All Stories

  1. Targeting angiogenesis: Effects and mechanisms of action of ginsenosides

    Article • Phytomedicine, November 2025, Elsevier

    Professor Chen Chen

  2. Therapeutic potential of ghrelin and synthetic GHS for heart failure from the perspective of its protective effect on cardiomyocytes

    Article • Cellular Signalling, October 2025, Elsevier

    Professor Chen Chen

  3. Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes

    Article • iScience, October 2025, Elsevier

    Professor Chen Chen

  4. Sulfated modification, characterizations, anti-oxidant and immunostimulatory activities of a polysaccharide from Arnebia euchroma (Royle) Johnst. Roots

    Article • Results in Chemistry, September 2025, Elsevier

    Professor Chen Chen

  5. Chemical structure and beneficial roles of active biomacromolecules from Ginseng: a narrative review

    Article • Acupuncture and Herbal Medicine, September 2025, Wolters Kluwer Health

    Professor Chen Chen

  6. Clinical and genetic analysis of X-linked nephrogenic diabetes insipidus caused by a novel <i>AVPR2</i> mutation (NM_000054.6:exon3:c.245G>A (p.Cys82Tyr)) in a Chinese boy

    Article • Intractable & Rare Diseases Research, August 2025, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Professor Chen Chen

  7. Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

    Article • Frontiers in Pharmacology, July 2025, Frontiers

    Professor Chen Chen

  8. Clinical and genetic analysis of ulnar-mammary syndrome caused by a novel <i>TBX3</i> mutation in a Chinese boy

    Article • Intractable & Rare Diseases Research, May 2025, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Professor Chen Chen

  9. A high-fat diet suppresses growth hormone synthesis and secretion by influencing the Vit D receptor and Pit1

    Article • Endocrine, May 2025, Springer Science + Business Media

    Professor Chen Chen

  10. A novel gastric ulcer model in rats using filter paper with acetic acid

    Article • PLOS One, April 2025, PLOS

    Professor Chen Chen

  11. Cinnamon ( Cinnamomum ) as a Food-Medicine Homologue: A Review of Pharmacological Mechanisms and Potential Applications in Metabolic Diseases

    Article • Food Reviews International, April 2025, Taylor & Francis

    Professor Chen Chen

  12. Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

    Article • Advanced Therapeutics, March 2025, Wiley

    Professor Chen Chen

  13. Pueraria Radix and Its Major Constituents Against Metabolic Diseases: Pharmacological Mechanisms and Potential Applications

    Article • Phytotherapy Research, March 2025, Wiley

    Professor Chen Chen

  14. Targeting pyroptosis: A novel strategy of ginseng for the treatment of diabetes and its chronic complications

    Article • Phytomedicine, March 2025, Elsevier

    Professor Chen Chen

  15. Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through suppression of endoplasmic reticulum stress in the hypothalamus

    Article • Metabolism, January 2025, Elsevier

    Professor Chen Chen

  16. Three-Dimensional Dynamic Cell Models for Metabolic Dysfunction-Associated Steatotic Liver Disease Progression

    Article • BME Frontiers, January 2025, American Association for the Advancement of Science

    Professor Chen Chen

  17. Intestinal NUCB2/nesfatin-1 regulates hepatic glucose production via the MC4R-cAMP-GLP-1 pathway

    Article • The EMBO Journal, November 2024, Springer Science + Business Media

    Professor Chen Chen

  18. The regulatory mechanism of natural polysaccharides in type 2 diabetes mellitus treatment

    Article • Drug Discovery Today, November 2024, Elsevier

    Professor Chen Chen

  19. Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders

    Article • Cellular Signalling, October 2024, Elsevier

    Professor Chen Chen

  20. Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms

    Article • Chinese Herbal Medicines, October 2024, Elsevier

    Professor Chen Chen

  21. LEAP2 ameliorates high fat diet-impaired glucose tolerance and enhances glucose-stimulated insulin secretion from β cells through PPARγ signal pathway

    Article • Chinese Medical Journal, August 2024, Wolters Kluwer Health

    Professor Chen Chen

  22. Elucidating thoracic aortic dissection pathogenesis: The interplay of m1A-related gene expressions and miR-16-5p/YTHDC1 Axis in NLRP3-dependent pyroptosis

    Article • International Journal of Biological Macromolecules, August 2024, Elsevier

    Professor Chen Chen

  23. Prevalence of very high cardiovascular disease risk in patients with type 2 diabetes mellitus: A population‐based cross‐sectional screening study

    Article • Diabetes Obesity and Metabolism, July 2024, Wiley

    Professor Chen Chen

  24. Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice

    Article • Journal of Ethnopharmacology, June 2024, Elsevier

    Professor Chen Chen

  25. Health-related quality of life measurements in children and adolescents with refractive errors: A scoping review

    Article • Advances in Ophthalmology Practice and Research, May 2024, Elsevier

    Professor Chen Chen

  26. AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation

    Article • Nature Communications, April 2024, Springer Science + Business Media

    Professor Chen Chen

  27. Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells

    Article • Reproductive Toxicology, April 2024, Elsevier

    Professor Chen Chen

  28. Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms

    Article • Frontiers in Pharmacology, February 2024, Frontiers

    Professor Chen Chen

  29. Hormonal changes in PCOS

    Article • Journal of Endocrinology, January 2024, Bioscientifica

    Professor Chen Chen

  30. Tangeretin, An Active Flavonoid in Citrus Peel, Alleviates Cisplatin-Induced Cardiotoxicity via the Activation of AMPK and the Prevention on Mitochondrial Dysfunction

    Article • January 2024, Springer Science + Business Media

    Professor Chen Chen

  31. Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery

    Article • Drug Delivery and Translational Research, January 2024, Springer Science + Business Media

    Professor Chen Chen

  32. Protective effects of scutellaria-coptis herb couple against non-alcoholic steatohepatitis via activating NRF2 and FXR pathways in vivo and in vitro

    Article • Journal of Ethnopharmacology, January 2024, Elsevier

    Professor Chen Chen

  33. Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway

    Article • Current Eye Research, October 2023, Taylor & Francis

    Professor Chen Chen

  34. Impact of Oat (Avena sativa L.) on Metabolic Syndrome and Potential Physiological Mechanisms of Action: A Current Review

    Article • Journal of Agricultural and Food Chemistry, October 2023, American Chemical Society (ACS)

    Professor Chen Chen

  35. Associations of lipid accumulation product, visceral adiposity index, and triglyceride-glucose index with subclinical organ damage in healthy Chinese adults

    Article • Frontiers in Endocrinology, September 2023, Frontiers

    Professor Chen Chen

  36. An online flipped classroom approach improves the physiology score and subsequent course scores of the top-performing students

    Article • AJP Advances in Physiology Education, September 2023, American Physiological Society

    Professor Chen Chen

  37. Application of digital-intelligence technology in the processing of Chinese materia medica

    Article • Frontiers in Pharmacology, August 2023, Frontiers

    Professor Chen Chen

  38. 17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells

    Article • Clinical and Translational Medicine, July 2023, Wiley

    Professor Chen Chen

  39. Preserving Privacy for Distributed Genome-Wide Analysis Against Identity Tracing Attacks

    Article • IEEE Transactions on Dependable and Secure Computing, July 2023, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Chen Chen

  40. TMT-Based Proteomics Analysis of the Intervention Effect of Orlistat on Polycystic Ovary Syndrome Rats Induced by Letrozole Combined with a High-Fat Diet

    Article • ACS Omega, June 2023, American Chemical Society (ACS)

    Professor Chen Chen

  41. Editorial: Epigenetic mechanisms and epigenetic-based therapies in cardiometabolic and vascular disease

    Article • Frontiers in Genetics, June 2023, Frontiers

    Professor Chen Chen

  42. Platycodin D stimulates AMPK activity to inhibit the neurodegeneration caused by reactive oxygen species-induced inflammation and apoptosis

    Article • Journal of Ethnopharmacology, May 2023, Elsevier

    Professor Chen Chen

  43. The NLRP3 inflammasome: role in the pathobiology of chronic pain

    Article • Inflammopharmacology, April 2023, Springer Science + Business Media

    Professor Chen Chen

  44. Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery

    Article • Pharmaceutics, March 2023, MDPI AG

    Professor Chen Chen

  45. Corrigendum to “Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis” [Eur. J. Pharmacol. 878 (2020) 17...

    Article • European Journal of Pharmacology, March 2023, Elsevier

    Professor Chen Chen

  46. Circulating HHIP Levels in Women with Insulin Resistance and PCOS: Effects of Physical Activity, Cold Stimulation and Anti-Diabetic Drug Therapy

    Article • Journal of Clinical Medicine, January 2023, MDPI AG

    Professor Chen Chen

  47. Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes

    Article • Drug Discovery Today, January 2023, Elsevier

    Professor Chen Chen

  48. Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development

    Article • Cells, November 2022, MDPI AG

    Professor Chen Chen

  49. Laparoscopic fundoplication versus laparoscopic Roux-en-Y gastric bypass for gastro-oesophageal reflux disease in obese patients: protocol for a randomized clinical trial

    Article • BJS Open, November 2022, Oxford University Press (OUP)

    Professor Chen Chen

  50. Sodium–glucose cotransporter 2 inhibitor ameliorates high fat diet‐induced hypothalamic–pituitary–ovarian axis disorders

    Article • The Journal of Physiology, September 2022, Wiley

    Professor Chen Chen

  51. Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease

    Article • Journal of Natural Medicines, September 2022, Springer Science + Business Media

    Professor Chen Chen

  52. Measurements of Higgs boson production cross-sections in the H → τ+τ− decay channel in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector

    Article • Journal of High Energy Physics, August 2022, Springer Science + Business Media

    Professor Chen Chen

  53. Correction to: Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways

    Article • Molecular & Cellular Toxicology, August 2022, Springer Science + Business Media

    Professor Chen Chen

  54. Dapagliflozin partially restores reproductive function in MC4R KO obese female mice

    Article • Journal of Endocrinology, August 2022, Bioscientifica

    Professor Chen Chen

  55. Hyperinsulinemia: beneficial or harmful or both on glucose homeostasis

    Article • AJP Endocrinology and Metabolism, July 2022, American Physiological Society

    Professor Chen Chen

  56. Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes

    Article • Biological Trace Element Research, June 2022, Springer Science + Business Media

    Professor Chen Chen

  57. The Modulatory Role of Growth Hormone in Inflammation and Macrophage Activation

    Article • Endocrinology, June 2022, Endocrine Society

    Professor Chen Chen

  58. GPHB5 Is a Biomarker in Women With Metabolic Syndrome: Results From Cross-Sectional and Intervention Studies

    Article • Frontiers in Endocrinology, June 2022, Frontiers

    Professor Chen Chen

  59. Effect of Sodium Fluoride on Reproductive Function Through Regulating Reproductive Hormone Level and Circulating SIRT1 in Female Rats

    Article • Biological Trace Element Research, May 2022, Springer Science + Business Media

    Professor Chen Chen

  60. N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

    Article • Frontiers in Cardiovascular Medicine, May 2022, Frontiers

    Professor Chen Chen

  61. Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways

    Article • Molecular & Cellular Toxicology, May 2022, Springer Science + Business Media

    Professor Chen Chen

  62. Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids

    Article • Endocrine Connections, May 2022, Bioscientifica

    Professor Chen Chen

  63. Hepatic lipid accumulation induced by a high‐fat diet is regulated by Nrf2 through multiple pathways

    Article • The FASEB Journal, April 2022, Wiley

    Professor Chen Chen

  64. CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross-Sectional and Intervention Studies In Vivo and In Vitro

    Article • Oxidative Medicine and Cellular Longevity, March 2022, Hindawi Publishing Corporation

    Professor Chen Chen

  65. Comprehensive Analysis of Key m6A Modification Related Genes and Immune Infiltrates in Human Aortic Dissection

    Article • Frontiers in Cardiovascular Medicine, March 2022, Frontiers

    Professor Chen Chen

  66. Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?

    Article • BMC Pregnancy and Childbirth, March 2022, Springer Science + Business Media

    Professor Chen Chen

  67. A Survey of College Students on the Preference for Online Teaching Videos of Variable Durations in Online Flipped Classroom

    Article • Frontiers in Public Health, March 2022, Frontiers

    Professor Chen Chen

  68. GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling

    Article • Cell Death and Disease, March 2022, Springer Science + Business Media

    Professor Chen Chen

  69. Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis

    Article • Trends in Endocrinology and Metabolism, March 2022, Elsevier

    Professor Chen Chen

  70. Obesity and insulin resistance: Pathophysiology and treatment

    Article • Drug Discovery Today, March 2022, Elsevier

    Professor Chen Chen

  71. Maltol mitigates cisplatin‐evoked cardiotoxicity via inhibiting the PI3K /Akt signaling pathway in rodents in vivo and in vitro

    Article • Phytotherapy Research, February 2022, Wiley

    Professor Chen Chen

  72. Luteinizing Hormone Suppression by Progestin-Primed Ovarian Stimulation Is Associated With Higher Implantation Rate for Patients With Polycystic Ovary Syndrome Who Underwent in vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: Comparing With...

    Article • Frontiers in Physiology, February 2022, Frontiers

    Professor Chen Chen

  73. Impact of uterine malformations on pregnancy and neonatal outcomes of IVF/ICSI–frozen embryo transfer

    Article • Human Reproduction, January 2022, Oxford University Press (OUP)

    Professor Chen Chen

  74. Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome

    Article • Frontiers in Endocrinology, November 2021, Frontiers

    Professor Chen Chen

  75. Author Correction: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Professor Chen Chen

  76. DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions

    Article • Biological Trace Element Research, October 2021, Springer Science + Business Media

    Professor Chen Chen

  77. Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process

    Article • Molecular Biology Reports, October 2021, Springer Science + Business Media

    Professor Chen Chen

  78. Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection

    Article • BMC Genomics, October 2021, Springer Science + Business Media

    Professor Chen Chen

  79. Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress

    Article • Oxidative Medicine and Cellular Longevity, October 2021, Hindawi Publishing Corporation

    Professor Chen Chen

  80. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

    Article • Nature Communications, September 2021, Springer Science + Business Media

    Professor Chen Chen

  81. Modulation of Vagal Sensory Neurons via High Mobility Group Box-1 and Receptor for Advanced Glycation End Products: Implications for Respiratory Viral Infections

    Article • Frontiers in Physiology, September 2021, Frontiers

    Professor Chen Chen

  82. The GH-IGF-1 Axis in Circadian Rhythm

    Article • Frontiers in Molecular Neuroscience, September 2021, Frontiers

    Professor Chen Chen

  83. Suppression of hyperinsulinemia restores growth hormone secretion and metabolism in obese mice

    Article • Journal of Endocrinology, September 2021, Bioscientifica

    Professor Chen Chen

  84. LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity

    Article • Frontiers in Endocrinology, August 2021, Frontiers

    Professor Chen Chen

  85. Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

    Article • PeerJ, August 2021, PeerJ

    Professor Chen Chen

  86. Corrigendum to “Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial” [Gynecologic Oncology 161 (2021) 143–151]

    Article • Gynecologic Oncology, August 2021, Elsevier

    Professor Chen Chen

  87. Rotating day and night disturb growth hormone secretion profiles, body energy metabolism and insulin levels in mice

    Article • Neuroendocrinology, July 2021, Karger Publishers

    Professor Chen Chen

  88. Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

    Article • Frontiers in Cellular and Infection Microbiology, July 2021, Frontiers

    Professor Chen Chen

  89. Circular RNA Expression: Its Potential Regulation and Function in Abdominal Aortic Aneurysms

    Article • Oxidative Medicine and Cellular Longevity, June 2021, Hindawi Publishing Corporation

    Professor Chen Chen

  90. CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

    Article • PLoS Genetics, June 2021, PLOS

    Professor Chen Chen

  91. Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

    Article • Trends in Endocrinology and Metabolism, June 2021, Elsevier

    Professor Chen Chen

  92. Assessment of chronic disease management mode (CDMM) on participants with primary hypertension

    Article • Tropical Medicine & International Health, May 2021, Wiley

    Professor Chen Chen

  93. Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial

    Article • Gynecologic Oncology, April 2021, Elsevier

    Professor Chen Chen

  94. Time-Restricted Feeding Restored Insulin-Growth Hormone Balance and Improved Substrate and Energy Metabolism in MC4RKO Obese Mice

    Article • Neuroendocrinology, March 2021, Karger Publishers

    Professor Chen Chen

  95. Mechanism and Basis of Traditional Chinese Medicine Against Obesity: Prevention and Treatment Strategies

    Article • Frontiers in Pharmacology, March 2021, Frontiers

    Professor Chen Chen

  96. Development of a sensitive and reliable ELISA kit of urinary haptoglobin to predict progress of diabetic kidney disease

    Article • Diabetes/Metabolism Research and Reviews, January 2021, Wiley

    Professor Chen Chen

  97. Effectiveness of progesterone-primed ovarian stimulation in assisted reproductive technology: a systematic review and meta-analysis

    Article • Archives of Gynecology and Obstetrics, January 2021, Springer Science + Business Media

    Professor Chen Chen

  98. miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride

    Article • Biological Trace Element Research, January 2021, Springer Science + Business Media

    Professor Chen Chen

  99. Privacy-Preserving Gradient Descent for Distributed Genome-Wide Analysis

    Article • January 2021, Springer Science + Business Media

    Professor Chen Chen

  100. Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway

    Article • The American Journal of Chinese Medicine, January 2021, World Scientific Pub Co Pte Lt

    Professor Chen Chen

  101. Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice

    Article • The FASEB Journal, December 2020, Wiley

    Professor Chen Chen

  102. <p>Prevalence and Correlation of Metabolic Syndrome: A Cross-Sectional Study of Nearly 10 Million Multi-Ethnic Chinese Adults</p>

    Article • Diabetes Metabolic Syndrome and Obesity, December 2020, Taylor & Francis

    Professor Chen Chen

  103. Suppression of Insulin Secretion in the Treatment of Obesity: A Systematic Review and Meta‐Analysis

    Article • Obesity, November 2020, Wiley

    Professor Chen Chen

  104. GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization

    Article • Endocrinology, September 2020, Endocrine Society

    Professor Chen Chen

  105. Insulin and Growth Hormone Balance: Implications for Obesity

    Article • Trends in Endocrinology and Metabolism, September 2020, Elsevier

    Professor Chen Chen

  106. Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies

    Article • Pharmacological Research, September 2020, Elsevier

    Professor Chen Chen

  107. Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

    Article • Neuroscience Letters, September 2020, Elsevier

    Professor Chen Chen

  108. Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat‐induced spermatogenic damage via inhibiting the MAPK mediated ox...

    Article • Phytotherapy Research, August 2020, Wiley

    Professor Chen Chen

  109. Ionomycin-induced mouse oocyte activation can disrupt preimplantation embryo development through increased reactive oxygen species reaction and DNA damage

    Article • Molecular Human Reproduction, July 2020, Oxford University Press (OUP)

    Professor Chen Chen

  110. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion

    Article • Biomedicine & Pharmacotherapy, July 2020, Elsevier

    Professor Chen Chen

  111. Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis

    Article • European Journal of Pharmacology, July 2020, Elsevier

    Professor Chen Chen

  112. Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

    Article • Frontiers in Pharmacology, June 2020, Frontiers

    Professor Chen Chen

  113. Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways

    Article • Biomedicine & Pharmacotherapy, June 2020, Elsevier

    Professor Chen Chen

  114. Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway

    Article • Cell Death and Disease, June 2020, Springer Science + Business Media

    Professor Chen Chen

  115. Excessive Activation of NMDA Receptors in the Pathogenesis of Multiple Peripheral Organs via Mitochondrial Dysfunction, Oxidative Stress, and Inflammation

    Article • SN Comprehensive Clinical Medicine, May 2020, Springer Science + Business Media

    Professor Chen Chen

  116. Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice

    Article • Journal of Endocrinology, May 2020, Bioscientifica

    Professor Chen Chen

  117. Facile conversion of cis into trans oxane as liquid crystals

    Article • Scientific Reports, April 2020, Springer Science + Business Media

    Professor Chen Chen

  118. Dapagliflozin restores insulin and growth hormone secretion in obese mice

    Article • Journal of Endocrinology, April 2020, Bioscientifica

    Professor Chen Chen

  119. PrivColl: Practical Privacy-Preserving Collaborative Machine Learning

    Article • January 2020, Springer Science + Business Media

    Professor Chen Chen

  120. Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles

    Article • January 2020, Springer Science + Business Media

    Professor Chen Chen

  121. 20(R)-ginsenoside Rg3, a product of high-efficiency thermal deglycosylation of ginsenoside Rd, exerts protective effects against scrotal heat-induced spermatogenic damage in mice

    Article • BIOCELL, January 2020, Computers, Materials and Continua (Tech Science Press)

    Professor Chen Chen

  122. Effects and Mechanisms of Traditional Chinese Herbal Medicine in the Treatment of Ischemic Cardiomyopathy

    Article • Pharmacological Research, January 2020, Elsevier

    Professor Chen Chen

  123. Radionuclide-labeled gold nanoparticles for nuclei-targeting internal radio-immunity therapy

    Article • Materials Horizons, January 2020, Royal Society of Chemistry

    Professor Chen Chen

  124. Combination of searches for Higgs boson pairs in pp collisions at s

    Article • Physics Letters B, January 2020, Elsevier

    Professor Chen Chen

  125. Analysis of the MicroRNA Profile by Sequencing in Ovarian Granular Cells from Women Suffering Fluorosis with Reproductive Dysfunction

    Article • Biological Trace Element Research, December 2019, Springer Science + Business Media

    Professor Chen Chen

  126. Rhythmic growth hormone secretion in physiological and pathological conditions: Lessons from rodent studies

    Article • Molecular and Cellular Endocrinology, December 2019, Elsevier

    Professor Chen Chen

  127. Insulin Receptor Trafficking: Consequences for Insulin Sensitivity and Diabetes

    Article • International Journal of Molecular Sciences, October 2019, MDPI AG

    Professor Chen Chen

  128. Maltol (3-Hydroxy-2-methyl-4-pyrone) Slows d-Galactose-Induced Brain Aging Process by Damping the Nrf2/HO-1-Mediated Oxidative Stress in Mice

    Article • Journal of Agricultural and Food Chemistry, August 2019, American Chemical Society (ACS)

    Professor Chen Chen

  129. Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B

    Article • The FASEB Journal, July 2019, Federation of American Societies For Experimental Biology (FASEB)

    Professor Chen Chen, Longhui Chen, Linbing QU

  130. Ginsenoside Rb3 provides protective effects against cisplatin‐induced nephrotoxicity via regulation of AMPK‐/mTOR‐mediated autophagy and inhibition of apoptosis in vitro and in vivo

    Article • Cell Proliferation, May 2019, Wiley

    Professor Chen Chen

  131. Arginyl-fructosyl-glucose, a Major Maillard Reaction Product of Red Ginseng, Attenuates Cisplatin-Induced Acute Kidney Injury by Regulating Nuclear Factor κB and Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathways

    Article • Journal of Agricultural and Food Chemistry, May 2019, American Chemical Society (ACS)

    Professor Chen Chen

  132. Combinations of single-top-quark production cross-section measurements and |fLVVtb| determinations at $$ \sqrt{s} $$ = 7 and 8 TeV with the ATLAS and CMS experiments

    Article • Journal of High Energy Physics, May 2019, Springer Science + Business Media

    Professor Chen Chen

  133. Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes

    Article • Nanomedicine, April 2019, Future Medicine

    Professor Chen Chen

  134. Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy

    Article • Biomaterials, April 2019, Elsevier

    Professor Chen Chen

  135. Platycodon grandiflorum Saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice

    Article • Journal of Functional Foods, March 2019, Elsevier

    Professor Chen Chen

  136. The CD25+/CD4+ T cell ratio and levels of CII, CIX and CXI antibodies in serum may serve as biomarkers of pristane-induced arthritis in rats and Rheumatoid Arthritis in humans

    Article • Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, March 2019, Elsevier

    Professor Chen Chen

  137. Exploration of the role of anti-Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome

    Article • Clinical Endocrinology, February 2019, Wiley

    Asso. Professor Minh Tam Le, Professor Chen Chen

  138. Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy

    Article • Frontiers in Immunology, February 2019, Frontiers

    Professor Chen Chen

  139. Enabling Privacy-Preserving Sharing of Genomic Data for GWASs in Decentralized Networks

    Article • January 2019, ACM (Association for Computing Machinery)

    Professor Chen Chen

  140. Enhancing PD-1 Gene Silence in T Lymphocytes by Comparing the Delivery Performance of Two Inorganic Nanoparticle Platforms

    Article • Nanomaterials, January 2019, MDPI AG

    Professor Chen Chen

  141. Maltol Mitigates Thioacetamide-induced Liver Fibrosis through TGF-β1-mediated Activation of PI3K/Akt Signaling Pathway

    Article • Journal of Agricultural and Food Chemistry, January 2019, American Chemical Society (ACS)

    Professor Chen Chen

  142. Ginsenoside Rb1, A Major Saponin from Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice

    Article • The American Journal of Chinese Medicine, January 2019, World Scientific Pub Co Pte Lt

    Professor Chen Chen

  143. Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway

    Article • Biomedicine & Pharmacotherapy, January 2019, Elsevier

    Professor Chen Chen

  144. From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion

    Article • Cell Reports, December 2018, Elsevier

    Professor Chen Chen

  145. Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways

    Article • Phytomedicine, December 2018, Elsevier

    Professor Chen Chen

  146. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice

    Article • Biomedicine & Pharmacotherapy, November 2018, Elsevier

    Professor Chen Chen

  147. The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Professor Chen Chen

  148. Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats

    Article • International Journal of Molecular Sciences, October 2018, MDPI AG

    Professor Chen Chen

  149. Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin

    Article • Diabetes Research and Clinical Practice, October 2018, Elsevier

    Professor Chen Chen

  150. Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

    Article • Nutrients, September 2018, MDPI AG

    Professor Chen Chen

  151. Metformin versus insulin for gestational diabetes: The reporting of ethnicity and a meta-analysis combining English and Chinese literatures

    Article • Obesity Medicine, September 2018, Elsevier

    Professor Chen Chen

  152. NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice

    Article • Phytotherapy Research, July 2018, Wiley

    Professor Chen Chen

  153. 20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis

    Article • International Immunopharmacology, June 2018, Elsevier

    Professor Chen Chen

  154. Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes

    Article • APL Bioengineering, June 2018, American Institute of Physics

    Professor Chen Chen

  155. Optimization of Formulations Consisting of Layered Double Hydroxide Nanoparticles and Small Interfering RNA for Efficient Knockdown of the Target Gene

    Article • ACS Omega, May 2018, American Chemical Society (ACS)

    Professor Chen Chen

  156. Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction

    Article • Physiological Reports, May 2018, Wiley

    Professor Chen Chen

  157. Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis

    Article • International Journal of Molecular Sciences, May 2018, MDPI AG

    Professor Chen Chen

  158. Knocking down Insulin Receptor in Pancreatic Beta Cell lines with Lentiviral-Small Hairpin RNA Reduces Glucose-Stimulated Insulin Secretion via Decreasing the Gene Expression of Insulin, GLUT2 and Pdx1

    Article • International Journal of Molecular Sciences, March 2018, MDPI AG

    Professor Chen Chen

  159. Meet Our Regional Editor

    Article • Current Medicinal Chemistry, March 2018, Bentham Science Publishers

    Professor Chen Chen

  160. Response to the Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice

    Article • Journal of Agricultural and Food Chemistry, February 2018, American Chemical Society (ACS)

    Professor Chen Chen

  161. Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats

    Article • Physiological Reports, February 2018, Wiley

    Professor Chen Chen

  162. Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic β-cells

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Professor Chen Chen

  163. Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice

    Article • AJP Regulatory Integrative and Comparative Physiology, January 2018, American Physiological Society

    Professor Chen Chen

  164. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways

    Article • Food and Chemical Toxicology, December 2017, Elsevier

    Professor Chen Chen

  165. Molecular Mechanisms of Antipsychotic Drug-Induced Diabetes

    Article • Frontiers in Neuroscience, November 2017, Frontiers

    Professor Chen Chen

  166. Glucose-Responsive Nanosystem Mimicking the Physiological Insulin Secretion via an Enzyme–Polymer Layer-by-Layer Coating Strategy

    Article • Chemistry of Materials, September 2017, American Chemical Society (ACS)

    Professor Chen Chen

  167. A Sustained Activation of Pancreatic NMDARs Is a Novel Factor of β-Cell Apoptosis and Dysfunction

    Article • Endocrinology, September 2017, Endocrine Society

    Professor Chen Chen, jianping Xu

  168. [OP.3B.05] HEXARELIN PRESERVES MYOCARDIAL FUNCTION AND REDUCES INFLAMMATION AND FIBROSIS IN A MOUSE MODEL OF MYOCARDIAL ISCHEMIA REPERFUSION

    Article • Journal of Hypertension, September 2017, Wolters Kluwer Health

    Professor Chen Chen

  169. An Electrochemical Biosensor with Dual Signal Outputs: Toward Simultaneous Quantification of pH and O2 in the Brain upon Ischemia and in a Tumor during Cancer Starvation Therapy

    Article • Angewandte Chemie, July 2017, Wiley

    Professor Chen Chen

  170. Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice

    Article • Endocrinology, July 2017, Endocrine Society

    Professor Chen Chen

  171. Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation

    Article • Bioscience Reports, May 2017, Portland Press Ltd.

    Professor Chen Chen

  172. Meet Our Editorial Board Member

    Article • Current Drug Targets, April 2017, Bentham Science Publishers

    Professor Chen Chen

  173. Increased PD-L1 expression in breast and colon cancer stem cells

    Article • Clinical and Experimental Pharmacology and Physiology, April 2017, Wiley

    Professor Chen Chen

  174. Rising maternal circulating GH during murine pregnancy suggests placental regulation

    Article • Endocrine Connections, April 2017, Bioscientifica

    Dr Kathy L Gatford, Professor Chen Chen

  175. Insights from engraftable immunodeficient mouse models of hyperinsulinaemia

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Professor Chen Chen

  176. An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Professor Chen Chen

  177. Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice

    Article • Reproduction, March 2017, Bioscientifica

    Professor Chen Chen

  178. Predicting Kidney Damage in Diabetes Patients with Urine Proteome Biomarker

    Article • Diabetes Care, November 2016, American Diabetes Association

    Professor Chen Chen

  179. Visualisation ofKiss1Neurone Distribution Using a Kiss1-CRE Transgenic Mouse

    Article • Journal of Neuroendocrinology, October 2016, Wiley

    Professor Chen Chen

  180. Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

    Article • The Journal of Physiology, October 2016, Wiley

    Professor Chen Chen

  181. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis

    Article • Nutrients, September 2016, MDPI AG

    Professor Chen Chen

  182. Neuroendocrine Regulation of Growth Hormone Secretion

    Article • March 2016, Wiley

    Professor Chen Chen

  183. Hexarelin Protects Rodent Pancreatic Β-Cells Function from Cytotoxic Effects of Streptozotocin Involving Mitochondrial Signalling Pathways In Vivo and In Vitro

    Article • PLOS One, February 2016, PLOS

    Professor Chen Chen

  184. Determination of nitrofurans metabolites residues in aquatic products by ultra-performance liquid chromatography–tandem mass spectrometry

    Article • Food Chemistry, February 2016, Elsevier

    Professor Chen Chen

  185. Effect of Deletion of Ghrelin-O -Acyltransferase on the Pulsatile Release of Growth Hormone in Mice

    Article • Journal of Neuroendocrinology, November 2015, Wiley

    Professor Chen Chen

  186. Meet Our Editorial Board Member:

    Article • Current Drug Targets, November 2015, Bentham Science Publishers

    Professor Chen Chen

  187. Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense

    Article • Journal of Natural Medicines, October 2015, Springer Science + Business Media

    Professor Chen Chen

  188. Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment

    Article • Clinical Endocrinology, October 2015, Wiley

    Professor Chen Chen

  189. 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

    Article • Experimental Cell Research, June 2015, Elsevier

    Professor Chen Chen

  190. Measure of PRL Secretion in Mice by uELISA

    Article • Endocrinology, May 2015, Endocrine Society

    Professor Chen Chen, Nicola Romano

  191. The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis

    Article • Journal of Neuroendocrinology, April 2015, Wiley

    Professor Chen Chen

  192. Meet the Editorial Board:

    Article • Current Drug Targets, March 2015, Bentham Science Publishers

    Professor Chen Chen

  193. Nanotechnology in the management of cervical cancer

    Article • Reviews in Medical Virology, March 2015, Wiley

    Professor Chen Chen

  194. PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells

    Article • Endocrine, February 2015, Springer Science + Business Media

    Professor Chen Chen

  195. Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases

    Article • Endocrine, February 2015, Springer Science + Business Media

    Professor Chao Deng, Professor Chen Chen

  196. Possible therapeutic implication of PD-L1/PD-1 axis in endometrial cancer

    Article • Journal of Solid Tumors, January 2015, Sciedu Press

    Professor Chen Chen

  197. Meet the Editorial Board:

    Article • Current Medicinal Chemistry, January 2015, Bentham Science Publishers

    Professor Chen Chen

  198. Isolation of Contractile Cardiomyocytes from Human Pluripotent Stem-Cell-Derived Cardiomyogenic Cultures Using a HumanNCX1-EGFPReporter

    Article • Stem Cells and Development, January 2015, Mary Ann Liebert Inc

    Professor Chen Chen

  199. Actions of NPY, and Its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State

    Article • Journal of Neuroscience, December 2014, Society for Neuroscience

    Professor Chen Chen

  200. Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species

    Article • December 2014, Springer Science + Business Media

    Professor Chen Chen

  201. OR3-5: NPY neurons as a critical hypothalamic node for the control of GH release relative to food intake

    Article • Growth Hormone & IGF Research, October 2014, Elsevier

    Professor Chen Chen

  202. OR3-6: Loss of acyl-ghrelin signalling in male ghrelin-O-acyltransferase knock-out mice results in reduced pulsatile growth hormone secretion and a derangement of GH pulse pattern

    Article • Growth Hormone & IGF Research, October 2014, Elsevier

    Professor Chen Chen

  203. An Early Reduction in GH Peak Amplitude in Preproghrelin-Deficient Male Mice Has a Minor Impact on Linear Growth

    Article • Endocrinology, September 2014, Endocrine Society

    Professor Chen Chen

  204. Editorial (Thematic Issue: Signalling Pathways in Anti-cancer Drug Resistance)

    Article • Current Medicinal Chemistry, August 2014, Bentham Science Publishers

    Professor Chen Chen

  205. Intermittent Fasting Attenuates Increases in Neurogenesis after Ischemia and Reperfusion and Improves Recovery

    Article • Journal of Cerebral Blood Flow & Metabolism, May 2014, SAGE Publications

    Professor Chen Chen

  206. Activation of PI3K/Akt/mTOR Pathway and Dual Inhibitors of PI3K and mTOR in Endometrial Cancer

    Article • Current Medicinal Chemistry, April 2014, Bentham Science Publishers

    Professor Chen Chen

  207. The Role of Src in Colon Cancer and Its Therapeutic Implications

    Article • Clinical Colorectal Cancer, March 2014, Elsevier

    Professor Chen Chen

  208. Growth Hormone Secretion Is Correlated With Neuromuscular Innervation Rather Than Motor Neuron Number in Early-Symptomatic Male Amyotrophic Lateral Sclerosis Mice

    Article • Endocrinology, December 2013, Endocrine Society

    Dr Mark Bellingham, Professor Chen Chen

  209. Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice

    Article • Endocrinology, December 2013, Endocrine Society

    Professor Chen Chen

  210. Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas

    Article • Tissue and Cell, December 2013, Elsevier

    Professor Chen Chen

  211. The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

    Article • Tissue Engineering Part B Reviews, December 2013, Mary Ann Liebert Inc

    Professor Chen Chen

  212. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

    Article • AGE, October 2013, Springer Science + Business Media

    Professor Chen Chen

  213. Increased levels of IL-6, IL-1β, and TNF-α in Kashin–Beck disease and rats induced by T-2 toxin and selenium deficiency

    Article • Rheumatology International, September 2013, Springer Science + Business Media

    Professor Chen Chen

  214. Hypothalamic Distribution of Somatostatin mRNA Expressing Neurones Relative to Pubertal and Adult Changes in Pulsatile Growth Hormone Secretion in Mice

    Article • Journal of Neuroendocrinology, September 2013, Wiley

    Professor Chen Chen

  215. Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic

    Article • Food and Chemical Toxicology, August 2013, Elsevier

    Professor Chen Chen

  216. Obesity and melanoma: Exploring molecular links

    Article • Journal of Cellular Biochemistry, July 2013, Wiley

    Professor Chen Chen

  217. Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo

    Article • AJP Endocrinology and Metabolism, July 2013, American Physiological Society

    Professor Chen Chen

  218. Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics

    Article • International Journal of Nanomedicine, July 2013, Taylor & Francis

    Professor Chen Chen

  219. Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain

    Article • Journal of Endocrinology, May 2013, Bioscientifica

    Professor Chen Chen

  220. GW9508 inhibits insulin secretion by activating ATP-sensitive potassium channels in rat pancreatic  -cells

    Article • April 2013, Bioscientifica

    Professor Chen Chen

  221. Linoleic Acid Stimulates [Ca2+]i Increase in Rat Pancreatic Beta-Cells through Both Membrane Receptor- and Intracellular Metabolite-Mediated Pathways

    Article • PLOS One, April 2013, PLOS

    Professor Chen Chen

  222. Phosphatidylinositol 3-kinase Signaling as a Therapeutic Target for Cervical Cancer

    Article • Current Cancer Drug Targets, March 2013, Bentham Science Publishers

    Professor Chen Chen

  223. Adiponectin

    Article • January 2013, Elsevier

    Professor Chen Chen

  224. Obesity-associated endometrial and cervical cancers

    Article • Frontiers in Bioscience-Elite, January 2013, IMR Press

    Professor Chen Chen

  225. Growth Hormone Secretagogues Preserve the Electrophysiological Properties of Mouse Cardiomyocytes Isolated fromin VitroIschemia/Reperfusion Heart

    Article • Endocrinology, November 2012, Endocrine Society

    Professor Chen Chen

  226. Irregular Rhythm Adversely Influences Calcium Handling in Ventricular Myocardium

    Article • Circulation Heart Failure, November 2012, Wolters Kluwer Health

    Professor Chen Chen

  227. Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat

    Article • AJP Heart and Circulatory Physiology, September 2012, American Physiological Society

    Professor Chen Chen

  228. The Decline in Pulsatile GH Secretion throughout Early Adulthood in Mice Is Exacerbated by Dietary-Induced Weight Gain

    Article • Endocrinology, September 2012, Endocrine Society

    Professor Chen Chen

  229. Impairments to the GH-IGF-I Axis in hSOD1G93AMice Give Insight into Possible Mechanisms of GH Dysregulation in Patients with Amyotrophic Lateral Sclerosis

    Article • Endocrinology, August 2012, Endocrine Society

    Dr Mark Bellingham, Professor Chen Chen

  230. Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms

    Article • Diabetes Obesity and Metabolism, June 2012, Wiley

    Professor Chen Chen

  231. Challenging the long tail recommendation

    Article • Proceedings of the VLDB Endowment, May 2012, VLDB Endowment

    Professor Chen Chen

  232. Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors

    Article • Clinical and Experimental Pharmacology and Physiology, April 2012, Wiley

    Professor Chen Chen

  233. Growth Hormone Secretagogues Protect Mouse Cardiomyocytes from in vitro Ischemia/Reperfusion Injury through Regulation of Intracellular Calcium

    Article • PLOS One, April 2012, PLOS

    Professor Chen Chen

  234. Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators

    Article • Cell Calcium, March 2012, Elsevier

    Professor Chen Chen

  235. A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy

    Article • Endocrine, February 2012, Springer Science + Business Media

    Professor Chen Chen

  236. Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions

    Article • Journal of Orthopaedic Research®, January 2012, Wiley

    Professor Chen Chen

  237. GH Does Not Modulate the Early Fasting-Induced Release of Free Fatty Acids in Mice

    Article • Endocrinology, January 2012, Endocrine Society

    Professor Chen Chen

  238. Low TWEAK expression is correlated to the progression of squamous cervical carcinoma

    Article • Gynecologic Oncology, October 2011, Elsevier

    Professor Chen Chen

  239. Ghrelin reduces voltage-gated calcium currents in GH3 cells via cyclic GMP pathways

    Article • Endocrine, August 2011, Springer Science + Business Media

    Professor Chen Chen

  240. Development of a Method for the Determination of Pulsatile Growth Hormone Secretion in Mice

    Article • Endocrinology, August 2011, Endocrine Society

    Professor Chen Chen

  241. Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons

    Article • European Journal of Neuroscience, July 2011, Wiley

    Professor Chen Chen

  242. Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells

    Article • Journal of Endocrinology, May 2011, Bioscientifica

    Professor Chen Chen

  243. Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways

    Article • Endocrine, December 2010, Springer Science + Business Media

    Professor Chen Chen

  244. Expression and In Vitro Functions of the Ghrelin Axis in Endometrial Cancer

    Article • Hormones and Cancer, October 2010, Springer Science + Business Media

    Professor Chen Chen

  245. Effects of GH Secretagogues on Contractility and Ca2+Homeostasis of Isolated Adult Rat Ventricular Myocytes

    Article • Endocrinology, September 2010, Endocrine Society

    Professor Chen Chen

  246. TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway

    Article • Cancer Letters, August 2010, Elsevier

    Professor Chen Chen

  247. G protein-coupled receptor 30 in tumor development

    Article • Endocrine, July 2010, Springer Science + Business Media

    Professor Chen Chen

  248. Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat

    Article • Peptides, April 2010, Elsevier

    Professor Chen Chen

  249. Growth Hormone Secretagogues Reduce Transient Outward K+Current via Phospholipase C/Protein Kinase C Signaling Pathway in Rat Ventricular Myocytes

    Article • Endocrinology, March 2010, Endocrine Society

    Professor Chen Chen

  250. Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic β-cells via angiotensin II type 2 receptors

    Article • AJP Cell Physiology, February 2010, American Physiological Society

    Professor Po Sing Leung, Professor Chen Chen

  251. Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells

    Article • Endocrine, October 2009, Springer Science + Business Media

    Professor Chen Chen

  252. Adiponectin Regulate Growth Hormone Secretion Via Adiponectin Receptor Mediated Ca2+Signalling in Rat SomatotrophsIn Vitro

    Article • Journal of Neuroendocrinology, August 2009, Wiley

    Professor Chen Chen

  253. Involvement of Tetrodotoxin-Resistant Na+Current and Protein Kinase C in the Action of Growth Hormone (GH)-Releasing Hormone on Primary Cultured Somatotropes from GH-Green Fluorescent Protein Transgenic Mice

    Article • Endocrinology, September 2008, Endocrine Society

    Professor Chen Chen

  254. Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins

    Article • Insect Biochemistry and Molecular Biology, August 2008, Elsevier

    Professor Chen Chen

  255. Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway

    Article • Journal of Endocrinology, June 2008, Bioscientifica

    Professor Chen Chen

  256. potassium ion channels in GH cells

    Article • Neuroendocrinology, April 2008, Karger Publishers

    Professor Chen Chen

  257. Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats

    Article • Endocrine, April 2008, Springer Science + Business Media

    Professor Chen Chen

  258. DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

    Article • Human Molecular Genetics, January 2008, Oxford University Press (OUP)

    Professor Chen Chen

  259. INVOLVEMENT OF SOMATOSTATIN RECEPTOR SUBTYPES IN MEMBRANE ION CHANNEL MODIFICATION BY SOMATOSTATIN IN PITUITARY SOMATOTROPES

    Article • Clinical and Experimental Pharmacology and Physiology, December 2007, Wiley

    Professor Chen Chen

  260. Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic β-cells

    Article • Journal of Endocrinology, November 2007, Bioscientifica

    Professor Chen Chen

  261. Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat

    Article • AJP Heart and Circulatory Physiology, November 2007, American Physiological Society

    Professor Chen Chen

  262. Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II

    Article • Molecular Pharmacology, August 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Chen Chen

  263. Somatostatin decreases voltage-gated Ca2+currents in GH3 cells through activation of somatostatin receptor 2

    Article • AJP Endocrinology and Metabolism, June 2007, American Physiological Society

    Professor Chen Chen

  264. Facilitation of decidualization by locally produced ghrelin in the human endometrium

    Article • Molecular Human Reproduction, May 2007, Oxford University Press (OUP)

    Professor Chen Chen

  265. 3T3-L1 adipocytes induce dysfunction of MIN6 insulin-secreting cells via multiple pathways mediated by secretory factors in a co-culture system

    Article • Endocrine, May 2007, Springer Science + Business Media

    Professor Chen Chen

  266. Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1

    Article • Ageing Research Reviews, November 2006, Elsevier

    Professor Chen Chen

  267. Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes

    Article • The International Journal of Biochemistry & Cell Biology, May 2006, Elsevier

    Professor Chen Chen

  268. Reduction in Voltage-Gated K+Currents in Primary Cultured Rat Pancreatic β-Cells by Linoleic Acids

    Article • Endocrinology, February 2006, Endocrine Society

    Professor Chen Chen

  269. Effects of ghrelin and synthetic GH secretagogues on the cardiovascular system

    Article • Trends in Endocrinology and Metabolism, January 2006, Elsevier

    Professor Chen Chen

  270. Differential Regulation of GHRH-Receptor and GHS-Receptor Expression by Long-Term In Vitro Treatment of Ovine Pituitary Cells with GHRP-2 and GHRH

    Article • Endocrine, January 2006, Springer Science + Business Media

    Professor Chen Chen

  271. Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43

    Article • Endocrinology, December 2005, Endocrine Society

    Professor Chen Chen

  272. Somatostatin Increases Voltage-Gated K+Currents in GH3 Cells through Activation of Multiple Somatostatin Receptors

    Article • Endocrinology, November 2005, Endocrine Society

    Professor Chen Chen

  273. GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure

    Article • AJP Heart and Circulatory Physiology, October 2005, American Physiological Society

    Professor Chen Chen

  274. Suppressing actions of butyrate on growth hormone (GH) secretion induced by GH-releasing hormone in rat anterior pituitary cells

    Article • General and Comparative Endocrinology, September 2005, Elsevier

    Professor Chen Chen

  275. Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: a new physiological mechanism

    Article • Journal of Endocrinology, August 2005, Bioscientifica

    Professor Chen Chen

  276. Long-term inhibition of protein tyrosine kinase impairs electrophysiologic activity and a rapid component of exocytosis in pancreatic β-cells

    Article • Journal of Molecular Endocrinology, August 2005, Bioscientifica

    Professor Chen Chen

  277. Ghrelin Reduces Voltage-Gated Potassium Currents in GH3 Cells Via Cyclic GMP Pathways

    Article • Endocrine, January 2005, Springer Science + Business Media

    Professor Chen Chen

  278. Oestrogen Replacement in vivo Rescues the Dysfunction of Pituitary Somatotropes in Ovariectomised Aromatase Knockout Mice

    Article • Neuroendocrinology, January 2005, Karger Publishers

    Professor Chen Chen

  279. Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells

    Article • Cell Biology International, June 2004, Wiley

    Professor Chen Chen

  280. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro

    Article • AJP Heart and Circulatory Physiology, March 2004, American Physiological Society

    Professor Chen Chen

  281. Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells

    Article • European Journal of Endocrinology, February 2004, Bioscientifica

    Professor Chen Chen

  282. Functional Modification of Pituitary Somatotropes in the Aromatase Knockout Mouse and the Effect of Estrogen Replacement

    Article • Endocrinology, February 2004, Endocrine Society

    Professor Chen Chen

  283. The Positive Inotropic and Calcium-Mobilizing Effects of Growth Hormone-Releasing Peptides on Rat Heart

    Article • Endocrinology, November 2003, Endocrine Society

    Professor Chen Chen

  284. Growth Hormone-Releasing Hormone Decreases Voltage-Gated Potassium Currents in GH4C1 Cells

    Article • Journal of Neuroendocrinology, June 2003, Wiley

    Professor Chen Chen

  285. The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis

    Article • Endocrinology, March 2003, Endocrine Society

    Professor Chen Chen

  286. Distinct Intracellular Ca<sup>2+</sup> Response to Extracellular Adenosine Triphosphate in Pancreatic β-Cells in Rats and Mice

    Article • Endocrine, January 2003, Springer Science + Business Media

    Professor Chen Chen

  287. Orexin-B Augments Voltage-Gated L-Type Ca<sup>2+</sup> Current via Protein Kinase C-Mediated Signalling Pathway in Ovine Somatotropes

    Article • Neuroendocrinology, January 2003, Karger Publishers

    Professor Chen Chen

  288. The In Vitro Regulation of Growth Hormone Secretion by Orexins

    Article • Endocrine, January 2003, Springer Science + Business Media

    Professor Chen Chen

  289. Orexin-A Augments Voltage-Gated Ca2+Currents and Synergistically Increases Growth Hormone (GH) Secretion with GH-Releasing Hormone in Primary Cultured Ovine Somatotropes

    Article • Endocrinology, December 2002, Endocrine Society

    Professor Chen Chen

  290. Growth hormone‐releasing peptide‐2 reduces inward rectifying K+currents via a PKA‐cAMP‐mediated signalling pathway in ovine somatotropes

    Article • The Journal of Physiology, December 2002, Wiley

    Professor Chen Chen

  291. Tyrosine kinase inhibitors suppress α1-adrenoceptor mediated contraction in human radial, internal mammary arteries and saphenous vein

    Article • Neuroscience Letters, November 2002, Elsevier

    Professor Chen Chen

  292. The Effect of Two-Day Treatment of Primary Cultured Ovine Somatotropes with GHRP-2 on Membrane Voltage-Gated K+Currents

    Article • Endocrinology, July 2002, Endocrine Society

    Professor Chen Chen

  293. Effects Of Molybdenum, Silicon And Nickel On alpha1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta

    Article • Clinical and Experimental Pharmacology and Physiology, May 2002, Wiley

    Professor Chen Chen

  294. Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M‐current

    Article • The Journal of Physiology, May 2002, Wiley

    Professor Chen Chen

  295. Effect of Growth Hormone-Releasing Peptide-2 (GHRP-2) and GH-Releasing Hormone (GHRH) on the cAMP Levels and GH Release from Cultured Acromegalic Tumours

    Article • Journal of Neuroendocrinology, December 2001, Wiley

    Professor Chen Chen

  296. The In Vitro Effect of Leptin on Growth Hormone Secretion from Primary Cultured Ovine Somatotrophs

    Article • Endocrine, January 2001, Springer Science + Business Media

    Professor Chen Chen

  297. Effects of Micromolar Concentrations of Manganese, Copper, and Zinc on α<sub>1</sub>-Adrenoceptor-Mediating Contraction in Rat Aorta

    Article • Biological Trace Element Research, January 2001, Springer Science + Business Media

    Professor Chen Chen

  298. Inhibition of GH release and synthesis by fatty acids in primary cultured caprine anterior pituitary cells

    Article • Regulatory Peptides, October 2000, Elsevier

    Professor Chen Chen

  299. Diverse intracellular signalling systems used by growth hormone‐releasing hormone in regulating voltage‐gated Ca2+or K+channels in pituitary somatotropes

    Article • Immunology and Cell Biology, August 2000, Wiley

    Professor Chen Chen

  300. Short-Chain Fatty Acids Inhibit the Release and Content of Growth Hormone in Anterior Pituitary Cells of the Goat

    Article • General and Comparative Endocrinology, June 2000, Elsevier

    Professor Chen Chen

  301. Growth Hormone Secretagogue Actions On The Pituitary Gland: Multiple Receptors For Multiple Ligands?

    Article • Clinical and Experimental Pharmacology and Physiology, May 2000, Wiley

    Professor Chen Chen

  302. Human GHRH reduces voltage‐gated K + currents via a non‐cAMP‐dependent but PKC‐mediated pathway in human GH adenoma cells

    Article • The Journal of Physiology, November 1999, Wiley

    Professor Chen Chen

  303. Intracellular GHRP Signalling

    Article • January 1999, Elsevier

    Professor Chen Chen

  304. Estrogen Transiently Increases Delayed Rectifier, Voltage-Dependent Potassium Currents in Ovine Gonadotropes

    Article • Neuroendocrinology, January 1999, Karger Publishers

    Professor Chen Chen

  305. Growth Hormone-Releasing Peptide-2 (GHRP-2) Does Not Act via the Human Growth Hormone-Releasing Factor Receptor in GC Cells

    Article • Endocrine, January 1998, Springer Science + Business Media

    Professor Chen Chen

  306. The in vitro Effect of Leptin onBasal and Growth Hormone-Releasing Hormone-StimulatedGrowth Hormone Secretion from theOvine Pituitary Gland

    Article • Neuroendocrinology, January 1998, Karger Publishers

    Professor Chen Chen

  307. The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs

    Article • Journal of Endocrinology, August 1997, Bioscientifica

    Professor Chen Chen

  308. G02 AND Gi3PROTEINS MEDIATE THE ACTION OF SOMATOSTATIN ON MEMBRANE Ca2+AND K+CURRENTS IN OVINE PITUITARY SOMATOTROPHS.

    Article • Clinical and Experimental Pharmacology and Physiology, August 1997, Wiley

    Professor Chen Chen

  309. Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs

    Article • Journal of Endocrinology, March 1996, Bioscientifica

    Professor Chen Chen

  310. G(o)-2 protein mediates the reduction in Ca2+ currents by somatostatin in cultured ovine somatotrophs.

    Article • The Journal of Physiology, February 1996, Wiley

    Professor Chen Chen

  311. The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs

    Article • Journal of Endocrinology, February 1996, Bioscientifica

    Professor Chen Chen

  312. Effects of Growth Hormone-Releasing Peptide-2 (GHRP-2) on Membrane Ca2+Permeability in Cultured Ovine Somatotrophs

    Article • Journal of Neuroendocrinology, March 1995, Wiley

    Professor Chen Chen

  313. Inward Membrane Currents and Electrophysiological Responses to GnRH in Ovine Gonadotropes

    Article • Neuroendocrinology, January 1995, Karger Publishers

    Professor Chen Chen

  314. Ion channels and the signal transduction pathways in the regulation of growth hormone secretion

    Article • Trends in Endocrinology and Metabolism, August 1994, Elsevier

    Professor Chen Chen

  315. Effects in vitro of New Growth Hormone Releasing Peptide (GHRP-1) on Growth Hormone Secretion from Ovine Pituitary Cells in Primary Culture

    Article • Journal of Neuroendocrinology, April 1994, Wiley

    Professor Chen Chen

  316. The Effect of GH-Releasing Peptide-2 (GHRP-2 or KP 102) on GH Secretion from Primary Cultured Ovine Pituitary Cells Can be Abolished by a Specific GH-Releasing Factor (GRF) Receptor Antagonist

    Article • Journal of Endocrinology, February 1994, Bioscientifica

    Professor Chen Chen

  317. Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling.

    Article • Proceedings of the National Academy of Sciences, October 1993, Proceedings of the National Academy of Sciences

    Professor Chen Chen

  318. Human growth hormone releasing factor (hGRF) modulates calcium currents in human growth hormone secreting adenoma cells

    Article • Brain Research, February 1993, Elsevier

    Professor Chen Chen

  319. Gonadotropin-Releasing Hormone Modifies Action Potential Generation in Sheep Pars distalis Gonadotropes

    Article • Neuroendocrinology, January 1993, Karger Publishers

    Professor Chen Chen

  320. Endothelin induces a nonselective cation current in vascular smooth muscle cells.

    Article • Circulation Research, August 1991, Wolters Kluwer Health

    Professor Chen Chen

  321. Functional Lactotroph Heterogeneity in Lactating Rats and in vitro Modification by 17Beta-Estradiol

    Article • Journal of Neuroendocrinology, December 1990, Wiley

    Professor Chen Chen

  322. Evidence for a relationship between lactotroph heterogeneity and physiological context

    Article • Neuroscience Letters, November 1990, Elsevier

    Professor Chen Chen

  323. Two types of voltage-dependent calcium current in rat somatotrophs are reduced by somatostatin.

    Article • The Journal of Physiology, June 1990, Wiley

    Professor Chen Chen

  324. In vitro Effects of 17Beta-Estradiol on Thyrotropin-Releasing Hormone-Induced and Dopamine-lnhibited Prolactin Release from Adult Male Rat Lactotrophs in Primary Culture

    Article • Journal of Neuroendocrinology, June 1990, Wiley

    Professor Chen Chen

  325. Sodium and calcium currents in action potentials of rat somatotrophs: Their possible functions in growth hormone secretion

    Article • Life Sciences, January 1990, Elsevier

    Professor Chen Chen

  326. Cationic currents on identified rat gonadotroph cells maintained in primary culture

    Article • Neurochemistry International, January 1989, Elsevier

    Professor Chen Chen

  327. Electrophysiological Responses of Rat Pituitary Cells in Somatotroph-Enriched Primary Culture to Human Growth-Hormone Releasing Factor

    Article • Neuroendocrinology, January 1989, Karger Publishers

    Professor Chen Chen

  328. Electrophysiological responses to somatostatin of rat hypophysial cells in somatotroph-enriched primary cultures.

    Article • The Journal of Physiology, January 1989, Wiley

    Professor Chen Chen