Dr. rer. nat. Marc Herb

Mitochondrial ROS in proinflammatory signaling

• Science Signaling
• February 2019

• A major function of macrophages during infection is initiation of the proinflammatory response, leading to the secretion of cytokines that help to orchestrate the immune response. Here, we identify...

LC3-associated phagocytosis - The highway to hell for phagocytosed microbes

• Seminars in Cell and Developmental Biology
• May 2020

• Phagocytes ingest, kill and degrade invading microbes in a process called phagocytosis. LC3-associated phagocytosis (LAP) combines the molecular machinery of phagocytosis with that of autophagy, th...

Preparation and Transfection of Primary Macrophages with In Vitro Transcribed mRNA

• Journal of Visualized Experiments
• November 2019

• Macrophages, especially primary macrophages, are challenging to transfect as they specialize in detecting molecules of non-self origin. We describe a protocol that allows highly efficient transfect...

Functions of ROS in Macrophages and Antimicrobial Immunity

• Antioxidants
• February 2021

• Reactive oxygen species (ROS) are a chemically defined group of reactive molecules derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all domains of life, rangin...

Reactive Oxygen Species: Not Omnipresent but Important in Many Locations

• Frontiers in Cell and Developmental Biology
• September 2021