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  1. Multimodal learning enables chat-based exploration of single-cell data

    Article • Nature Biotechnology, November 2025, Springer Science + Business Media

    Dr Christoph Bock

  2. Systematic discovery of CRISPR-boosted CAR T cell immunotherapies

    Article • Nature, September 2025, Springer Science + Business Media

    Dr Christoph Bock

  3. Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines

    Article • Cell Reports, September 2025, Elsevier

    Dr Christoph Bock

  4. Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC ‐unique features

    Article • International Journal of Cancer, August 2025, Wiley

    Dr Christoph Bock

  5. Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions

    Article • Nature Communications, August 2025, Springer Science + Business Media

    Dr Christoph Bock

  6. Molecularly informed analysis of histopathology images using natural language

    Article • July 2025, openRxiv

    Dr Christoph Bock

  7. HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

    Article • Journal of Experimental Medicine, June 2025, Rockefeller University Press

    Dr Christoph Bock

  8. Protecting centrosomes from fracturing enables efficient cell navigation

    Article • Science Advances, April 2025, American Association for the Advancement of Science

    Dr Christoph Bock

  9. PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

    Article • Proceedings of the National Academy of Sciences, April 2025, Proceedings of the National Academy of Sciences

    Thomas Leonard, Dr Christoph Bock

  10. Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

    Article • Nature Communications, March 2025, Springer Science + Business Media

    Dr Christoph Bock

  11. 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T H 17 pathogenicity and transdifferentiation

    Article • Gut, March 2025, BMJ

    Dr Christoph Bock

  12. Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions

    Article • Cellular and Molecular Life Sciences, March 2025, Springer Science + Business Media

    Dr Christoph Bock

  13. Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring

    Article • PLOS One, February 2025, PLOS

    Kaja Helvik Skjærven, Dr Christoph Bock

  14. Single-cell CRISPR screening in mouse brain

    Article • Nature Protocols, February 2025, Springer Science + Business Media

    Dr Christoph Bock

  15. Time-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy

    Article • January 2025, openRxiv

    Dr Christoph Bock

  16. Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols

    Article • November 2024, openRxiv

    Dr Christoph Bock

  17. Engineering Next-Generation CAR T Cells Via Genetic Screens

    Article • Blood, November 2024, American Society of Hematology

    Dr Christoph Bock

  18. Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

    Article • eLife, October 2024, eLife

    Dr Christoph Bock

  19. Multimodal learning of transcriptomes and text enables interactive single-cell RNA-seq data exploration with natural-language chats

    Article • October 2024, openRxiv

    Dr Christoph Bock

  20. Mechanical Centrosome Fracturing during Cell Navigation

    Article • October 2024, openRxiv

    Dr Christoph Bock

  21. Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

    Article • Science Immunology, June 2024, American Association for the Advancement of Science

    Dr Christoph Bock

  22. Mapping the brain’s gene-regulatory maze

    Article • Science, May 2024, American Association for the Advancement of Science

    Dr Christoph Bock

  23. Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis

    Article • American Review of Respiratory Disease, May 2024, Oxford University Press (OUP)

    Dr Christoph Bock

  24. Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual

    Article • The Lancet Infectious Diseases, May 2024, Elsevier

    Dr Christoph Bock

  25. Baseline JAK–STAT signaling maintains immune cell homeostasis

    Article • Nature Immunology, April 2024, Springer Science + Business Media

    Dr Christoph Bock

  26. JAK-STAT signaling maintains homeostasis in T cells and macrophages

    Article • Nature Immunology, April 2024, Springer Science + Business Media

    Shweta Tikoo, Dr Rohit Jain, Dr Christoph Bock

  27. Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

    Article • Journal of Clinical Investigation, April 2024, American Society for Clinical Investigation

    Dr Christoph Bock

  28. Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice

    Article • Nature Communications, March 2024, Springer Science + Business Media

    Dr Christoph Bock

  29. HDAC1 controls the generation and maintenance of effector-like CD8 + T cells during chronic viral infection

    Article • March 2024, openRxiv

    Dr Christoph Bock

  30. One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon

    Article • Epigenetics, February 2024, Taylor & Francis

    Dr Christoph Bock

  31. Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring

    Article • February 2024, openRxiv

    Dr Christoph Bock

  32. Multi‐organ single‐cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation

    Article • The FASEB Journal, February 2024, Wiley

    Dr Christoph Bock

  33. Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial

    Article • The Lancet Rheumatology, February 2024, Elsevier

    Dr Christoph Bock

  34. The pathophysiology of sepsis and precision-medicine-based immunotherapy

    Article • Nature Immunology, January 2024, Springer Science + Business Media

    Dr Christoph Bock

  35. Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity

    Article • Immunity, January 2024, Elsevier

    Dr Christoph Bock

  36. Multipotent progenitors instruct ontogeny of the superior colliculus

    Article • Neuron, January 2024, Elsevier

    Dr Christoph Bock

  37. Endoscope-enhanced fluorescence-guided microsurgery increases survival in patients with glioblastoma

    Article • Acta Neurochirurgica, November 2023, Springer Science + Business Media

    Dr Christoph Bock

  38. Metabolic support by macrophages sustains colonic epithelial homeostasis

    Article • Cell Metabolism, November 2023, Elsevier

    Dr Christoph Bock

  39. One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic Salmon

    Article • September 2023, openRxiv

    Dr Christoph Bock

  40. Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis

    Article • Blood, August 2023, American Society of Hematology

    Dr Christoph Bock

  41. Pharmacological perturbation of the phase-separating protein SMNDC1

    Article • Nature Communications, August 2023, Springer Science + Business Media

    Dr Christoph Bock

  42. Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis

    Article • Immunity, August 2023, Elsevier

    Dr Christoph Bock

  43. Large language models are universal biomedical simulators

    Article • June 2023, openRxiv

    Dr Christoph Bock

  44. Buffy coat signatures of breast cancer risk in a prospective cohort study

    Article • Clinical Epigenetics, June 2023, Springer Science + Business Media

    Dr Marina Laplana, Dr Christoph Bock

  45. Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

    Article • April 2023, openRxiv

    Dr Christoph Bock

  46. Epigenetic regulation of T cell lineages in skin and blood following hematopoietic stem cell transplantation

    Article • Clinical Immunology, March 2023, Elsevier

    Dr Christoph Bock

  47. Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species

    Article • Nature Communications, January 2023, Springer Science + Business Media

    Dr Christoph Bock

  48. Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma

    Article • Neuro-Oncology Advances, January 2023, Oxford University Press (OUP)

    Dr Christoph Bock

  49. Interleukin‐6 initiates muscle‐ and adipose tissue wasting in a novel C57BL/6 model of cancer‐associated cachexia

    Article • Journal of Cachexia Sarcopenia and Muscle, November 2022, Wiley

    Dr Christoph Bock

  50. Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

    Article • eLife, September 2022, eLife

    Dr Christoph Bock

  51. SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression

    Article • Cell Reports, August 2022, Elsevier

    Dr Christoph Bock

  52. Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

    Article • March 2022, openRxiv

    Dr Christoph Bock

  53. High-content CRISPR screening

    Article • Nature Reviews Methods Primers, February 2022, Springer Science + Business Media

    Dr Christoph Bock

  54. Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles

    Article • Cardiovascular Research, February 2022, Oxford University Press (OUP)

    Prof Daniel C Anthony, Dr Christoph Bock

  55. LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data

    Article • Bioinformatics Advances, January 2022, Oxford University Press (OUP)

    Dr Christoph Bock

  56. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

    Article • Nature Genetics, September 2021, Springer Science + Business Media

    Dr Christoph Bock, Jari Lahti, Prof. John W Holloway

  57. Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity

    Article • ImmunoMedicine, August 2021, Wiley

    Dr Christoph Bock

  58. Rapid, early and accurate SARS-CoV-2 detection using RT-qPCR in primary care: a prospective cohort study (REAP-1)

    Article • BMJ Open, August 2021, BMJ

    Dr Christoph Bock

  59. Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

    Article • Journal of Allergy and Clinical Immunology, August 2021, Elsevier

    Dr Christoph Bock

  60. High-throughput Mutational Surveillance of the SARS-CoV-2 Spike Gene

    Article • July 2021, openRxiv

    Dr Christoph Bock

  61. High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells

    Article • Blood Cancer Journal, July 2021, Springer Science + Business Media

    Dr Christoph Bock

  62. Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3

    Article • Nature Communications, June 2021, Springer Science + Business Media

    Dr Christoph Bock

  63. Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing

    Article • Nature Chemical Biology, May 2021, Springer Science + Business Media

    Dr Christoph Bock

  64. Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

    Article • Nature Communications, May 2021, Springer Science + Business Media

    Dr Christoph Bock

  65. Hematopoietic expression of a chimeric murine‐human CALR oncoprotein allows the assessment of anti‐CALR antibody immunotherapies in vivo

    Article • American Journal of Hematology, May 2021, Wiley

    Dr Christoph Bock

  66. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases

    Article • Journal of Autoimmunity, May 2021, Elsevier

    Dr Christoph Bock

  67. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells

    Article • Frontiers in Immunology, March 2021, Frontiers

    Dr Christoph Bock

  68. SARS-CoV-2 mutations in MHC-I–restricted epitopes evade CD8 + T cell responses

    Article • Science Immunology, March 2021, American Association for the Advancement of Science

    Dr Christoph Bock

  69. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements

    Article • Molecular Cell, March 2021, Elsevier

    Dr Christoph Bock

  70. Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct From Healthy Control Skin

    Article • Frontiers in Immunology, February 2021, Frontiers

    Dr Christoph Bock

  71. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions

    Article • HemaSphere, February 2021, Wolters Kluwer Health

    Dr Christoph Bock

  72. αβγδ T cells play a vital role in fetal human skin development and immunity

    Article • Journal of Experimental Medicine, February 2021, Rockefeller University Press

    Dr Christoph Bock

  73. Acute BAF perturbation causes immediate changes in chromatin accessibility

    Article • Nature Genetics, February 2021, Springer Science + Business Media

    Dr Christoph Bock

  74. Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling

    Article • Nature Chemical Biology, January 2021, Springer Science + Business Media

    Dr Christoph Bock

  75. Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

    Article • Science Immunology, January 2021, American Association for the Advancement of Science

    Dr Christoph Bock

  76. The Organoid Cell Atlas

    Article • Nature Biotechnology, December 2020, Springer Science + Business Media

    Dr Christoph Bock

  77. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

    Article • Nature, December 2020, Springer Science + Business Media

    Dr Christoph Bock, Professor Alexandra Kautzky-Willer

  78. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

    Article • Oncogene, December 2020, Springer Science + Business Media

    Dr Christoph Bock

  79. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis

    Article • Life Science Alliance, December 2020, Life Science Alliance, LLC

    Dr Christoph Bock

  80. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2

    Article • Science Translational Medicine, November 2020, American Association for the Advancement of Science

    Dr Christoph Bock

  81. Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

    Article • Science Translational Medicine, November 2020, American Association for the Advancement of Science

    Dr Christoph Bock

  82. Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction

    Article • Circulation, November 2020, Wolters Kluwer Health

    Dr Christoph Bock

  83. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease

    Article • Journal of Investigative Dermatology, November 2020, Elsevier

    Dr Christoph Bock

  84. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis

    Article • Journal of Allergy and Clinical Immunology, November 2020, Elsevier

    Dr Christoph Bock

  85. Distributed changes of the functional connectome in patients with glioblastoma

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Dr Christoph Bock

  86. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses

    Article • Science Immunology, October 2020, American Association for the Advancement of Science

    Dr Christoph Bock

  87. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

    Article • Nature Immunology, October 2020, Springer Science + Business Media

    Dr Christoph Bock

  88. Circadian rhythm influences induction of trained immunity by BCG vaccination

    Article • Journal of Clinical Investigation, September 2020, American Society for Clinical Investigation

    Dr Christoph Bock

  89. LifeTime and improving European healthcare through cell-based interceptive medicine

    Article • Nature, September 2020, Springer Science + Business Media

    Dr Christoph Bock, Dr Herve Chneiweiss, Dr Giacomo Cavalli, Catherine Brooksbank

  90. Emergence of coronavirus disease 2019 (COVID-19) in Austria

    Article • Wiener klinische Wochenschrift, August 2020, Springer Science + Business Media

    Dr Christoph Bock

  91. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

    Article • Eurosurveillance, August 2020, European Centre for Disease Control and Prevention (ECDC)

    Dr Christoph Bock, prof. dr.-med. Michal Holub

  92. Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

    Article • August 2020, Springer Science + Business Media

    Dr Christoph Bock

  93. Rational discovery of molecular glue degraders via scalable chemical profiling

    Article • Nature Chemical Biology, August 2020, Springer Science + Business Media

    Dr Christoph Bock

  94. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

    Article • Science Immunology, July 2020, American Association for the Advancement of Science

    Prof. Vahid Ziaee, Dr Christoph Bock

  95. Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex

    Article • Neuron, July 2020, Elsevier

    Dr Christoph Bock

  96. Structural cells are key regulators of organ-specific immune responses

    Article • Nature, July 2020, Springer Science + Business Media

    Dr Christoph Bock

  97. Selective Mediator dependence of cell-type-specifying transcription

    Article • Nature Genetics, June 2020, Springer Science + Business Media

    Dr Christoph Bock

  98. Detailed temporal dissection of an enhancer cluster reveals two distinct roles for individual elements

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  99. Molecular design of hypothalamus development

    Article • Nature, May 2020, Springer Science + Business Media

    Dr Christoph Bock

  100. Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

    Article • May 2020, Springer Science + Business Media

    Dr Christoph Bock

  101. NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells

    Article • Frontiers in Immunology, April 2020, Frontiers

    Dr Christoph Bock

  102. Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

    Article • Cell Metabolism, April 2020, Elsevier

    Dr Christoph Bock

  103. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

    Article • Gut, March 2020, BMJ

    Dr Christoph Bock

  104. DNA methylation QTL analysis identifies new regulators of human longevity

    Article • Human Molecular Genetics, March 2020, Oxford University Press (OUP)

    Dr Christoph Bock

  105. Quantitative comparison of within-sample heterogeneity scores for DNA methylation data

    Article • Nucleic Acids Research, February 2020, Oxford University Press (OUP)

    Dr Christoph Bock

  106. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation

    Article • JCI Insight, February 2020, American Society for Clinical Investigation

    Dr Christoph Bock

  107. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

    Article • Immunity, February 2020, Elsevier

    Dr Christoph Bock

  108. Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

    Article • Nature Communications, January 2020, Springer Science + Business Media

    Dr Christoph Bock

  109. Ultra-high throughput single-cell RNA sequencing by combinatorial fluidic indexing

    Article • December 2019, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  110. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

    Article • Cell Reports, December 2019, Elsevier

    Dr Christoph Bock, Professor Tim D Sparwasser

  111. Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

    Article • The EMBO Journal, November 2019, EMBO

    Dr Christoph Bock

  112. Longitudinal molecular trajectories of diffuse glioma in adults

    Article • Nature, November 2019, Springer Science + Business Media

    Dr Christoph Bock

  113. Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy

    Article • Molecular Psychiatry, November 2019, Springer Science + Business Media

    Dr Christoph Bock

  114. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

    Article • Cell Reports, November 2019, Elsevier

    Dr Christoph Bock

  115. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells

    Article • Scientific Reports, October 2019, Springer Science + Business Media

    Dr Christoph Bock

  116. Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

    Article • Nature Communications, October 2019, Springer Science + Business Media

    Dr Christoph Bock

  117. Guadecitabine plus ipilimumab in unresectable melanoma: the NIBIT-M4 clinical trial

    Article • Clinical Cancer Research, September 2019, American Association for Cancer Research (AACR)

    Dr Christoph Bock

  118. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Dr Christoph Bock

  119. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

    Article • Nature Genetics, August 2019, Springer Science + Business Media

    Dr Christoph Bock

  120. Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis

    Article • Cancer Discovery, July 2019, American Association for Cancer Research (AACR)

    Dr Christoph Bock, Professor Milen Minkov

  121. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms

    Article • Blood, July 2019, American Society of Hematology

    Dr Christoph Bock

  122. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

    Article • Circulation Research, June 2019, Wolters Kluwer Health

    Dr Christoph Bock

  123. Spatiotemporal structure of cell fate decisions in murine neural crest

    Article • Science, June 2019, American Association for the Advancement of Science

    Dr Christoph Bock

  124. HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

    Article • Gastroenterology, June 2019, Elsevier

    Dr Christoph Bock

  125. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

    Article • Nature Genetics, May 2019, Springer Science + Business Media

    Dr Christoph Bock

  126. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks

    Article • Blood, April 2019, American Society of Hematology

    Dr Christoph Bock

  127. RnBeads 2.0: comprehensive analysis of DNA methylation data

    Article • March 2019, Springer Science + Business Media

    Dr Christoph Bock

  128. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity

    Article • The Journal of Immunology, February 2019, The American Association of Immunologists

    Dr Christoph Bock

  129. Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

    Article • Nature Chemical Biology, January 2019, Springer Science + Business Media

    Dr Christoph Bock

  130. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

    Article • Cell Reports, January 2019, Elsevier

    Dr Christoph Bock

  131. Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency

    Article • Cell Stem Cell, January 2019, Elsevier

    Dr Christoph Bock

  132. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

    Article • Cancer Cell, January 2019, Elsevier

    Dr Christoph Bock

  133. Colocalization analyses of genomic elements: approaches, recommendations and challenges

    Article • Bioinformatics, October 2018, Oxford University Press (OUP)

    Dr Christoph Bock

  134. The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

    Article • Nature Medicine, August 2018, Springer Science + Business Media

    Dr Christoph Bock

  135. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

    Article • Cell Stem Cell, August 2018, Elsevier

    Dr Christoph Bock

  136. Epigenome-based prediction of gene expression across species

    Article • July 2018, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  137. Coloc-stats: a unified web interface to perform colocalization analysis of genomic features

    Article • Nucleic Acids Research, June 2018, Oxford University Press (OUP)

    Dr Christoph Bock

  138. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

    Article • Cell Stem Cell, June 2018, Elsevier

    Dr Christoph Bock, Professor Manuela Baccarini

  139. Targeted mutation screening of 292 candidate genes in 38 children with inborn haematological cytopenias efficiently identifies novel disease-causing mutations

    Article • British Journal of Haematology, May 2018, Wiley

    Dr Christoph Bock

  140. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Dr Paul Robson, Dr Christoph Bock

  141. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  142. MIRA: an R package for DNA methylation-based inference of regulatory activity

    Article • Bioinformatics, March 2018, Oxford University Press (OUP)

    Dr Christoph Bock

  143. Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

    Article • February 2018, Springer Science + Business Media

    Dr Christoph Bock

  144. Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring

    Article • Scientific Reports, February 2018, Nature

    Dr Christoph Bock

  145. Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

    Article • Neuro-Oncology, February 2018, Oxford University Press (OUP)

    Dr Christoph Bock

  146. STAT5BN642H is a driver mutation for T cell neoplasia

    Article • Journal of Clinical Investigation, December 2017, American Society for Clinical Investigation

    Dr Christoph Bock

  147. Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal

    Article • EBioMedicine, December 2017, Elsevier

    Dr Christoph Bock

  148. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

    Article • Nature Communications, November 2017, Nature

    Dr Christoph Bock

  149. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis

    Article • Journal of Autoimmunity, September 2017, Elsevier

    Dr Christoph Bock

  150. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Article • eLife, August 2017, eLife

    Dr Christoph Bock

  151. Functional dissection of the enhancer repertoire in human embryonic stem cells

    Article • July 2017, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  152. A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

    Article • Nature Chemical Biology, May 2017, Nature

    Dr Christoph Bock

  153. VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data

    Article • Nucleic Acids Research, May 2017, Oxford University Press (OUP)

    Dr Christoph Bock

  154. DeepBlueR: large-scale epigenomic analysis in R

    Article • Bioinformatics, February 2017, Oxford University Press (OUP)

    Dr Christoph Bock

  155. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice

    Article • Hepatology, February 2017, Wiley

    Dr Christoph Bock

  156. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

    Article • Nature Medicine, January 2017, Nature

    Dr Christoph Bock

  157. Pooled CRISPR screening with single-cell transcriptome readout

    Article • Nature Chemical Biology, January 2017, Nature

    Dr Christoph Bock

  158. Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

    Article • Cell, January 2017, Elsevier

    Dr Christoph Bock

  159. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

    Article • Nature Neuroscience, December 2016, Nature

    Dr Christoph Bock

  160. Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia

    Article • Leukemia, November 2016, Springer Science + Business Media

    Dr Christoph Bock

  161. DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

    Article • Cell Stem Cell, November 2016, Elsevier

    Dr Christoph Bock

  162. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Article • Cell, November 2016, Elsevier

    Dr Stephen Yip , Dr Christoph Bock

  163. Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer

    Article • Gastroenterology, November 2016, Elsevier

    Dr Christoph Bock

  164. Preserve personal freedom in networked societies

    Article • Nature, August 2016, Nature

    Dr Christoph Bock

  165. Specification of tissue-resident macrophages during organogenesis

    Article • Science, August 2016, American Association for the Advancement of Science

    Dr Christoph Bock

  166. Multi-Omics of Single Cells: Strategies and Applications

    Article • Trends in Biotechnology, August 2016, Elsevier

    Dr Christoph Bock

  167. Parallel reverse genetic screening in mutant human cells using transcriptomics

    Article • Molecular Systems Biology, August 2016, EMBO

    Dr Christoph Bock

  168. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

    Article • Nature Biotechnology, June 2016, Nature

    Dr Christoph Bock

  169. Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

    Article • Nature Communications, June 2016, Nature

    Dr Christoph Bock

  170. Making sense of big data in health research: Towards an EU action plan

    Article • Genome Medicine, June 2016, Springer Science + Business Media

    Professor Werner Muller, DR Juan Antonio Vizcaino, Dr Christoph Bock, Dr Niklas U Blomberg

  171. Familial early-onset dementia with complex neuropathologic phenotype and genomic background

    Article • Neurobiology of Aging, June 2016, Elsevier

    Dr Christoph Bock

  172. Next-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia

    Article • Leukemia, May 2016, Nature

    Dr Christoph Bock

  173. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

    Article • Nature Chemical Biology, May 2016, Nature

    Dr Christoph Bock

  174. Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

    Article • Biotechnology and Bioengineering, April 2016, Wiley

    Dr Christoph Bock, Dr Vaibhav Jadhav

  175. DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets

    Article • Nucleic Acids Research, April 2016, Oxford University Press (OUP)

    Dr Christoph Bock

  176. A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN

    Article • Cell Reports, April 2016, Elsevier

    Dr Christoph Bock

  177. Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types

    Article • EMBO Reports, December 2015, EMBO

    Dr Christoph Bock

  178. Differential DNA Methylation Analysis without a Reference Genome

    Article • Cell Reports, December 2015, Elsevier

    Dr Christoph Bock

  179. LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor

    Article • Bioinformatics, October 2015, Oxford University Press (OUP)

    Dr Christoph Bock

  180. Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms

    Article • Blood, September 2015, American Society of Hematology

    Dr Christoph Bock

  181. ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

    Article • Nature Chemical Biology, August 2015, Nature

    Dr Christoph Bock

  182. Toward understanding and exploiting tumor heterogeneity

    Article • Nature Medicine, August 2015, Nature

    Dr Christoph Bock

  183. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

    Article • Nature Chemical Biology, July 2015, Nature

    Dr Christoph Bock

  184. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, June 2015, New England Journal of Medicine (NEJM/MMS)

    Dr Christoph Bock

  185. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

    Article • Developmental Biology, June 2015, Elsevier

    Dr Christoph Bock

  186. Dissecting the role of aberrant DNA methylation in human leukaemia

    Article • Nature Communications, May 2015, Nature

    Dr Christoph Bock

  187. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia

    Article • Leukemia, April 2015, Nature

    Dr Christoph Bock

  188. Improving reference epigenome catalogs by computational prediction

    Article • Nature Biotechnology, April 2015, Nature

    Dr Christoph Bock

  189. Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity

    Article • Leukemia, March 2015, Nature

    Dr Christoph Bock

  190. Single-Cell DNA Methylome Sequencing and Bioinformatic Inference of Epigenomic Cell-State Dynamics

    Article • Cell Reports, March 2015, Elsevier

    Dr Christoph Bock

  191. Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

    Article • Cell Reports, February 2015, Elsevier

    Dr Christoph Bock

  192. Model-Based Whole-Genome Analysis of DNA Methylation Fidelity

    Article • January 2015, Springer Science + Business Media

    Dr Christoph Bock

  193. DNA methylation signatures link prenatal famine exposure to growth and metabolism

    Article • Nature Communications, November 2014, Nature

    Dr Christoph Bock

  194. NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

    Article • Oncogene, September 2014, Nature

    Dr Christoph Bock

  195. Comprehensive analysis of DNA methylation data with RnBeads

    Article • Nature Chemical Biology, September 2014, Nature

    Dr Christoph Bock

  196. Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a

    Article • Cell Reports, August 2014, Elsevier

    Dr Christoph Bock

  197. Notch inhibition allows oncogene-independent generation of iPS cells

    Article • Nature Chemical Biology, June 2014, Nature

    Dr Christoph Bock

  198. BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives

    Article • Nucleic Acids Research, May 2014, Oxford University Press (OUP)

    Dr Christoph Bock

  199. Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

    Article • Cell Stem Cell, May 2014, Elsevier

    Dr Christoph Bock

  200. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA‐dependent TAU phosphorylation and CREB activation in Alzheimer's disease

    Article • Hippocampus, January 2014, Wiley

    Dr Christoph Bock

  201. Relationship between genome and epigenome - challenges and requirements for future research

    Article • BMC Genomics, January 2014, Springer Science + Business Media

    Dr Ekaterini Tiligada, Professor Alireza Fazeli, Dr Christoph Bock

  202. Synergy and competition between cancer genome sequencing and epigenome mapping projects

    Article • Genome Medicine, January 2014, Springer Science + Business Media

    Dr Christoph Bock

  203. Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, December 2013, New England Journal of Medicine (NEJM/MMS)

    Dr Christoph Bock

  204. A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

    Article • Journal of Clinical Oncology, November 2013, American Society of Clinical Oncology (ASCO)

    Dr Christoph Bock

  205. Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2

    Article • PLOS One, October 2013, PLOS

    Dr Christoph Bock

  206. Recommendations for the design and analysis of epigenome-wide association studies

    Article • Nature Chemical Biology, September 2013, Nature

    Dr Christoph Bock

  207. A reversible gene trap collection empowers haploid genetics in human cells

    Article • Nature Chemical Biology, August 2013, Nature

    Dr Christoph Bock

  208. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

    Article • Cancer Cell, August 2013, Elsevier

    Dr Marcos Malumbres, Dr Christoph Bock

  209. Identification of Novel Imprinted Differentially Methylated Regions by Global Analysis of Human-Parthenogenetic-Induced Pluripotent Stem Cells

    Article • Stem Cell Reports, June 2013, Elsevier

    Dr Christoph Bock

  210. High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells

    Article • PLoS Genetics, April 2013, PLOS

    Dr Christoph Bock

  211. Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

    Article • Cell Stem Cell, April 2013, Elsevier

    Dr Christoph Bock

  212. DNA methylation: a matter of culture

    Article • Nature Structural & Molecular Biology, March 2013, Nature

    Dr Christoph Bock

  213. Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

    Article • Epigenetics, December 2012, Taylor & Francis

    Dr Christoph Bock

  214. Analysing and interpreting DNA methylation data

    Article • Nature Reviews Genetics, October 2012, Nature

    Dr Christoph Bock

  215. DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells

    Article • Molecular Cell, August 2012, Elsevier

    Dr Christoph Bock

  216. Managing drug resistance in cancer: lessons from HIV therapy

    Article • Nature Reviews Drug Discovery, June 2012, Nature

    Dr Christoph Bock

  217. DNA methylation biomarkers in cancer: progress towards clinical implementation

    Article • Expert Review of Molecular Diagnostics, June 2012, Taylor & Francis

    Professor Alexander Dobrovic, Dr Christoph Bock

  218. Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

    Article • Cell Stem Cell, May 2012, Elsevier

    Dr Christoph Bock

  219. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

    Article • Genome Research, March 2012, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  220. BLUEPRINT to decode the epigenetic signature written in blood

    Article • Nature Biotechnology, March 2012, Nature

    Dr Christoph Bock

  221. Epigenom-Karten erstellen und nutzen

    Article • BIOspektrum, March 2012, Springer Science + Business Media

    Dr Christoph Bock

  222. EpiExplorer: live exploration and global analysis of large epigenomic datasets

    Article • Genome Biology, January 2012, Springer Science + Business Media

    Dr Christoph Bock

  223. Analyzing Epigenome Data in Context of Genome Evolution and Human Diseases

    Article • January 2012, Springer Science + Business Media

    Dr Christoph Bock

  224. Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

    Article • PLoS Genetics, December 2011, PLOS

    Dr Christoph Bock

  225. RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing

    Article • Bioinformatics, December 2011, Oxford University Press (OUP)

    Dr Christoph Bock

  226. Dnmt3a is essential for hematopoietic stem cell differentiation

    Article • Nature Genetics, December 2011, Nature

    Dr Christoph Bock

  227. Global DNA Demethylation During Mouse Erythropoiesis in Vivo

    Article • Science, November 2011, American Association for the Advancement of Science

    Dr Christoph Bock

  228. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

    Article • BDJ, November 2011, Nature

    Dr Christoph Bock

  229. A promoter DNA demethylation landscape of human hematopoietic differentiation

    Article • Nucleic Acids Research, September 2011, Oxford University Press (OUP)

    Dr Vincenzo Calvanese, Dr Christoph Bock

  230. Lung Stem Cell Self-Renewal Relies on BMI1-Dependent Control of Expression at Imprinted Loci

    Article • Cell Stem Cell, September 2011, Elsevier

    Dr Christoph Bock, Carla Kim

  231. A DNA methylation fingerprint of 1628 human samples

    Article • Genome Research, May 2011, Cold Spring Harbor Laboratory Press

    Dr Christoph Bock

  232. BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing

    Article • Nucleic Acids Research, May 2011, Oxford University Press (OUP)

    Dr Christoph Bock

  233. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

    Article • Nature Protocols, March 2011, Nature

    Dr Christoph Bock

  234. Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

    Article • Cell, February 2011, Elsevier

    Dr Christoph Bock

  235. Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

    Article • Cell, December 2010, Elsevier

    Dr Christoph Bock

  236. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

    Article • Nature Biotechnology, September 2010, Springer Science + Business Media

    Dr Joseph R Ecker, Dr Christoph Bock

  237. Quantitative comparison of genome-wide DNA methylation mapping technologies

    Article • Nature Biotechnology, September 2010, Nature

    Dr Christoph Bock

  238. Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution

    Article • Nature Chemical Biology, January 2010, Nature

    Dr Christoph Bock

  239. Web-Based Analysis of (Epi-) Genome Data Using EpiGRAPH and Galaxy

    Article • January 2010, Springer Science + Business Media

    Dr Christoph Bock

  240. Epigenetic biomarker development

    Article • Epigenomics, October 2009, Future Medicine

    Dr Christoph Bock

  241. High-throughput bisulfite sequencing in mammalian genomes

    Article • Methods, July 2009, Elsevier

    Dr Christoph Bock

  242. DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution

    Article • PLoS Genetics, March 2009, PLOS

    Dr Christoph Bock

  243. MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

    Article • Genome Biology, January 2009, Springer Science + Business Media

    Dr Christoph Bock

  244. EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data

    Article • Genome Biology, January 2009, Springer Science + Business Media

    Dr Christoph Bock

  245. IVF: stars may have to consider the risk of stolen parenthood

    Article • Nature, August 2008, Nature

    Dr Christoph Bock

  246. Functional Analysis of a Potassium-Chloride Co-Transporter 3 (SLC12A6) Promoter Polymorphism Leading to an Additional DNA Methylation Site

    Article • Neuropsychopharmacology, June 2008, Nature

    Dr Christoph Bock

  247. Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping

    Article • Nucleic Acids Research, April 2008, Oxford University Press (OUP)

    Dr Christoph Bock

  248. Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region

    Article • BMC Genomics, January 2008, Springer Science + Business Media

    Dr Christoph Bock

  249. Computational epigenetics

    Article • Bioinformatics, November 2007, Oxford University Press (OUP)

    Dr Christoph Bock

  250. Optimization of Quantitative MGMT Promoter Methylation Analysis Using Pyrosequencing and Combined Bisulfite Restriction Analysis

    Article • Journal of Molecular Diagnostics, July 2007, Elsevier

    Dr Christoph Bock

  251. The Human Genomic Melting Map

    Article • PLoS Computational Biology, January 2007, PLOS

    Dr Christoph Bock

  252. CpG Island Mapping by Epigenome Prediction

    Article • PLoS Computational Biology, January 2007, PLOS

    Dr Christoph Bock

  253. CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure

    Article • PLoS Genetics, January 2006, PLOS

    Dr Christoph Bock

  254. BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing

    Article • Bioinformatics, September 2005, Oxford University Press (OUP)

    Dr Christoph Bock