All Stories

  1. Case study application of high-throughput new approach methodologies for exposure to the interpretation of matched biomarker and indoor media measurements
  2. Incorporating a dermal absorption route into high throughput toxicokinetic modeling
  3. Applying high throughput toxicokinetics (HTTK) to per- and polyfluoro alkyl substances (PFAS)
  4. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays
  5. Collaborative evaluation of in silico predictions for high throughput toxicokinetics
  6. Interpretation of thyroid-relevant bioactivity data for comparison to in vivo exposures: A prioritization approach for putative chemical inhibitors of in vitro deiodinase activity
  7. Applying New Approach Methods for Toxicokinetics for Chemical Risk Assessment
  8. Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs)
  9. Informatics for toxicokinetics
  10. Enabling transparent toxicokinetic modeling for public health risk assessment
  11. Integration of new approach methods for the assessment of data-poor chemicals
  12. A Simple Physiologically Based Toxicokinetic Model for Multi-Route In Vitro–In Vivo Extrapolation
  13. Developing Chemical Signatures for Categories of Household Consumer Products Using Suspect Screening Analysis
  14. Discerning Emittable from Extractable Chemicals Identified in Consumer Products by Suspect Screening GCxGC-TOFMS
  15. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories
  16. Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment
  17. Enabling Transparent Toxicokinetic Modeling for Public Health Risk Assessment
  18. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS)
  19. Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS
  20. Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment
  21. Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data
  22. Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use
  23. Reproducibility of organ-level effects in repeat dose animal studies
  24. Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency
  25. Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments
  26. Screening for drinking water contaminants of concern using an automated exposure-focused workflow
  27. Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry
  28. Plasma Protein Binding Evaluations of Per- and Polyfluoroalkyl Substances for Category-Based Toxicokinetic Assessment
  29. In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
  30. A Data-Driven Approach to Estimating Occupational Inhalation Exposure Using Workplace Compliance Data
  31. A Machine Learning Model to Estimate Toxicokinetic Half-Lives of Per- and Polyfluoro-Alkyl Substances (PFAS) in Multiple Species
  32. Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis
  33. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin
  34. A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target
  35. Characterizing surface water concentrations of hundreds of organic chemicals in United States for environmental risk prioritization
  36. The chemical landscape of high-throughput new approach methodologies for exposure
  37. Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment
  38. Simulating toxicokinetic variability to identify susceptible and highly exposed populations
  39. Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods
  40. Evaluation of a rapid, generic human gestational dose model
  41. Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
  42. Bayesian inference of chemical exposures from NHANES urine biomonitoring data
  43. Chemical screening of food-related chemicals for human fatty liver risk: Combining high content imaging of cellular responses with in vitro to in vivo extrapolation
  44. Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
  45. IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
  46. Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies
  47. Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment
  48. Predicting compound amenability with liquid chromatography-mass spectrometry to improve non-targeted analysis
  49. Correction to Designing QSARs for Parameters of High Throughput Toxicokinetic Models Using Open-Source Descriptors
  50. Chemical Characterization of Recycled Consumer Products Using Suspect Screening Analysis
  51. Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study
  52. High-throughput PBTK models for in vitro to in vivo extrapolation
  53. Designing QSARs for Parameters of High-Throughput Toxicokinetic Models Using Open-Source Descriptors
  54. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures
  55. GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence—An overview in the context of health decision-making
  56. Using chemical structure information to develop predictive models for in vitro toxicokinetic parameters to inform high-throughput risk-assessment
  57. PBPK model reporting template for chemical risk assessment applications
  58. Pharmacokinetic profile of Perfluorobutane Sulfonate and activation of hepatic nuclear receptor target genes in mice
  59. Correction: Development and evaluation of a high throughput inhalation model for organic chemicals
  60. Development and evaluation of a high throughput inhalation model for organic chemicals
  61. Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals
  62. High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity
  63. New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing
  64. Toxicity testing in the 21st century: progress in the past decade and future perspectives
  65. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization
  66. New approach methodologies for exposure science
  67. Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions
  68. Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation
  69. Estimating Uncertainty in the Context of New Approach Methodologies for Potential Use in Chemical Safety Evaluation
  70. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop
  71. The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency
  72. Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways
  73. Comment on: Dong et al. (2017) “Issues raised by the reference doses for perfluorooctonate sulfonate and perfluorooctanoic acid.”
  74. Advancements in Life Cycle Human Exposure and Toxicity Characterization
  75. Empirical Models for Anatomical and Physiological Changes in a Human Mother and Fetus During Pregnancy and Gestation
  76. Free access platforms for integrating environmental chemical exposure and hazard information
  77. Rapid experimental measurements of physicochemical properties to inform models and testing
  78. Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
  79. Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals
  80. In vitro to in vivo extrapolation for high throughput prioritization and decision making
  81. Suspect Screening Analysis of Chemicals in Consumer Products
  82. Defining toxicological tipping points in neuronal network development
  83. High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling
  84. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics
  85. Computational Tools for ADMET Profiling
  86. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
  87. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
  88. High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization
  89. Evaluation and calibration of high-throughput predictions of chemical distribution to tissues
  90. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability
  91. A Method for Identifying Prevalent Chemical Combinations in the U.S. Population
  92. An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library
  93. From the exposome to mechanistic understanding of chemical-induced adverse effects
  94. httk: R Package for High-Throughput Toxicokinetics
  95. High-throughput screening of chemicals as functional substitutes using structure-based classification models
  96. A Liver-Centric Multiscale Modeling Framework for Xenobiotics
  97. Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space
  98. ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology
  99. Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space
  100. Using mass spectrometry and reference databases to identify chemicals in house dust
  101. Development of a quantitative morphological assessment of toxicant-treated zebrafish larvae using brightfield imaging and high-content analysis
  102. Characterization and prediction of chemical functions and weight fractions in consumer products
  103. Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment
  104. Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
  105. Identifiability of PBPK models with applications to dimethylarsinic acid exposure
  106. Toxicokinetic Triage for Environmental Chemicals
  107. Exploring consumer exposure pathways and patterns of use for chemicals in the environment
  108. Dosimetric Anchoring of Toxicological Studies
  109. Rapid, automated approach to estimate human exposure to over 8,000 environmental chemicals
  110. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing
  111. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
  112. Development of a consumer product ingredient database for chemical exposure screening and prioritization
  113. Erratum
  114. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate
  115. Comparison of modeling approaches to prioritize chemicals based on estimates of exposure and exposure potential
  116. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project
  117. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays
  118. Incorporating exposure information into the toxicological prioritization index decision support framework
  119. Systems Toxicology from Genes to Organs
  120. P68—Parsimonious development of a physiologically based pharmacokinetic model for PFOA
  121. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"
  122. Modeling In Vitro Cell-Based Assays Experiments
  123. Physiologically Based Pharmacokinetic Model Use in Risk Assessment--Why Being Published Is Not Enough
  124. Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment
  125. Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse☆
  126. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
  127. Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles
  128. Simple models for granular force networks
  129. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening
  130. Virtual Tissues in Toxicology
  131. Force networks and elasticity in granular silos
  132. Simulating Microdosimetry in a Virtual Hepatic Lobule
  133. Modeling single and repeated dose pharmacokinetics of PFOA in mice
  134. Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice
  135. Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis
  136. Response to perturbations for granular flow in a hopper
  137. Shear and loading in channels: Oscillatory shearing and edge currents of superconducting vortices
  138. Ratchet-induced segregation and transport of nonspherical grains
  139. Superconducting Fluxon Pumps and Lenses
  140. The electronic design notebook: Performing medium and processing medium