All Stories

  1. Left behind but not left alone: Excluded cell populations in the non-small cell lung cancer stroma predict superior long-term overall survival
  2. The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion
  3. Turning the Tables: Loss of Adaptive Immunity Reverses Sex Differences in Tuberculosis
  4. C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis
  5. Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection
  6. The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer
  7. Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6
  8. Transrenal Mycobacterium tuberculosis DNA in pulmonary tuberculosis patients during the first 14 days of treatment
  9. CYP19A1 mediates severe SARS-CoV-2 disease outcome in males
  10. Antiviral CD8+T-cell immune responses are impaired by cigarette smoke and in COPD
  11. Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas
  12. Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers
  13. Air exposure and cell differentiation are essential for investigation of SARS-CoV-2 entry genes in human primary airway epithelial cells in vitro
  14. Characterization of phospholipid-modified lung surfactant in vitro and in a neonatal ARDS model reveals anti-inflammatory potential and surfactant lipidome signatures
  15. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes
  16. Editorial: Treatment for Non-Small Cell Lung Cancer in Distinct Patient Populations
  17. Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations
  18. PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis
  19. WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis
  20. Pathogen-free diagnosis of tuberculosis
  21. Immune-evasion of KRAS-mutant lung adenocarcinoma mediated by cAMP response element-binding protein
  22. Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma
  23. Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
  24. Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
  25. Haemophilus influenzae causes cellular trans-differentiation in human bronchial epithelia
  26. DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer
  27. PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
  28. Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
  29. Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer
  30. Molekularpathologie der Tuberkulose
  31. Mycobacterium szulgai als Posititivkontrolle zur Detektion von Kontaminationen beim Nachweis des Mycobacterium tuberculosis-Komplexes durch eine spezifische 16S-rDNA-PCR an FFPE-Material
  32. Gene Expression Signatures Identify Biologically and Clinically Distinct Tuberculosis Endotypes
  33. Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0
  34. A 22-gene transcriptomic model indicating individual therapy durations in multidrug-resistant tuberculosis
  35. The impact of heated tobacco products on arterial stiffness
  36. WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by M. tuberculosis
  37. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes
  38. The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC
  39. Role of the erythropoietin receptor in Lung Cancer cells: erythropoietin exhibits angiogenic potential
  40. Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy
  41. Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma
  42. Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers
  43. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
  44. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5
  45. Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
  46. The epigenetic clock of Non Small cell lung Cancer ticks differently
  47. Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
  48. ΙκΒ kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma.
  49. Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation
  50. Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils
  51. Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung
  52. Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression
  53. Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells
  54. Signalling mechanisms in PAF-induced intestinal failure
  55. Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema
  56. P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis
  57. Meat allergy associated with galactosyl-α-(1,3)-galactose (α-Gal)-Closing diagnostic gaps by anti-α-Gal IgE immune profiling
  58. Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma
  59. Back into focus: tumour-associated macrophages and their role in immune checkpoint inhibition
  60. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits
  61. Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression
  62. The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease
  63. PilY1 Promotes Legionella pneumophila Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility
  64. Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis
  65. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
  66. Downregulation of the TGF  Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGF  Signaling and Invasion
  67. Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells
  68. Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: A large scale study of 1465 non-small cell lung cancer cases
  69. PD-L1 copy number gain in nonsmall-cell lung cancer defines a new subset of patients for anti PD-L1 therapy
  70. Budesonide Inhibits Intracellular Infection with Non-Typeable Haemophilus influenzae despite Its Anti-Inflammatory Effects in Respiratory Cells and Human Lung Tissue: A Role for p38 MAP Kinase
  71. Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients
  72. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides
  73. Placenta-derived conditioned medium with anti-tumor properties on human NSCLC
  74. Enhanced neutrophil extracellular trap (NET) formation in sputum of stable COPD patients
  75. Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
  76. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis
  77. Nontypeable Haemophilus influenzae (NTHi) reguliert die TGF-β-Signaltransduktion durch Induktion des TGF-β-Pseudorezeptors BAMBI im Lungengewebe und in respiratorischen Zellen
  78. Hydroxyethyl Starch (HES 130/0.4) Impairs Intestinal Barrier Integrity and Metabolic Function: Findings from a Mouse Model of the Isolated Perfused Small Intestine
  79. Quinidine, but Not Eicosanoid Antagonists or Dexamethasone, Protect the Gut from Platelet Activating Factor-Induced Vasoconstriction, Edema and Paralysis
  80. Multi-analyte profiling of inflammatory mediators in COPD sputum – The effects of processing
  81. Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases
  82. Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC
  83. Reduzierte Dosis von TKI führt nicht zu Wirkungsverlust bei Patienten mit aktivierender EGFR-Mutation
  84. Mechanisms of Cilia-Driven Transport in the Airways in the Absence of Mucus
  85. The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique
  86. HOPE-Fixation of Lung Tissue Allows Retrospective Proteome and Phosphoproteome Studies
  87. Transforming Growth Factor-Beta Signaling Leads to uPA/PAI-1 Activation and Metastasis: A Study on Human Breast Cancer Tissues
  88. Induktion des TGF-ß-Pseudorezeptors BAMBI durch Nontypeable Haemophilus influenzae (NTHi) und Auswirkungen auf TGF-ß vermittelte Effekte
  89. Reduzierte Dosis von TKI führt nicht zu Wirkungsverlust bei Patienten mit aktivierender EGFR Mutation
  90. Induktion des TGF-ß-Pseudorezeptors BAMBI durch Nontypeable Haemophilus influenzae (NTHi) und Auswirkungen auf TGF-ß vermittelte Effekte
  91. Roasting and lipid binding provide allergenic and proteolytic stability to the peanut allergen Ara h 8
  92. Human Lung Tissue Explants Reveal Novel Interactions during Legionella pneumophila Infections
  93. Optimized immunohistochemistry in combination with image analysis: A reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer
  94. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
  95. Comment on Nietner et al. [Virchows Arch (s2012) 461:259–269]
  96. Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD
  97. HOPE-preservation of paraffin-embedded sputum samples–A new way of bioprofiling in COPD
  98. Expression of the CTL2 transcript variants in human peripheral blood cells and human tissues
  99. Atypische Alterationen am EML-4 ALK Gen gehen nicht mit einem Ansprechen auf den ALKInhibitor Crizotinib einher
  100. Triggering receptor expressed on myeloid cells − 1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis
  101. Glioma infiltration of the corpus callosum: early signs detected by DTI
  102. Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors
  103. The Effect of Dithiothreitol on the Transcriptome of Induced Sputum Cells
  104. Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung
  105. Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation
  106. Effects of Antimicrobial Peptides on Methanogenic Archaea
  107. Proteomics?
  108. Erratum to: effect of low tidal ventilation on lung function and inflammation in mice
  109. Pulmonary Haptoglobin and CD163 Are Functional Immunoregulatory Elements in the Human Lung
  110. Virtual slides in peer reviewed, open access medical publication
  111. Pathologie und Diagnose der Lungentuberkulose sowie nichttuberkulöser Mykobakterien
  112. Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung
  113. To be at the right place at the right time
  114. Identification Of The CCL18 Receptor - Effects Of CCL18 On Human Lung Fibroblasts In Pulmonary Fibrosis Are Mediated Via CCR6
  115. COX2 Inhibition Attenuates Th2 Type Cytokine-Induced Mucus Expression In Human Airways
  116. A definition of time by relation of energy and mass
  117. Multiple Peptide Resistance Factor (MprF)-mediated Resistance ofStaphylococcus aureusagainst Antimicrobial Peptides Coincides with a Modulated Peptide Interaction with Artificial Membranes Comprising Lysyl-Phosphatidylglycerol
  118. Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways
  119. HOPE-BAL
  120. Erreger-induzierte Modulation von Inflammation und Remodeling im humanen Lungengewebe durch Regulation des Transforming Growth Factor beta (TGF-β)-Pseudorezeptors BAMBI
  121. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureusdetection
  122. Pulmonary haptoglobin: a new marker for adenocarcinomas of the lung?
  123. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa
  124. Innate immunity in the human lung: pathogen recognition and lung disease
  125. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
  126. The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae
  127. Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 againstEscherichia coliandProteus mirabilis
  128. Effect Of Dexamethasone And Acetyl-cysteine On Pseudomonas-induced Mucus Expression
  129. Effect of low tidal volume ventilation on lung function and inflammation in mice
  130. Comparison of the effect of lps and pam3 on ventilated lungs
  131. Facilities of a novel tissue fixation method: the HOPE-technology
  132. Improved molecular read-out options via adequate tissue fixation
  133. Molecular high throughput analyses and automated detection systems
  134. Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP
  135. AI (artificial intelligence) in histopathology--from image analysis to automated diagnosis.
  136. Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients
  137. Measuring Immune Responses In Situ
  138. Proteomics Out of the Archive: Two-dimensional Electrophoresis and Mass Spectrometry Using HOPE-fixed, Paraffin-embedded Tissues
  139. Expression of the acute phase protein haptoglobin in human lung cancer and tumor-free lung tissues
  140. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs
  141. Theory of sampling and its application in tissue based diagnosis
  142. The human placenta releases substances that drive lung cancer into apoptosis
  143. On the significance of Surfactant Protein-A within the human lungs
  144. Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes
  145. Structural Analysis of the Capsular Polysaccharide fromAcinetobacter lwoffiiF78
  146. Modulation of the Inflammatory Response toStreptococcus pneumoniaein a Model of Acute Lung Tissue Infection
  147. Effect of Steroids, Acetyl-cysteine and Calcium-Activated Chloride Channel Inhibitors on Allergic Mucin Expression in Sinus Mucosa
  148. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
  149. Structure and mode of action of the antimicrobial peptide arenicin
  150. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy
  151. TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens
  152. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer
  153. LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification
  154. Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology)
  155. How to measure image quality in tissue-based diagnosis (diagnostic surgical pathology)
  156. Interaction of aeroallergens with the respiratory interphase
  157. Effect of Dexamethasone and ACC on Bacteria-Induced Mucin Expression in Human Airway Mucosa
  158. Pore-formation by a NK-lysin derived peptide antibiotic in artificial and bacterial membranes
  159. DNA methylation markers of surfactant proteins in lung cancer
  160. A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy
  161. Disparate Innate Immune Responses to Persistent and AcuteChlamydia pneumoniaeInfection in Chronic Obstructive Pulmonary Disease
  162. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors
  163. Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens
  164. HMGA2 overexpression in non-small cell lung cancer
  165. Pulmonary Responses to Overventilation in Late Multiple Organ Failure
  166. Legionella pneumophila Induces IFNbeta in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication
  167. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
  168. Mycobacteria Induce IFN-  Production in Human Dendritic Cells via Triggering of TLR2
  169. A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via CCL18
  170. High-throughput DNA methylation profiling using universal bead arrays
  171. Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis
  172. Natural Killer Cell-Mediated Rejection of Experimental Human Lung Cancer by Genetic Overexpression of Major Histocompatibility Complex Class I Chain-Related Gene A
  173. Natural Killer Cell-Mediated Rejection of Experimental Human Lung Cancer by Genetic Overexpression of Major Histocompatibility Complex Class I Chain-Related Gene A
  174. Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material
  175. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
  176. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients
  177. Inter-laboratory validation of PCR-based detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues
  178. Pulmonale Infektionen im humanen Lungengewebsmodell
  179. Improved detection of mycobacterial DNA by PCR in formalin-fixed, paraffin-embedded tissues using thin sections
  180. Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa
  181. Human lung cancer cells express functionally active Toll-like receptor 9
  182. The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues
  183. HOPE technique enables western blot analysis from paraffin-embedded tissues
  184. Alveolar epithelial cells type II are major target cells forC. pneumoniaein chronic but not in acute respiratory infection
  185. Transkriptionelle Aktivität der Surfactant-Apoproteine A1 und A2 in nicht kleinzelligen Bronchialkarzinomen und tumorfreien Lungengeweben
  186. Phosphoinositide 3-OH Kinase Inhibition Prevents Ventilation-induced Lung Cell Activation
  187. Stretch Activates Nitric Oxide Production in Pulmonary Vascular Endothelial CellsIn Situ
  188. What's Cooking? Detection of Important Biomarkers in HOPE-Fixed, Paraffin-Embedded Tissues Eliminates the Need for Antigen Retrieval
  189. Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization
  190. Progrediente L�hmungen infolge eines strahleninduzierten zervikalen malignen peripheren Nervenscheidentumors
  191. HOPE Fixation of Cytospin Preparations of Human Cells for In Situ Hybridization and Immunocytochemistry
  192. Alveolar macrophages are the main source for tumour necrosis factor‐α in patients with sarcoidosis
  193. Differential Haemoglobin Gene Expression in the Crustacean Daphnia magna Exposed to Different Oxygen Partial Pressures
  194. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung
  195. HOPE-Fixation Enables Improved PCR-Based Detection and Differentiation of Mycobacterium tuberculosis Complex in Paraffin-Embedded Tissues
  196. Direct and Indirect In Situ PCR
  197. Ventilation-induced activation of the mitogen-activated protein kinase pathway
  198. Detection ofChlamydia pneumoniaein unexplained pulmonary hypertension
  199. HOPE – ANew Fixing Technique Enables Preservation and Extraction of High Molecular Weight DNAand RNA of >20 kb from Paraffin-embedded Tissues
  200. Human alveolar epithelial cells induce nitric oxide synthase‐2 expression in alveolar macrophages
  201. Assessment of Transcriptional Gene Activity in situ by Application of HOPE-fixed, Paraffin-embedded Tissues
  202. Cost-effective gel documentation using a web-cam
  203. Redox states of type 1 ryanodine receptor alter Ca 2+ release channel response to modulators
  204. Localization of Ceramide and Glucosylceramide in Human Epidermis by Immunogold Electron Microscopy
  205. Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II
  206. EnVision+, a New Dextran Polymer-based Signal Enhancement Technique for In Situ Hybridization (ISH)
  207. Formation of Granulomas in the Lungs of Severe Combined Immunodeficient Mice after Infection with Bacillus Calmette-Guerin
  208. Diagnostic value of immunohistochemically detected surfactant—apoprotein-A in malignant tumors located in the lungs: Report of two cases
  209. The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry
  210. HOPE Fixation: A Novel Fixing Method and Paraffin-embedding Technique for Human Soft Tissues
  211. DNA-printing: utilization of a standard inkjet printer for the transfer of nucleic acids to solid supports
  212. Epipodite and fat cells as sites of hemoglobin synthesis in the branchiopod crustacean Daphnia magna
  213. Epipodite and fat cells as sites of hemoglobin synthesis in the branchiopod crustacean
  214. The Expression of Proteolytic Enzymes at the Dermal Invading Front of Primary Cutaneous Melanoma Predicts Metastasis
  215. Prognostic Classification of Malignant Melanomas by Combining Clinical, Histological, and Immunohistochemical Parameters
  216. Direct and Indirect In Situ PCR