All Stories

  1. Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective

    Article • Journal of Pharmacological and Toxicological Methods, November 2022, Elsevier

    Dr Eric Dean Watt

  2. Early Drug-Induced Liver Injury Risk Screening: “Free,” as Good as It Gets

    Article • Toxicological Sciences, May 2022, Oxford University Press (OUP)

    Dr Eric Dean Watt

  3. Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters

    Article • European Journal of Pharmacology, December 2021, Elsevier

    Dr Eric Dean Watt

  4. Uncertainty quantification in ToxCast high throughput screening

    Article • PLOS One, July 2018, PLOS

    Dr Eric Dean Watt, Dr Richard S Judson

  5. QSAR models for thyroperoxidase inhibition and screening of U.S. and EU chemical inventories

    Article • Computational Toxicology, November 2017, Elsevier

    Dr Eric Dean Watt

  6. On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity

    Article • Regulatory Toxicology and Pharmacology, October 2017, Elsevier

    Dr Richard S Judson, Dr Eric Dean Watt

  7. Development and Validation of a Computational Model for Androgen Receptor Activity

    Article • Chemical Research in Toxicology, November 2016, American Chemical Society (ACS)

    Dr Nicole Kleinstreuer, Dr Eric Dean Watt

  8. High-Resolution NMR Studies of Human Tissue Factor

    Article • PLOS One, September 2016, PLOS

    Dr Eric Dean Watt

  9. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

    Article • Toxicological Sciences, February 2016, Oxford University Press (OUP)

    Dr Eric Dean Watt, Dr Kevin M Crofton

  10. Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum

    Article • Structure, October 2015, Elsevier

    Dr Eric Dean Watt

  11. Recent Advances in Solid-State Nuclear Magnetic Resonance Techniques to Quantify Biomolecular Dynamics

    Article • Analytical Chemistry, January 2014, American Chemical Society (ACS)

    Dr Eric Dean Watt

  12. Reengineering Rate-Limiting, Millisecond Enzyme Motions by Introduction of an Unnatural Amino Acid

    Article • Biophysical Journal, July 2011, Elsevier

    Dr Eric Dean Watt

  13. The Flexibility of a Distant Loop Modulates Active Site Motion and Product Release in Ribonuclease A

    Article • Biochemistry, August 2009, American Chemical Society (ACS)

    Dr Eric Dean Watt

  14. Characterizing Complex Dynamics in the Transactivation Response Element Apical Loop and Motional Correlations with the Bulge by NMR, Molecular Dynamics, and Mutagenesis

    Article • Biophysical Journal, October 2008, Elsevier

    Dr Eric Dean Watt

  15. Hydrogen exchange of monomeric α-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding inEscherichia coli

    Article • Protein Science, August 2008, Wiley

    Dr Eric Dean Watt

  16. Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion

    Article • Accounts of Chemical Research, February 2008, American Chemical Society (ACS)

    Dr Eric Dean Watt

  17. The mechanism of rate-limiting motions in enzyme function

    Article • Proceedings of the National Academy of Sciences, July 2007, Proceedings of the National Academy of Sciences

    Dr Eric Dean Watt

  18. Resolving the Motional Modes That Code for RNA Adaptation

    Article • Science, February 2006, American Association for the Advancement of Science

    Dr Eric Dean Watt