All Stories

  1. Applying high throughput toxicokinetics (HTTK) to per- and polyfluoro alkyl substances (PFAS)
  2. Collaborative evaluation of in silico predictions for high throughput toxicokinetics
  3. Interpretation of thyroid-relevant bioactivity data for comparison to in vivo exposures: A prioritization approach for putative chemical inhibitors of in vitro deiodinase activity
  4. Applying New Approach Methods for Toxicokinetics for Chemical Risk Assessment
  5. Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)
  6. Informatics for toxicokinetics
  7. Enabling transparent toxicokinetic modeling for public health risk assessment
  8. Integration of new approach methods for the assessment of data-poor chemicals
  9. A Simple Physiologically Based Toxicokinetic Model for Multi-Route In Vitro–In Vivo Extrapolation
  10. Developing Chemical Signatures for Categories of Household Consumer Products Using Suspect Screening Analysis
  11. Discerning Emittable from Extractable Chemicals Identified in Consumer Products by Suspect Screening GCxGC-TOFMS
  12. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories
  13. Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment
  14. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS)
  15. Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS
  16. Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment
  17. Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data
  18. Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use
  19. Reproducibility of organ-level effects in repeat dose animal studies
  20. Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency
  21. Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments
  22. Screening for drinking water contaminants of concern using an automated exposure-focused workflow
  23. Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry
  24. Plasma Protein Binding Evaluations of Per- and Polyfluoroalkyl Substances for Category-Based Toxicokinetic Assessment
  25. In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
  26. A Data-Driven Approach to Estimating Occupational Inhalation Exposure Using Workplace Compliance Data
  27. A Machine Learning Model to Estimate Toxicokinetic Half-Lives of Per- and Polyfluoro-Alkyl Substances (PFAS) in Multiple Species
  28. Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis
  29. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin
  30. A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target
  31. Characterizing surface water concentrations of hundreds of organic chemicals in United States for environmental risk prioritization
  32. The chemical landscape of high-throughput new approach methodologies for exposure
  33. Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment
  34. Simulating toxicokinetic variability to identify susceptible and highly exposed populations
  35. Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods
  36. Evaluation of a rapid, generic human gestational dose model
  37. Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
  38. Bayesian inference of chemical exposures from NHANES urine biomonitoring data
  39. Chemical screening of food-related chemicals for human fatty liver risk: Combining high content imaging of cellular responses with in vitro to in vivo extrapolation
  40. Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
  41. IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
  42. Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies
  43. Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment
  44. Predicting compound amenability with liquid chromatography-mass spectrometry to improve non-targeted analysis
  45. Correction to Designing QSARs for Parameters of High Throughput Toxicokinetic Models Using Open-Source Descriptors
  46. Chemical Characterization of Recycled Consumer Products Using Suspect Screening Analysis
  47. Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study
  48. High-throughput PBTK models for in vitro to in vivo extrapolation
  49. Designing QSARs for Parameters of High-Throughput Toxicokinetic Models Using Open-Source Descriptors
  50. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures
  51. GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence—An overview in the context of health decision-making
  52. Using chemical structure information to develop predictive models for in vitro toxicokinetic parameters to inform high-throughput risk-assessment
  53. PBPK model reporting template for chemical risk assessment applications
  54. Pharmacokinetic profile of Perfluorobutane Sulfonate and activation of hepatic nuclear receptor target genes in mice
  55. Correction: Development and evaluation of a high throughput inhalation model for organic chemicals
  56. Development and evaluation of a high throughput inhalation model for organic chemicals
  57. Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals
  58. High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity
  59. New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing
  60. Toxicity testing in the 21st century: progress in the past decade and future perspectives
  61. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization
  62. New approach methodologies for exposure science
  63. Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions
  64. Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation
  65. Estimating Uncertainty in the Context of New Approach Methodologies for Potential Use in Chemical Safety Evaluation
  66. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop
  67. The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency
  68. Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways
  69. Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”
  70. Advancements in Life Cycle Human Exposure and Toxicity Characterization
  71. Empirical Models for Anatomical and Physiological Changes in a Human Mother and Fetus During Pregnancy and Gestation
  72. Rapid experimental measurements of physicochemical properties to inform models and testing
  73. Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
  74. Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals
  75. In vitro to in vivo extrapolation for high throughput prioritization and decision making
  76. Suspect Screening Analysis of Chemicals in Consumer Products
  77. Defining toxicological tipping points in neuronal network development
  78. High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling
  79. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics
  80. Computational Tools for ADMET Profiling
  81. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
  82. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
  83. High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization
  84. Evaluation and calibration of high-throughput predictions of chemical distribution to tissues
  85. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability
  86. A Method for Identifying Prevalent Chemical Combinations in the U.S. Population
  87. An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library
  88. From the exposome to mechanistic understanding of chemical-induced adverse effects
  89. httk: R Package for High-Throughput Toxicokinetics
  90. High-throughput screening of chemicals as functional substitutes using structure-based classification models
  91. A Liver-Centric Multiscale Modeling Framework for Xenobiotics
  92. Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space
  93. ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology
  94. Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space
  95. Using mass spectrometry and reference databases to identify chemicals in house dust
  96. Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis
  97. Characterization and prediction of chemical functions and weight fractions in consumer products
  98. Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment
  99. Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
  100. Identifiability of PBPK models with applications to dimethylarsinic acid exposure
  101. Toxicokinetic Triage for Environmental Chemicals
  102. Exploring consumer exposure pathways and patterns of use for chemicals in the environment
  103. Dosimetric Anchoring of Toxicological Studies
  104. Rapid, automated approach to estimate human exposure to over 8,000 environmental chemicals
  105. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing
  106. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
  107. Development of a consumer product ingredient database for chemical exposure screening and prioritization
  108. Erratum
  109. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate
  110. Comparison of modeling approaches to prioritize chemicals based on estimates of exposure and exposure potential
  111. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project
  112. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays
  113. Incorporating exposure information into the toxicological prioritization index decision support framework
  114. Systems Toxicology from Genes to Organs
  115. P68—Parsimonious development of a physiologically based pharmacokinetic model for PFOA
  116. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"
  117. Modeling In Vitro Cell-Based Assays Experiments
  118. Physiologically Based Pharmacokinetic Model Use in Risk Assessment--Why Being Published Is Not Enough
  119. Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment
  120. Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse☆
  121. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
  122. Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles
  123. Simple models for granular force networks
  124. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening
  125. Virtual Tissues in Toxicology
  126. Force networks and elasticity in granular silos
  127. Simulating Microdosimetry in a Virtual Hepatic Lobule
  128. Modeling single and repeated dose pharmacokinetics of PFOA in mice
  129. Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice
  130. Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis
  131. Response to perturbations for granular flow in a hopper
  132. Shear and loading in channels: Oscillatory shearing and edge currents of superconducting vortices
  133. Ratchet-induced segregation and transport of nonspherical grains
  134. Superconducting Fluxon Pumps and Lenses
  135. The electronic design notebook: Performing medium and processing medium