All Stories

  1. Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation

    Article • Cells, December 2024, MDPI AG

    Mariagrazia Grilli

  2. ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism

    Article • Communications Biology, October 2024, Springer Science + Business Media

    Mariagrazia Grilli, Nicoletta Filigheddu

  3. The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models

    Article • Antioxidants, August 2024, MDPI AG

    Mariagrazia Grilli

  4. Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease

    Article • Glia, January 2024, Wiley

    Mariagrazia Grilli

  5. Neural stem cell-derived extracellular vesicles: mini players with key roles in neurogenesis, immunomodulation, neuroprotection and aging

    Article • Frontiers in Molecular Biosciences, May 2023, Frontiers

    Mariagrazia Grilli

  6. Heterogenous response to aging of astrocytes in murine Substantia Nigra pars compacta and pars reticulata

    Article • Neurobiology of Aging, March 2023, Elsevier

    Mariagrazia Grilli

  7. Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction

    Article • Cell Death and Disease, October 2022, Springer Science + Business Media

    Mariagrazia Grilli

  8. Complex and regional-specific changes in the morphological complexity of GFAP+ astrocytes in middle-aged mice

    Article • Neurobiology of Aging, April 2021, Elsevier

    Mariagrazia Grilli

  9. β2 and α2 adrenergic receptors mediate the proneurogenic in vitro effects of norquetiapine

    Article • Neural Regeneration Research, January 2021, Medknow

    Mariagrazia Grilli

  10. Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Mariagrazia Grilli

  11. Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice

    Article • Cell Death and Disease, August 2020, Springer Science + Business Media

    Mariagrazia Grilli

  12. Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome

    Article • Neurobiology of Disease, July 2020, Elsevier

    Mariagrazia Grilli

  13. Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model

    Article • Cell Death and Disease, April 2020, Springer Science + Business Media

    Mariagrazia Grilli

  14. Activation of β2 adrenergic receptors promotes adult hippocampal neurogenesis

    Article • Neural Regeneration Research, January 2020, Medknow

    Mariagrazia Grilli

  15. Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity

    Article • Frontiers in Pharmacology, November 2019, Frontiers

    Mariagrazia Grilli

  16. Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na + /K + ATPase

    Article • Glia, October 2019, Wiley

    Mariagrazia Grilli

  17. Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner

    Article • Frontiers in Pharmacology, September 2019, Frontiers

    Mariagrazia Grilli

  18. Neonatal treatment with cyclosporine A restores neurogenesis and spinogenesis in the Ts65Dn model of Down syndrome

    Article • Neurobiology of Disease, September 2019, Elsevier

    Mariagrazia Grilli

  19. Tapentadol: an effective option for the treatment of back pain [Corrigendum]

    Article • Journal of Pain Research, June 2019, Dove Medical Press

    Ulderico Freo, Mariagrazia Grilli

  20. Pharmacological rationale for tapentadol therapy: a review of new evidence

    Article • Journal of Pain Research, May 2019, Dove Medical Press

    Mariagrazia Grilli, Prof. Massimo COLLINO

  21. Tapentadol: an effective option for the treatment of back pain

    Article • Journal of Pain Research, May 2019, Dove Medical Press

    Mariagrazia Grilli, Ulderico Freo

  22. Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model

    Article • Cell Death and Disease, January 2019, Springer Science + Business Media

    Mariagrazia Grilli

  23. Advances in stem cell therapy for amyotrophic lateral sclerosis

    Article • Expert Opinion on Biological Therapy, July 2018, Taylor & Francis

    Mariagrazia Grilli, Rosario Sanchez Pernaute, Maurizio Gelati

  24. Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling

    Article • The International Journal of Neuropsychopharmacology, June 2018, Oxford University Press (OUP)

    Mariagrazia Grilli

  25. Treatment with corn oil improves neurogenesis and cognitive performance in the Ts65Dn mouse model of Down syndrome

    Article • Brain Research Bulletin, June 2018, Elsevier

    Mariagrazia Grilli

  26. Melanocortin 4 receptor stimulation improves social deficits in mice through oxytocin pathway

    Article • Neuropharmacology, May 2018, Elsevier

    Mariagrazia Grilli

  27. Every Cloud Has a Silver Lining: Proneurogenic Effects of Aβ Oligomers and HMGB-1 via Activation of the RAGE-NF-κB Axis

    Article • CNS & Neurological Disorders - Drug Targets, March 2018, Bentham Science Publishers

    Mariagrazia Grilli

  28. TGF-β2 and TGF-β3 from cultured β-amyloid-treated or 3xTg-AD-derived astrocytes may mediate astrocyte-neuron communication

    Article • European Journal of Neuroscience, January 2018, Wiley

    Mariagrazia Grilli

  29. l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug

    Article • International Journal of Molecular Sciences, December 2017, MDPI AG

    Mariagrazia Grilli

  30. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS

    Article • December 2017, Elsevier

    Mariagrazia Grilli

  31. Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies

    Article • Journal of Pain Research, September 2017, Dove Medical Press

    Mariagrazia Grilli

  32. Proneurogenic Effects of Trazodone in Murine and Human Neural Progenitor Cells

    Article • ACS Chemical Neuroscience, July 2017, American Chemical Society (ACS)

    Mariagrazia Grilli

  33. Opiate Analgesics as Negative Modulators of Adult Hippocampal Neurogenesis: Potential Implications in Clinical Practice

    Article • Frontiers in Pharmacology, May 2017, Frontiers

    Mariagrazia Grilli

  34. Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells

    Article • Neural Regeneration Research, January 2017, Medknow

    Mariagrazia Grilli

  35. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

    Article • December 2016, Elsevier

    Mariagrazia Grilli

  36. Cell autonomous and noncell-autonomous role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells

    Article • Glia, October 2016, Wiley

    Mariagrazia Grilli

  37. New insights on trazodone effect in promoting neuronal differentiation of adult murine hippocampal neural progenitor cells

    Article • European Neuropsychopharmacology, October 2016, Elsevier

    Mariagrazia Grilli

  38. Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice

    Article • Cerebral Cortex, March 2016, Oxford University Press (OUP)

    Mariagrazia Grilli

  39. Not only a bad guy: potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain

    Article • Neural Regeneration Research, January 2016, Medknow

    Mariagrazia Grilli

  40. Dopamine Receptor Agonists for Protection and Repair in Parkinson's Disease: An Update

    Article • February 2015, Bentham Science Publishers

    Mariagrazia Grilli, Dr Giovanna Cenini

  41. Early growth response 2 (Egr-2) expression is triggered by NF-κB activation

    Article • January 2015, Elsevier

    Mariagrazia Grilli

  42. The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells

    Article • Neural Plasticity, January 2015, Hindawi Publishing Corporation

    Mariagrazia Grilli

  43. Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

    Article • October 2014, Elsevier

    Mariagrazia Grilli

  44. The Noradrenergic Component in Tapentadol Action Counteracts μ-Opioid Receptor–Mediated Adverse Effects on Adult Neurogenesis

    Article • Molecular Pharmacology, February 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Mariagrazia Grilli

  45. NF-κB Mediated Regulation of Adult Hippocampal Neurogenesis: Relevance to Mood Disorders and Antidepressant Activity

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Mariagrazia Grilli

  46. Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine

    Article • Neuropsychopharmacology, May 2013, Springer Science + Business Media

    Mariagrazia Grilli

  47. High-Mobility Group Box-1 Protein and  -Amyloid Oligomers Promote Neuronal Differentiation of Adult Hippocampal Neural Progenitors via Receptor for Advanced Glycation End Products/Nuclear Factor- B Axis: Relevance for Alzheimer's Disease

    Article • Journal of Neuroscience, April 2013, Society for Neuroscience

    Mariagrazia Grilli

  48. Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

    Article • Bioorganic & Medicinal Chemistry Letters, December 2012, Elsevier

    Mariagrazia Grilli

  49. α2δ Ligands Act as Positive Modulators of Adult Hippocampal Neurogenesis and Prevent Depression-Like Behavior Induced by Chronic Restraint Stress

    Article • Molecular Pharmacology, May 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Mariagrazia Grilli

  50. NF-κB Proteins in Adult Neurogenesis: Relevance for Learning and Memory in Physiology and Pathology

    Article • March 2012, Bentham Science Publishers

    Mariagrazia Grilli

  51. Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

    Article • Bioorganic & Medicinal Chemistry Letters, February 2012, Elsevier

    Mariagrazia Grilli

  52. F640 DISTINCT DIFFERENCES BETWEEN TAPENTADOL AND MORPHINE IN AN IN VITRO MODEL OF ADULT NEUROGENESIS

    Article • European Journal of Pain Supplements, September 2011, Wiley

    Mariagrazia Grilli

  53. Nuclear Factor  B-Dependent Neurite Remodeling Is Mediated by Notch Pathway

    Article • Journal of Neuroscience, August 2011, Society for Neuroscience

    Mariagrazia Grilli

  54. A novel role for the Receptor for Advanced Glycation End-products in neural progenitor cells derived from adult SubVentricular Zone

    Article • October 2010, Elsevier

    Mariagrazia Grilli

  55. A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties

    Article • Bioorganic & Medicinal Chemistry Letters, April 2010, Elsevier

    Mariagrazia Grilli

  56. Tricyclic thienopyridine–pyrimidones/thienopyrimidine–pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain

    Article • Bioorganic & Medicinal Chemistry Letters, June 2009, Elsevier

    Mariagrazia Grilli

  57. Astroglial-NF-kB is a critical regulator of learning and memory and hippocampal neurogenesis in female mice

    Article • Frontiers in Behavioral Neuroscience, January 2009, Frontiers

    Mariagrazia Grilli

  58. Adult dorsal root ganglia sensory neurons express the early neuronal fate marker doublecortin

    Article • The Journal of Comparative Neurology, November 2008, Wiley

    Mariagrazia Grilli

  59. Dopamine Receptor Agonists for Protection and Repair in Parkinsons Disease

    Article • Current Topics in Medicinal Chemistry, August 2008, Bentham Science Publishers

    Mariagrazia Grilli

  60. Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF- B p50-Deficient Mice

    Article • Journal of Neuroscience, April 2008, Society for Neuroscience

    Mariagrazia Grilli

  61. Ecdysone-Based System for Controlled Inducible Expression of Metabotropic Glutamate Receptor Subtypes 2, 5, and 8

    Article • SLAS DISCOVERY, December 2005, SAGE Publications

    Mariagrazia Grilli

  62. Erratum to “Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice” [Behav. Brain Res. 160 (2005) 344–355]

    Article • Behavioural Brain Research, September 2005, Elsevier

    Mariagrazia Grilli

  63. Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

    Article • Behavioural Brain Research, May 2005, Elsevier

    Mariagrazia Grilli

  64. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles

    Article • Psychopharmacology, January 2005, Springer Science + Business Media

    Mariagrazia Grilli

  65. Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain

    Article • Developmental Brain Research, January 2005, Elsevier

    Mariagrazia Grilli

  66. Long-lasting induction of Notch2 in the hippocampus of kainate-treated adult mice

    Article • Neuroreport, May 2003, Wolters Kluwer Health

    Mariagrazia Grilli

  67. Long-lasting induction of Notch2 in the hippocampus of kainate-treated adult mice

    Article • Neuroreport, May 2003, Wolters Kluwer Health

    Mariagrazia Grilli

  68. Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

    Article • Journal of Biological Chemistry, March 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Mariagrazia Grilli

  69. Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically

    Article • Proceedings of the National Academy of Sciences, November 2000, Proceedings of the National Academy of Sciences

    Mariagrazia Grilli

  70. Induction of p53 in the glutamate-induced cell death program

    Article • Amino Acids, August 2000, Springer Science + Business Media

    Mariagrazia Grilli

  71. Contribution of NF-κB and p53 in the glutamate-induced apoptosis

    Article • International Journal of Developmental Neuroscience, July 2000, Elsevier

    Mariagrazia Grilli

  72. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage

    Article • July 2000, Wiley

    Mariagrazia Grilli

  73. Nuclear factor-κB/Rel proteins

    Article • Biochemical Pharmacology, January 1999, Elsevier

    Mariagrazia Grilli

  74. Possible role of NF-κB and p53 in the glutamate-induced pro-apoptotic neuronal pathway

    Article • Cell Death and Differentiation, January 1999, Springer Science + Business Media

    Mariagrazia Grilli

  75. Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids

    Article • European Journal of Neuroscience, January 1998, Wiley

    Mariagrazia Grilli

  76. Transcriptional pharmacology of neurodegenerative disorders: novel venue towards neuroprotection against excitotoxicity?

    Article • Molecular Psychiatry, May 1997, Springer Science + Business Media

    Mariagrazia Grilli

  77. Regulation of Mouse Neuropeptide Y Y1 Receptor Gene Transcription: A Potential Role for Nuclear Factor-κB/Rel Proteins

    Article • Molecular Pharmacology, January 1997, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Mariagrazia Grilli

  78. Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-kappa B Activation

    Article • Science, November 1996, American Association for the Advancement of Science

    Mariagrazia Grilli

  79. Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures

    Article • Journal of Biological Chemistry, June 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Mariagrazia Grilli

  80. Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

    Article • Journal of Biological Chemistry, November 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Mariagrazia Grilli

  81. Opposing regulation of amyloid precursor protein by ionotropic and metabotropic glutamate receptors

    Article • Neuroreport, June 1995, Wolters Kluwer Health

    Mariagrazia Grilli

  82. Molecular mechanisms of glutamate-induced neurodegeneration

    Article • International Review of Psychiatry, January 1995, Taylor & Francis

    Mariagrazia Grilli

  83. Tumor necrosis factor α mediates a T cell receptor-independent induction of the gene regulatory factor NF-κB in T lymphocytes

    Article • Molecular Immunology, October 1993, Elsevier

    Mariagrazia Grilli

  84. IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

    Article • January 1993, Elsevier

    Mariagrazia Grilli

  85. NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes

    Article • Science, June 1992, American Association for the Advancement of Science

    Mariagrazia Grilli

  86. Molecular mechanisms involved in transport and release of dopamine in primary cultures of mesencephalic neurons

    Article • Neurochemistry International, March 1992, Elsevier

    Mariagrazia Grilli

  87. A Novel Nuclear Factor Binds to the NF-ΚB Motif in the Interleukin-2 Enhancer

    Article • January 1992, Springer Science + Business Media

    Mariagrazia Grilli

  88. Characterization of [3H]Dopamine Uptake Sites and [3H]Cocaine Recognition Sites in Primary Cultures of Mesencephalic Neurons During In Vitro Development

    Article • Journal of Neurochemistry, June 1991, Wiley

    Mariagrazia Grilli

  89. Evidence for the involvement of distinct voltage-sensitive calcium channels in the release of 3H-dopamine from primary cultures of mesencephalic neurons

    Article • Neuropharmacology, November 1989, Elsevier

    Mariagrazia Grilli

  90. Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus

    Article • Neuroscience Letters, May 1988, Elsevier

    Mariagrazia Grilli

  91. Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. I. Frontal cortex

    Article • Neuroscience Letters, May 1988, Elsevier

    Mariagrazia Grilli