All Stories

  1. Structure-guided approaches to modulate endosomal toll-like receptors TLR7, TLR8 and TLR9: advances, challenges and therapeutic promise

    Article • Drug Discovery Today, November 2025, Elsevier

    Professor Günther Weindl

  2. Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins

    Article • npj Antimicrobials and Resistance, July 2025, Springer Science + Business Media

    Professor Günther Weindl

  3. The monomeric but not homotrimeric spike protein of SARS-CoV-2 activates TLR4 signaling

    Article • Molecular Biology Reports, June 2025, Springer Science + Business Media

    Professor Günther Weindl

  4. Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists

    Article • Acta Pharmaceutica, June 2025, De Gruyter

    Professor Günther Weindl

  5. The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β

    Article • World Journal of Surgery, February 2025, Springer Science + Business Media

    Professor Günther Weindl

  6. Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 Antagonists

    Article • Journal of Medicinal Chemistry, February 2025, American Chemical Society (ACS)

    Professor Günther Weindl

  7. Degrading the key component of the inflammasome: development of an NLRP3 PROTAC

    Article • Chemical Communications, January 2025, Royal Society of Chemistry

    Professor Günther Weindl

  8. Lipopolysaccharide-Neutralizing Peptide Modulates P2X7 Receptor-Mediated Interleukin-1β Release

    Article • ACS Pharmacology & Translational Science, December 2024, American Chemical Society (ACS)

    Professor Günther Weindl

  9. Degrading the key component of the inflammasome: Development of an NLRP3 PROTAC

    Article • November 2024, American Chemical Society (ACS)

    Professor Günther Weindl

  10. Development of the First-in-Class Degrader of NLRP3

    Article • November 2024, American Chemical Society (ACS)

    Professor Günther Weindl

  11. Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Professor Günther Weindl

  12. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

    Article • Bioorganic Chemistry, February 2024, Elsevier

    Professor Günther Weindl

  13. Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Professor Günther Weindl

  14. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

    Article • December 2023, American Chemical Society (ACS)

    Professor Günther Weindl

  15. P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages

    Article • Cell Communication and Signaling, November 2023, Springer Science + Business Media

    Professor Günther Weindl

  16. A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

    Article • International Journal of Molecular Sciences, October 2023, MDPI AG

    Professor Günther Weindl

  17. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

    Article • September 2023, American Chemical Society (ACS)

    Professor Günther Weindl

  18. Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release

    Article • Biochemical Pharmacology, September 2023, Elsevier

    Professor Günther Weindl

  19. A Comparison between SARS-CoV-2 and Gram-Negative Bacteria-Induced Hyperinflammation and Sepsis

    Article • August 2023, MDPI AG

    Professor Günther Weindl

  20. Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5

    Article • Microorganisms, December 2022, MDPI AG

    Professor Günther Weindl

  21. Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Professor Günther Weindl

  22. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl

  23. Immunocompetent Human Intestinal Models in Preclinical Drug Development

    Article • December 2020, Springer Science + Business Media

    Professor Günther Weindl

  24. An update on endotoxin neutralization strategies in Gram-negative bacterial infections

    Article • Expert Review of Anti-infective Therapy, November 2020, Taylor & Francis

    Professor Günther Weindl

  25. TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research

    Article • Archives of Toxicology, July 2020, Springer Science + Business Media

    Professor Günther Weindl

  26. Biological Characterization, Mechanistic Investigation and Structure‐Activity Relationships of Chemically Stable TLR2 Antagonists

    Article • ChemMedChem, June 2020, Wiley

    Professor Günther Weindl

  27. The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling

    Article • Biochemical Pharmacology, January 2020, Elsevier

    Professor Günther Weindl

  28. Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells

    Article • Autophagy, November 2019, Taylor & Francis

    Professor Günther Weindl

  29. Identification and characterization of a novel chemotype for human TLR8 inhibitors

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Professor Günther Weindl

  30. LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, October 2019, Elsevier

    Professor Günther Weindl

  31. Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

    Article • Trends in Pharmacological Sciences, January 2019, Elsevier

    Professor Günther Weindl

  32. Synthetic Anti-lipopolysaccharide Peptides (SALPs) as Effective Inhibitors of Pathogen-Associated Molecular Patterns (PAMPs)

    Article • January 2019, Springer Science + Business Media

    Professor Günther Weindl

  33. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening

    Article • Biochemical Pharmacology, August 2018, Elsevier

    Professor Günther Weindl

  34. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

    Article • Frontiers in Immunology, July 2018, Frontiers

    Professor Günther Weindl, Prof. Dr. Torsten Goldmann

  35. Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

    Article • Bone Marrow Transplantation, June 2018, Wiley

    Professor Günther Weindl

  36. Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

    Article • Frontiers in Pharmacology, March 2018, Frontiers

    Professor Günther Weindl

  37. Characterization of reconstructed human skin containing Langerhans cells to monitor molecular events in skin sensitization

    Article • Toxicology in Vitro, February 2018, Elsevier

    Professor Günther Weindl

  38. Glucocorticoids and Toll-like receptor 2 cooperatively induce acute-phase serum amyloid A

    Article • Pharmacological Research, February 2018, Elsevier

    Professor Günther Weindl

  39. Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses

    Article • Biochemical Pharmacology, September 2017, Elsevier

    Professor Günther Weindl

  40. Cell type-specific regulatory effects of glucocorticoids on cutaneous TLR2 expression and signalling

    Article • The Journal of Steroid Biochemistry and Molecular Biology, July 2017, Elsevier

    Professor Günther Weindl

  41. Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues

    Article • Archives of Toxicology, March 2017, Springer Science + Business Media

    Professor Günther Weindl

  42. Recognition of Propionibacterium acnes by human TLR2 heterodimers

    Article • International Journal of Medical Microbiology, February 2017, Elsevier

    Professor Günther Weindl

  43. Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    Professor Günther Weindl

  44. Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells

    Article • Journal of Dermatological Science, April 2016, Elsevier

    Professor Günther Weindl

  45. Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement

    Article • Pharmacological Research, March 2016, Elsevier

    Professor Günther Weindl

  46. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl

  47. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla

  48. IL-4 abrogates T H 17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells

    Article • Proceedings of the National Academy of Sciences, February 2015, Proceedings of the National Academy of Sciences

    Professor Günther Weindl

  49. Inflammatory conditions distinctively alter immunological functions of Langerhans-like cells and dendritic cellsin vitro

    Article • Immunology, January 2015, Wiley

    Professor Günther Weindl

  50. Regulation of Dendritic Cell Function in Inflammation

    Article • Journal of Immunology Research, January 2015, Hindawi Publishing Corporation

    Professor Günther Weindl

  51. Chloroquine Promotes IL-17 Production by CD4+T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells

    Article • The Journal of Immunology, November 2014, The American Association of Immunologists

    Professor Günther Weindl

  52. Impact of structural differences in hyperbranched polyglycerol–polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2014, Elsevier

    Professor Günther Weindl

  53. Core-multishell nanotransporters enhance skin penetration of the cell-penetrating peptide low molecular weight protamine

    Article • Polymers for Advanced Technologies, July 2014, Wiley

    Professor Günther Weindl

  54. Cationic membrane-active peptides - anticancer and antifungal activity as well as penetration into human skin

    Article • Experimental Dermatology, April 2014, Wiley

    Professor Günther Weindl

  55. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, April 2014, Elsevier

    Professor Günther Weindl

  56. Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders

    Article • Experimental Dermatology, March 2014, Wiley

    Professor Günther Weindl

  57. Improving Topical Non-Melanoma Skin Cancer Treatment: In vitro Efficacy of a Novel Guanosine-Analog Phosphonate

    Article • Skin Pharmacology and Physiology, January 2014, Karger Publishers

    Professor Günther Weindl

  58. 9 Mucosal Immunology in Candida albicans Infection

    Article • October 2013, Springer Science + Business Media

    Dr Julian Naglik, Professor Günther Weindl

  59. Esterase activity in excised and reconstructed human skin – Biotransformation of prednicarbate and the model dye fluorescein diacetate

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2013, Elsevier

    Professor Günther Weindl

  60. Glycosylation of Candida albicans Cell Wall Proteins Is Critical for Induction of Innate Immune Responses and Apoptosis of Epithelial Cells

    Article • PLOS One, November 2012, PLOS

    Dr Julian Naglik, Professor Günther Weindl

  61. Host Defence Against Candida albicans and the Role of Pattern-recognition Receptors

    Article • Acta Dermato Venereologica, January 2012, Acta Dermato-Venereologica

    Professor Günther Weindl

  62. Interaction of the mucosal barrier with accessory immune cells during fungal infection

    Article • International Journal of Medical Microbiology, June 2011, Elsevier

    Professor Günther Weindl

  63. 3D-Wound healing model: Influence of morphine and solid lipid nanoparticles

    Article • Journal of Biotechnology, July 2010, Elsevier

    Professor Günther Weindl

  64. The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence

    Article • Yeast, June 2010, Wiley

    Professor Günther Weindl

  65. Epithelial Cells and Innate Antifungal Defense

    Article • Journal of Dental Research, April 2010, SAGE Publications

    Professor Günther Weindl

  66. Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine againstTrichophyton rubrumin anin vitromodel of dermatophyte nail infection

    Article • Medical Mycology, November 2009, Oxford University Press (OUP)

    Professor Günther Weindl

  67. Influences of opioids and nanoparticles on in vitro wound healing models

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2009, Elsevier

    Professor Günther Weindl

  68. Models of Oral and Vaginal Candidiasis Based on In Vitro Reconstituted Human Epithelia for the Study of Host-Pathogen Interactions

    Article • January 2009, Springer Science + Business Media

    Professor Günther Weindl

  69. Introduction: Host Responses

    Article • January 2009, Springer Science + Business Media

    Professor Günther Weindl

  70. Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection

    Article • Medical Mycology, January 2009, Oxford University Press (OUP)

    Professor Günther Weindl

  71. Charakterisierung der Interaktion zwischen Candida albicans und Wirtszellen

    Article • Der Hautarzt, November 2008, Springer Science + Business Media

    Professor Günther Weindl

  72. Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis

    Article • Microbiology, November 2008, Society for General Microbiology

    Dr Julian Naglik, Professor Günther Weindl

  73. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling

    Article • Journal of Clinical Investigation, November 2007, American Society for Clinical Investigation

    Dr Julian Naglik, Professor Günther Weindl

  74. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IκBα Protein-Mediated Inflammatory Disease of the Skin

    Article • Immunity, August 2007, Elsevier

    Professor Günther Weindl

  75. The Early Transcriptional Response of Human Granulocytes to Infection with Candida albicans Is Not Essential for Killing but Reflects Cellular Communications

    Article • Infection and Immunity, December 2006, ASM Journals

    Professor Günther Weindl

  76. Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia

    Article • Nature Protocols, December 2006, Springer Science + Business Media

    Dr Julian Naglik, Professor Günther Weindl

  77. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

    Article • Clinical Interventions in Aging, December 2006, Dove Medical Press

    Professor Günther Weindl

  78. In vivo Porphyrin Production by P. acnes in Untreated Acne Patients and its Modulation by Acne Treatment

    Article • Acta Dermato Venereologica, January 2006, Acta Dermato-Venereologica

    Professor Günther Weindl

  79. Receptor-Selective Retinoids for Psoriasis

    Article • American Journal of Clinical Dermatology, January 2006, Springer Science + Business Media

    Professor Günther Weindl

  80. Stroma-Mediated Dysregulation of Myelopoiesis in Mice Lacking IκBα

    Article • Immunity, April 2005, Elsevier

    Professor Günther Weindl

  81. Peroxisome Proliferator-Activated Receptors and their Ligands

    Article • Drugs, January 2005, Springer Science + Business Media

    Professor Günther Weindl

  82. Induction of Nuclear Factor–κB and c‐Jun/Activator Protein–1 via Toll‐Like Receptor 2 in Macrophages by Antimycotic‐TreatedCandida albicans

    Article • The Journal of Infectious Diseases, October 2004, Oxford University Press (OUP)

    Professor Günther Weindl

  83. Hyaluronic Acid in the Treatment and Prevention of Skin Diseases: Molecular Biological, Pharmaceutical and Clinical Aspects

    Article • Skin Pharmacology and Physiology, September 2004, Karger Publishers

    Professor Günther Weindl

  84. Toll-like receptors as key mediators in innate antifungal immunity

    Article • Medical Mycology, January 2004, Oxford University Press (OUP)

    Professor Günther Weindl