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  1. Un rôle possible de l’épigénétique dans l’initiation du cancer

    Article • Comptes Rendus Biologies, May 2025, Cellule MathDoc/CEDRAM

    Dr Giacomo Cavalli

  2. 3D genome folding in epigenetic regulation and cellular memory

    Article • Trends in Cell Biology, April 2025, Elsevier

    Dr Giacomo Cavalli

  3. Revealing how acquired traits evolve

    Article • Proceedings of the National Academy of Sciences, March 2025, Proceedings of the National Academy of Sciences

    Dr Giacomo Cavalli, Gonzalo Sabarís

  4. A possible role for epigenetics in cancer initiation

    Article • Comptes Rendus Biologies, February 2025, Cellule MathDoc/CEDRAM

    Dr Giacomo Cavalli

  5. Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila

    Article • Molecular Cell, February 2025, Elsevier

    Dr Giacomo Cavalli

  6. Evolution and function of chromatin domains across the tree of life

    Article • Nature Structural & Molecular Biology, November 2024, Springer Science + Business Media

    Dr Giacomo Cavalli

  7. Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  8. A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication

    Article • Nature Structural & Molecular Biology, August 2024, Springer Science + Business Media

    Dr Giacomo Cavalli

  9. Organ transformation by environmental disruption of protein integrity and epigenetic memory in Drosophila

    Article • PLoS Biology, May 2024, PLOS

    Dr Giacomo Cavalli

  10. A Scaffolding Element Rewires Local 3D Chromatin Architecture During Differentiation

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  11. The mechanistic basis of genetic assimilation in natural fly populations

    Article • May 2024, Springer Science + Business Media

    Dr Giacomo Cavalli

  12. Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity

    Article • Science Advances, May 2024, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  13. Transient loss of Polycomb components induces an epigenetic cancer fate

    Article • Nature, April 2024, Springer Science + Business Media

    Dr Giacomo Cavalli

  14. The Density of Regulatory Information Is a Major Determinant of Evolutionary Constraint on Noncoding DNA in Drosophila

    Article • Molecular Biology and Evolution, February 2024, Oxford University Press (OUP)

    Dr Giacomo Cavalli

  15. PRE loops constitute a topological chromatin structure that restricts and specifies enhancer promoter communication

    Article • November 2023, Springer Science + Business Media

    Dr Giacomo Cavalli

  16. The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA inDrosophila

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  17. Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  18. Epigenetic inheritance in adaptive evolution

    Article • Annals of the New York Academy of Sciences, March 2023, Wiley

    Dr Giacomo Cavalli

  19. Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements

    Article • Science Advances, February 2023, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  20. Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination betweenDrosophilaPolycomb genes

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  21. A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg

    Article • PLoS Genetics, March 2022, PLOS

    Dr Giacomo Cavalli

  22. HiCmapTools: a tool to access HiC contact maps

    Article • BMC Bioinformatics, February 2022, Springer Science + Business Media

    Dr Giacomo Cavalli

  23. SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

    Article • Molecular Cell, February 2022, Elsevier

    Dr Giacomo Cavalli

  24. Mechanisms of Polycomb group protein function in cancer

    Article • BDJ, January 2022, Springer Science + Business Media

    Dr Giacomo Cavalli

  25. Molecular mechanisms of transgenerational epigenetic inheritance

    Article • Nature Reviews Genetics, January 2022, Springer Science + Business Media

    Dr Giacomo Cavalli

  26. Understanding 3D genome organization by multidisciplinary methods

    Article • Nature Reviews Molecular Cell Biology, May 2021, Springer Science + Business Media

    Dr Giacomo Cavalli

  27. Tissue-specific versus pleiotropic enhancers within thebric-a-bractandem gene duplicates display differential regulatory activity and evolutionary conservation

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  28. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

    Article • Nature, March 2021, Springer Science + Business Media

    Dr Herve Chneiweiss, Dr Giacomo Cavalli, Catherine Brooksbank

  29. Regulation of single-cell genome organization into TADs and chromatin nanodomains

    Article • Nature Genetics, October 2020, Springer Science + Business Media

    Dr Giacomo Cavalli

  30. LifeTime and improving European healthcare through cell-based interceptive medicine

    Article • Nature, September 2020, Springer Science + Business Media

    Dr Christoph Bock, Dr Herve Chneiweiss, Dr Giacomo Cavalli, Catherine Brooksbank

  31. Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin

    Article • PLoS Genetics, March 2020, PLOS

    Yuheng Huang, Dr Giacomo Cavalli

  32. Higher-Order Chromosomal Structures Mediate Genome Function

    Article • Journal of Molecular Biology, February 2020, Elsevier

    Dr Giacomo Cavalli

  33. Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

    Article • Science Advances, January 2020, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  34. Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

    Article • Nature Communications, November 2019, Springer Science + Business Media

    Dr Giacomo Cavalli

  35. The multiscale effects of polycomb mechanisms on 3D chromatin folding

    Article • Critical Reviews in Biochemistry and Molecular Biology, November 2019, Taylor & Francis

    Dr Giacomo Cavalli

  36. Principles of genome folding into topologically associating domains

    Article • Science Advances, April 2019, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  37. Waddington Revisited: Organ transformation by environmental disruption of epigenetic memory

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  38. Challenges and guidelines toward 4D nucleome data and model standards

    Article • Nature Genetics, September 2018, Springer Science + Business Media

    Dr Giacomo Cavalli

  39. Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis

    Article • Nature Communications, September 2018, Springer Science + Business Media

    Dr Giacomo Cavalli

  40. TADs are 3D structural units of higher-order chromosome organization in Drosophila

    Article • Science Advances, February 2018, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  41. PRC1-dependent compaction of Hox gene clusters prevents transcriptional derepression during early Drosophila embryogenesis

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  42. Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

    Article • Nature Communications, November 2017, Springer Science + Business Media

    Dr Giacomo Cavalli

  43. Technical Review: A Hitchhiker’s Guide to Chromosome Conformation Capture

    Article • October 2017, Springer Science + Business Media

    Dr Giacomo Cavalli

  44. Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

    Article • Cell, September 2017, Elsevier

    Dr Giacomo Cavalli

  45. Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation

    Article • EMBO Reports, August 2017, EMBO

    Dr Giacomo Cavalli

  46. Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

    Article • Nature Genetics, April 2017, Springer Science + Business Media

    Dr Giacomo Cavalli

  47. Three-Dimensional Genome Organization and Function in Drosophila

    Article • Genetics, January 2017, Oxford University Press (OUP)

    Dr Giacomo Cavalli

  48. Organization and function of the 3D genome

    Article • Nature Reviews Genetics, October 2016, Springer Science + Business Media

    Dr Giacomo Cavalli

  49. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development

    Article • Nature Genetics, September 2016, Springer Science + Business Media

    Dr Giacomo Cavalli

  50. Regulation of Genome Architecture and Function by Polycomb Proteins

    Article • Trends in Cell Biology, July 2016, Elsevier

    Dr Giacomo Cavalli

  51. Chromosome conformation capture technologies and their impact in understanding genome function

    Article • Chromosoma, April 2016, Springer Science + Business Media

    Dr Giacomo Cavalli

  52. Chromosome Conformation Capture on Chip (4C): Data Processing

    Article • January 2016, Springer Science + Business Media

    Dr Giacomo Cavalli

  53. MACVIA-LR (FIGHTING CHRONIC DISEASES FOR ACTIVE AND HEALTHY AGEING IN LANGUEDOC-ROUSSILLON): A SUCCESS STORY OF THE EUROPEAN INNOVATION PARTNERSHIP ON ACTIVE AND HEALTHY AGEING

    Article • Journal of Frailty & Aging, January 2016, Elsevier

    Dr Giacomo Cavalli

  54. EZH2 in normal hematopoiesis and hematological malignancies

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Dr Jerome Moreaux, Dr Giacomo Cavalli

  55. PRC1 proteins orchestrate three-dimensional genome architecture

    Article • Nature Genetics, September 2015, Springer Science + Business Media

    Dr Giacomo Cavalli

  56. Enhancer of zeste acts as a major developmental regulator ofCiona intestinalisembryogenesis

    Article • Biology Open, August 2015, The Company of Biologists

    Dr Giacomo Cavalli

  57. Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila

    Article • Cell Reports, June 2015, Elsevier

    Dr Giacomo Cavalli

  58. The Role of Chromosome Domains in Shaping the Functional Genome

    Article • Cell, March 2015, Elsevier

    Dr Giacomo Cavalli

  59. Chromatin-Driven Behavior of Topologically Associating Domains

    Article • Journal of Molecular Biology, February 2015, Elsevier

    Dr Giacomo Cavalli

  60. Developmental determinants in non-communicable chronic diseases and ageing

    Article • Thorax, January 2015, BMJ

    Prof. John W Holloway, Dr Giacomo Cavalli

  61. Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen

    Article • Molecular Cell, May 2014, Elsevier

    Dr Giacomo Cavalli

  62. Polycomb silencing: from linear chromatin domains to 3D chromosome folding

    Article • Current Opinion in Genetics & Development, April 2014, Elsevier

    Dr Giacomo Cavalli

  63. A RING to Rule Them All: RING1 as Silencer and Activator

    Article • Developmental Cell, January 2014, Elsevier

    Dr Giacomo Cavalli

  64. Topological Organization of Drosophila Hox Genes Using DNA Fluorescent In Situ Hybridization

    Article • January 2014, Springer Science + Business Media

    Dr Giacomo Cavalli

  65. Chromosomes: now in 3D!

    Article • Nature Reviews Molecular Cell Biology, November 2013, Springer Science + Business Media

    Dr Giacomo Cavalli

  66. PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes

    Article • Developmental Cell, August 2013, Elsevier

    Dr Giacomo Cavalli

  67. The 3D Genome Shapes Up For Pluripotency

    Article • Cell Stem Cell, July 2013, Elsevier

    Dr Giacomo Cavalli

  68. Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization

    Article • Current Opinion in Genetics & Development, April 2013, Elsevier

    Dr Giacomo Cavalli

  69. Functional implications of genome topology

    Article • Nature Structural & Molecular Biology, March 2013, Springer Science + Business Media

    Dr Giacomo Cavalli

  70. Polycomb Domain Formation Depends on Short and Long Distance Regulatory Cues

    Article • PLOS One, February 2013, PLOS

    Dr Giacomo Cavalli

  71. Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm/Glide Fate Determinant

    Article • PLoS Genetics, December 2012, PLOS

    Dr Giacomo Cavalli

  72. EZH2 Goes Solo

    Article • Science, December 2012, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  73. Polycomb: a paradigm for genome organization from one to three dimensions

    Article • Current Opinion in Cell Biology, June 2012, Elsevier

    Dr Giacomo Cavalli

  74. Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

    Article • Cell, February 2012, Elsevier

    Dr Giacomo Cavalli

  75. Polycomb group proteins: repression in 3D

    Article • Trends in Genetics, November 2011, Elsevier

    Dr Giacomo Cavalli

  76. Integrated Gene Regulatory Circuits: Celebrating the 50th Anniversary of the Operon Model

    Article • Molecular Cell, August 2011, Elsevier

    Dr Giacomo Cavalli

  77. Editorial overview

    Article • Current Opinion in Cell Biology, June 2011, Elsevier

    Dr Giacomo Cavalli

  78. Rolling ES Cells Down the Waddington Landscape with Oct4 and Sox2

    Article • Cell, June 2011, Elsevier

    Dr Giacomo Cavalli

  79. From Linear Genes to Epigenetic Inheritance of Three-dimensional Epigenomes

    Article • Journal of Molecular Biology, May 2011, Elsevier

    Dr Giacomo Cavalli

  80. A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Dr Giacomo Cavalli

  81. Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila

    Article • Cell, January 2011, Elsevier

    Dr Giacomo Cavalli

  82. The DUBle Life of Polycomb Complexes

    Article • Developmental Cell, June 2010, Elsevier

    Dr Giacomo Cavalli

  83. Chromatin Folding: From Linear Chromosomes to the 4D Nucleus

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2010, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  84. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

    Article • Nature Genetics, September 2009, Springer Science + Business Media

    Professor Cayetano Gonzalez, Dr Giacomo Cavalli

  85. Genomic interactions: Chromatin loops and gene meeting points in transcriptional regulation

    Article • Seminars in Cell and Developmental Biology, September 2009, Elsevier

    Dr Giacomo Cavalli

  86. Epigenetics and the control of multicellularity

    Article • EMBO Reports, November 2008, Springer Science + Business Media

    Dr Giacomo Cavalli

  87. Polycomb proteins and nuclear organization

    Article • March 2008, Elsevier

    Dr Giacomo Cavalli

  88. Chapter 2 Polycomb Group Proteins and Long‐Range Gene Regulation

    Article • January 2008, Elsevier

    Dr Giacomo Cavalli

  89. Chromosome kissing

    Article • Current Opinion in Genetics & Development, October 2007, Elsevier

    Dr Giacomo Cavalli

  90. Combinatorial epigenetics, “junk DNA”, and the evolution of complex organisms

    Article • Gene, April 2007, Elsevier

    Dr Giacomo Cavalli

  91. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

    Article • Nature Reviews Genetics, February 2007, Nature

    Dr Giacomo Cavalli

  92. Genome Regulation by Polycomb and Trithorax Proteins

    Article • Cell, February 2007, Elsevier

    Dr Giacomo Cavalli

  93. Polycomb maîtrise la destinée cellulaire

    Article • médecine/sciences, December 2006, EDP Sciences

    Dr Giacomo Cavalli

  94. PRE-Mediated Bypass of Two Su(Hw) Insulators Targets PcG Proteins to a Downstream Promoter

    Article • Developmental Cell, July 2006, Elsevier

    Dr Giacomo Cavalli

  95. Cellular memory and dynamic regulation of polycomb group proteins

    Article • Current Opinion in Cell Biology, June 2006, Elsevier

    Dr Giacomo Cavalli

  96. Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity

    Article • Development, June 2006, The Company of Biologists

    Dr Giacomo Cavalli

  97. The role of Polycomb Group Proteins in Cell Cycle Regulation During Development

    Article • Cell Cycle, May 2006, Taylor & Francis

    Dr Giacomo Cavalli

  98. From genetics to epigenetics: the tale of Polycomb group and trithorax group genes

    Article • Chromosome Research, May 2006, Springer Science + Business Media

    Dr Giacomo Cavalli

  99. RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements

    Article • Cell, March 2006, Elsevier

    Dr Giacomo Cavalli

  100. Polycomb group-dependent Cyclin A repression in Drosophila

    Article • Genes & Development, February 2006, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  101. Mapping the Distribution of Chromatin Proteins by ChIP on Chip

    Article • January 2006, Elsevier

    Dr Giacomo Cavalli

  102. Dsp1 favorise le recrutement des protéines du groupe Polycomb sur la chromatine

    Article • médecine/sciences, August 2005, EDP Sciences

    Dr Giacomo Cavalli

  103. The Epigenome Network of Excellence

    Article • PLoS Biology, May 2005, PLOS

    Dr Giacomo Cavalli

  104. Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

    Article • Nature, March 2005, Springer Science + Business Media

    Dr Giacomo Cavalli

  105. Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila

    Article • Proceedings of the National Academy of Sciences, October 2004, Proceedings of the National Academy of Sciences

    Dr Giacomo Cavalli

  106. Dissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line

    Article • Molecular and Cellular Biology, August 2004, ASM Journals

    Dr Giacomo Cavalli

  107. Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation

    Article • Developmental Biology, August 2004, Elsevier

    Dr Giacomo Cavalli

  108. Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module

    Article • The EMBO Journal, February 2004, Springer Science + Business Media

    Dr Giacomo Cavalli

  109. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila

    Article • Genes & Development, October 2003, Cold Spring Harbor Laboratory Press

    Dr Giacomo Cavalli

  110. Identification and characterization of polyhomeotic PREs and TREs

    Article • Developmental Biology, September 2003, Elsevier

    Dr Giacomo Cavalli

  111. Protein–DNA interaction mapping using genomic tiling path microarrays in Drosophila

    Article • Proceedings of the National Academy of Sciences, July 2003, Proceedings of the National Academy of Sciences

    Dr Giacomo Cavalli

  112. SNR1 is an essential subunit in a subset of drosophila brm complexes, targeting specific functions during development

    Article • Developmental Biology, January 2003, Elsevier

    Dr Giacomo Cavalli

  113. Chromatin as a eukaryotic template of genetic information

    Article • Current Opinion in Cell Biology, June 2002, Elsevier

    Dr Giacomo Cavalli

  114. The MYST Domain Acetyltransferase Chameau Functions in Epigenetic Mechanisms of Transcriptional Repression

    Article • Current Biology, April 2002, Elsevier

    vincent GELI, Dr Giacomo Cavalli

  115. Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

    Article • Science, October 1999, American Association for the Advancement of Science

    Dr Giacomo Cavalli

  116. Chromo-domain proteins: linking chromatin structure to epigenetic regulation

    Article • Current Opinion in Cell Biology, June 1998, Elsevier

    Dr Giacomo Cavalli

  117. The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis

    Article • Cell, May 1998, Elsevier

    Dr Giacomo Cavalli

  118. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

    Article • The EMBO Journal, June 1997, Springer Science + Business Media

    Dr Giacomo Cavalli

  119. Identification of the peroxidation product hydroxystearic acid in Lewis lung carcinoma cells

    Article • Biochemical and Biophysical Research Communications, August 1991, Elsevier

    Dr Giacomo Cavalli

  120. Combined Immunostaining and FISH Analysis of Polytene Chromosomes

    Article • Springer Science + Business Media

    Dr Giacomo Cavalli