All Stories

  1. Editorial: Understanding the gene expression of β cell dysfunction in diabetes

    Article • Frontiers in Endocrinology, November 2022, Frontiers

    Professor Po Sing Leung

  2. Protocatechualdehyde restores endothelial dysfunction in streptozotocin-induced diabetic rats

    Article • Annals of Translational Medicine, April 2021, AME Publishing Company

    Professor Po Sing Leung

  3. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen

  4. Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

    Article • Cell Regeneration, September 2020, Springer Science + Business Media

    Professor Po Sing Leung

  5. Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer

    Article • Molecular Therapy — Oncolytics, September 2020, Elsevier

    Professor Po Sing Leung

  6. Revisiting the use of biological fluids for noninvasive glucose detection

    Article • Future Medicinal Chemistry, April 2020, Future Science

    Professor Po Sing Leung

  7. Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance

    Article • Annals of Translational Medicine, March 2020, AME Publishing Company

    Professor Po Sing Leung

  8. Roles of FGF21 and irisin in obesity-related diabetes and pancreatic diseases

    Article • Journal of Pancreatology, March 2020, Wolters Kluwer Health

    Professor Po Sing Leung

  9. Does vitamin D supplementation reduce type 2 diabetes risk?

    Article • Annals of Translational Medicine, November 2019, AME Publishing Company

    Professor Po Sing Leung

  10. Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

    Article • Clinical Science, October 2019, Portland Press Ltd.

    Professor Po Sing Leung

  11. SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation

    Article • Stem Cells, August 2019, Wiley

    Professor Po Sing Leung

  12. Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters

    Article • International Journal of Molecular Sciences, August 2019, MDPI AG

    Professor Po Sing Leung

  13. The Modulatory Action of Vitamin D on the Renin–Angiotensin System and the Determination of Hepatic Insulin Resistance

    Article • Molecules, July 2019, MDPI AG

    Professor Po Sing Leung

  14. Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling

    Article • International Journal of Molecular Sciences, May 2019, MDPI AG

    Professor Po Sing Leung

  15. FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential

    Article • Future Medicinal Chemistry, April 2019, Future Science

    Professor Po Sing Leung

  16. GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation

    Article • Clinical Science, December 2018, Portland Press Ltd.

    Professor Po Sing Leung

  17. GPR120 is an important inflammatory regulator in the development of osteoarthritis

    Article • August 2018, Springer Science + Business Media

    Professor Po Sing Leung

  18. Isodon eriocalyx and its bioactive component Eriocalyxin B enhance cytotoxic and apoptotic effects of gemcitabine in pancreatic cancer

    Article • Phytomedicine, May 2018, Elsevier

    Professor Po Sing Leung

  19. Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Professor Po Sing Leung

  20. Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

    Article • Frontiers in Pharmacology, December 2017, Frontiers

    Professor Po Sing Leung

  21. Na+ /H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine

    Article • Diabetes Obesity and Metabolism, December 2017, Wiley

    Professor Po Sing Leung

  22. Fibroblast growth factor 21: a regulator of metabolic disease and health span

    Article • AJP Endocrinology and Metabolism, September 2017, American Physiological Society

    Professor Po Sing Leung

  23. Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies

    Article • Oncotarget, May 2017, Impact Journals, LLC

    Professor Po Sing Leung

  24. The potential of irisin as a therapeutic for diabetes

    Article • Future Medicinal Chemistry, April 2017, Future Science

    Professor Po Sing Leung

  25. Angiotensin II Type 2 Receptor Activation With Compound 21 Augments Islet Function and Regeneration in Streptozotocin-Induced Neonatal Rats and Human Pancreatic Progenitor Cells

    Article • Pancreas, March 2017, Wolters Kluwer Health

    Professor Po Sing Leung

  26. Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic β-Cells and Type 2 Diabetes

    Article • Diabetes, February 2017, American Diabetes Association

    Professor Po Sing Leung

  27. Pancreatic Cancer, Pancreatitis, and Oxidative Stress

    Article • January 2017, Elsevier

    Professor Po Sing Leung

  28. Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states

    Article • Clinical Science, December 2016, Portland Press Ltd.

    Professor Po Sing Leung

  29. Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus

    Article • Current Molecular Medicine, November 2016, Bentham Science Publishers

    Professor Po Sing Leung

  30. Hedgehog signaling in bone regulates whole-body energy metabolism through a bone–adipose endocrine relay mediated by PTHrP and adiponectin

    Article • Cell Death and Differentiation, October 2016, Springer Science + Business Media

    Professor Po Sing Leung

  31. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling

    Article • The International Journal of Biochemistry & Cell Biology, September 2016, Elsevier

    Professor Po Sing Leung

  32. Combination of Telmisartan and Linagliptin Preserves Pancreatic Islet Cell Function and Morphology in db/db Mice

    Article • Pancreas, April 2016, Wolters Kluwer Health

    Professor Po Sing Leung

  33. Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus

    Article • Medicinal Research Reviews, March 2016, Wiley

    Professor Po Sing Leung

  34. NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration Through Differentiation of Endocrine Progenitors in Murine Pancreas

    Article • Antioxidants & Redox Signaling, March 2016, Mary Ann Liebert Inc

    Professor Po Sing Leung

  35. The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus

    Article • Nutrients, March 2016, MDPI AG

    Professor Po Sing Leung

  36. IL-1β inhibits β-Klotho expression and FGF19 signaling in hepatocytes

    Article • AJP Endocrinology and Metabolism, February 2016, American Physiological Society

    Professor Po Sing Leung

  37. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes

    Article • PLoS ONE, January 2016, PLOS

    Eric Mayoux, Professor Po Sing Leung

  38. Multifaceted interplay among mediators and regulators of intestinal glucose absorption: potential impacts on diabetes research and treatment

    Article • AJP Endocrinology and Metabolism, December 2015, American Physiological Society

    Professor Po Sing Leung

  39. Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice

    Article • Nutrients, September 2015, MDPI AG

    Professor Po Sing Leung

  40. “Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism”: Might Reduced Vitamin D Availability Due to Increases in Maternal Body Fat Contribute to This Effect?

    Article • Lipids, July 2015, Wiley

    Professor Po Sing Leung

  41. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

    Article • Carcinogenesis, June 2015, Oxford University Press (OUP)

    Dr Chiara Mondello, Dr Nicole Kleinstreuer, Dr GRAEME P WILLIAMS, Dr VALERIAN DORMOY, Professor Po Sing Leung, Colleen Curran, Laura Soucek

  42. Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

    Article • Carcinogenesis, June 2015, Oxford University Press (OUP)

    Dr Chiara Mondello, Professor Po Sing Leung

  43. The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos

    Article • PLoS ONE, June 2015, PLOS

    Professor Po Sing Leung

  44. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

    Article • Cell Death and Disease, March 2015, Springer Science + Business Media

    Professor Po Sing Leung

  45. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets

    Article • Molecular and Cellular Endocrinology, March 2015, Elsevier

    Professor Po Sing Leung

  46. Establishment of an Orthotopic Model of Pancreatic Cancer to Evaluate the Antitumor Effects of Irinotecan Through the Biomarker Carbohydrate Antigen 19-9 in Mice

    Article • Pancreas, October 2014, Wolters Kluwer Health

    Professor Po Sing Leung

  47. Use of herbal medicines and natural products: An alternative approach to overcoming the apoptotic resistance of pancreatic cancer

    Article • The International Journal of Biochemistry & Cell Biology, August 2014, Elsevier

    Professor Po Sing Leung

  48. Potential roles of GPR120 and its agonists in the management of diabetes

    Article • Drug Design Development and Therapy, July 2014, Dove Medical Press

    Professor Po Sing Leung

  49. Eriocalyxin B-Induced Apoptosis in Pancreatic Adenocarcinoma Cells Through Thiol-Containing Antioxidant Systems and Downstream Signalling Pathways

    Article • Current Molecular Medicine, June 2014, Bentham Science Publishers

    Professor Po Sing Leung

  50. Familial Young-Onset Diabetes, Pre-Diabetes and Cardiovascular Disease Are Associated with Genetic Variants of DACH1 in Chinese

    Article • PLoS ONE, January 2014, PLOS

    Professor Po Sing Leung

  51. Human Fetal Liver Stromal Cell Co-Culture Enhances the Differentiation of Pancreatic Progenitor Cells into Islet-Like Cell Clusters

    Article • Stem Cell Reviews and Reports, January 2014, Springer Science + Business Media

    Professor Po Sing Leung

  52. The role of renin-angiotensin system in cellular differentiation: Implications in pancreatic islet cell development and islet transplantation

    Article • Molecular and Cellular Endocrinology, December 2013, Elsevier

    Professor Po Sing Leung

  53. Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos

    Article • Developmental Dynamics, November 2013, Wiley

    Professor Po Sing Leung

  54. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia

    Article • Experimental Physiology, October 2013, Wiley

    Professor Po Sing Leung

  55. No evidence for a local renin-angiotensin system in liver mitochondria

    Article • Scientific Reports, August 2013, Nature

    Dr Anthony P Davenport, Hugh Montgomery, Professor Po Sing Leung

  56. High Glucose Represses  -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor   Signaling

    Article • Diabetes, July 2013, American Diabetes Association

    Professor Po Sing Leung

  57. Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus

    Article • Diabetes Obesity and Metabolism, February 2013, Wiley

    Professor Po Sing Leung

  58. Current Progress in Stem Cell Research and its Potential for Islet Cell Transplantation

    Article • Current Molecular Medicine, January 2013, Bentham Science Publishers

    Professor Po Sing Leung

  59. Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice

    Article • Diabetologia, December 2012, Springer Science + Business Media

    Professor Po Sing Leung

  60. Upregulation of ACE2-ANG-(1–7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport

    Article • AJP Endocrinology and Metabolism, September 2012, American Physiological Society

    Professor Po Sing Leung

  61. Effects of Combining Linagliptin Treatment with BI-38335, A Novel SGLT2 Inhibitor, on Pancreatic Islet Function and Inflammation in db/db Mice

    Article • Current Molecular Medicine, August 2012, Bentham Science Publishers

    Professor Po Sing Leung

  62. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways

    Article • Toxicology and Applied Pharmacology, July 2012, Elsevier

    Professor Po Sing Leung

  63. Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells

    Article • Diabetes Obesity and Metabolism, May 2012, Wiley

    Professor Po Sing Leung

  64. Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

    Article • International Journal of Molecular Medicine, April 2012, Spandidos Publications

    Professor Po Sing Leung

  65. Angiotensin II Type 2 Receptor Is Critical for the Development of Human Fetal Pancreatic Progenitor Cells into Islet-like Cell Clusters and Their Potential for Transplantation

    Article • Stem Cells, February 2012, Wiley

    Professor Po Sing Leung

  66. The Renin–Angiotensin System and Reactive Oxygen Species: Implications in Pancreatitis

    Article • Antioxidants & Redox Signaling, November 2011, Mary Ann Liebert Inc

    Professor Po Sing Leung

  67. Bruceines K and L from the Ripe Fruits of Brucea javanica

    Article • Helvetica Chimica Acta, November 2011, Wiley

    Professor Po Sing Leung

  68. Review article: pancreatic renin-angiotensin systems in health and disease

    Article • Alimentary Pharmacology & Therapeutics, August 2011, Wiley

    Hugh Montgomery, Professor Po Sing Leung

  69. An update on the islet renin–angiotensin system

    Article • Peptides, May 2011, Elsevier

    Professor Po Sing Leung

  70. Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas

    Article • The International Journal of Biochemistry & Cell Biology, May 2011, Elsevier

    Professor Po Sing Leung

  71. Seven Quassinoids from Fructus Bruceae with Cytotoxic Effects on Pancreatic Adenocarcinoma Cell Lines

    Article • Phytotherapy Research, April 2011, Wiley

    Professor Po Sing Leung

  72. A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets

    Article • Diabetologia, March 2011, Springer Science + Business Media

    Professor Po Sing Leung

  73. Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro

    Article • Regulatory Peptides, January 2011, Elsevier

    Professor Po Sing Leung

  74. Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency

    Article • Diabetes, September 2010, American Diabetes Association

    Professor Po Sing Leung

  75. Vitamin D and Vitamin A Receptor Expression and the Proliferative Effects of Ligand Activation of These Receptors on the Development of Pancreatic Progenitor Cells Derived from Human Fetal Pancreas

    Article • Stem Cell Reviews and Reports, March 2010, Springer Science + Business Media

    Professor Po Sing Leung

  76. Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic β-cells via angiotensin II type 2 receptors

    Article • AJP Cell Physiology, February 2010, American Physiological Society

    Professor Po Sing Leung, Professor Chen Chen

  77. Increased basal insulin secretion in Pdzd2-deficient mice

    Article • Molecular and Cellular Endocrinology, February 2010, Elsevier

    Professor Po Sing Leung

  78. Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-κB signalling pathways in human pancreatic adenocarcinoma cells

    Article • British Journal of Cancer, January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  79. Basic Techniques for Pancreatic Research

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  80. Circulating RAS

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  81. Common Pancreatic Disease

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  82. Current Research Concerning the RAS in Pancreatic Stem Cells

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  83. Current Research of the RAS in Diabetes Mellitus

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  84. Current Research of the RAS in Pancreatitis and Pancreatic Cancer

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  85. Local RAS

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  86. Overview of the Pancreas

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  87. Pancreatic RAS

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  88. Physiology of the Pancreas

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  89. The Novel Roles of Glucagon-Like Peptide-1, Angiotensin II, and Vitamin D in Islet Function

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  90. The Renin-Angiotensin System: Current Research Progress in The Pancreas

    Article • January 2010, Springer Science + Business Media

    Professor Po Sing Leung

  91. Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane

    Article • AJP Cell Physiology, September 2009, American Physiological Society

    Professor Po Sing Leung

  92. PDZ-Domain Containing-2 (PDZD2) Drives the Maturity of Human Fetal Pancreatic Progenitor-Derived Islet-Like Cell Clusters With Functional Responsiveness Against Membrane Depolarization

    Article • Stem Cells and Development, September 2009, Mary Ann Liebert Inc

    Professor Po Sing Leung

  93. Brucein D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase

    Article • Cancer Letters, August 2009, Elsevier

    Professor Po Sing Leung

  94. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice

    Article • Phytomedicine, May 2009, Elsevier

    Professor Po Sing Leung

  95. Involvement of Redox-Sensitive Extracellular-Regulated Kinases in Angiotensin II-Induced Interleukin-6 Expression in Pancreatic Acinar Cells

    Article • Journal of Pharmacology and Experimental Therapeutics, February 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Po Sing Leung

  96. The Roles of the PDZ-containing Proteins Bridge-1 and PDZD2 in the Regulation of Insulin Production and Pancreatic Beta-Cell Mass

    Article • Current Protein and Peptide Science, February 2009, Bentham Science Publishers

    Professor Po Sing Leung

  97. Angiotensin II in Type 2 Diabetes Mellitus

    Article • Current Protein and Peptide Science, February 2009, Bentham Science Publishers

    Professor Po Sing Leung

  98. Role of Oxidative Stress in Pancreatic Inflammation

    Article • Antioxidants & Redox Signaling, January 2009, Mary Ann Liebert Inc

    Professor Po Sing Leung

  99. Combination of the Dipeptidyl Peptidase IV Inhibitor LAF237 [(S)-1-[(3-Hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the Angiotensin II Type 1 Receptor Antagonist Valsartan [N-(1-Oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]meth...

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Po Sing Leung

  100. Enantiospecific Synthesis of Pseudoacarviosin as a Potential Antidiabetic Agent

    Article • Organic Letters, July 2008, American Chemical Society (ACS)

    Professor Po Sing Leung

  101. Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines

    Article • Phytotherapy Research, January 2008, Wiley

    Professor Po Sing Leung

  102. Diarylheptanoids and a Monoterpenoid from the Rhizomes ofZingiber officinale: Antioxidant and Cytoprotective Properties

    Article • Journal of Natural Products, January 2008, American Chemical Society (ACS)

    Professor Po Sing Leung

  103. PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells

    Article • The International Journal of Biochemistry & Cell Biology, January 2008, Elsevier

    Professor Po Sing Leung

  104. Carotid Body AT4 Receptor Expression and its Upregulation in Chronic Hypoxia

    Article • The Open Cardiovascular Medicine Journal, December 2007, Bentham Science Publishers

    Professor Po Sing Leung

  105. Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane

    Article • The Journal of Physiology, October 2007, Wiley

    Professor Po Sing Leung

  106. EFFECT OF ANGIOTENSIN AT1RECEPTOR ANTAGONIST ON d-GALACTOSAMINE-INDUCED ACUTE LIVER INJURY

    Article • Clinical and Experimental Pharmacology and Physiology, October 2007, Wiley

    Professor Po Sing Leung

  107. The Ghrelin System in Acinar Cells

    Article • Pancreas, October 2007, Wolters Kluwer Health

    Professor Po Sing Leung

  108. Angiotensin II Type 1 Receptor-Dependent Nuclear Factor-κB Activation-Mediated Proinflammatory Actions in a Rat Model of Obstructive Acute Pancreatitis

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Po Sing Leung

  109. Angiotensin II Type 1 Receptor Antagonism Mediates Uncoupling Protein 2-Driven Oxidative Stress and Ameliorates Pancreatic Islet β-Cell Function in Young Type 2 Diabetic Mice

    Article • Antioxidants & Redox Signaling, July 2007, Mary Ann Liebert Inc

    Professor Po Sing Leung

  110. Antioxidant Actions of Phenolic Compounds Found in Dietary Plants on Low-Density Lipoprotein and Erythrocytes in Vitro

    Article • Journal of the American College of Nutrition, June 2007, Taylor & Francis

    Professor Po Sing Leung

  111. PGE2suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease

    Article • Allergy, June 2007, Wiley

    Professor Po Sing Leung

  112. The physiology of a local renin-angiotensin system in the pancreas

    Article • The Journal of Physiology, March 2007, Wiley

    Professor Po Sing Leung

  113. Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes

    Article • Diabetic Medicine, February 2007, Wiley

    Professor Po Sing Leung

  114. Acute Pancreatitis

    Article • Pancreas, January 2007, Wolters Kluwer Health

    Professor Po Sing Leung

  115. Mitogen-Activated Protein Kinases and Chemoresistance in Pancreatic Cancer Cells

    Article • Journal of Surgical Research, December 2006, Elsevier

    Professor Po Sing Leung

  116. THE PROTECTIVE EFFECT OF AT1 RECEPTOR BLOCKADE ON OBSTRUCTION-INDUCED ACUTE PANCREATITIS

    Article • Pancreas, November 2006, Wolters Kluwer Health

    Professor Po Sing Leung

  117. Desoxyrhaponticin (3,5-Dihydroxy-4′-methoxystilbene 3-O-β-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies

    Article • Journal of Pharmacology and Experimental Therapeutics, October 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Po Sing Leung

  118. Novel roles of a local angiotensin-generating system in the carotid body

    Article • The Journal of Physiology, August 2006, Wiley

    Professor Po Sing Leung

  119. Frontiers in diabetic research

    Article • The International Journal of Biochemistry & Cell Biology, May 2006, Elsevier

    Professor Po Sing Leung

  120. In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice

    Article • The International Journal of Biochemistry & Cell Biology, May 2006, Elsevier

    Professor Po Sing Leung

  121. Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin

    Article • The International Journal of Biochemistry & Cell Biology, May 2006, Elsevier

    Professor Po Sing Leung

  122. Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells

    Article • The International Journal of Biochemistry & Cell Biology, May 2006, Elsevier

    Professor Po Sing Leung

  123. AT1 receptor antagonism ameliorates acute pancreatitis-associated pulmonary injury

    Article • Regulatory Peptides, March 2006, Elsevier

    Professor Po Sing Leung

  124. Angiotensin II Type 1 Receptor Blockade Improves  -Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes

    Article • Diabetes, January 2006, American Diabetes Association

    Professor Po Sing Leung

  125. Cells of the anterior pituitary

    Article • The International Journal of Biochemistry & Cell Biology, January 2006, Elsevier

    Professor Po Sing Leung

  126. Pancreatic acinar cell: Its role in acute pancreatitis

    Article • The International Journal of Biochemistry & Cell Biology, January 2006, Elsevier

    Professor Po Sing Leung

  127. Asian-Oceanic Pancreatic Association

    Article • Pancreas, November 2005, Wolters Kluwer Health

    Professor Po Sing Leung

  128. Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression

    Article • Gut, October 2005, BMJ

    Professor Po Sing Leung

  129. Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularised syngeneic mouse islet grafts

    Article • Diabetologia, May 2005, Springer Science + Business Media

    Professor Po Sing Leung

  130. Pancreatic Islet Renin Angiotensin System

    Article • Pancreas, May 2005, Wolters Kluwer Health

    Professor Po Sing Leung

  131. Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors

    Article • The International Journal of Biochemistry & Cell Biology, April 2005, Elsevier

    Professor Po Sing Leung

  132. Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell

    Article • Regulatory Peptides, April 2005, Elsevier

    Professor Po Sing Leung

  133. Roles of the renin–angiotensin system and its blockade in pancreatic inflammation

    Article • The International Journal of Biochemistry & Cell Biology, January 2005, Elsevier

    Professor Po Sing Leung

  134. The Peptide Hormone Angiotensin II: Its New Functions in Tissues and Organs

    Article • Current Protein and Peptide Science, August 2004, Bentham Science Publishers

    Professor Po Sing Leung

  135. Effect of Hypoxia on Urocortin Production in Human Gestational Trophoblasts In Vitro

    Article • American Journal of Reproductive Immunology, August 2004, Wiley

    Professor Po Sing Leung

  136. The role of the pancreatic renin–angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis

    Article • Regulatory Peptides, July 2004, Elsevier

    Professor Po Sing Leung

  137. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets

    Article • Diabetologia, February 2004, Springer Science + Business Media

    Professor Po Sing Leung

  138. Prophylactic and therapeutic treatments with AT1 and AT2 receptor antagonists and their effects on changes in the severity of pancreatitis

    Article • The International Journal of Biochemistry & Cell Biology, February 2004, Elsevier

    Professor Po Sing Leung

  139. Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body

    Article • Journal of Applied Physiology, February 2004, American Physiological Society

    Professor Po Sing Leung

  140. The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition

    Article • Journal of Molecular Endocrinology, December 2003, Bioscientifica

    Professor Po Sing Leung

  141. Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response

    Article • Regulatory Peptides, November 2003, Elsevier

    Professor Po Sing Leung

  142. A local pancreatic renin-angiotensin system: endocrine and exocrine roles

    Article • The International Journal of Biochemistry & Cell Biology, June 2003, Elsevier

    Professor Po Sing Leung

  143. Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis

    Article • The International Journal of Biochemistry & Cell Biology, June 2003, Elsevier

    Professor Po Sing Leung

  144. Renin–angiotensin system in the carotid body

    Article • The International Journal of Biochemistry & Cell Biology, June 2003, Elsevier

    Professor Po Sing Leung

  145. Renin–angiotensin systems: the new frontier

    Article • The International Journal of Biochemistry & Cell Biology, June 2003, Elsevier

    Professor Po Sing Leung, Hugh Montgomery

  146. The renin-angiotensin system and male reproduction: new functions for old hormones

    Article • Journal of Molecular Endocrinology, June 2003, Bioscientifica

    Professor Po Sing Leung

  147. Chronic hypoxia activates a local angiotensin-generating system in rat carotid body

    Article • Molecular and Cellular Endocrinology, May 2003, Elsevier

    Professor Po Sing Leung

  148. Saralasin, a Nonspecific Angiotensin II Receptor Antagonist, Attenuates Oxidative Stress and Tissue Injury in Cerulein-Induced Acute Pancreatitis

    Article • Pancreas, April 2003, Wolters Kluwer Health

    Professor Po Sing Leung

  149. Differential effects of saralasin and ramiprilat, the inhibitors of renin–angiotensin system, on cerulein-induced acute pancreatitis

    Article • Regulatory Peptides, March 2003, Elsevier

    Professor Po Sing Leung

  150. Expression, Immunolocalization, and Functional Activity of Na+/H+ Exchanger Isoforms in Mouse Endometrial Epithelium1

    Article • Biology of Reproduction, January 2003, Oxford University Press (OUP)

    Professor Po Sing Leung

  151. High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas

    Article • European Journal of Endocrinology, December 2002, Bioscientifica

    Professor Alfred King Lam, Professor Po Sing Leung

  152. Effects of Chronic Hypoxia on the Circulating and Pancreatic Renin-Angiotensin System

    Article • Pancreas, October 2002, Wolters Kluwer Health

    Professor Po Sing Leung

  153. A locally generated angiotensin system in rat carotid body

    Article • Regulatory Peptides, July 2002, Elsevier

    Professor Po Sing Leung

  154. Regulation of the angiotensin II AT1 receptor in patients with end-stage idiopathic dilated cardiomyopathy

    Article • Journal of Molecular and Cellular Cardiology, June 2002, Elsevier

    Professor Po Sing Leung

  155. Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium

    Article • British Journal of Ophthalmology, June 2002, BMJ

    Professor Po Sing Leung

  156. Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors

    Article • Journal of Endocrinology, May 2002, Bioscientifica

    Professor Po Sing Leung

  157. Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours

    Article • European Journal of Endocrinology, April 2002, Bioscientifica

    Professor Po Sing Leung

  158. ANDROGEN DEPENDENT EXPRESSION OF AT1 RECEPTOR AND ITS REGULATION OF ANION SECRETION IN RAT EPIDIDYMIS

    Article • Cell Biology International, January 2002, Wiley

    Professor Po Sing Leung

  159. Effect of chronic hypoxia on glutathione status and membrane integrity in the pancreas

    Article • Pancreatology, January 2002, Elsevier

    Professor Po Sing Leung

  160. The upregulation of angiotensin II receptor AT1 in human preeclamptic placenta

    Article • Molecular and Cellular Endocrinology, November 2001, Elsevier

    Professor Po Sing Leung

  161. Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression

    Article • Pflügers Archiv - European Journal of Physiology, October 2001, Springer Science + Business Media

    Professor Po Sing Leung

  162. Secretin Facilitates GABA Transmission in the Cerebellum

    Article • Journal of Neuroscience, September 2001, Society for Neuroscience

    Professor Po Sing Leung

  163. Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas

    Article • Journal of Molecular Endocrinology, June 2001, Bioscientifica

    Professor Po Sing Leung

  164. LOCAL REGULATION OF ANION SECRETION BY PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IN HUMAN COLONIC T84 CELLS

    Article • Cell Biology International, February 2001, Wiley

    Professor Po Sing Leung

  165. The effect of chronic hypoxia on the changes of reactive oxygen species and apoptosis in the pancreas

    Article • Biochemical Society Transactions, February 2001, Portland Press Ltd.

    Professor Po Sing Leung

  166. Functional expression of angiotensin II receptors in type-I cells of the rat carotid body

    Article • Pflügers Archiv - European Journal of Physiology, January 2001, Springer Science + Business Media

    Professor Po Sing Leung

  167. Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis

    Article • Regulatory Peptides, January 2001, Elsevier

    Professor Po Sing Leung

  168. Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body

    Article • Journal of Endocrinology, December 2000, Bioscientifica

    Professor Po Sing Leung

  169. Androgen Control of Cyclooxygenase Expression in the Rat Epididymis1

    Article • Biology of Reproduction, September 2000, Oxford University Press (OUP)

    Professor Po Sing Leung

  170. Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis

    Article • Molecular and Cellular Endocrinology, August 2000, Elsevier

    Professor Po Sing Leung

  171. Activation of local renin-angiotensin system by chronic hypoxia in rat pancreas

    Article • Molecular and Cellular Endocrinology, February 2000, Elsevier

    Professor Po Sing Leung

  172. Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis

    Article • Life Sciences, February 2000, Elsevier

    Professor Po Sing Leung

  173. Angiotensinogen expression by rat epididymis: evidence for an intrinsic, angiotensin-generating system

    Article • Molecular and Cellular Endocrinology, September 1999, Elsevier

    Professor Po Sing Leung

  174. Activation of an Adenosine 3′,5′-Cyclic Monophosphate-Dependent Cl− Conductance in Response to Neurohormonal Stimuli in Mouse Endometrial Epithelial Cells: The Role of Cystic Fibrosis Transmembrane Conductance Regulator1

    Article • Biology of Reproduction, February 1999, Oxford University Press (OUP)

    Professor Po Sing Leung

  175. Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat

    Article • The Journal of Physiology, February 1999, Wiley

    Professor Po Sing Leung

  176. Rod-type cyclic nucleotide-gated cation channel is expressed in vascular endothelium and vascular smooth muscle cells

    Article • Cardiovascular Research, January 1999, European Society of Cardiology

    Professor Po Sing Leung

  177. Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide

    Article • Blood Pressure, January 1999, Taylor & Francis

    Professor Po Sing Leung

  178. Expression and localization of the renin-angiotensin system in the rat pancreas

    Article • Journal of Endocrinology, January 1999, Bioscientifica

    Professor Po Sing Leung

  179. Functional expression of sperm angiotensin II type I receptor in Xenopus oocyte: modulation of a sperm Ca2+-activated K+ channel

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, December 1998, Elsevier

    Professor Po Sing Leung

  180. Expression of sperm Ca2+ -activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP

    Article • FEBS Letters, November 1998, Wiley

    Professor Po Sing Leung

  181. Concurrent and Independent HCO − 3 and Cl −; Secretion in a Human Pancreatic Duct Cell Line (CAPAN-1)

    Article • The Journal of Membrane Biology, July 1998, Springer Science + Business Media

    Professor Po Sing Leung

  182. LOCALIZATION AND DISTRIBUTION OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IN THE RAT EPIDIDYMIS

    Article • Cell Biology International, March 1998, Wiley

    Professor Po Sing Leung

  183. Article • The Histochemical Journal, January 1998, Springer Science + Business Media

    Professor Po Sing Leung

  184. DIFFERENTIAL GENE EXPRESSION OF ANGIOTENSIN II RECEPTOR SUBTYPES IN THE EPIDIDYMIDES OF MATURE AND IMMATURE RATS

    Article • Life Sciences, December 1997, Elsevier

    Professor Po Sing Leung

  185. Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide

    Article • Journal of Endocrinology, September 1997, Bioscientifica

    Professor Po Sing Leung

  186. Angiotensin II receptors, AT1 and AT2 in the rat epididymis

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 1997, Elsevier

    Professor Po Sing Leung

  187. Angiotensin II receptors: Localization of type I and type II in rat epididymides of different developmental stages

    Article • The Journal of Membrane Biology, May 1997, Springer Science + Business Media

    Professor Po Sing Leung

  188. Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents

    Article • Journal of Endocrinology, May 1997, Bioscientifica

    Professor Po Sing Leung

  189. Angiotensin II Receptor Type I-Regulated Anion Secretion in Cystic Fibrosis Pancreatic Duct Cells

    Article • The Journal of Membrane Biology, April 1997, Springer Science + Business Media

    Professor Po Sing Leung

  190. Electrogenic ion transport in the mouse endometrium: functional aspects of the cultured epithelium

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, April 1997, Elsevier

    Professor Po Sing Leung

  191. Cadmium-induced dna fragmentation is inhibitable by zinc in porcine kidney LLC-PK1 cells

    Article • Life Sciences, March 1995, Elsevier

    Professor Po Sing Leung

  192. A molecular dynamics study ofHelix aspersaNPF

    Article • Biochemical Society Transactions, February 1994, Portland Press Ltd.

    Professor Po Sing Leung

  193. Immunocytochemical distribution of neuropeptide F (NPF) in the gastropod mollusc, Helix aspersa, and in several other invertebrates

    Article • Cell and Tissue Research, February 1994, Springer Science + Business Media

    Professor Po Sing Leung

  194. Immunocytochemical localization of neuropeptide F-Immunoreactivity in the circumoesophageal ganglia of the gastropod mollusc, Helix aspersa using electron microscopy

    Article • Tissue and Cell, February 1994, Elsevier

    Professor Po Sing Leung

  195. Quantitation and Chromatographic Characterisation of Neuropeptide F (NPF) Immunoreactivity in Molluscan Nervous Tissue Using Region-Specific Antisera

    Article • General and Comparative Endocrinology, February 1994, Elsevier

    Professor Po Sing Leung

  196. Immunochemical characterisation of tachykinin immunoreactivity in the nervous system of the garden snail, Helix aspersa

    Article • Comparative Biochemistry and Physiology Part C Comparative Pharmacology, September 1992, Elsevier

    Professor Po Sing Leung

  197. The primary structure of neuropeptide F (NPF) from the garden snail, Helix aspersa

    Article • Regulatory Peptides, September 1992, Elsevier

    Professor Po Sing Leung

  198. Immunocytochemical demonstration of neuropeptide F (Helix aspersa) immunoreactivity in Helix and related gastropod molluscs using an antiserum to a synthetic N-terminal fragment

    Article • Regulatory Peptides, June 1992, Elsevier

    Professor Po Sing Leung

  199. Role of Local Renin-Angiotensin System in the Carotid Body and in Diseases

    Article • Springer Science + Business Media

    Professor Po Sing Leung

  200. Importance of the Local Renin-Angiotensin System in Pancreatic Disease

    Article • Springer Science + Business Media

    Professor Po Sing Leung