What is it about?
The aim of this review was to identify the efficacy of gene therapy to restore cognition in Alzheimer’s disease.
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Why is it important?
Alzheimer's disease (AD) is the main cause of dementia and it is a progressive neurogenerative disease characterized by the accumulation of neurofibrillary tangles and senile plaques. There is currently no cure; however, some treatments are available to slow down the progression of the disease, including gene therapy, which has been investigated to have great potential for the treatment of AD.
Perspectives
Gene therapy has shown a great potential for the treatment of AD in preclinical trials, but results should be interpreted with caution since preclinical studies presented limitations to predict the efficacy of the treatment outcome in humans
Desyrre Valiarine Tedeschi
Universidade Federal de Sao Carlos
Read the Original
This page is a summary of: Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review, Current Gene Therapy, June 2021, Bentham Science Publishers,
DOI: 10.2174/1566523221666210120091146.
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