All Stories

  1. Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space
  2. Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays
  3. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries
  4. Expanding the test set: Chemicals with potential to disrupt mammalian brain development
  5. Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure
  6. Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor
  7. TOxRTool and Toxicology Data
  8. Regulatory Roadmap for Developmental Neurotoxicity Testing
  9. Adverse Outcome Pathways for Neurotoxicity
  10. The Human Toxome Project
  11. International STakeholder NETwork (ISTNET) for Developmental Neurotoxicity Testing (DNT)
  12. Developmental Neurotoxicity Guidelines
  13. AOPs and IATAs
  14. Pyrethroid Mixture Kinetics
  15. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
  16. Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening
  17. t4 workshop report: Pathways of Toxicity
  18. Thyroid Peroxidase Screening
  19. Triclosan Human Rat Nuclear Receptors
  20. Current Perspectives on the Use of Alternative Species in Human Health and Ecological Hazard Assessments
  21. Thyroid Hormone Disruptors and In Vitro Screening
  22. An Empirical Approach to Sufficient Similarity: Combining Exposure Data and Mixtures Toxicology Data
  23. Evaluation of Iodide Deficiency in the Lactating Rat and Pup Using a Biologically Based Dose-Response Model
  24. An Animal Model of Marginal Iodine Deficiency During Development: The Thyroid Axis and Neurodevelopmental Outcome
  25. Juvenile toxicity testing protocols for chemicals
  26. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action
  27. Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals
  28. In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis
  29. Developmental neurotoxicity testing: A path forward
  30. Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regulation*
  31. Environmentally Relevant Mixtures in Cumulative Assessments: An Acute Study of Toxicokinetics and Effects on Motor Activity in Rats Exposed to a Mixture of Pyrethroids
  32. Optimal Design for the Precise Estimation of an Interaction Threshold: The Impact of Exposure to a Mixture of 18 Polyhalogenated Aromatic Hydrocarbons
  33. Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
  34. Commentary on Use of Commercial Pyrethroids
  35. Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework
  36. Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture
  37. Marginal iodide deficiency and thyroid function: Dose–response analysis for quantitative pharmacokinetic modeling
  38. Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment
  39. Using a Chemical Mixture of Pyrethroid Pesticides to Determine Rodent Tissue Clearance Rates
  40. Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study
  41. Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats
  42. Gene expression in developing brain is altered by modest reductions in circulating levels of thyroid hormone
  43. Behavioral toxicology in the 21st century: Challenges and opportunities for behavioral scientists
  44. Splice variant specific increase in Ca2+/calmodulin-dependent protein kinase 1-gamma mRNA expression in response to acute pyrethroid exposure
  45. Developmental neurotoxicity - Recommendations for chemical screening
  46. Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology
  47. Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis
  48. Short-term Exposure to Triclosan Decreases Thyroxine In Vivo via Upregulation of Hepatic Catabolism in Young Long-Evans Rats
  49. In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats
  50. Thyroid Hormone Disruptors and Mixture Additivity
  51. In Vivo Acute Exposure to Polychlorinated Biphenyls: Effects on Free and Total Thyroxine in Rats
  52. Developmental neurotoxicity and thyroid hormone disruptors: Past, present and future
  53. Evidence for Dose-Additive Effects of Pyrethroids on Motor Activity in Rats
  54. Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes
  55. The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats
  56. A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426
  57. Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making
  58. Undertaking positive control studies as part of developmental neurotoxicity testing
  59. Identification and interpretation of developmental neurotoxicity effects
  60. DNT Database
  61. Thyroid disrupting chemicals: mechanisms and mixtures
  62. Transcriptional Response of Rat Frontal Cortex following Acute In Vivo Exposure to the Pyrethroid Insecticides Permethrin and Deltamethrin
  63. Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/β1 expressing Xenopus laevis oocytes
  64. Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine
  65. The Flame Retardants, Polybrominated Diphenyl Ethers, Are Pregnane X Receptor Activators
  66. Influence of dosing volume on the neurotoxicity of bifenthrin
  67. The impact of exposure to a mixture of eighteen polyhalogenated aromatic hydrocarbons on thyroid function: Estimation of an interaction threshold
  68. In Vitro Methods for Developmental Neurotoxicity Testing
  69. Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126
  70. Confounds with use of commercial products in toxicity research - Deltamethrin
  71. Inhalational Exposure to Carbonyl Sulfide Produces Altered Brainstem Auditory and Somatosensory-Evoked Potentials in Fischer 344N Rats
  72. Bromate: Concern for developmental neurotoxicity?
  73. Effect of PCB 126 on Hepatic Metabolism of Thyroxine and Perturbations in the Hypothalamic-Pituitary-Thyroid Axis in the Rat
  74. Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats
  75. Thyroid-Hormone–Disrupting Chemicals: Evidence for Dose-Dependent Additivity or Synergism
  76. Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes☆
  77. Behavioral test methods workshop
  78. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine
  79. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of methylphenidate
  80. Overview: Using Mode of Action and Life Stage Information to Evaluate the Human Relevance of Animal Toxicity Data
  81. Mode of Action: Neurotoxicity Induced by Thyroid Hormone Disruption During Development—Hearing Loss Resulting From Exposure to PHAHs
  82. Mode of Action: Developmental Thyroid Hormone Insufficiency—Neurological Abnormalities Resulting From Exposure to Propylthiouracil
  83. Thyroid Hormones and Correlation with Hearing Loss
  84. Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs
  85. Accumulation of PBDE-47 in Primary Cultures of Rat Neocortical Cells
  86. A qualitative retrospective analysis of positive control data in developmental neurotoxicity studies
  87. Assessment of DE-71, a Commercial Polybrominated Diphenyl Ether (PBDE) Mixture, in the EDSP Male and Female Pubertal Protocols
  88. Perinatal Exposure to Aroclor 1254 Impairs Distortion Product Otoacoustic Emissions (DPOAEs) in Rats
  89. Comparative Responsiveness of Hypothyroxinemia and Hepatic Enzyme Induction in Long-Evans Rats Versus C57BL/6J Mice Exposed to TCDD-like and Phenobarbital-like Polychlorinated Biphenyl Congeners
  90. Schedule-controlled behavior in rats exposed perinatally to the PCB mixture Aroclor 1254
  91. PBDEs and Development Thyroid Disruption
  92. Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254
  93. Spatial Reversal Learning in Aroclor 1254-Exposed Rats: Sex-Specific Deficits in Associative Ability and Inhibitory Control
  94. Effects of Short-Term in Vivo Exposure to Polybrominated Diphenyl Ethers on Thyroid Hormones and Hepatic Enzyme Activities in Weanling Rats
  95. Developmental Neurotoxicity Testing - Reveiw of Behavioral Methods
  96. Methods to Identify and Characterize Developmental Neurotoxicity for Human Health Risk Assessment. I: Behavioral Effects
  97. Spatial Learning and Long-Term Potentiation in the Dentate Gyrus of the Hippocampus in Animals Developmentally Exposed to Aroclor 1254
  98. PCBs, Thyroid Hormones, and Ototoxicity in Rats: Cross-Fostering Experiments Demonstrate the Impact of Postnatal Lactation Exposure
  99. Gestational-Lactational Exposure to Aroclor 1254 Impairs Radial-Arm Maze Performance in Male Rats
  100. Hearing loss following exposure during development to polychlorinated biphenyls: A cochlear site of action
  101. Neurotoxic and Pharmacokinetic Responses to Trichloroethylene as a Function of Exposure Scenario
  102. PCBs, thyroid hormones and learning
  103. Screening methods for thyroid hormone disruptors
  104. Low-Frequency Hearing Loss Following Perinatal Exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) in Rats11This manuscript has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publicatio...
  105. Screening Methods for Thyroid Hormone Disruptors
  106. Thyroxine Replacement Attenuates Hypothyroxinemia, Hearing Loss, and Motor Deficits Following Developmental Exposure to Aroclor 1254 in Rats,
  107. Trichloroethylene Ototoxicity: Evidence for a Cochlear Origin,
  108. Trichloroethylene Ototoxicity: Evidence for a Cochlear Origin
  109. Thyroxine Replacement Attenuates Hypothyroxinemia, Hearing Loss, and Motor Deficits Following Developmental Exposure to Aroclor 1254 in Rats
  110. The Ototoxicity of Trichloroethylene: Extrapolation and Relevance of High-Concentration, Short-Duration Animal Exposure Data,
  111. Effect of Methimazole, an FMO Substrate and Competitive Inhibitor, on the Neurotoxicity of 3,3′-Iminodipropionitrile in Male Rats,
  112. Developmental Exposure to Aroclor 1254 Produces Low-Frequency Alterations in Adult Rat Brainstem Auditory Evoked Responses,
  113. The Impact of Dose Rate on the Neurotoxicity of Acrylamide: The Interaction of Administered Dose, Target Tissue Concentrations, Tissue Damage, and Functional Effects
  114. Re: The Use of Uncertainty Factors in Estimating Health Risks
  115. Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats
  116. Setting exposure standards: a decision process
  117. Setting Exposure Standards: A Decision Process
  118. A structure-activity relationship for the neurotoxicity of triazole fungicides
  119. Characterization of Olfactory Deficits in the Rat Following Administration of 2,6-Dichlorobenzonitrile (Dichlobenil), 3,3′-Iminodipropionitrile, or Methimazole
  120. Re: The Use of Uncertainty Factors in Estimating Health Risks
  121. Developmental Exposure to Aroclor 1254 Produces Low-Frequency Alterations in Adult Rat Brainstem Auditory Evoked Responses
  122. Characterization of Olfactory Deficits in the Rat Following Administration of 2,6-Dichlorobenzonitrile (Dichlobenil), 3,3′-Iminodipropionitrile, or Methimazole
  123. Alterations in flash evoked potentials (FEPs) in rats produced by 3,3′-iminodipropionitrile (IDPN),
  124. Effects of Developmental Hypothyroidism on Auditory and Motor Function in the Rat
  125. Developmental Exposure to Polychlorinated Biphenyls (Aroclor 1254) Reduces Circulating Thyroid Hormone Concentrations and Causes Hearing Deficits in Rats
  126. Assessment of Offspring Development and Behavior Following Gestational Exposure to Inhaled Methanol in the Rat
  127. Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat
  128. Implications of the use of neonatal birth weight, growth, viability, and survival data for predicting developmental neurotoxicity: A survey of the literature
  129. Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk
  130. Assessment of Offspring Development and Behavior Following Gestational Exposure to Inhaled Methanol in the Rat
  131. The ototoxicity of 3,3′-iminodipropionitrile: Functional and morphological evidence of cochlear damage
  132. Effects of 3,3′-iminodipropionitrile on acquisition and performance of spatial tasks in rats
  133. Solvent-induced ototoxicity in rats: An atypical selective mid-frequency hearing deficit
  134. Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury
  135. Relationships between Biomarkers of Exposure and Neurological Effects in a Group of Workers Exposed to Acrylamide
  136. Age Dependent Toxicity of Pyrethroid Insecticides
  137. Effects of toluene inhalation on detection of auditory signals in rats
  138. Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury
  139. Mid-frequency hearing loss in rats following inhalation exposure to trichloroethylene: Evidence from reflex modification audiometry
  140. The sensitivity to 3,3′-iminodipropionitrile differs for high-and midfrequency hearing loss in the developing rat
  141. Developmental neurotoxicity following neonatal exposure to 3,3′-iminodipropionitrile in the rat
  142. Characterization of Disulfoton-Induced Behavioral and Neurochemical Effects Following Repeated Exposure
  143. Characterization of Disulfoton-Induced Behavioral and Neurochemical Effects Following Repeated Exposure
  144. Behavioral development following daily episodes of mother-infant separation in the rat*1
  145. LETTERS TO THE EDITOR
  146. Motor Activity Testing and Neurotoxicity
  147. Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat
  148. The effects of 2,4-dithiobiuret on sensory and motor function*1
  149. Learning and memory deficits in rats following exposure to 3,3′-iminodipropionitrile
  150. Reflex modification and the detection of toxicant-induced auditory dysfunction
  151. Trimethyltin effects on auditory function and cochlear morphology
  152. Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats
  153. Evidence for monoaminergic involvement in triadimefon-induced hyperactivity
  154. Pyrethroids and enhanced inhibition in the hippocampus of the rat
  155. Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: Postnatal evaluation of teratology and behavior
  156. Acute effects of amitraz on the acoustic startle response and motor activity
  157. Pyrethroids Effects on Motor Activity and Startle
  158. Triadimefon Induces Hyperactivity
  159. The Effects of Type I and II Pyrethroids on Motor Activity and the Acoustic Startle Response in the Rat
  160. Pyrethroid effects on schedule-controlled behavior: Time and dosage relationships
  161. Pyrethroids Bind to GABA receptor
  162. Postnatal evaluation of prenatal exposure to p-xylene in the rat
  163. Pyrethroids and Neurotoxicity
  164. Developmental delays in exploration and locomotor activity in male rats exposed to low level lead