive Director, The Hormel Institute Robert Clarke

  86. Integrating Proteotoxic Stress Response Pathways for Induction of Cell Death in Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities

    Article • October 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  87. KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring

    Article • Bioinformatics, September 2014, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  88. UNDO: a Bioconductor R package for unsupervised deconvolution of mixed gene expressions in tumor samples

    Article • Bioinformatics, September 2014, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  89. Correction: Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  90. BADGE: A novel Bayesian model for accurate abundance quantification and differential analysis of RNA-Seq data

    Article • BMC Bioinformatics, September 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  91. BSSV: Bayesian based somatic structural variation identification with whole genome DNA-seq data

    Article • August 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  92. Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks

    Article • BMC Systems Biology, July 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  93. Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?

    Article • Cancer Research, July 2014, American Association for Cancer Research (AACR)

    Dr Benjamin Haibe-Kains, Executive Director, The Hormel Institute Robert Clarke

  94. Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

    Article • Clinical Cancer Research, June 2014, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  95. Knockdown of estrogen receptor‐α induces autophagy and inhibits antiestrogen‐mediated unfolded protein response activation, promoting ROS‐induced breast cancer cell death

    Article • The FASEB Journal, May 2014, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  96. Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells

    Article • Zeitschrift für Ernährungswissenschaft, May 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  97. Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer

    Article • Journal of The Royal Society Interface, May 2014, Royal Society Publishing

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

  98. A Markov random field-based Bayesian model to identify genes with differential methylation

    Article • May 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  99. Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic

    Article • Bioinformatics, April 2014, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  100. Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters

    Article • Breast Cancer Research, April 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  101. Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy

    Article • Cell & Bioscience, March 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  102. Blockage of Lysosomal Degradation is Detrimental to Cancer Cell Survival

    Article • January 2014, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  103. Glutamine metabolism and the unfolded protein response in MYC-driven breast cancer

    Article • Cancer & Metabolism, January 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  104. MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

    Article • Molecular Cancer, January 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  105. Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1

    Article • Cancer & Metabolism, January 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  106. VAV3 mediates resistance to breast cancer endocrine therapy

    Article • Breast Cancer Research, January 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  107. Integrative Analysis Workflow for Untargeted Metabolomics in Translational Research

    Article • Journal of Postgenomics Drug & Biomarker Development, January 2014, OMICS Publishing Group

    Executive Director, The Hormel Institute Robert Clarke

  108. Statistical Identification of Co-regulatory Gene Modules using Multiple ChIP-Seq Experiments

    Article • January 2014, Scitepress

    Executive Director, The Hormel Institute Robert Clarke

  109. A novel statistical approach to identify co-regulatory gene modules

    Article • December 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  110. mAPC-GibbsOS: an integrated approach for robust identification of gene regulatory networks

    Article • BMC Systems Biology, December 2013, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  111. AISAIC: a software suite for accurate identification of significant aberrations in cancers

    Article • Bioinformatics, November 2013, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  112. Reconstruction of Transcriptional Regulatory Networks by Stability-Based Network Component Analysis

    Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, November 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  113. Reconstructing transcriptional regulatory networks by probabilistic network component analysis

    Article • September 2013, ACM (Association for Computing Machinery)

    Executive Director, The Hormel Institute Robert Clarke

  114. Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells

    Article • FEBS Letters, August 2013, Wiley

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

  115. Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

    Article • Interface Focus, June 2013, Royal Society Publishing

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

  116. ANTIHORMONE DRUG RESISTANCE

    Article • June 2013, World Scientific Pub Co Pte Lt

    Executive Director, The Hormel Institute Robert Clarke

  117. Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers

    Article • Molecular Carcinogenesis, June 2013, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  118. Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

    Article • Clinical Cancer Research, June 2013, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  119. Targeting GRP78 and antiestrogen resistance in breast cancer

    Article • Future Medicinal Chemistry, June 2013, Future Science

    Executive Director, The Hormel Institute Robert Clarke

  120. GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells

    Article • Molecular Cancer Therapeutics, April 2013, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  121. Advancing Translational Research through Facility Design in Non-AMC Hospitals

    Article • HERD Health Environments Research & Design Journal, April 2013, SAGE Publications

    Executive Director, The Hormel Institute Robert Clarke

  122. Module-based breast cancer classification

    Article • International Journal of Data Mining and Bioinformatics, January 2013, Inderscience Publishers

    Executive Director, The Hormel Institute Robert Clarke

  123. Genomic and network analysis to study the origin of ovarian cancer

    Article • Systems Biomedicine, January 2013, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  124. In Silico Discovery of Mitosis Regulation Networks Associated with Early Distant Metastases in Estrogen Receptor Positive Breast Cancers

    Article • Cancer Informatics, January 2013, SAGE Publications

    Executive Director, The Hormel Institute Robert Clarke

  125. Identifying Early Events of Gene Expression in Breast Cancer with Systems Biology Phylogenetics

    Article • Cytogenetic and Genome Research, January 2013, Karger Publishers

    Executive Director, The Hormel Institute Robert Clarke

  126. Heat shock 70 kDa protein 5/glucose-regulated protein 78 “AMP”ing up autophagy

    Article • Autophagy, December 2012, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  127. Accurate identification of significant aberrations in contaminated cancer genome

    Article • December 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  128. Sampling-Based Subnetwork Identification from Microarray Data and Protein-Protein Interaction Network

    Article • December 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  129. Identifying protein interaction subnetworks by a bagging Markov random field-based method

    Article • Nucleic Acids Research, November 2012, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  130. Regulatory component analysis: A semi-blind extraction approach to infer gene regulatory networks with imperfect biological knowledge

    Article • Signal Processing, August 2012, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  131. Genome-wide identification of significant aberrations in cancer genome

    Article • BMC Genomics, July 2012, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  132. Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

    Article • Cancer Research, July 2012, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  133. Antiestrogen resistance and the application of systems biology

    Article • Drug Discovery Today Disease Mechanisms, June 2012, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  134. Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic

    Article • Bioinformatics, May 2012, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  135. Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)

    Article • Journal of Biological Chemistry, May 2012, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  136. Interaction of dietary polyphenols with molecular signaling pathways of antiestrogen resistance: possible role in breast cancer recurrence

    Article • Hormone Molecular Biology and Clinical Investigation, April 2012, De Gruyter

    Executive Director, The Hormel Institute Robert Clarke

  137. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke

  138. Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate

    Article • Cancer Research, March 2012, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

  139. Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention

    Article • Journal of Agricultural and Food Chemistry, February 2012, American Chemical Society (ACS)

    Executive Director, The Hormel Institute Robert Clarke

  140. Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines

    Article • International Journal of Breast Cancer, January 2012, Hindawi Publishing Corporation

    Executive Director, The Hormel Institute Robert Clarke

  141. Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells

    Article • The Journal of Nutritional Biochemistry, January 2012, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  142. Pregnancy hormonal environment and mother’s breast cancer risk

    Article • Hormone Molecular Biology and Clinical Investigation, January 2012, De Gruyter

    Executive Director, The Hormel Institute Robert Clarke

  143. Reconstruction of Transcription Regulatory Networks by Stability-Based Network Component Analysis

    Article • January 2012, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  144. Identifying cancer biomarkers by network-constrained support vector machines

    Article • BMC Systems Biology, October 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  145. NTP-CERHR expert panel report on the developmental toxicity of soy infant formula

    Article • Birth Defects Research Part B Developmental and Reproductive Toxicology, September 2011, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  146. G-DOC: A Systems Medicine Platform for Personalized Oncology

    Article • Neoplasia, September 2011, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  147. Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells

    Article • Genes & Nutrition, August 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  148. Cannibalism, cell survival, and endocrine resistance in breast cancer

    Article • August 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  149. Autophagy and endocrine resistance in breast cancer

    Article • Expert Review of Anticancer Therapy, August 2011, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  150. GIST: A Gibbs sampler to identify intracellular signal transduction pathways

    Article • August 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  151. Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells

    Article • Nature Reviews Cancer, June 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  152. Overexpression of the Dominant-Negative Form of Interferon Regulatory Factor 1 in Oligodendrocytes Protects against Experimental Autoimmune Encephalomyelitis

    Article • Journal of Neuroscience, June 2011, Society for Neuroscience

    Executive Director, The Hormel Institute Robert Clarke

  153. Profile of Robert Clarke

    Article • BioTechniques, June 2011, Informa UK (Informa Life Sciences)

    Executive Director, The Hormel Institute Robert Clarke

  154. Abstract 2070: XBP-1 promotes cell survival by activating the unfolded protein response (UPR) in antiestrogen resistance in breast cancer

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  155. Abstract LB-148: XBP1 regulates NFkappaB signaling in antiestrogen resistant breast cancer cells

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  156. Motif-guided sparse decomposition of gene expression data for regulatory module identification

    Article • BMC Bioinformatics, March 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  157. Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

    Article • Endocrine Related Cancer, March 2011, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  158. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer

    Article • Hormone Molecular Biology and Clinical Investigation, March 2011, De Gruyter

    Executive Director, The Hormel Institute Robert Clarke

  159. DDN: a caBIG® analytical tool for differential network analysis

    Article • Bioinformatics, February 2011, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  160. The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer

    Article • International Journal of Breast Cancer, January 2011, Hindawi Publishing Corporation

    Executive Director, The Hormel Institute Robert Clarke

  161. G-CODE: enabling systems medicine through innovative informatics

    Article • Genome Biology, January 2011, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  162. PUGSVM: a caBIGTM analytical tool for multiclass gene selection and predictive classification

    Article • Bioinformatics, December 2010, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  163. Module-based biomarker discovery in breast cancer

    Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  164. Identification of Transcriptional Regulatory Networks by Learning the Marginal Function of Outlier Sum Statistic

    Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  165. Differential Dependency Network Analysis to Identify Topological Changes in Biological Networks

    Article • July 2010, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  166. Changes in mammary caveolin-1 signaling pathways are associated with breast cancer risk in rats exposed to estradiol in utero or during prepuberty

    Article • Hormone Molecular Biology and Clinical Investigation, June 2010, De Gruyter

    Executive Director, The Hormel Institute Robert Clarke

  167. Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response

    Article • June 2010, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  168. The Proapoptotic Molecule BLID Interacts with Bcl-XL and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival

    Article • Clinical Cancer Research, May 2010, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  169. IFNγ Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IFN Regulatory Factor 1, NF-κB, BCL2 Family Members, and Signaling to Caspase-Dependent Apoptosis

    Article • Molecular Cancer Therapeutics, May 2010, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  170. Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration

    Article • PLoS ONE, April 2010, PLOS

    Executive Director, The Hormel Institute Robert Clarke

  171. Multilevel support vector regression analysis to identify condition-specific regulatory networks

    Article • Bioinformatics, April 2010, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  172. Abstract 2919: XBP1 and the unfolded protein response in antiestrogen resistance in breast cancer

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  173. Abstract 4601: XBP1 regulated function of c-MYC and BCL2 in antiestrogen resistance in breast cancer

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  174. Knowledge-guided gene ranking by coordinative component analysis

    Article • BMC Bioinformatics, March 2010, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  175. DBC-1 mediates endocrine resistant breast cancer cell survival

    Article • Cell Cycle, March 2010, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  176. BCL2 and CASP8 regulation by NF‐κB differentially affect mitochondrial function and cell fate in antiestrogen‐sensitive and ‐resistant breast cancer cells

    Article • The FASEB Journal, February 2010, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  177. Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis

    Article • PLoS ONE, January 2010, PLOS

    Executive Director, The Hormel Institute Robert Clarke

  178. Signaling Pathways in the Normal and Neoplastic Breast

    Article • January 2010, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  179. Cross phenotype normalization of microarray data

    Article • Frontiers in Bioscience-Elite, January 2010, IMR Press

    Executive Director, The Hormel Institute Robert Clarke

  180. The role of preclinical animal models in breast cancer drug development

    Article • December 2009, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  181. Learning a highly resolved tree of phenotypes using genomic data clustering

    Article • November 2009, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  182. Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer

    Article • Breast Cancer Research and Treatment, August 2009, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  183. Reverse engineering module networks by PSO-RNN hybrid modeling

    Article • BMC Genomics, July 2009, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  184. Molecular mechanisms of resistance to HER2-targeted therapy

    Article • June 2009, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  185. XBP1, Unfolded Protein Response, and Endocrine Responsiveness

    Article • May 2009, Defense Technical Information Center (DTIC)

    Executive Director, The Hormel Institute Robert Clarke

  186. Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, March 2009, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  187. A Systems Biology Approach to Identify Affected Regulatory and Signaling Circuits in Protein Interaction Networks

    Article • January 2009, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  188. Biomarker identification by knowledge-driven multilevel ICA and motif analysis

    Article • International Journal of Data Mining and Bioinformatics, January 2009, Inderscience Publishers

    Executive Director, The Hormel Institute Robert Clarke

  189. Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis

    Article • International Journal of Computational Biology and Drug Design, January 2009, Inderscience Publishers

    Executive Director, The Hormel Institute Robert Clarke

  190. The role of X-box binding protein-1 in tumorigenicity

    Article • Drug News & Perspectives, January 2009, Thomson Reuters (Scientific) Inc. & Affiliates

    Executive Director, The Hormel Institute Robert Clarke

  191. Differential dependency network analysis to identify condition-specific topological changes in biological networks

    Article • Bioinformatics, December 2008, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  192. Gene Signaling Pathways Mediating the Opposite Effects of Prepubertal Low-Fat and High-Fat n-3 Polyunsaturated Fatty Acid Diets on Mammary Cancer Risk

    Article • Cancer Prevention Research, December 2008, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  193. ERRγ Mediates Tamoxifen Resistance in Novel Models of Invasive Lobular Breast Cancer

    Article • Cancer Research, October 2008, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  194. Knowledge-guided multi-scale independent component analysis for biomarker identification

    Article • BMC Bioinformatics, October 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  195. caBIG™ VISDA: Modeling, visualization, and discovery for cluster analysis of genomic data

    Article • BMC Bioinformatics, September 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  196. Network motif-based identification of breast cancer susceptibility genes

    Article • August 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  197. Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data

    Article • BMC Bioinformatics, April 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  198. The Importance of Estrogen Receptors in Breast Cancer

    Article • April 2008, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  199. Approaches to working in high-dimensional data spaces: gene expression microarrays

    Article • British Journal of Cancer, February 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  200. Motif-directed network component analysis for regulatory network inference

    Article • BMC Bioinformatics, February 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  201. The properties of high-dimensional data spaces: implications for exploring gene and protein expression data

    Article • Nature Reviews Cancer, January 2008, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  202. A ground truth based comparative study on clustering of gene expression data

    Article • Frontiers in Bioscience, January 2008, IMR Press

    Executive Director, The Hormel Institute Robert Clarke

  203. Classification algorithms for phenotype prediction in genomics and proteomics

    Article • Frontiers in Bioscience, January 2008, IMR Press

    Executive Director, The Hormel Institute Robert Clarke

  204. Network-Constrained Support Vector Machine for Classification

    Article • January 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  205. An Iterative Nonlinear Regression Method for Microarray Data Normalization

    Article • The Open Applied Informatics Journal, December 2007, Bentham Science Publishers

    Executive Director, The Hormel Institute Robert Clarke

  206. Web-based parallel corpora for statistical machine translation

    Article • December 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  207. Biomarker identification by knowledge-driven multi-scale independent component analysis

    Article • November 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  208. Integrating multi-source biological data for transcriptional regulatory module discovery

    Article • November 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  209. Progressive Loss of Estrogen Receptor α Cofactor Recruitment in Endocrine Resistance

    Article • Molecular Endocrinology, November 2007, Endocrine Society

    Executive Director, The Hormel Institute Robert Clarke

  210. Human Tumours in Animal Hosts

    Article • October 2007, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  211. Human X‐Box binding protein‐1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines

    Article • The FASEB Journal, July 2007, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  212. VISDA: an open-source caBIG™ analytical tool for data clustering and beyond

    Article • Bioinformatics, May 2007, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  213. The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

    Article • Cancer Genetics and Cytogenetics, May 2007, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  214. Caveolin-1 Tyrosine Phosphorylation Enhances Paclitaxel-mediated Cytotoxicity

    Article • Journal of Biological Chemistry, February 2007, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  215. Gene Selection for Multiclass Prediction by Weighted Fisher Criterion

    Article • EURASIP Journal on Bioinformatics and Systems Biology, January 2007, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  216. Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer

    Article • Cancer Cell, December 2006, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  217. Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures

    Article • International Journal of Oncology, December 2006, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

  218. Robert B. Dickson: In Memoriam (1952–2006)

    Article • Cancer Research, December 2006, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  219. Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models

    Article • Endocrine Related Cancer, December 2006, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  220. Robert B. Dickson

    Article • Breast Cancer Online, November 2006, Cambridge University Press

    Executive Director, The Hormel Institute Robert Clarke

  221. 128 POSTER Vitamin E succinate inhibits the in vitro growth of pancreatic cancer cells

    Article • European Journal of Cancer Supplements, November 2006, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  222. Learning the Tree of Phenotypes Using Genomic Data and VISDA

    Article • October 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  223. Inference of Gene Regulatory Networks from Time Course Gene Expression Data Using Neural Networks and Swarm Intelligence

    Article • September 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  224. Inferring Network Interactions Using Recurrent Neural Networks and Swarm Intelligence

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  225. Latent Variable and nICA Modeling of Pathway Gene Module Composite

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  226. Physical and Functional Interactions between Cas and c-Src Induce Tamoxifen Resistance of Breast Cancer Cells through Pathways Involving Epidermal Growth Factor Receptor and Signal Transducer and Activator of Transcription 5b

    Article • Cancer Research, July 2006, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  227. Composite Gene Module Discovery using Non-negative Independent Component Analysis

    Article • July 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  228. AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines

    Article • BMC Cancer, May 2006, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  229. Meta-Analysis of Soy Intake and Breast Cancer Risk

    Article • JNCI Journal of the National Cancer Institute, April 2006, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  230. Optimized multilayer perceptrons for molecular classification and diagnosis using genomic data

    Article • Bioinformatics, January 2006, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  231. Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays

    Article • International Journal of Oncology, January 2006, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

  232. The Disposition of Reduced Haloperidol and HPP,+ Metabolites of Haloperidol, is Not Influenced by P-Glycoprotein

    Article • Journal of Korean Society for Clinical Pharmacology and Therapeutics, January 2006, Korean Society for Clinical Pharmacology and Therapeutics (KAMJE)

    Executive Director, The Hormel Institute Robert Clarke

  233. Multidrug Resistance/P-Glycoprotein and Breast Cancer: Review and Meta-Analysis

    Article • Seminars in Oncology, December 2005, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  234. Mechanisms Mediating the Effects of Prepubertal (n-3) Polyunsaturated Fatty Acid Diet on Breast Cancer Risk in Rats

    Article • Journal of Nutrition, December 2005, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  235. The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1α/CXCL12

    Article • Carcinogenesis, May 2005, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  236. Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis

    Article • Carcinogenesis, May 2005, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  237. Adjuvant and neoadjuvant therapy in non-small cell lung cancer

    Article • Seminars in Oncology, April 2005, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  238. Human Tumours in Animal Hosts

    Article • January 2005, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  239. Antiestrogens, Aromatase Inhibitors, and Apoptosis in Breast Cancer

    Article • January 2005, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  240. Nutritional modulation of the cell cycle and breast cancer

    Article • Endocrine Related Cancer, December 2004, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  241. Common origins of MDA-MB-435 cells from various sources with those shown to have melonoma properties

    Article • Clinical & Experimental Metastasis, December 2004, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  242. LCC15-MB Cells are MDA-MB-435: A Review of Misidentified Breast and prostate cell lines

    Article • Clinical & Experimental Metastasis, December 2004, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  243. Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel

    Article • Toxicology and Applied Pharmacology, October 2004, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  244. Expression of an estrogen receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance

    Article • Journal of Molecular Endocrinology, June 2004, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  245. Interferon Regulatory Factor-1 Mediates the Proapoptotic but Not Cell Cycle Arrest Effects of the Steroidal Antiestrogen ICI 182,780 (Faslodex, Fulvestrant)

    Article • Cancer Research, June 2004, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

  246. Gene selection in class space for molecular classification of cancer

    Article • Science in China Series F Information Sciences, January 2004, Science China Press., Co. Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  247. Robust feature selection by weighted Fisher criterion for multiclass prediction in gene expression profiling

    Article • January 2004, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  248. Discriminatory Mining of Gene Expression Microarray Data

    Article • The Journal of VLSI Signal Processing Systems for Signal Image and Video Technology, November 2003, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  249. Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

    Article • Oncogene, October 2003, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  250. Estrogen Withdrawal-Induced NF-κB Activity and Bcl-3 Expression in Breast Cancer Cells: Roles in Growth and Hormone Independence

    Article • Molecular and Cellular Biology, October 2003, ASM Journals

    Executive Director, The Hormel Institute Robert Clarke

  251. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland

    Article • Nature Reports Stem Cells, July 2003, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  252. ATP binding cassette transporters and drug resistance in breast cancer.

    Article • Endocrine Related Cancer, March 2003, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  253. Animal models of endocrine-responsive and -unresponsive breast cancers

    Article • May 2002, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  254. Iterative normalization of cDNA microarray data

    Article • IEEE Transactions on Information Technology in Biomedicine, March 2002, Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  255. Do estrogens always increase breast cancer risk?

    Article • The Journal of Steroid Biochemistry and Molecular Biology, February 2002, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  256. Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women

    Article • Cancer, January 2002, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  257. Block principal component analysis with application to gene microarray data classification

    Article • Statistics in Medicine, January 2002, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  258. C-7 Analogues of Progesterone as Potent Inhibitors of the P-Glycoprotein Efflux Pump

    Article • Journal of Medicinal Chemistry, December 2001, American Chemical Society (ACS)

    Executive Director, The Hormel Institute Robert Clarke

  259. Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo1

    Article • Endocrinology, April 2001, Endocrine Society

    Executive Director, The Hormel Institute Robert Clarke

  260. Molecular and pharmacological aspects of antiestrogen resistance

    Article • The Journal of Steroid Biochemistry and Molecular Biology, March 2001, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  261. Competitive and Allosteric Interactions in Ligand Binding to P-glycoprotein as Observed on an Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase

    Article • Molecular Pharmacology, January 2001, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Executive Director, The Hormel Institute Robert Clarke

  262. Article • Pharmaceutical Research, January 2001, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  263. Maternal and Prepubertal Diet, Mammary Development and Breast Cancer Risk

    Article • Journal of Nutrition, January 2001, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  264. Genistein: Does it Prevent or Promote Breast Cancer?

    Article • Environmental Health Perspectives, June 2000, Environmental Health Perspectives

    Executive Director, The Hormel Institute Robert Clarke

  265. Identification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using splice targeted primer approach

    Article • The Journal of Steroid Biochemistry and Molecular Biology, April 2000, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  266. Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities

    Article • Journal of Chromatography B Biomedical Sciences and Applications, February 2000, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  267. Article • Journal of Mammary Gland Biology and Neoplasia, January 2000, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  268. ER in normal and pre-cancerous breast

    Article • December 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  269. Stromelysin-1 promotes mammary carcinogenesis

    Article • December 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  270. Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract

    Article • European Journal of Cancer, October 1999, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  271. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring.

    Article • Oncology Reports, September 1999, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

  272. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis

    Article • British Journal of Cancer, July 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  273. Inhibition of estrogen receptor function promotes porcine coronary artery smooth muscle cell proliferation

    Article • Steroids, July 1999, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  274. The influence of maternal diet on breast cancer risk among female offspring

    Article • Nutrition, May 1999, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  275. Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status

    Article • Cancer Letters, March 1999, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  276. Growth and phenotypic characterization of porcine coronary artery smooth muscle cells

    Article • In Vitro Cellular & Developmental Biology - Animal, March 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  277. Organochlorine pesticides: an effect on estrogen activity?

    Article • February 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  278. Progesterone in mouse mammary gland carcinogenesis

    Article • February 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  279. Reversal of Tamoxifen Resistance of Human Breast Carcinomas In Vivo by Neutralizing Antibodies to Transforming Growth Factor- 

    Article • JNCI Journal of the National Cancer Institute, January 1999, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  280. The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants

    Article • January 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  281. Article • Clinical & Experimental Metastasis, January 1999, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  282. Use of ERE and Reporter Gene Constructs to Assess Putative Estrogenic Activity

    Article • Journal of Medicinal Food, January 1999, Mary Ann Liebert Inc

    Executive Director, The Hormel Institute Robert Clarke

  283. Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, December 1998, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  284. The LCC15-MB Human Breast Cancer Cell Line Expresses Osteopontin and Exhibits an Invasive and Metastatic Phenotype

    Article • Experimental Cell Research, June 1998, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  285. Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring.

    Article • Oncology Reports, May 1998, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

  286. Article • Molecular and Cellular Biochemistry, January 1998, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  287. Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models

    Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  288. Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

    Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  289. Mechanisms by which high maternal fat intake during pregnancy increases breast cancer risk in female rodent offspring

    Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  290. Estrogen-regulated non-reproductive behaviors and breast cancer risk: Animal models and human studies

    Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  291. Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations and

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 1997, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  292. A maternal diet high in n − 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring

    Article • Proceedings of the National Academy of Sciences, August 1997, Proceedings of the National Academy of Sciences

    Executive Director, The Hormel Institute Robert Clarke

  293. Multidrug Resistance in Breast Cancer: a Meta-analysis of MDR1/gp170 Expression and Its Possible Functional Significance

    Article • JNCI Journal of the National Cancer Institute, July 1997, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  294. Breast Cancer Risk in Rats Fed a Diet High in n-6 Polyunsaturated Fatty Acids During Pregnancy

    Article • JNCI Journal of the National Cancer Institute, December 1996, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  295. Acquired estrogen independence and antiestrogen resistance in breast cancer

    Article • Trends in Endocrinology and Metabolism, October 1996, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  296. Specific binding of estradiol to rat coronary artery smooth muscle cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, April 1996, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  297. Animal models of breast cancer: Their diversity and role in biomedical research

    Article • Breast Cancer Research and Treatment, February 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  298. Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines

    Article • Breast Cancer Research and Treatment, February 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  299. Estrogens, Phytoestrogens, and Breast Cancer

    Article • January 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  300. Acquisition of an Antiestrogen-Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms

    Article • January 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  301. Mechanisms of Resistance to Antiestrogens and Their Implications for Crossresistance

    Article • January 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  302. MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer

    Article • British Journal of Cancer, January 1996, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  303. Early Life Affects the Risk of Developing Breast Cancer

    Article • Annals of the New York Academy of Sciences, September 1995, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  304. Hormone dependence of breast cancer cells and the effects of tamoxifen and estrogen:31P NMR studies

    Article • Breast Cancer Research and Treatment, March 1995, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  305. Acquisition of estrogen independence and antiestrogen resistance in breast cancer: association with the invasive and metastatic phenotype

    Article • Endocrine Related Cancer, March 1995, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  306. Cross-resistance and molecular mechanisms in antiestrogen resistance

    Article • Endocrine Related Cancer, March 1995, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  307. Anti‐proliferative and anti‐estrogenic effects of ICI 164,384 and ICI 182,780 in 4‐OH‐tamoxifen‐resistant human breast‐cancer cells

    Article • International Journal of Cancer, January 1994, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  308. Perinatal factors increase breast cancer risk

    Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  309. Psychosocial factors in the development and progression of breast cancer

    Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  310. Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression

    Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  311. Hormone resistance, invasiveness, and metastatic potential in breast cancer

    Article • Breast Cancer Research and Treatment, October 1993, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  312. Opposing behavioural alterations in male and female transgenic TGFα mice: association with tumour susceptibility

    Article • British Journal of Cancer, May 1993, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  313. The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells

    Article • Clinical & Experimental Metastasis, January 1993, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  314. Effect of P-glycoprotein Expression on Sensitivity to Hormones in MCF-7 Human Breast Cancer Cells

    Article • JNCI Journal of the National Cancer Institute, October 1992, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  315. Alterations in behavior, steroid hormones and natural killer cell activity in male transgenic TGFα mice

    Article • Brain Research, August 1992, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  316. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

    Article • Journal of Cellular Physiology, March 1992, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  317. Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF‐7 breast‐cancer cells

    Article • International Journal of Cancer, February 1992, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  318. IGF-I and IGF-II expression in human breast cancer xenografts: Relationship to hormone independence

    Article • Breast Cancer Research and Treatment, February 1992, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  319. Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH

    Article • Breast Cancer Research and Treatment, February 1992, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  320. In vitro antineoplastic activity of C7-substituted mitomycin C analogues MC-77 and MC-62 against human breast-cancer cell lines

    Article • Cancer Chemotherapy and Pharmacology, January 1992, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  321. Hormonal aspects of breast cancer

    Article • Critical Reviews in Oncology/Hematology, January 1992, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  322. The Biology of Breast Tumor Progression: Acquisition of hormone independence and resistance to cytotoxic drugs

    Article • Acta Oncologica, January 1992, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  323. Vascular Non-genomic Effects of Estrogen

    Article • January 1992, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  324. Reduction of the Membrane Fluidity of Human Breast Cancer Cells by Tamoxifen and 17beta-Estradiol

    Article • JNCI Journal of the National Cancer Institute, November 1990, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

  325. The process of malignant progression in human breast cancer

    Article • Annals of Oncology, November 1990, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  326. Adverse interactions between cytotoxic drugs and hormonal agents in human breast cancer cells.

    Article • Journal of Clinical Oncology, October 1989, American Society of Clinical Oncology (ASCO)

    Executive Director, The Hormel Institute Robert Clarke

  327. The inter-relationships between ovarian-independent growth, tumorigenicity, invasiveness and antioestrogen resistance in the malignant progression of human breast cancer

    Article • Journal of Endocrinology, July 1989, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

  328. Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

    Article • Proceedings of the National Academy of Sciences, May 1989, Proceedings of the National Academy of Sciences

    Executive Director, The Hormel Institute Robert Clarke

  329. Steroid receptors and disease: cancer, autoimmune, bone and circulatory disorders

    Article • Trends in Pharmacological Sciences, March 1989, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  330. The Effects of a Constitutive Expression of Transforming Growth Factor-α on the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo

    Article • Molecular Endocrinology, February 1989, Endocrine Society

    Executive Director, The Hormel Institute Robert Clarke

  331. Regulation of Breast Cancer Cells by Hormones and Growth Factors: Effects on Proliferation and Basement Membrane Invasiveness

    Article • Hormone Research, January 1989, Karger Publishers

    Executive Director, The Hormel Institute Robert Clarke

  332. Regulation of Human Breast Cancer by Secreted Growth Factors

    Article • Acta Oncologica, January 1989, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

  333. Conformational and receptor binding properties of human EGF and TGF-α second loop fragments

    Article • Journal of Molecular Recognition, June 1988, Wiley

    Executive Director, The Hormel Institute Robert Clarke

  334. Morpho-functional effects of Phenol Red on oestrogen-sensitive breast cancer cells

    Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  335. The ability of oestrogen to modulate the effects of cytotoxic drugs in human breast cancer cells: influence of oestrogen receptor status and choice of drug

    Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  336. Pharmacological and suprapharmacological concentrations of both 17β-oestradiol and tamoxifen reduce the membrane fluidity of MCF-7 and MDA-MB-436 human breast cancer cells

    Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  337. Human recombinant interferon α increases oestrogen receptor expression in ZR-75-1 human breast cancer cells and sensitizes them to the anti-proliferative effects of tamoxifen

    Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  338. The response of human breast cancer cells to glucagon

    Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  339. Recombinant human interferon alpha increases oestrogen receptor expression in human breast cancer cells (ZR-75-1) and sensitises them to the anti-proliferative effects of tamoxifen

    Article • British Journal of Cancer, March 1987, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  340. The effects of Mg2+ ions or EDTA on nuclear integrity and apparent subcellular distribution of unoccupied oestrogen receptors in breast cancer cells

    Article • Journal of Steroid Biochemistry, November 1986, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  341. Enhancement of methotrexate cytotoxicity towards the MDA.MB.436 human breast cancer cell line by dipyridamole

    Article • Biochemical Pharmacology, September 1986, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  342. The unoccupied estrogen receptor: Some comments on localization

    Article • Steroids, July 1986, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  343. The influence of vincristine on the oestrogen-binding capacity of two human breast cancer cell lines in vitro

    Article • Biochemical Society Transactions, April 1986, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  344. The effects of Mg2+ or EDTA on the subcellular distribution of unoccupied oestrogen receptor in ZR-75-1 and MCF-7 cells

    Article • Biochemical Society Transactions, April 1986, Portland Press Ltd.

    Executive Director, The Hormel Institute Robert Clarke

  345. The effect of the rate of cell proliferation on the synthesis of methotrexate poly-γ-glutamates in two human breast cancer cell lines

    Article • Biochemical Pharmacology, September 1985, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  346. The effect of leucovorin on the synthesis of methotrexate poly-γ-glutamates in the MCF-7 human breast cancer cell line

    Article • Biochemical Pharmacology, August 1985, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  347. Oestrogen receptor status and the response of human breast cancer cell lines to a combination of methotrexate and 17-beta oestradiol

    Article • British Journal of Cancer, March 1985, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  348. Reduction of the anti-metabolic and anti-proliferative effects of methotrexate by 17β-oestradiol in a human breast carcinoma cell line, MDA-MB-436

    Article • European Journal of Cancer and Clinical Oncology, January 1983, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  349. The kinetics of methotrexate polyglutamate formation and efflux in a human breast cancer cell line (MDA.MB.436): The effect of insulin

    Article • Biochemical Pharmacology, January 1983, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  350. Failure of 5-fluorouracil and methotrexate to destroy the reproductive integrity of a human breast cancer cell line (MCF-7) growingin vitro

    Article • European Journal of Cancer and Clinical Oncology, December 1981, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

  351. The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants: Their Potential Roles in Breast Cancer

    Article • Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  352. Human Breast-Cancer Xenografts as Models of the Human Disease

    Article • Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  353. Integrative Network Component Analysis for Regulatory Network Reconstruction

    Article • Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  354. Sparse Decomposition of Gene Expression Data to Infer Transcriptional Modules Guided by Motif Information

    Article • Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

  355. Normalization of Microarray Data by Iterative Nonlinear Regression

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  356. Optimizing multilayer perceptrons by discriminatory component analysis

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke

  357. Partially-independent component analysis for tissue heterogeneity correction in microarray gene expression analysis

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Executive Director, The Hormel Institute Robert Clarke