All Stories

  1. Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
  2. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes
  3. Developmental Expression of the Cytosolic Sulfotransferases in Human Liver
  4. Construction of a per- and polyfluoroalkyl substances (PFAS) screening library
  5. The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM)
  6. Application of epigenetic data in human health risk assessment
  7. Ontogeny of human hepatic CYP2C8 and CYP1A2
  8. FutureTox III: Bridges for Translation
  9. Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards
  10. Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models
  11. Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
  12. Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells
  13. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
  14. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
  15. Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporine, and deltamethrin
  16. Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting
  17. Raising the Bar for Reproducible Science at the U.S. Environmental Protection Agency Office of Research and Development
  18. Human Hepatic UGT2B15 Developmental Expression
  19. Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes
  20. Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children
  21. Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants
  22. Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
  23. A TIR domain receptor–associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth
  24. Amine Oxidases and Reductases
  25. Age-Dependent Expression of Human Drug-Metabolizing Enzymes
  26. A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia
  27. Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate
  28. The NFKB1 (g.-24519delATTG) Variant is Associated with Necrotizing Enterocolitis (NEC) in Premature Infants
  29. Hepatic differentiation of amniotic epithelial cells
  30. Human and environmental health challenges for the next decade (2010–2020)
  31. Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population
  32. Human hepatic CYP2B6 developmental expression: The impact of age and genotype
  33. Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein β (C/EBPβ) liver inhibitory and liver activating proteins
  34. Developmental Changes in Human Liver CYP2D6 Expression
  35. The ontogeny of drug metabolism enzymes and implications for adverse drug events
  36. Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
  37. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
  38. Identification and Functional Analysis of a Novel Human CYP2E1 Far Upstream Enhancer
  39. Phase I Biotransformation Reactions-Flavin Monooxygenase
  40. Mechanisms Regulating HumanFMO3Transcription
  41. Ontogeny of human hepatic cytochromes P450
  42. Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants
  43. Epirubicin Glucuronidation and UGT2B7 Developmental Expression
  44. Pharmacogenomics and the Future of Drug Therapy
  45. Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: II. Expression and Role of Flavin-Containing Monooxygenases and Peroxidases
  46. Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450
  47. Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene
  48. Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model
  49. Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3
  50. A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment
  51. The Role of Flavin-Containing Monooxygenase (FMO) in the Metabolism of Tamoxifen and Other Tertiary Amines
  52. Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver
  53. Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development
  54. MOLECULAR MECHANISMS REGULATING HUMAN CYP4B1 LUNG-SELECTIVE EXPRESSION
  55. SP1 AND SP3 REGULATE BASAL TRANSCRIPTION OF THE HUMAN CYP2F1 GENE
  56. Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Variants
  57. DIFFERENCES IN FMO2*1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT
  58. Two distinct classes of CCAAT box elements that bind nuclear factor-Y/?-actinin-4: potential role in human CYP1A1 regulation
  59. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine
  60. Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
  61. Developmental Expression of the Major Human Hepatic CYP3A Enzymes
  62. Human Hepatic CYP2E1 Expression during Development
  63. PUBLICATION OF STAND-ALONE SINGLE NUCLEOTIDE POLYMORPHISM (SNP) DISCOVERY DATA
  64. Genetic Variability at the Human FMO1 Locus: Significance of a Basal Promoter Yin Yang 1 Element Polymorphism (FMO1*6)
  65. Workshop Overview: Use of Genomic Data in Risk Assessment
  66. Biochemical and Clinical Aspects of the Human Flavin-Containing Monooxygenase Form 3 (FMO3) Related to Trimethylaminuria
  67. Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation
  68. Characterization of the Human LungCYP2F1Gene and Identification of a Novel Lung-specific Binding Motif
  69. Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?
  70. Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis
  71. Alternative Processing of the Human FMO6 Gene Renders Transcripts Incapable of Encoding a Functional Flavin-Containing Monooxygenase
  72. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms: Table 1
  73. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes: Table 1
  74. Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression
  75. Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities
  76. GENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)
  77. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells22Abbreviations: AhR, aryl hydrocarbon receptor; CAT, chloramphenicol acetyl transfera...
  78. Ethnic Differences in Human Flavin-Containing Monooxygenase 2 (FMO2) Polymorphisms: Detection of Expressed Protein in African-Americans
  79. Diflubenzuron, a Benzoyl-Urea Insecticide, Is a Potent Inhibitor of TCDD-Induced CYP1A1 Expression in HepG2 Cells
  80. ROLE OF CANONICAL GLUCOCORTICOID RESPONSIVE ELEMENTS IN MODULATING EXPRESSION OF GENES REGULATED BY THE ARYLHYDROCARBON RECEPTOR*
  81. A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake
  82. Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity
  83. Further Characterization of the Major and Minor RabbitFMO1Promoters and Identification of both Positive and Negative Distal Regulatory Elements
  84. Variation in Induction of Human Placental CYP2E1: Possible Role in Susceptibility to Fetal Alcohol Syndrome?
  85. Identification of Multiple Rabbit Flavin-Containing Monooxygenase Form 1 (FMO1) Gene Promoters and Observation of Tissue-Specific DNase I Hypersensitive Sites
  86. VARIATION IN INDUCTION OF PLACENTAL CYTOCHROME P4502E1: POSSIBLE ROLE IN SUSCEPTIBILITY TO FETAL ALCOHOL SYNDROME? • 484
  87. Differential expression and activity of flavin-containing monooxygenases in euryhaline and stenohaline flatfishes indicates potential osmoregulatory role
  88. Developmental regulation of flavin-containing monooxygenase (FMO) isoforms 1 and 2 in pregnant rabbit
  89. In vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes
  90. Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.)
  91. The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression
  92. A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities
  93. Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas
  94. Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities
  95. Altered Regulation of the Cytochrome P4501A1 Gene: Novel Inducer-Independent Gene Expression in Pulmonary Carcinoma Cell Lines
  96. Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I
  97. Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells
  98. Identification of multiple regulatory elements on the human cytochrome P450IA1 gene
  99. Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines
  100. The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P-450; the past is prologue
  101. Implication of the "4S" polycyclic aromatic hydrocarbon binding protein in the transregulation of rat cytochrome P-450c expression
  102. Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo[a]pyrene by thin-layer chromatography
  103. Molecular induction by phenobarbital of a rat hepatic form of cytochrome P-450: Expression of a 4-kilobase messenger RNA
  104. Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line p815) cells
  105. The molecular cloning of cytochrome P-450c information
  106. EVIDENCE FOR INHIBITORY COMPLEXES FORMED WITH CYTOCHROME P-450 AND A METABOLITE OF 1,1-DISUBSTITUTED HYDRAZINES
  107. The role of Pi in glycolytic inhibition of calcium ion uptake by ELD ascites tumor cells