All Stories

  1. Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models

    Article • Nature Communications, April 2026, Springer Science + Business Media

    Nicoletta Filigheddu

  2. Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia

    Article • Nature Metabolism, November 2025, Springer Science + Business Media

    Nicoletta Filigheddu

  3. The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance

    Article • Clinical Nutrition, October 2025, Elsevier

    Nicoletta Filigheddu

  4. Diet-Derived Advanced Glycation End-Products (AGEs) Induce Muscle Wasting In Vitro, and a Standardized Vaccinium macrocarpon Extract Restrains AGE Formation and AGE-Dependent C2C12 Myotube Atrophy

    Article • Antioxidants, July 2025, MDPI AG

    Nicoletta Filigheddu

  5. Vegetal oil-based ketogenic diet improves inflammation and fibrosis in experimental metabolic dysfunction-associated steatohepatitis

    Article • Frontiers in Immunology, April 2025, Frontiers

    Nicoletta Filigheddu

  6. ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism

    Article • Communications Biology, October 2024, Springer Science + Business Media

    Mariagrazia Grilli, Nicoletta Filigheddu

  7. Unravelling the metabolic rewiring in the context of doxorubicin-induced cardiotoxicity: Fuel preference changes from fatty acids to glucose oxidation

    Article • Vascular Pharmacology, June 2024, Elsevier

    Nicoletta Filigheddu

  8. Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting

    Article • May 2024, Springer Science + Business Media

    Nicoletta Filigheddu

  9. Equisetum arvense standardized dried extract hinders age-related osteosarcopenia

    Article • Biomedicine & Pharmacotherapy, May 2024, Elsevier

    Michela Bosetti, Nicoletta Filigheddu

  10. Astroglial calcium signaling and homeostasis in tuberous sclerosis complex

    Article • Acta Neuropathologica, February 2024, Springer Science + Business Media

    Nicoletta Filigheddu

  11. CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy

    Article • Blood Advances, August 2022, American Society of Hematology

    Nicoletta Filigheddu

  12. KYMASIN UP Natural Product Inhibits Osteoclastogenesis and Improves Osteoblast Activity by Modulating Src and p38 MAPK

    Article • Nutrients, July 2022, MDPI AG

    Michela Bosetti, Nicoletta Filigheddu

  13. The Atrophic Effect of 1,25(OH)2 Vitamin D3 (Calcitriol) on C2C12 Myotubes Depends on Oxidative Stress

    Article • Antioxidants, December 2021, MDPI AG

    Nicoletta Filigheddu

  14. Effect of unacylated ghrelin on peripheral nerve regeneration

    Article • European Journal of Histochemistry, November 2021, PAGEPress Publications

    Nicoletta Filigheddu

  15. Regulation of GH and GH Signaling by Nutrients

    Article • Cells, June 2021, MDPI AG

    Nicoletta Filigheddu

  16. Cholecalciferol (vitamin D3) has a direct protective activity against interleukin 6-induced atrophy in C2C12 myotubes

    Article • Aging, February 2021, Impact Journals, LLC

    Nicoletta Filigheddu

  17. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl, Professor Nektarios Tavernarakis, Jie Chao

  18. Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Article • Nutrients, July 2020, MDPI AG

    Nicoletta Filigheddu

  19. A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy

    Article • Disease Models & Mechanisms, December 2019, The Company of Biologists

    Nicoletta Filigheddu

  20. Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies

    Article • Nutrients, October 2019, MDPI AG

    Nicoletta Filigheddu

  21. Identification of Haptoglobin as a Readout of rhGH Therapy in GH Deficiency

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2019, Endocrine Society

    Nicoletta Filigheddu

  22. Opposing effects of 25‐hydroxy‐ and 1α,25‐dihydroxy‐vitamin D 3 on pro‐cachectic cytokine‐and cancer conditioned medium‐induced atrophy in C2C12 myotubes

    Article • Acta Physiologica, March 2019, Wiley

    Nicoletta Filigheddu

  23. Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal

    Article • Endocrine, May 2018, Springer Science + Business Media

    Nicoletta Filigheddu

  24. Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting

    Article • Oxidative Medicine and Cellular Longevity, January 2018, Hindawi Publishing Corporation

    Nicoletta Filigheddu, Professor Emilio Hirsch, Elisabeth Wyart, Alessandra Ghigo

  25. Mouse Satellite Cell Isolation and Transplantation

    Article • BIO-PROTOCOL, January 2018, Bio-Protocol, LLC

    Nicoletta Filigheddu

  26. Mitochondrial metabolism and cancer

    Article • BDJ, December 2017, Nature

    Nicoletta Filigheddu

  27. The role of vitamin D in cancer cachexia

    Article • Current Opinion in Supportive and Palliative Care, December 2017, Wolters Kluwer Health

    Nicoletta Filigheddu

  28. Unacylated Ghrelin Enhances Satellite Cell Function and Relieves the Dystrophic Phenotype in Duchenne Muscular Dystrophy mdx Model

    Article • Stem Cells, May 2017, Wiley

    Professor Stefano Geuna, Nicoletta Filigheddu, Giulia Ruozi

  29. Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet–Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents

    Article • Diabetes, January 2016, American Diabetes Association

    Nicoletta Filigheddu, Giulia Ruozi, Spg Spgspg

  30. Unacylated ghrelin does not alter mitochondrial function, redox state and triglyceride content in rat liver in vivo

    Article • Clinical Nutrition Experimental, December 2015, Elsevier

    Nicoletta Filigheddu, Giulia Ruozi, Spg Spgspg

  31. Correction: Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential

    Article • PLOS One, October 2015, PLOS

    Nicoletta Filigheddu

  32. Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential

    Article • PLOS One, September 2015, PLOS

    Nicoletta Filigheddu

  33. AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

    Article • Nature Communications, June 2015, Nature

    Nicoletta Filigheddu, Giulia Ruozi

  34. Antifibrotic Activity of Acylated and Unacylated Ghrelin

    Article • International Journal of Endocrinology, January 2015, Hindawi Publishing Corporation

    Nicoletta Filigheddu

  35. The Diacylglycerol Kinase α/Atypical PKC/β1 Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness

    Article • PLOS One, June 2014, PLOS

    Nicoletta Filigheddu

  36. Acylated and unacylated ghrelin administration to blunt muscle wasting

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, May 2014, Wolters Kluwer Health

    Nicoletta Filigheddu

  37. Ghrelin Gene Products in Acute and Chronic Inflammation

    Article • Archivum Immunologiae et Therapiae Experimentalis, April 2014, Springer Science + Business Media

    Nicoletta Filigheddu

  38. Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice

    Article • Journal of Clinical Investigation, January 2013, American Society for Clinical Investigation

    Nicoletta Filigheddu

  39. Ghrelin

    Article • January 2013, Elsevier

    Nicoletta Filigheddu

  40. Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30

    Article • Cellular Signalling, December 2011, Elsevier

    Nicoletta Filigheddu

  41. SAP-Mediated Inhibition of Diacylglycerol Kinase   Regulates TCR-Induced Diacylglycerol Signaling

    Article • The Journal of Immunology, November 2011, The American Association of Immunologists

    Nicoletta Filigheddu

  42. Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi’s sarcoma cells

    Article • Cancer Science, May 2011, Wiley

    Nicoletta Filigheddu

  43. Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

    Article • Proceedings of the National Academy of Sciences, February 2010, Proceedings of the National Academy of Sciences

    Nicoletta Filigheddu

  44. Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis

    Article • Journal of Biomedicine and Biotechnology, January 2010, Hindawi Publishing Corporation

    Nicoletta Filigheddu

  45. Morphological and biomolecular characterization of the neonatal olfactory bulb ensheathing cell line

    Article • Journal of Neuroscience Methods, December 2009, Elsevier

    Nicoletta Filigheddu

  46. Calcium signals activated by ghrelin and D-Lys3-GHRP-6 ghrelin antagonist in developing dorsal root ganglion glial cells

    Article • Cell Calcium, September 2009, Elsevier

    Nicoletta Filigheddu

  47. Diacylglycerol Kinase-  Mediates Hepatocyte Growth Factor-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling

    Article • Molecular Biology of the Cell, September 2007, American Society for Cell Biology (ASCB)

    Nicoletta Filigheddu

  48. Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

    Article • Oncogene, August 2007, Nature

    Nicoletta Filigheddu

  49. Ghrelin and Des-Acyl Ghrelin Promote Differentiation and Fusion of C2C12 Skeletal Muscle Cells

    Article • Molecular Biology of the Cell, January 2007, American Society for Cell Biology (ASCB)

    Nicoletta Filigheddu

  50. p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis

    Article • International Journal of Cancer, June 2006, Wiley

    Nicoletta Filigheddu

  51. Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning

    Article • Gastroenterology, September 2004, Elsevier

    Nicoletta Filigheddu

  52. Activation of diacylglycerol kinase α is required for VEGF-induced angiogenic signaling in vitro

    Article • Oncogene, May 2004, Nature

    Nicoletta Filigheddu

  53. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

    Article • Journal of Cell Biology, December 2002, Rockefeller University Press

    Nicoletta Filigheddu

  54. Hexarelin Protects H9c2 Cardiomyocytes from Doxorubicin-Induced Cell Death

    Article • Endocrine, January 2001, Springer Science + Business Media

    Nicoletta Filigheddu