All Stories

  1. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
  2. Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity
  3. Rapid, early and accurate SARS-CoV-2 detection using RT-qPCR in primary care: a prospective cohort study (REAP-1)
  4. Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis
  5. High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells
  6. Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
  7. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing
  8. Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
  9. Hematopoietic expression of a chimeric murine‐human CALR oncoprotein allows the assessment of anti‐CALR antibody immunotherapies in vivo
  10. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases
  11. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells
  12. SARS-CoV-2 mutations in MHC-I–restricted epitopes evade CD8 + T cell responses
  13. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements
  14. Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct From Healthy Control Skin
  15. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions
  16. αβγδ T cells play a vital role in fetal human skin development and immunity
  17. Acute BAF perturbation causes immediate changes in chromatin accessibility
  18. Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
  19. The Organoid Cell Atlas
  20. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy
  21. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway
  22. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis
  23. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
  24. Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease
  25. Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction
  26. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease
  27. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis
  28. Distributed changes of the functional connectome in patients with glioblastoma
  29. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses
  30. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
  31. Circadian rhythm influences induction of trained immunity by BCG vaccination
  32. LifeTime and improving European healthcare through cell-based interceptive medicine
  33. Emergence of coronavirus disease 2019 (COVID-19) in Austria
  34. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020
  35. Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data
  36. Rational discovery of molecular glue degraders via scalable chemical profiling
  37. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
  38. Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex
  39. Structural cells are key regulators of organ-specific immune responses
  40. Selective Mediator dependence of cell-type-specifying transcription
  41. Detailed temporal dissection of an enhancer cluster reveals two distinct roles for individual elements
  42. Molecular design of hypothalamus development
  43. Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets
  44. NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells
  45. Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
  46. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma
  47. DNA methylation QTL analysis identifies new regulators of human longevity
  48. Quantitative comparison of within-sample heterogeneity scores for DNA methylation data
  49. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
  50. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF
  51. Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
  52. Ultra-high throughput single-cell RNA sequencing by combinatorial fluidic indexing
  53. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
  54. Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants
  55. Longitudinal molecular trajectories of diffuse glioma in adults
  56. Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy
  57. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells
  58. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
  59. Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
  60. Guadecitabine plus ipilimumab in unresectable melanoma: the NIBIT-M4 clinical trial
  61. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
  62. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers
  63. Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis
  64. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms
  65. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells
  66. Spatiotemporal structure of cell fate decisions in murine neural crest
  67. HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response
  68. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation
  69. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
  70. RnBeads 2.0: comprehensive analysis of DNA methylation data
  71. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
  72. Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
  73. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
  74. Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency
  75. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
  76. Colocalization analyses of genomic elements: approaches, recommendations and challenges
  77. The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
  78. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells
  79. Epigenome-based prediction of gene expression across species
  80. Coloc-stats: a unified web interface to perform colocalization analysis of genomic features
  81. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
  82. Targeted mutation screening of 292 candidate genes in 38 children with inborn haematological cytopenias efficiently identifies novel disease-causing mutations
  83. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
  84. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
  85. MIRA: an R package for DNA methylation-based inference of regulatory activity
  86. Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species
  87. Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
  88. Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium
  89. STAT5BN642H is a driver mutation for T cell neoplasia
  90. Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal
  91. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
  92. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis
  93. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression
  94. Functional dissection of the enhancer repertoire in human embryonic stem cells
  95. A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor
  96. VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data
  97. DeepBlueR: large-scale epigenomic analysis in R
  98. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice
  99. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
  100. Pooled CRISPR screening with single-cell transcriptome readout
  101. Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
  102. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
  103. Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia
  104. DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation
  105. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
  106. Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer
  107. Preserve personal freedom in networked societies
  108. Specification of tissue-resident macrophages during organogenesis
  109. Multi-Omics of Single Cells: Strategies and Applications
  110. Parallel reverse genetic screening in mutant human cells using transcriptomics
  111. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications
  112. Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks
  113. Making sense of big data in health research: Towards an EU action plan
  114. Familial early-onset dementia with complex neuropathologic phenotype and genomic background
  115. Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia
  116. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk
  117. Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
  118. DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets
  119. A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN
  120. Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types
  121. Differential DNA Methylation Analysis without a Reference Genome
  122. LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor
  123. Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms
  124. ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors
  125. Toward understanding and exploiting tumor heterogeneity
  126. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
  127. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections
  128. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern
  129. Dissecting the role of aberrant DNA methylation in human leukaemia
  130. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia
  131. Improving reference epigenome catalogs by computational prediction
  132. Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity
  133. Single-Cell DNA Methylome Sequencing and Bioinformatic Inference of Epigenomic Cell-State Dynamics
  134. Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1
  135. Model-Based Whole-Genome Analysis of DNA Methylation Fidelity
  136. DNA methylation signatures link prenatal famine exposure to growth and metabolism
  137. NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
  138. Comprehensive analysis of DNA methylation data with RnBeads
  139. Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a
  140. Notch inhibition allows oncogene-independent generation of iPS cells
  141. BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives
  142. Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
  143. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA‐dependent TAU phosphorylation and CREB activation in Alzheimer's disease
  144. Relationship between genome and epigenome - challenges and requirements for future research
  145. Synergy and competition between cancer genome sequencing and epigenome mapping projects
  146. Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms
  147. A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer
  148. Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2
  149. Recommendations for the design and analysis of epigenome-wide association studies
  150. A reversible gene trap collection empowers haploid genetics in human cells
  151. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis
  152. Identification of Novel Imprinted Differentially Methylated Regions by Global Analysis of Human-Parthenogenetic-Induced Pluripotent Stem Cells
  153. High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells
  154. Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
  155. DNA methylation: a matter of culture
  156. Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
  157. Analysing and interpreting DNA methylation data
  158. DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
  159. Managing drug resistance in cancer: lessons from HIV therapy
  160. DNA methylation biomarkers in cancer: progress towards clinical implementation
  161. Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling
  162. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk
  163. BLUEPRINT to decode the epigenetic signature written in blood
  164. Epigenom-Karten erstellen und nutzen
  165. EpiExplorer: live exploration and global analysis of large epigenomic datasets
  166. Analyzing Epigenome Data in Context of Genome Evolution and Human Diseases
  167. Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types
  168. RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing
  169. Dnmt3a is essential for hematopoietic stem cell differentiation
  170. Global DNA Demethylation During Mouse Erythropoiesis in Vivo
  171. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
  172. A promoter DNA demethylation landscape of human hematopoietic differentiation
  173. Lung Stem Cell Self-Renewal Relies on BMI1-Dependent Control of Expression at Imprinted Loci
  174. A DNA methylation fingerprint of 1628 human samples
  175. BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
  176. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
  177. Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
  178. Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
  179. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
  180. Quantitative comparison of genome-wide DNA methylation mapping technologies
  181. Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
  182. Web-Based Analysis of (Epi-) Genome Data Using EpiGRAPH and Galaxy
  183. Epigenetic biomarker development
  184. High-throughput bisulfite sequencing in mammalian genomes
  185. DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution
  186. MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays
  187. EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data
  188. IVF: stars may have to consider the risk of stolen parenthood
  189. Functional Analysis of a Potassium-Chloride Co-Transporter 3 (SLC12A6) Promoter Polymorphism Leading to an Additional DNA Methylation Site
  190. Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
  191. Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region
  192. Computational epigenetics
  193. Optimization of Quantitative MGMT Promoter Methylation Analysis Using Pyrosequencing and Combined Bisulfite Restriction Analysis
  194. The Human Genomic Melting Map
  195. CpG Island Mapping by Epigenome Prediction
  196. CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure
  197. BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing