All Stories

  1. Methods for evaluating variability in human health dose–response characterization
  2. Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor
  3. Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
  4. An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core
  5. Screening the ToxCast Phase I and II libraries for acute neurotoxicity using cortical neurons grown on multi-well microelectrode array (mwMEA) plates
  6. An evaluation of 25 selected ToxCast chemicals in medium-throughput assays to detect genotoxicity
  7. Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor
  8. Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds
  9. Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses
  10. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
  11. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
  12. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
  13. Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform
  14. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells
  15. Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays
  16. Characterization of physicochemical properties of nanomaterials and their immediate environments in high-throughput screening of nanomaterial biological activity
  17. ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling
  18. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management
  19. Zebrafish developmental screening of the ToxCast™ Phase I chemical library
  20. Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential
  21. Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening
  22. Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
  23. Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment
  24. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
  25. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
  26. Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
  27. Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity
  28. Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals
  29. Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program
  30. In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
  31. Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals
  32. Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems
  33. The Toxicity Data Landscape for Environmental Chemicals
  34. ACToR — Aggregated Computational Toxicology Resource
  35. Understanding mechanisms of toxicity: Insights from drug discovery research
  36. The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals
  37. Reporter Gene Assays for Drug Discovery
  38. Screening for Activators of the Wingless Type/Frizzled Pathway by Automated Fluorescent Microscopy
  39. Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin
  40. High-Content Screening Assay for Activators of the Wnt/Fzd Pathway in Primary Human Cells
  41. T0901317 is a dual LXR/FXR agonist
  42. Retinoid X Receptor Is a Nonsilent Major Contributor to Vitamin D Receptor-Mediated Transcriptional Activation
  43. Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene
  44. Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins
  45. The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies
  46. The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA
  47. The vascular endothelial growth factor family of polypeptides
  48. Hepatopoietins A and B and hepatocyte growth
  49. Acidic fibroblast growth factor (HBGF-1) stimulates DNA synthesis in primary rat hepatocyte cultures
  50. Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type ?
  51. Norepinephrine modulates the growth-inhibitory effect of transforming growth factor-beta in primary rat hepatocyte cultures
  52. Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture
  53. Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture
  54. Proline is required for the stimulation of DNA synthesis in hepatocyte cultures by EGF