Dr Nicole Kleinstreuer
NICEATM
United States
My co-authors include
Dr Patrick Allard
Dr Carolina Horta Andrade
Dr Ellen L Berg
My Publications
Predictive models for acute oral systemic toxicity: A workshop to bridge the gap from r...
Computational Toxicology
November 2018
Evaluation of androgen assay results using a curated Hershberger database
Reproductive Toxicology
September 2018
International regulatory requirements for skin sensitization testing
Regulatory Toxicology and Pharmacology
June 2018
Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory...
Regulatory Toxicology and Pharmacology
April 2018
In vitro to in vivo extrapolation for high throughput prioritization and decision making
Toxicology in Vitro
March 2018
Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database
Critical Reviews in Toxicology
February 2018
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
Critical Reviews in Toxicology
February 2018
Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable sum...
Archives of Toxicology
January 2018
Integrated decision strategies for skin sensitization hazard
Journal of Applied Toxicology
November 2017
Standardisation of defined approaches for skin sensitisation testing to support regulat...
Archives of Toxicology
November 2017
Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signa...
Reproductive Toxicology
August 2017
Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signa...
Reproductive Toxicology
June 2017
Identifying environmental chemicals as agonists of the androgen receptor by using a qua...
Toxicology
June 2017
An Integrated Chemical Environment to Support 21st-Century Toxicology
Environmental Health Perspectives
May 2017
Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of C...
Journal of Chemical Information and Computer Sciences
May 2017
Prediction of skin sensitization potency using machine learning approaches
Journal of Applied Toxicology
January 2017
Machine Learning Approaches to Predict PhysChem Properties of Environmental Chemicals
Journal of Chemical Information and Computer Sciences
December 2016
Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for dev...
Reproductive Toxicology
December 2016
Development and Validation of a Computational Model for Androgen Receptor Activity
Chemical Research in Toxicology
November 2016
Identification of vascular disruptor compounds by analysis in zebrafish embryos and mou...
Reproductive Toxicology
November 2016
Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across...
Toxicological Sciences
September 2016
Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Re...
Environmental Health Perspectives
August 2016
Multivariate models for prediction of human skin sensitization hazard
Journal of Applied Toxicology
August 2016
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroA...
Toxicological Sciences
May 2016
Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Out...
Toxicological Sciences
May 2016
Adverse outcome pathways: From research to regulation scientific workshop report
Regulatory Toxicology and Pharmacology
April 2016
Integrated decision strategies for skin sensitization hazard
Journal of Applied Toxicology
February 2016
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization
Green Chemistry
January 2016
Toward Good Read-Across Practice (GRAP) guidance
ALTEX
January 2016
Supporting read-across using biological data
ALTEX
January 2016
A Curated Database of Rodent Uterotrophic Bioactivity
Environmental Health Perspectives
October 2015
Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model
Environmental Science & Technology
July 2015
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the ...
Carcinogenesis
June 2015
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the ...
Carcinogenesis
June 2015
Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability...
Toxicology and Applied Pharmacology
April 2015
Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization...
Toxicology and Applied Pharmacology
April 2015
A Vision of Toxicity Testing in the 21st Century
Applied In Vitro Toxicology
March 2015
Application of Reverse Dosimetry to Compare In Vitro and In Vivo Estrogen Receptor Act...
Applied In Vitro Toxicology
March 2015
Immediate and long-term consequences of vascular toxicity during zebrafish development
Reproductive Toxicology
September 2014
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic ...
Nature Biotechnology
May 2014
Integrated Testing Strategies (ITS) for safety assessment
ALTEX
January 2014
Open source software implementation of an integrated testing strategy for skin sensitiz...
ALTEX
January 2014
Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluo...
Toxicological Sciences
September 2013
A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germ...
Environmental Health Perspectives
April 2013
A Computational Model Predicting Disruption of Blood Vessel Development
PLoS Computational Biology
April 2013
Predictive Models and Computational Toxicology
October 2012
In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical ...
Toxicological Sciences
September 2012
Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models ...
Toxicological Sciences
September 2012
Computational toxicology and in silico modeling of embryogenesis
Reproductive Toxicology
September 2012
Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for C...
Chemical Research in Toxicology
July 2012
Zebrafish developmental screening of the ToxCast™ Phase I chemical library
Reproductive Toxicology
April 2012
Predictive modeling and computational toxicology
December 2011
Disruption of embryonic vascular development in predictive toxicology
Birth Defects Research Part C Embryo Today Reviews
December 2011
Identifying developmental toxicity pathways for a subset of ToxCast chemicals using hum...
Toxicology and Applied Pharmacology
November 2011
Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Scree...
Toxicological Sciences
August 2011
Environmental Impact on Vascular Development Predicted by High-Throughput Screening
Environmental Health Perspectives
July 2011
Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Ce...
PLoS ONE
June 2011
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
Toxicology
March 2011
Dynamic myogenic autoregulation in the rat kidney: a whole-organ model
AJP Renal Physiology
April 2008
