All Stories

  1. The Role of Lactate Metabolism in Tumors
  2. Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023
  3. Autophagy–senescence interplay in kidney disease: mechanistic insights and therapeutic potential
  4. Exposure–Response Analysis of Efsubaglutide Alfa in Patients with Type 2 Diabetes Mellitus
  5. Global burden of rheumatic vs non-rheumatic valvular heart disease, 1990–2021: a systematic analysis of the global burden of disease study
  6. Flavonoids in Metabolic Disease: A Narrative Review of Mechanisms and Therapeutic Potential
  7. Ribosome collisions and ZAKα activation: explores the therapeutic potential of metabolic diseases
  8. Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study...
  9. Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
  10. METTL3-mediated m6A methylation: implications for diabetes pathogenesis and therapeutic potential
  11. The role and therapeutic potential of exosome-mediated microRNAs regulatory networks in diabetic kidney disease
  12. Efficacy and safety benefits of HR17031 , a fixed‐ratio combination of INS068 and noiiglutide, versus its components alone in Chinese patients with ty...
  13. Pathophysiology of type 2 diabetes: A focus on the metabolic differences among southeast Asian, Chinese and Indian populations and how this impacts treatment
  14. Multimodal Neuroimaging of Brain Structure, Metabolism, and Function in Obesity: Current Landscape and Future Perspectives
  15. Global epidemiology and burden of type 2 diabetes in adults aged 55 and older: insights from 1990 to 2021
  16. The global, regional, and national burden and attributable risk factors of Alzheimer's disease and other dementias, 1990-2021: A systematic analysis for the Global Burden of Disease Study
  17. Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies
  18. Global burden and future trends of metabolic dysfunction-associated Steatotic liver disease: 1990-2021 to 2045
  19. Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications
  20. Glycerophospholipid and Sphingosine- 1-phosphate Metabolism in Cardiovascular Disease: Mechanisms and Therapeutic Potential
  21. Revolutionizing public health through digital health technology
  22. Empagliflozin alleviates obesity-related cardiac dysfunction via the activation of SIRT3-mediated autophagosome formation
  23. The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities
  24. Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
  25. Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review
  26. The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy
  27. Environmental toxicology of bisphenol A: Mechanistic insights and clinical implications on the neuroendocrine system
  28. Unraveling the role of the FHL family in cardiac diseases: Mechanisms, implications, and future directions
  29. The role of a novel mineralocorticoid receptor antagonist, finerenone, in chronic kidney disease: mechanisms and clinical advances
  30. Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health
  31. BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases
  32. Changing trends of the diseases burden attributable to high BMI in Asia from 1990 to 2019: results from the global burden of disease study 2019
  33. Secreted frizzled-related protein 5: A promising therapeutic target for metabolic diseases via regulation of Wnt signaling
  34. Secreted frizzled-related proteins: A promising therapeutic target for cancer therapy through Wnt signaling inhibition
  35. Role of dysfunctional peri-organ adipose tissue in metabolic disease
  36. Editorial: Incretin agonists in the treatment of obesity
  37. Mechanisms and efficacy of traditional Chinese herb monomers in diabetic kidney disease
  38. Global, Regional, and National Epidemiology of Diabetes in Children From 1990 to 2019
  39. Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
  40. Editorial: Clinical and genetic determinants of diabetes and complications
  41. Optimizing glycation control in diabetes: An integrated approach for inhibiting nonenzymatic glycation reactions of biological macromolecules
  42. Editorial: The impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II
  43. Global, Regional, and National Burden of Pancreatic Cancer, 1990–2019: Results from the Global Burden of Disease Study 2019
  44. Editorial: Aging and chronic disease: public health challenge and education reform
  45. NTRK fusions in thyroid cancer: Pathology and clinical aspects
  46. Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019
  47. Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance (Review)
  48. Global burden of non-alcoholic fatty liver disease in 204 countries and territories from 1990 to 2019
  49. Integrated multi-omics analyses reveal effects of empagliflozin on intestinal homeostasis in high-fat-diet mice
  50. Identification of Potential Indicators for Survival in Patients with Thyroid Cancer Based on Expression of FAM3 Members
  51. Advances in Understanding the Roles of Mesenchymal Stem Cells in Lung Cancer
  52. Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells
  53. Irisin protects against obesity-related chronic kidney disease by regulating perirenal adipose tissue function in obese mice
  54. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2019
  55. Glutaminolysis and CD4+ T-cell metabolism in autoimmunity: From pathogenesis to therapy prospects
  56. Empagliflozin activates Sestrin2-mediated AMPK/mTOR pathway and ameliorates lipid accumulation in obesity-related nonalcoholic fatty liver disease
  57. The protective effects of SGLT-2 inhibitors, GLP-1 receptor agonists, and RAAS blockers against renal injury in patients with type 2 diabetes
  58. COL1A1: A novel oncogenic gene and therapeutic target in malignancies
  59. The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Diabetes Mellitus
  60. Empagliflozin Attenuates Obesity-Related Kidney Dysfunction and NLRP3 Inflammasome Activity Through the HO-1–Adiponectin Axis
  61. Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy
  62. Thyroid Cancer and COVID-19: Prospects for Therapeutic Approaches and Drug Development
  63. Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension
  64. Novel HNF1A gene mutation in maturity-onset diabetes of the young: A case report
  65. Doctor of Public Health-Crisis Management and COVID-19 Prevention and Control: A Case Study in China
  66. Online Education Plight and Countermeasures for MBBS in Chinese Regional Medical Schools Based on the OBE Concept During COVID-19 Pandemic
  67. Editorial: The Impact of Adipose Tissue Dysfunction on Cardiovascular and Renal Disease
  68. Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway
  69. Comprehensive Analysis of Tumor Immune Microenvironment and Prognosis of m6A-Related lncRNAs in Lung Adenocarcinoma
  70. Association between serum Sestrin2 level and diabetic peripheral neuropathy in type 2 diabetic patients
  71. Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease
  72. A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
  73. Mortality Risk of Antidiabetic Agents for Type 2 Diabetes With COVID-19: A Systematic Review and Meta-Analysis
  74. Identification of tRNA-derived Fragments and Their Potential Roles in Atherosclerosis
  75. Comprehensive overview of human serum albumin glycation in diabetes mellitus
  76. DL‑3‑n‑butylphthalide protects H9c2 cardiomyoblasts from ischemia/reperfusion injury by regulating HSP70 expression via PI3K/AKT pathway activation
  77. The analgesic efficacy of extracorporeal shock wave combined with percutaneous vertebroplasty in the treatment of osteoporotic thoracolumbar compression fractures in postmenopausal women
  78. Growth differentiation factor 11: a “rejuvenation factor” involved in regulation of age-related diseases?
  79. How to recognize and respond to viral re-positivity and disease relapse in patients with COVID-19
  80. Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes
  81. Attaching clinical significance to COVID-19-associated diarrhea
  82. Identification of Potential Indicators for Survival in Patients With Thyroid Cancer Based on Mrna Expression Levels of Family With Sequence Similarity 3 Members
  83. Liraglutide improves obesity‐induced renal injury by alleviating uncoupling of the glomerular VEGF–NO axis in obese mice
  84. Epidemiology and clinical characteristics of 43 COVID-19 patients in Weifang, China
  85. Bioinformatic and biochemical findings disclosed anti-hepatic steatosis mechanism of calycosin
  86. SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion
  87. Novel insight into perirenal adipose tissue: A neglected adipose depot linking cardiovascular and chronic kidney disease
  88. Decreased shedding dipeptidyl peptidase 4 from membrane in Hashimoto's thyroiditis
  89. Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet–Induced Obese Mice
  90. Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway
  91. Empagliflozin attenuates ischemia and reperfusion injury through LKB1/AMPK signaling pathway
  92. Identification of Potential Indicators for Survival in Patients with Thyroid Cancer Based on mRNA Expression Levels of Family with Sequence Similarity 3 Members
  93. Liraglutide improves vascular dysfunction by regulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue in obese mice
  94. A Meta-Analysis of Pregnancy Outcomes with Levothyroxine Treatment in Euthyroid Women with Thyroid Autoimmunity
  95. AMPK: a balancer of the renin–angiotensin system
  96. AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases
  97. AMPK: a therapeutic target of heart failure—not only metabolism regulation
  98. Screening of differentially expressed proteins from syncytiotrophoblast for severe early-onset preeclampsia in women with gestational diabetes mellitus using tandem mass tag quantitative proteomics
  99. Calycosin directly improves perivascular adipose tissue dysfunction by upregulating the adiponectin/AMPK/eNOS pathway in obese mice
  100. C1q/TNF-related protein 9 improves the anti-contractile effects of perivascular adipose tissue via the AMPK-eNOS pathway in diet-induced obese mice
  101. Irisin Improves Endothelial Dysfunction through Perivascular Adipose Tissue
  102. Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice
  103. Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway
  104. Renal protective effects of induction of haem oxygenase-1 combined with increased adiponectin on the glomerular vascular endothelial growth factor-nitric oxide axis in obese rats
  105. Induction of Haemeoxygenase-1 Directly Improves Endothelial Function in Isolated Aortas from Obese Rats through the Ampk-Pi3k/Akt-Enos Pathway
  106. Induction of Haemeoxygenase-1 Improves FFA-Induced Endothelial Dysfunction in Rat Aorta
  107. The relationship between circulating irisin levels and endothelial function in lean and obese subjects
  108. Protective effects of adiponectin on uncoupling of glomerular VEGF–NO axis in early streptozotocin-induced type 2 diabetic rats
  109. Perirenal fat associated with microalbuminuria in obese rats
  110. Effect of high free fatty acids on the anti-contractile response of perivascular adipose tissue in rat aorta
  111. High FFA levels related to microalbuminuria and uncoupling of VEGF-NO axis in obese rats
  112. Sonographic evaluation of para- and perirenal fat thickness is an independent predictor of early kidney damage in obese patients
  113. The effect of telomerase activity on vascular smooth muscle cell proliferation in type 2 diabetes in vivo and in vitro
  114. Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats
  115. Time–Action Profile of an Oral Enteric Insulin Formulation in Healthy Chinese Volunteers
  116. Correlation of ultrasonographic measurement of intrarenal arterial resistance index with microalbuminuria in nonhypertensive, nondiabetic obese patients
  117. Blockers of sulfonylureas receptor 1 subunits may lead to cardiac protection against isoprenaline-induced injury in obese rats
  118. Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK–eNOS pathways
  119. High free fatty acids level related with cardiac dysfunction in obese rats
  120. Effect of Aspirin on the Expression of Hepatocyte NF-κB and Serum TNF-α in Streptozotocin-Induced Type 2 Diabetic Rats
  121. Effect of polysaccharides of theEuphoria longan(Lour.) Steud on inflammatory response induced by focal cerebral ischemia/reperfusion injury in rats