Executive Director, The Hormel Institute Robert Clarke

All Stories

1. 
   DLL1-responsive PD-L1 + tumor-associated macrophages promote endocrine resistance in breast cancer

   Article • Science Translational Medicine, November 2025, American Association for the Advancement of Science

   Executive Director, The Hormel Institute Robert Clarke

2. 
   BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells

   Article • Oncology Letters, June 2025, Spandidos Publications

   Executive Director, The Hormel Institute Robert Clarke

3. 
   Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy

   Article • Cell Metabolism, June 2025, Elsevier

   Executive Director, The Hormel Institute Robert Clarke

4. 
   Molecular mechanisms underlying TXNIP’s anti-tumor role in breast cancer, including interaction with a novel, pro-tumor partner: CAST

   Article • Cell Death and Disease, April 2025, Springer Science + Business Media

   Executive Director, The Hormel Institute Robert Clarke

5. 
   Bayesian identification of differentially expressed isoforms using a novel joint model of RNA-seq data

   Article • PLoS Computational Biology, January 2025, PLOS

   Executive Director, The Hormel Institute Robert Clarke

6. 
   iDDN: determining trans-omics network structure and rewiring with integrative differential dependency networks

   Article • Bioinformatics Advances, December 2024, Oxford University Press (OUP)

   Executive Director, The Hormel Institute Robert Clarke

7. 
   Embracing the informative missingness and silent gene in analyzing biologically diverse samples

   Article • Scientific Reports, November 2024, Springer Science + Business Media

   Executive Director, The Hormel Institute Robert Clarke

8. 
   DDN3.0: determining significant rewiring of biological network structure with differential dependency networks

   Article • Bioinformatics, June 2024, Oxford University Press (OUP)

   Executive Director, The Hormel Institute Robert Clarke

9. 
   Abstract PO5-23-08: Adenylosuccinate lyase is essential for proliferation and mitochondrial function of endocrine therapy resistant breast cancer cells

   Article • Cancer Research, May 2024, American Association for Cancer Research (AACR)

   Executive Director, The Hormel Institute Robert Clarke

10. 
    Iron Oxide Nanoparticles Inhibit Tumor Progression and Suppress Lung Metastases in Mouse Models of Breast Cancer

    Article • ACS Nano, April 2024, American Chemical Society (ACS)

    Executive Director, The Hormel Institute Robert Clarke

11. 
    CAM3.0: determining cell type composition and expression from bulk tissues with fully unsupervised deconvolution

    Article • Bioinformatics, February 2024, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

12. 
    Beyond October, Beyond Pink: A Year-Round Revelation for Women's Breast Health

    Article • Journal of Women s Health, November 2023, Mary Ann Liebert Inc

    Executive Director, The Hormel Institute Robert Clarke

13. 
    Cyclin-Dependent Kinase 4/6 Inhibitors for Treatment of Hormone Receptor–Positive, ERBB2-Negative Breast Cancer

    Article • JAMA Oncology, September 2023, American Medical Association (AMA)

    Executive Director, The Hormel Institute Robert Clarke

14. 
    Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland

    Article • Cells, March 2023, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

15. 
    The complex nature of heterogeneity and its roles in breast cancer biology and therapeutic responsiveness

    Article • Frontiers in Endocrinology, February 2023, Frontiers

    Executive Director, The Hormel Institute Robert Clarke

16. 
    Introduction: Cancer Systems and Integrative Biology

    Article • January 2023, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

17. 
    Mathematical Models of Death Signaling Networks

    Article • Entropy, October 2022, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

18. 
    Treatment against glucose-dependent cancers through metabolic PFKFB3 targeting of glycolytic flux

    Article • Cancer and Metastasis Reviews, April 2022, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

19. 
    AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWo

    Article • Frontiers in Bioscience-Landmark, April 2022, IMR Press

    Executive Director, The Hormel Institute Robert Clarke

20. 
    Comparative assessment and novel strategy on methods for imputing proteomics data

    Article • Scientific Reports, January 2022, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

21. 
    COT: an efficient and accurate method for detecting marker genes among many subtypes

    Article • Bioinformatics Advances, January 2022, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

22. 
    Cosbin: cosine score-based iterative normalization of biologically diverse samples

    Article • Bioinformatics Advances, January 2022, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

23. 
    swCAM: estimation of subtype-specific expressions in individual samples with unsupervised sample-wise deconvolution

    Article • Bioinformatics, December 2021, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

24. 
    A Bayesian approach for accurate de novo transcriptome assembly

    Article • Scientific Reports, September 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

25. 
    ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements

    Article • PLoS Computational Biology, July 2021, PLOS

    Executive Director, The Hormel Institute Robert Clarke

26. 
    Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor

    Article • Nutrients, May 2021, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

27. 
    ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

    Article • BMC Bioinformatics, April 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

28. 
    Data-driven detection of subtype-specific differentially expressed genes

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

29. 
    Identifying intracellular signaling modules and exploring pathways associated with breast cancer recurrence

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

30. 
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl, Professor Nektarios Tavernarakis

31. 
    Experimental models of endocrine responsive breast cancer: strengths, limitations, and use

    Article • January 2021, OAE Publishing

    Executive Director, The Hormel Institute Robert Clarke

32. 
    Author Correction: BICORN: An R package for integrative inference of de novo cis-regulatory modules

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

33. 
    IntAPT: integrated assembly of phenotype-specific transcripts from multiple RNA-seq profiles

    Article • Bioinformatics, October 2020, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

34. 
    IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

    Article • Neoplasia, October 2020, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

35. 
    Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer

    Article • Nature Communications, September 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

36. 
    Maternal obesity increases offspring’s mammary cancer recurrence and impairs tumor immune response

    Article • Endocrine Related Cancer, September 2020, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

37. 
    Preface

    Article • Cancer and Metastasis Reviews, August 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke, Dr Simak Ali

38. 
    A systems biology approach to discovering pathway signaling dysregulation in metastasis

    Article • Cancer and Metastasis Reviews, August 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

39. 
    BICORN: An R package for integrative inference of de novo cis-regulatory modules

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

40. 
    debCAM: a bioconductor R package for fully unsupervised deconvolution of complex tissues

    Article • Bioinformatics, March 2020, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

41. 
    RNA interference screening methods to identify proliferation determinants and mechanisms of resistance to immune attack

    Article • January 2020, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

42. 
    Biomedical image characterization and radiogenomics

    Article • January 2020, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

43. 
    Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer

    Article • Frontiers in Oncology, August 2019, Frontiers

    Executive Director, The Hormel Institute Robert Clarke

44. 
    Systems biology: perspectives on multiscale modeling in research on endocrine-related cancers

    Article • Endocrine Related Cancer, June 2019, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

45. 
    Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) Protein

    Article • Molecular Cancer Research, April 2019, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

46. 
    Effects of Jaeumkanghwa-tang on tamoxifen responsiveness in preclinical ER+ breast cancer model

    Article • Endocrine Related Cancer, March 2019, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

47. 
    Microbiome signatures in prostate cancer

    Article • Carcinogenesis, February 2019, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

48. 
    SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Executive Director, The Hormel Institute Robert Clarke

49. 
    Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

    Article • Cancers, January 2019, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

50. 
    Introduction: The Unfolded Protein Response

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

51. 
    Role of Protein Translation in Unfolded Protein Response

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

52. 
    Roles of Spliced and Unspliced XBP1 in Breast Cancer

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

53. 
    The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

54. 
    The Unfolded Protein Response in Cancer

    Article • January 2019, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

55. 
    Dielectrophoretic properties distinguish responses to estrogen and fulvestrant in breast cancer cells

    Article • Sensors and Actuators B Chemical, December 2018, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

56. 
    Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes

    Article • Cell Death Discovery, October 2018, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

57. 
    CRNET: an efficient sampling approach to infer functional regulatory networks by integrating large-scale ChIP-seq and time-course RNA-seq data

    Article • Bioinformatics, December 2017, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

58. 
    SparseIso: a novel Bayesian approach to identify alternatively spliced isoforms from RNA-seq data

    Article • Bioinformatics, September 2017, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

59. 
    Breast cancer cell obatoclax response characterization using passivated-electrode insulator-based dielectrophoresis

    Article • Electrophoresis, July 2017, Wiley

    Executive Director, The Hormel Institute Robert Clarke

60. 
    EGR1 regulates cellular metabolism and survival in endocrine resistant breast cancer

    Article • Oncotarget, May 2017, Impact Journals, LLC

    Executive Director, The Hormel Institute Robert Clarke

61. 
    Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats

    Article • Clinical Cancer Research, January 2017, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

62. 
    CyNetSVM: A Cytoscape App for Cancer Biomarker Identification Using Network Constrained Support Vector Machines

    Article • PLOS One, January 2017, PLOS

    Executive Director, The Hormel Institute Robert Clarke

63. 
    Autophagy, Inflammation, and Breast Cancer Risk

    Article • January 2017, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

64. 
    RNA Interference Screening to Identify Proliferation Determinants in Breast Cancer Cells

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Executive Director, The Hormel Institute Robert Clarke

65. 
    Introduction: Cancer Gene Networks

    Article • November 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

66. 
    Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

    Article • Cancer Research, October 2016, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

67. 
    Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants

    Article • Computers in Biology and Medicine, October 2016, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

68. 
    PSSV: a novel pattern-based probabilistic approach for somatic structural variation identification

    Article • Bioinformatics, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

69. 
    DM-BLD: differential methylation detection using a hierarchical Bayesian model exploiting local dependency

    Article • Bioinformatics, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

70. 
    Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model

    Article • JNCI Journal of the National Cancer Institute, September 2016, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

71. 
    Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk

    Article • Endocrine Related Cancer, August 2016, Bioscientifica

    Executive Director, The Hormel Institute Robert Clarke

72. 
    G-DOC Plus – an integrative bioinformatics platform for precision medicine

    Article • BMC Bioinformatics, April 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

73. 
    Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl, Dr Marc Etienne Poirot

74. 
    Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

75. 
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla, Dave Bridges

76. 
    ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles

    Article • Nucleic Acids Research, December 2015, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

77. 
    Endocrine resistance in breast cancer – An overview and update

    Article • Molecular and Cellular Endocrinology, December 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

78. 
    A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Executive Director, The Hormel Institute Robert Clarke

79. 
    BACOM2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor

    Article • Scientific Reports, September 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

80. 
    TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling

    Article • Breast Cancer Research and Treatment, August 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

81. 
    Role of GRP78 in promoting therapeutic-resistant breast cancer

    Article • Future Medicinal Chemistry, August 2015, Future Science

    Executive Director, The Hormel Institute Robert Clarke

82. 
    Overcoming cancer resistance

    Article • Future Medicinal Chemistry, August 2015, Future Science

    Executive Director, The Hormel Institute Robert Clarke

83. 
    Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation

    Article • Oncogene, July 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

84. 
    Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers

    Article • Frontiers in Oncology, June 2015, Frontiers

    Executive Director, The Hormel Institute Robert Clarke

85. 
    BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency

    Article • BMC Genomics, June 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

86. 
    Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

    Article • Molecular & Cellular Oncology, April 2015, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

87. 
    Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells

    Article • CPT Pharmacometrics & Systems Pharmacology, April 2015, Wiley

    Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

88. 
    Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate

    Article • Cancer Research, March 2015, American Association for Cancer Research (AACR)

    Executive Director, The Hormel Institute Robert Clarke

89. 
    BMRF-Net: a software tool for identification of protein interaction subnetworks by a bagging Markov random field-based method: Fig. 1.

    Article • Bioinformatics, March 2015, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

90. 
    Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement

    Article • Breast Cancer Research and Treatment, February 2015, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

91. 
    Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research

    Article • The FASEB Journal, February 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Ed O'Brien, Executive Director, The Hormel Institute Robert Clarke

92. 
    Application of Metabolomics in Drug Resistant Breast Cancer Research

    Article • Metabolites, February 2015, MDPI AG

    Executive Director, The Hormel Institute Robert Clarke

93. 
    Molecular mechanisms of tamoxifen-associated endometrial cancer (Review)

    Article • Oncology Letters, February 2015, Spandidos Publications

    Executive Director, The Hormel Institute Robert Clarke

94. 
    The Changing Spectrum of Biomedical and Clinical Research

    Article • January 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

95. 
    Blockage of Lysosomal Degradation Is Detrimental to Cancer Cell Survival

    Article • January 2015, Elsevier

    Executive Director, The Hormel Institute Robert Clarke

96. 
    Aromatase inhibitor plus ovarian suppression as adjuvant therapy in premenopausal women with breast cancer

    Article • Cancer Biology & Therapy, December 2014, Taylor & Francis

    Executive Director, The Hormel Institute Robert Clarke

97. 
    Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α

    Article • Molecular Endocrinology, December 2014, Endocrine Society

    Executive Director, The Hormel Institute Robert Clarke

98. 
    Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance

    Article • Carcinogenesis, November 2014, Oxford University Press (OUP)

    Executive Director, The Hormel Institute Robert Clarke

99. 
    When is a vesicle not just a vesicle: mitochondrial spheroids and mitochondrial autophagosomes

    Article • Cell & Bioscience, November 2014, Springer Science + Business Media

    Executive Director, The Hormel Institute Robert Clarke

100. 
     Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics

     Article • PLOS One, November 2014, PLOS

     Executive Director, The Hormel Institute Robert Clarke

101. 
     NF-κB Signaling Is Required for XBP1 (Unspliced and Spliced)-Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer

     Article • Molecular and Cellular Biology, November 2014, ASM Journals

     Executive Director, The Hormel Institute Robert Clarke

102. 
     Integration of Network Biology and Imaging to Study Cancer Phenotypes and Responses

     Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, November 2014, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

103. 
     ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway

     Article • Oncogene, October 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

104. 
     Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer

     Article • Receptors & Clinical Investigation, October 2014, Smart Science and Technology, LLC

     Executive Director, The Hormel Institute Robert Clarke

105. 
     Integrating Proteotoxic Stress Response Pathways for Induction of Cell Death in Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities

     Article • October 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

106. 
     KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring

     Article • Bioinformatics, September 2014, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

107. 
     UNDO: a Bioconductor R package for unsupervised deconvolution of mixed gene expressions in tumor samples

     Article • Bioinformatics, September 2014, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

108. 
     Correction: Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?

     Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

109. 
     BADGE: A novel Bayesian model for accurate abundance quantification and differential analysis of RNA-Seq data

     Article • BMC Bioinformatics, September 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

110. 
     BSSV: Bayesian based somatic structural variation identification with whole genome DNA-seq data

     Article • August 2014, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

111. 
     Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks

     Article • BMC Systems Biology, July 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

112. 
     Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?

     Article • Cancer Research, July 2014, American Association for Cancer Research (AACR)

     Dr Benjamin Haibe-Kains, Executive Director, The Hormel Institute Robert Clarke

113. 
     Hydroxychloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

     Article • Clinical Cancer Research, June 2014, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

114. 
     Knockdown of estrogen receptor‐α induces autophagy and inhibits antiestrogen‐mediated unfolded protein response activation, promoting ROS‐induced breast cancer cell death

     Article • The FASEB Journal, May 2014, Wiley

     Executive Director, The Hormel Institute Robert Clarke

115. 
     Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells

     Article • Zeitschrift für Ernährungswissenschaft, May 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

116. 
     Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer

     Article • Journal of The Royal Society Interface, May 2014, Royal Society Publishing

     Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

117. 
     A Markov random field-based Bayesian model to identify genes with differential methylation

     Article • May 2014, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

118. 
     Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic

     Article • Bioinformatics, April 2014, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

119. 
     Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters

     Article • Breast Cancer Research, April 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

120. 
     Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy

     Article • Cell & Bioscience, March 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

121. 
     Blockage of Lysosomal Degradation is Detrimental to Cancer Cell Survival

     Article • January 2014, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

122. 
     Glutamine metabolism and the unfolded protein response in MYC-driven breast cancer

     Article • Cancer & Metabolism, January 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

123. 
     MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

     Article • Molecular Cancer, January 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

124. 
     Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1

     Article • Cancer & Metabolism, January 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

125. 
     VAV3 mediates resistance to breast cancer endocrine therapy

     Article • Breast Cancer Research, January 2014, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

126. 
     Integrative Analysis Workflow for Untargeted Metabolomics in Translational Research

     Article • Journal of Postgenomics Drug & Biomarker Development, January 2014, OMICS Publishing Group

     Executive Director, The Hormel Institute Robert Clarke

127. 
     Statistical Identification of Co-regulatory Gene Modules using Multiple ChIP-Seq Experiments

     Article • January 2014, Scitepress

     Executive Director, The Hormel Institute Robert Clarke

128. 
     A novel statistical approach to identify co-regulatory gene modules

     Article • December 2013, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

129. 
     mAPC-GibbsOS: an integrated approach for robust identification of gene regulatory networks

     Article • BMC Systems Biology, December 2013, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

130. 
     AISAIC: a software suite for accurate identification of significant aberrations in cancers

     Article • Bioinformatics, November 2013, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

131. 
     Reconstruction of Transcriptional Regulatory Networks by Stability-Based Network Component Analysis

     Article • IEEE/ACM Transactions on Computational Biology and Bioinformatics, November 2013, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

132. 
     Reconstructing transcriptional regulatory networks by probabilistic network component analysis

     Article • September 2013, ACM (Association for Computing Machinery)

     Executive Director, The Hormel Institute Robert Clarke

133. 
     Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells

     Article • FEBS Letters, August 2013, Wiley

     Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

134. 
     Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

     Article • Interface Focus, June 2013, Royal Society Publishing

     Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

135. 
     ANTIHORMONE DRUG RESISTANCE

     Article • June 2013, World Scientific Pub Co Pte Lt

     Executive Director, The Hormel Institute Robert Clarke

136. 
     Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers

     Article • Molecular Carcinogenesis, June 2013, Wiley

     Executive Director, The Hormel Institute Robert Clarke

137. 
     Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

     Article • Clinical Cancer Research, June 2013, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

138. 
     Targeting GRP78 and antiestrogen resistance in breast cancer

     Article • Future Medicinal Chemistry, June 2013, Future Science

     Executive Director, The Hormel Institute Robert Clarke

139. 
     GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells

     Article • Molecular Cancer Therapeutics, April 2013, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

140. 
     Advancing Translational Research through Facility Design in Non-AMC Hospitals

     Article • HERD Health Environments Research & Design Journal, April 2013, SAGE Publications

     Executive Director, The Hormel Institute Robert Clarke

141. 
     Module-based breast cancer classification

     Article • International Journal of Data Mining and Bioinformatics, January 2013, Inderscience Publishers

     Executive Director, The Hormel Institute Robert Clarke

142. 
     Genomic and network analysis to study the origin of ovarian cancer

     Article • Systems Biomedicine, January 2013, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

143. 
     In Silico Discovery of Mitosis Regulation Networks Associated with Early Distant Metastases in Estrogen Receptor Positive Breast Cancers

     Article • Cancer Informatics, January 2013, SAGE Publications

     Executive Director, The Hormel Institute Robert Clarke

144. 
     Identifying Early Events of Gene Expression in Breast Cancer with Systems Biology Phylogenetics

     Article • Cytogenetic and Genome Research, January 2013, Karger Publishers

     Executive Director, The Hormel Institute Robert Clarke

145. 
     Heat shock 70 kDa protein 5/glucose-regulated protein 78 “AMP”ing up autophagy

     Article • Autophagy, December 2012, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

146. 
     Accurate identification of significant aberrations in contaminated cancer genome

     Article • December 2012, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

147. 
     Sampling-Based Subnetwork Identification from Microarray Data and Protein-Protein Interaction Network

     Article • December 2012, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

148. 
     Identifying protein interaction subnetworks by a bagging Markov random field-based method

     Article • Nucleic Acids Research, November 2012, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

149. 
     Regulatory component analysis: A semi-blind extraction approach to infer gene regulatory networks with imperfect biological knowledge

     Article • Signal Processing, August 2012, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

150. 
     Genome-wide identification of significant aberrations in cancer genome

     Article • BMC Genomics, July 2012, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

151. 
     Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

     Article • Cancer Research, July 2012, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

152. 
     Antiestrogen resistance and the application of systems biology

     Article • Drug Discovery Today Disease Mechanisms, June 2012, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

153. 
     Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic

     Article • Bioinformatics, May 2012, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

154. 
     Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)

     Article • Journal of Biological Chemistry, May 2012, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

155. 
     Interaction of dietary polyphenols with molecular signaling pathways of antiestrogen resistance: possible role in breast cancer recurrence

     Article • Hormone Molecular Biology and Clinical Investigation, April 2012, De Gruyter

     Executive Director, The Hormel Institute Robert Clarke

156. 
     Guidelines for the use and interpretation of assays for monitoring autophagy

     Article • Autophagy, April 2012, Taylor & Francis

     Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Professor Godefridus J Peters, Professor Brigitte Galliot, Professor Luca Scorrano

157. 
     Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate

     Article • Cancer Research, March 2012, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke, Professor John J Tyson

158. 
     Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention

     Article • Journal of Agricultural and Food Chemistry, February 2012, American Chemical Society (ACS)

     Executive Director, The Hormel Institute Robert Clarke

159. 
     Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines

     Article • International Journal of Breast Cancer, January 2012, Wiley

     Executive Director, The Hormel Institute Robert Clarke

160. 
     Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells

     Article • The Journal of Nutritional Biochemistry, January 2012, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

161. 
     Pregnancy hormonal environment and mother’s breast cancer risk

     Article • Hormone Molecular Biology and Clinical Investigation, January 2012, De Gruyter

     Executive Director, The Hormel Institute Robert Clarke

162. 
     Reconstruction of Transcription Regulatory Networks by Stability-Based Network Component Analysis

     Article • January 2012, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

163. 
     Identifying cancer biomarkers by network-constrained support vector machines

     Article • BMC Systems Biology, October 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

164. 
     NTP-CERHR expert panel report on the developmental toxicity of soy infant formula

     Article • Birth Defects Research Part B Developmental and Reproductive Toxicology, September 2011, Wiley

     Executive Director, The Hormel Institute Robert Clarke

165. 
     G-DOC: A Systems Medicine Platform for Personalized Oncology

     Article • Neoplasia, September 2011, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

166. 
     Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells

     Article • Genes & Nutrition, August 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

167. 
     Cannibalism, cell survival, and endocrine resistance in breast cancer

     Article • Breast Cancer Research, August 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

168. 
     Autophagy and endocrine resistance in breast cancer

     Article • Expert Review of Anticancer Therapy, August 2011, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

169. 
     GIST: A Gibbs sampler to identify intracellular signal transduction pathways

     Article • August 2011, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

170. 
     Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells

     Article • Nature Reviews Drug Discovery, June 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

171. 
     Overexpression of the Dominant-Negative Form of Interferon Regulatory Factor 1 in Oligodendrocytes Protects against Experimental Autoimmune Encephalomyelitis

     Article • Journal of Neuroscience, June 2011, Society for Neuroscience

     Executive Director, The Hormel Institute Robert Clarke

172. 
     Profile of Robert Clarke

     Article • BioTechniques, June 2011, Informa UK (Informa Life Sciences)

     Executive Director, The Hormel Institute Robert Clarke

173. 
     Abstract 2070: XBP-1 promotes cell survival by activating the unfolded protein response (UPR) in antiestrogen resistance in breast cancer

     Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

174. 
     Abstract LB-148: XBP1 regulates NFkappaB signaling in antiestrogen resistant breast cancer cells

     Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

175. 
     Motif-guided sparse decomposition of gene expression data for regulatory module identification

     Article • BMC Bioinformatics, March 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

176. 
     Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

     Article • Endocrine Related Cancer, March 2011, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

177. 
     Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer

     Article • Hormone Molecular Biology and Clinical Investigation, March 2011, De Gruyter

     Executive Director, The Hormel Institute Robert Clarke

178. 
     DDN: a caBIG® analytical tool for differential network analysis

     Article • Bioinformatics, February 2011, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

179. 
     The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer

     Article • International Journal of Breast Cancer, January 2011, Wiley

     Executive Director, The Hormel Institute Robert Clarke

180. 
     G-CODE: enabling systems medicine through innovative informatics

     Article • Genome Biology, January 2011, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

181. 
     PUGSVM: a caBIGTM analytical tool for multiclass gene selection and predictive classification

     Article • Bioinformatics, December 2010, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

182. 
     Module-based biomarker discovery in breast cancer

     Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

183. 
     Identification of Transcriptional Regulatory Networks by Learning the Marginal Function of Outlier Sum Statistic

     Article • December 2010, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

184. 
     Differential Dependency Network Analysis to Identify Topological Changes in Biological Networks

     Article • July 2010, Wiley

     Executive Director, The Hormel Institute Robert Clarke

185. 
     Changes in mammary caveolin-1 signaling pathways are associated with breast cancer risk in rats exposed to estradiol in utero or during prepuberty

     Article • Hormone Molecular Biology and Clinical Investigation, June 2010, De Gruyter

     Executive Director, The Hormel Institute Robert Clarke

186. 
     Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response

     Article • June 2010, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

187. 
     The Proapoptotic Molecule BLID Interacts with Bcl-XL and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival

     Article • Clinical Cancer Research, May 2010, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

188. 
     IFNγ Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IFN Regulatory Factor 1, NF-κB, BCL2 Family Members, and Signaling to Caspase-Dependent Apoptosis

     Article • Molecular Cancer Therapeutics, May 2010, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

189. 
     Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration

     Article • PLOS One, April 2010, PLOS

     Executive Director, The Hormel Institute Robert Clarke

190. 
     Multilevel support vector regression analysis to identify condition-specific regulatory networks

     Article • Bioinformatics, April 2010, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

191. 
     Abstract 2919: XBP1 and the unfolded protein response in antiestrogen resistance in breast cancer

     Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

192. 
     Abstract 4601: XBP1 regulated function of c-MYC and BCL2 in antiestrogen resistance in breast cancer

     Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

193. 
     Knowledge-guided gene ranking by coordinative component analysis

     Article • BMC Bioinformatics, March 2010, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

194. 
     DBC-1 mediates endocrine resistant breast cancer cell survival

     Article • Cell Cycle, March 2010, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

195. 
     BCL2 and CASP8 regulation by NF‐κB differentially affect mitochondrial function and cell fate in antiestrogen‐sensitive and ‐resistant breast cancer cells

     Article • The FASEB Journal, February 2010, Wiley

     Executive Director, The Hormel Institute Robert Clarke

196. 
     Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis

     Article • PLOS One, January 2010, PLOS

     Executive Director, The Hormel Institute Robert Clarke

197. 
     Signaling Pathways in the Normal and Neoplastic Breast

     Article • January 2010, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

198. 
     Cross phenotype normalization of microarray data

     Article • Frontiers in Bioscience-Elite, January 2010, IMR Press

     Executive Director, The Hormel Institute Robert Clarke

199. 
     The role of preclinical animal models in breast cancer drug development

     Article • Breast Cancer Research, December 2009, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

200. 
     Learning a highly resolved tree of phenotypes using genomic data clustering

     Article • November 2009, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

201. 
     Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer

     Article • Breast Cancer Research and Treatment, August 2009, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

202. 
     Reverse engineering module networks by PSO-RNN hybrid modeling

     Article • BMC Genomics, July 2009, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

203. 
     Molecular mechanisms of resistance to HER2-targeted therapy

     Article • June 2009, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

204. 
     XBP1, Unfolded Protein Response, and Endocrine Responsiveness

     Article • May 2009, Defense Technical Information Center (DTIC)

     Executive Director, The Hormel Institute Robert Clarke

205. 
     Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells

     Article • The Journal of Steroid Biochemistry and Molecular Biology, March 2009, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

206. 
     A Systems Biology Approach to Identify Affected Regulatory and Signaling Circuits in Protein Interaction Networks

     Article • January 2009, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

207. 
     Biomarker identification by knowledge-driven multilevel ICA and motif analysis

     Article • International Journal of Data Mining and Bioinformatics, January 2009, Inderscience Publishers

     Executive Director, The Hormel Institute Robert Clarke

208. 
     Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis

     Article • International Journal of Computational Biology and Drug Design, January 2009, Inderscience Publishers

     Executive Director, The Hormel Institute Robert Clarke

209. 
     The role of X-box binding protein-1 in tumorigenicity

     Article • Drug News & Perspectives, January 2009, Thomson Reuters (Scientific) Inc. & Affiliates

     Executive Director, The Hormel Institute Robert Clarke

210. 
     Differential dependency network analysis to identify condition-specific topological changes in biological networks

     Article • Bioinformatics, December 2008, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

211. 
     Gene Signaling Pathways Mediating the Opposite Effects of Prepubertal Low-Fat and High-Fat n-3 Polyunsaturated Fatty Acid Diets on Mammary Cancer Risk

     Article • Cancer Prevention Research, December 2008, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

212. 
     ERRγ Mediates Tamoxifen Resistance in Novel Models of Invasive Lobular Breast Cancer

     Article • Cancer Research, October 2008, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

213. 
     Knowledge-guided multi-scale independent component analysis for biomarker identification

     Article • BMC Bioinformatics, October 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

214. 
     caBIG™ VISDA: Modeling, visualization, and discovery for cluster analysis of genomic data

     Article • BMC Bioinformatics, September 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

215. 
     Network motif-based identification of breast cancer susceptibility genes

     Article • August 2008, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

216. 
     Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data

     Article • BMC Bioinformatics, April 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

217. 
     The Importance of Estrogen Receptors in Breast Cancer

     Article • April 2008, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

218. 
     Approaches to working in high-dimensional data spaces: gene expression microarrays

     Article • British Journal of Cancer, February 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

219. 
     Motif-directed network component analysis for regulatory network inference

     Article • BMC Bioinformatics, February 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

220. 
     The properties of high-dimensional data spaces: implications for exploring gene and protein expression data

     Article • Nature Reviews Drug Discovery, January 2008, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

221. 
     A ground truth based comparative study on clustering of gene expression data

     Article • Frontiers in Bioscience, January 2008, IMR Press

     Executive Director, The Hormel Institute Robert Clarke

222. 
     Classification algorithms for phenotype prediction in genomics and proteomics

     Article • Frontiers in Bioscience, January 2008, IMR Press

     Executive Director, The Hormel Institute Robert Clarke

223. 
     Network-Constrained Support Vector Machine for Classification

     Article • January 2008, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

224. 
     An Iterative Nonlinear Regression Method for Microarray Data Normalization

     Article • The Open Applied Informatics Journal, December 2007, Bentham Science Publishers

     Executive Director, The Hormel Institute Robert Clarke

225. 
     Web-based parallel corpora for statistical machine translation

     Article • December 2007, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

226. 
     Biomarker identification by knowledge-driven multi-scale independent component analysis

     Article • November 2007, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

227. 
     Integrating multi-source biological data for transcriptional regulatory module discovery

     Article • November 2007, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

228. 
     Progressive Loss of Estrogen Receptor α Cofactor Recruitment in Endocrine Resistance

     Article • Molecular Endocrinology, November 2007, Endocrine Society

     Executive Director, The Hormel Institute Robert Clarke

229. 
     Human Tumours in Animal Hosts

     Article • October 2007, Wiley

     Executive Director, The Hormel Institute Robert Clarke

230. 
     Human X‐Box binding protein‐1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines

     Article • The FASEB Journal, July 2007, Wiley

     Executive Director, The Hormel Institute Robert Clarke

231. 
     VISDA: an open-source caBIG™ analytical tool for data clustering and beyond

     Article • Bioinformatics, May 2007, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

232. 
     The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines

     Article • Cancer Genetics and Cytogenetics, May 2007, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

233. 
     Caveolin-1 Tyrosine Phosphorylation Enhances Paclitaxel-mediated Cytotoxicity

     Article • Journal of Biological Chemistry, February 2007, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

234. 
     Gene Selection for Multiclass Prediction by Weighted Fisher Criterion

     Article • EURASIP Journal on Bioinformatics and Systems Biology, January 2007, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

235. 
     Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer

     Article • Cancer Cell, December 2006, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

236. 
     Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures

     Article • International Journal of Oncology, December 2006, Spandidos Publications

     Executive Director, The Hormel Institute Robert Clarke

237. 
     Robert B. Dickson: In Memoriam (1952–2006)

     Article • Cancer Research, December 2006, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

238. 
     Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models

     Article • Endocrine Related Cancer, December 2006, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

239. 
     Robert B. Dickson

     Article • Breast Cancer Online, November 2006, Cambridge University Press

     Executive Director, The Hormel Institute Robert Clarke

240. 
     128 POSTER Vitamin E succinate inhibits the in vitro growth of pancreatic cancer cells

     Article • European Journal of Cancer Supplements, November 2006, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

241. 
     Learning the Tree of Phenotypes Using Genomic Data and VISDA

     Article • October 2006, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

242. 
     Inference of Gene Regulatory Networks from Time Course Gene Expression Data Using Neural Networks and Swarm Intelligence

     Article • September 2006, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

243. 
     Inferring Network Interactions Using Recurrent Neural Networks and Swarm Intelligence

     Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

244. 
     Latent Variable and nICA Modeling of Pathway Gene Module Composite

     Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

245. 
     Physical and Functional Interactions between Cas and c-Src Induce Tamoxifen Resistance of Breast Cancer Cells through Pathways Involving Epidermal Growth Factor Receptor and Signal Transducer and Activator of Transcription 5b

     Article • Cancer Research, July 2006, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

246. 
     Composite Gene Module Discovery using Non-negative Independent Component Analysis

     Article • July 2006, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

247. 
     AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines

     Article • BMC Cancer, May 2006, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

248. 
     Meta-Analysis of Soy Intake and Breast Cancer Risk

     Article • JNCI Journal of the National Cancer Institute, April 2006, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

249. 
     Optimized multilayer perceptrons for molecular classification and diagnosis using genomic data

     Article • Bioinformatics, January 2006, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

250. 
     Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays

     Article • International Journal of Oncology, January 2006, Spandidos Publications

     Executive Director, The Hormel Institute Robert Clarke

251. 
     The Disposition of Reduced Haloperidol and HPP,+ Metabolites of Haloperidol, is Not Influenced by P-Glycoprotein

     Article • Journal of Korean Society for Clinical Pharmacology and Therapeutics, January 2006, Korean Society for Clinical Pharmacology and Therapeutics (KAMJE)

     Executive Director, The Hormel Institute Robert Clarke

252. 
     Multidrug Resistance/P-Glycoprotein and Breast Cancer: Review and Meta-Analysis

     Article • Seminars in Oncology, December 2005, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

253. 
     Mechanisms Mediating the Effects of Prepubertal (n-3) Polyunsaturated Fatty Acid Diet on Breast Cancer Risk in Rats

     Article • Journal of Nutrition, December 2005, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

254. 
     The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1α/CXCL12

     Article • Carcinogenesis, May 2005, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

255. 
     Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis

     Article • Carcinogenesis, May 2005, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

256. 
     Adjuvant and neoadjuvant therapy in non-small cell lung cancer

     Article • Seminars in Oncology, April 2005, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

257. 
     Human Tumours in Animal Hosts

     Article • January 2005, Wiley

     Executive Director, The Hormel Institute Robert Clarke

258. 
     Antiestrogens, Aromatase Inhibitors, and Apoptosis in Breast Cancer

     Article • January 2005, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

259. 
     The nuclear factor κB inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)–induced apoptosis in antiestrogen-resistant breast cancer cells

     Article • Molecular Cancer Therapeutics, January 2005, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

260. 
     Nutritional modulation of the cell cycle and breast cancer

     Article • Endocrine Related Cancer, December 2004, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

261. 
     Common origins of MDA-MB-435 cells from various sources with those shown to have melonoma properties

     Article • Clinical & Experimental Metastasis, December 2004, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

262. 
     LCC15-MB Cells are MDA-MB-435: A Review of Misidentified Breast and prostate cell lines

     Article • Clinical & Experimental Metastasis, December 2004, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

263. 
     Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel

     Article • Toxicology and Applied Pharmacology, October 2004, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

264. 
     Expression of an estrogen receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance

     Article • Journal of Molecular Endocrinology, June 2004, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

265. 
     Interferon Regulatory Factor-1 Mediates the Proapoptotic but Not Cell Cycle Arrest Effects of the Steroidal Antiestrogen ICI 182,780 (Faslodex, Fulvestrant)

     Article • Cancer Research, June 2004, American Association for Cancer Research (AACR)

     Executive Director, The Hormel Institute Robert Clarke

266. 
     Gene selection in class space for molecular classification of cancer

     Article • Science in China Series F Information Sciences, January 2004, Science China Press., Co. Ltd.

     Executive Director, The Hormel Institute Robert Clarke

267. 
     Robust feature selection by weighted Fisher criterion for multiclass prediction in gene expression profiling

     Article • January 2004, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

268. 
     Discriminatory Mining of Gene Expression Microarray Data

     Article • The Journal of VLSI Signal Processing Systems for Signal Image and Video Technology, November 2003, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

269. 
     Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

     Article • Oncogene, October 2003, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

270. 
     Estrogen Withdrawal-Induced NF-κB Activity and Bcl-3 Expression in Breast Cancer Cells: Roles in Growth and Hormone Independence

     Article • Molecular and Cellular Biology, October 2003, ASM Journals

     Executive Director, The Hormel Institute Robert Clarke

271. 
     Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland

     Article • Nature Reports Stem Cells, July 2003, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

272. 
     ATP binding cassette transporters and drug resistance in breast cancer.

     Article • Endocrine Related Cancer, March 2003, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

273. 
     Animal models of endocrine-responsive and -unresponsive breast cancers

     Article • May 2002, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

274. 
     Iterative normalization of cDNA microarray data

     Article • IEEE Transactions on Information Technology in Biomedicine, March 2002, Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

275. 
     Do estrogens always increase breast cancer risk?

     Article • The Journal of Steroid Biochemistry and Molecular Biology, February 2002, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

276. 
     Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women

     Article • Cancer, January 2002, Wiley

     Executive Director, The Hormel Institute Robert Clarke

277. 
     Block principal component analysis with application to gene microarray data classification

     Article • Statistics in Medicine, January 2002, Wiley

     Executive Director, The Hormel Institute Robert Clarke

278. 
     C-7 Analogues of Progesterone as Potent Inhibitors of the P-Glycoprotein Efflux Pump

     Article • Journal of Medicinal Chemistry, December 2001, American Chemical Society (ACS)

     Executive Director, The Hormel Institute Robert Clarke

279. 
     Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo1

     Article • Endocrinology, April 2001, Endocrine Society

     Executive Director, The Hormel Institute Robert Clarke

280. 
     Molecular and pharmacological aspects of antiestrogen resistance

     Article • The Journal of Steroid Biochemistry and Molecular Biology, March 2001, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

281. 
     Competitive and Allosteric Interactions in Ligand Binding to P-glycoprotein as Observed on an Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase

     Article • Molecular Pharmacology, January 2001, American Society for Pharmacology & Experimental Therapeutics (ASPET)

     Executive Director, The Hormel Institute Robert Clarke

282. 
     Article • Pharmaceutical Research, January 2001, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

283. 
     Maternal and Prepubertal Diet, Mammary Development and Breast Cancer Risk

     Article • Journal of Nutrition, January 2001, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

284. 
     Competitive and Allosteric Interactions in Ligand Binding to P-glycoprotein as Observed on an Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase

     Article • Molecular Pharmacology, January 2001, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

285. 
     Genistein: Does it Prevent or Promote Breast Cancer?

     Article • Environmental Health Perspectives, June 2000, Environmental Health Perspectives

     Executive Director, The Hormel Institute Robert Clarke

286. 
     Identification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using splice targeted primer approach

     Article • The Journal of Steroid Biochemistry and Molecular Biology, April 2000, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

287. 
     Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities

     Article • Journal of Chromatography B Biomedical Sciences and Applications, February 2000, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

288. 
     Article • Journal of Mammary Gland Biology and Neoplasia, January 2000, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

289. 
     ER in normal and pre-cancerous breast

     Article • December 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

290. 
     Stromelysin-1 promotes mammary carcinogenesis

     Article • December 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

291. 
     Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract

     Article • European Journal of Cancer, October 1999, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

292. 
     Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring.

     Article • Oncology Reports, September 1999, Spandidos Publications

     Executive Director, The Hormel Institute Robert Clarke

293. 
     Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis

     Article • British Journal of Cancer, July 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

294. 
     Inhibition of estrogen receptor function promotes porcine coronary artery smooth muscle cell proliferation

     Article • Steroids, July 1999, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

295. 
     The influence of maternal diet on breast cancer risk among female offspring

     Article • Nutrition, May 1999, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

296. 
     Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status

     Article • Cancer Letters, March 1999, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

297. 
     Growth and phenotypic characterization of porcine coronary artery smooth muscle cells

     Article • In Vitro Cellular & Developmental Biology, March 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

298. 
     Organochlorine pesticides: an effect on estrogen activity?

     Article • February 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

299. 
     Progesterone in mouse mammary gland carcinogenesis

     Article • February 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

300. 
     Reversal of Tamoxifen Resistance of Human Breast Carcinomas In Vivo by Neutralizing Antibodies to Transforming Growth Factor- 

     Article • JNCI Journal of the National Cancer Institute, January 1999, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

301. 
     The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants

     Article • January 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

302. 
     Article • Clinical & Experimental Metastasis, January 1999, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

303. 
     Use of ERE and Reporter Gene Constructs to Assess Putative Estrogenic Activity

     Article • Journal of Medicinal Food, January 1999, Mary Ann Liebert Inc

     Executive Director, The Hormel Institute Robert Clarke

304. 
     Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells

     Article • The Journal of Steroid Biochemistry and Molecular Biology, December 1998, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

305. 
     The LCC15-MB Human Breast Cancer Cell Line Expresses Osteopontin and Exhibits an Invasive and Metastatic Phenotype

     Article • Experimental Cell Research, June 1998, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

306. 
     Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring.

     Article • Oncology Reports, May 1998, Spandidos Publications

     Executive Director, The Hormel Institute Robert Clarke

307. 
     Article • Molecular and Cellular Biochemistry, January 1998, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

308. 
     Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models

     Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

309. 
     Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

     Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

310. 
     Mechanisms by which high maternal fat intake during pregnancy increases breast cancer risk in female rodent offspring

     Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

311. 
     Estrogen-regulated non-reproductive behaviors and breast cancer risk: Animal models and human studies

     Article • Breast Cancer Research and Treatment, November 1997, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

312. 
     Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations and

     Article • The Journal of Steroid Biochemistry and Molecular Biology, November 1997, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

313. 
     A maternal diet high in n − 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring

     Article • Proceedings of the National Academy of Sciences, August 1997, Proceedings of the National Academy of Sciences

     Executive Director, The Hormel Institute Robert Clarke

314. 
     Multidrug Resistance in Breast Cancer: a Meta-analysis of MDR1/gp170 Expression and Its Possible Functional Significance

     Article • JNCI Journal of the National Cancer Institute, July 1997, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

315. 
     Breast Cancer Risk in Rats Fed a Diet High in n-6 Polyunsaturated Fatty Acids During Pregnancy

     Article • JNCI Journal of the National Cancer Institute, December 1996, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

316. 
     Acquired estrogen independence and antiestrogen resistance in breast cancer

     Article • Trends in Endocrinology and Metabolism, October 1996, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

317. 
     Specific binding of estradiol to rat coronary artery smooth muscle cells

     Article • The Journal of Steroid Biochemistry and Molecular Biology, April 1996, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

318. 
     Animal models of breast cancer: Their diversity and role in biomedical research

     Article • Breast Cancer Research and Treatment, February 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

319. 
     Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines

     Article • Breast Cancer Research and Treatment, February 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

320. 
     Estrogens, Phytoestrogens, and Breast Cancer

     Article • January 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

321. 
     Acquisition of an Antiestrogen-Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms

     Article • January 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

322. 
     Mechanisms of Resistance to Antiestrogens and Their Implications for Crossresistance

     Article • January 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

323. 
     MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer

     Article • British Journal of Cancer, January 1996, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

324. 
     Early Life Affects the Risk of Developing Breast Cancer

     Article • Annals of the New York Academy of Sciences, September 1995, Wiley

     Executive Director, The Hormel Institute Robert Clarke

325. 
     Hormone dependence of breast cancer cells and the effects of tamoxifen and estrogen:31P NMR studies

     Article • Breast Cancer Research and Treatment, March 1995, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

326. 
     Acquisition of estrogen independence and antiestrogen resistance in breast cancer: association with the invasive and metastatic phenotype

     Article • Endocrine Related Cancer, March 1995, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

327. 
     Cross-resistance and molecular mechanisms in antiestrogen resistance

     Article • Endocrine Related Cancer, March 1995, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

328. 
     Anti‐proliferative and anti‐estrogenic effects of ICI 164,384 and ICI 182,780 in 4‐OH‐tamoxifen‐resistant human breast‐cancer cells

     Article • International Journal of Cancer, January 1994, Wiley

     Executive Director, The Hormel Institute Robert Clarke

329. 
     Perinatal factors increase breast cancer risk

     Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

330. 
     Psychosocial factors in the development and progression of breast cancer

     Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

331. 
     Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression

     Article • Breast Cancer Research and Treatment, January 1994, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

332. 
     Hormone resistance, invasiveness, and metastatic potential in breast cancer

     Article • Breast Cancer Research and Treatment, October 1993, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

333. 
     Opposing behavioural alterations in male and female transgenic TGFα mice: association with tumour susceptibility

     Article • British Journal of Cancer, May 1993, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

334. 
     The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells

     Article • Clinical & Experimental Metastasis, January 1993, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

335. 
     Effect of P-glycoprotein Expression on Sensitivity to Hormones in MCF-7 Human Breast Cancer Cells

     Article • JNCI Journal of the National Cancer Institute, October 1992, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

336. 
     Alterations in behavior, steroid hormones and natural killer cell activity in male transgenic TGFα mice

     Article • Brain Research, August 1992, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

337. 
     Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

     Article • Journal of Cellular Physiology, March 1992, Wiley

     Executive Director, The Hormel Institute Robert Clarke

338. 
     Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF‐7 breast‐cancer cells

     Article • International Journal of Cancer, February 1992, Wiley

     Executive Director, The Hormel Institute Robert Clarke

339. 
     IGF-I and IGF-II expression in human breast cancer xenografts: Relationship to hormone independence

     Article • Breast Cancer Research and Treatment, February 1992, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

340. 
     Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH

     Article • Breast Cancer Research and Treatment, February 1992, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

341. 
     In vitro antineoplastic activity of C7-substituted mitomycin C analogues MC-77 and MC-62 against human breast-cancer cell lines

     Article • Cancer Chemotherapy and Pharmacology, January 1992, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

342. 
     Hormonal aspects of breast cancer

     Article • Critical Reviews in Oncology/Hematology, January 1992, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

343. 
     The Biology of Breast Tumor Progression: Acquisition of hormone independence and resistance to cytotoxic drugs

     Article • Acta Oncologica, January 1992, Acta Dermato-Venereologica

     Executive Director, The Hormel Institute Robert Clarke

344. 
     Vascular Non-genomic Effects of Estrogen

     Article • January 1992, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

345. 
     Reduction of the Membrane Fluidity of Human Breast Cancer Cells by Tamoxifen and 17beta-Estradiol

     Article • JNCI Journal of the National Cancer Institute, November 1990, Oxford University Press (OUP)

     Executive Director, The Hormel Institute Robert Clarke

346. 
     The process of malignant progression in human breast cancer

     Article • Annals of Oncology, November 1990, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

347. 
     Adverse interactions between cytotoxic drugs and hormonal agents in human breast cancer cells.

     Article • Journal of Clinical Oncology, October 1989, American Society of Clinical Oncology (ASCO)

     Executive Director, The Hormel Institute Robert Clarke

348. 
     The inter-relationships between ovarian-independent growth, tumorigenicity, invasiveness and antioestrogen resistance in the malignant progression of human breast cancer

     Article • Journal of Endocrinology, July 1989, Bioscientifica

     Executive Director, The Hormel Institute Robert Clarke

349. 
     Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

     Article • Proceedings of the National Academy of Sciences, May 1989, Proceedings of the National Academy of Sciences

     Executive Director, The Hormel Institute Robert Clarke

350. 
     Steroid receptors and disease: cancer, autoimmune, bone and circulatory disorders

     Article • Trends in Pharmacological Sciences, March 1989, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

351. 
     The Effects of a Constitutive Expression of Transforming Growth Factor-α on the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo

     Article • Molecular Endocrinology, February 1989, Endocrine Society

     Executive Director, The Hormel Institute Robert Clarke

352. 
     Regulation of Breast Cancer Cells by Hormones and Growth Factors: Effects on Proliferation and Basement Membrane Invasiveness

     Article • Hormone Research, January 1989, Karger Publishers

     Executive Director, The Hormel Institute Robert Clarke

353. 
     Regulation of Human Breast Cancer by Secreted Growth Factors

     Article • Acta Oncologica, January 1989, Taylor & Francis

     Executive Director, The Hormel Institute Robert Clarke

354. 
     Conformational and receptor binding properties of human EGF and TGF-α second loop fragments

     Article • Journal of Molecular Recognition, June 1988, Wiley

     Executive Director, The Hormel Institute Robert Clarke

355. 
     Morpho-functional effects of Phenol Red on oestrogen-sensitive breast cancer cells

     Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

356. 
     The ability of oestrogen to modulate the effects of cytotoxic drugs in human breast cancer cells: influence of oestrogen receptor status and choice of drug

     Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

357. 
     Pharmacological and suprapharmacological concentrations of both 17β-oestradiol and tamoxifen reduce the membrane fluidity of MCF-7 and MDA-MB-436 human breast cancer cells

     Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

358. 
     Human recombinant interferon α increases oestrogen receptor expression in ZR-75-1 human breast cancer cells and sensitizes them to the anti-proliferative effects of tamoxifen

     Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

359. 
     The response of human breast cancer cells to glucagon

     Article • Biochemical Society Transactions, April 1987, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

360. 
     Recombinant human interferon alpha increases oestrogen receptor expression in human breast cancer cells (ZR-75-1) and sensitises them to the anti-proliferative effects of tamoxifen

     Article • British Journal of Cancer, March 1987, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

361. 
     The effects of Mg2+ ions or EDTA on nuclear integrity and apparent subcellular distribution of unoccupied oestrogen receptors in breast cancer cells

     Article • Journal of Steroid Biochemistry, November 1986, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

362. 
     Enhancement of methotrexate cytotoxicity towards the MDA.MB.436 human breast cancer cell line by dipyridamole

     Article • Biochemical Pharmacology, September 1986, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

363. 
     The unoccupied estrogen receptor: Some comments on localization

     Article • Steroids, July 1986, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

364. 
     The influence of vincristine on the oestrogen-binding capacity of two human breast cancer cell lines in vitro

     Article • Biochemical Society Transactions, April 1986, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

365. 
     The effects of Mg2+ or EDTA on the subcellular distribution of unoccupied oestrogen receptor in ZR-75-1 and MCF-7 cells

     Article • Biochemical Society Transactions, April 1986, Portland Press Ltd.

     Executive Director, The Hormel Institute Robert Clarke

366. 
     The effect of the rate of cell proliferation on the synthesis of methotrexate poly-γ-glutamates in two human breast cancer cell lines

     Article • Biochemical Pharmacology, September 1985, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

367. 
     The effect of leucovorin on the synthesis of methotrexate poly-γ-glutamates in the MCF-7 human breast cancer cell line

     Article • Biochemical Pharmacology, August 1985, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

368. 
     Oestrogen receptor status and the response of human breast cancer cell lines to a combination of methotrexate and 17-beta oestradiol

     Article • British Journal of Cancer, March 1985, Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

369. 
     Reduction of the anti-metabolic and anti-proliferative effects of methotrexate by 17β-oestradiol in a human breast carcinoma cell line, MDA-MB-436

     Article • European Journal of Cancer and Clinical Oncology, January 1983, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

370. 
     The kinetics of methotrexate polyglutamate formation and efflux in a human breast cancer cell line (MDA.MB.436): The effect of insulin

     Article • Biochemical Pharmacology, January 1983, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

371. 
     Failure of 5-fluorouracil and methotrexate to destroy the reproductive integrity of a human breast cancer cell line (MCF-7) growingin vitro

     Article • European Journal of Cancer and Clinical Oncology, December 1981, Elsevier

     Executive Director, The Hormel Institute Robert Clarke

372. 
     The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants: Their Potential Roles in Breast Cancer

     Article • Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

373. 
     Human Breast-Cancer Xenografts as Models of the Human Disease

     Article • Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

374. 
     Integrative Network Component Analysis for Regulatory Network Reconstruction

     Article • Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

375. 
     Sparse Decomposition of Gene Expression Data to Infer Transcriptional Modules Guided by Motif Information

     Article • Springer Science + Business Media

     Executive Director, The Hormel Institute Robert Clarke

376. 
     Normalization of Microarray Data by Iterative Nonlinear Regression

     Article • Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

377. 
     Optimizing multilayer perceptrons by discriminatory component analysis

     Article • Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke

378. 
     Partially-independent component analysis for tissue heterogeneity correction in microarray gene expression analysis

     Article • Institute of Electrical & Electronics Engineers (IEEE)

     Executive Director, The Hormel Institute Robert Clarke