All Stories

  1. Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging

    Article • Nature Methods, July 2023, Springer Science + Business Media

    Professor Werner Muller

  2. Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa

    Article • AJP Gastrointestinal and Liver Physiology, October 2022, American Physiological Society

    Professor Werner Muller

  3. Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

    Article • Frontiers in Immunology, September 2022, Frontiers

    Professor Werner Muller

  4. Genetic diversity of honeybee colonies predicts gut bacterial diversity of individual colony members

    Article • Environmental Microbiology, August 2022, Wiley

    Professor Werner Muller

  5. Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  6. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

    Article • Development, March 2022, The Company of Biologists

    Professor Werner Muller

  7. Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses

    Article • Biomedicines, March 2022, MDPI AG

    Professor Werner Muller

  8. MACSima imaging cyclic staining (MICS) technology reveals combinatorial target pairs for CAR T cell treatment of solid tumors

    Article • Scientific Reports, February 2022, Springer Science + Business Media

    Professor Werner Muller

  9. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  10. Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages

    Article • PLoS Pathogens, July 2021, PLOS

    Professor Werner Muller, Kathryn Else, Dr Jo Pennock

  11. Advanced high dynamic range fluorescence microscopy with Poisson noise modeling and integrated edge-preserving denoising

    Article • Journal of Physics Communications, July 2021, Institute of Physics Publishing

    Professor Werner Muller

  12. Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals

    Article • Frontiers in Immunology, June 2021, Frontiers

    Professor Werner Muller

  13. The genetic diversity of honeybee colonies predicts the gut bacterial diversity of individual colony members

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  14. Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells

    Article • Nature Communications, March 2021, Springer Science + Business Media

    Professor Werner Muller

  15. The role of β2 integrin in dendritic cell migration during infection

    Article • BMC Immunology, January 2021, Springer Science + Business Media

    Professor Werner Muller

  16. Cell-intrinsic IL4R alpha independence of large intestinal RELMα+ Ym1+ macrophages

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  17. A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System

    Article • The Journal of Immunology, November 2020, The American Association of Immunologists

    Professor Werner Muller

  18. Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

    Article • Immunity, November 2020, Elsevier

    Professor Werner Muller

  19. The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function

    Article • Frontiers in Immunology, August 2020, Frontiers

    Professor Werner Muller

  20. Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse

    Article • Journal of Molecular Medicine, August 2020, Springer Science + Business Media

    Professor Werner Muller

  21. A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  22. Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease

    Article • Journal of Molecular Medicine, May 2020, Springer Science + Business Media

    Professor Werner Muller

  23. Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

    Article • PLoS Pathogens, February 2020, PLOS

    Professor Werner Muller

  24. Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease

    Article • Disease Models & Mechanisms, January 2020, The Company of Biologists

    Professor Werner Muller

  25. The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background

    Article • Frontiers in Immunology, December 2019, Frontiers

    Professor Werner Muller

  26. Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

    Article • Frontiers in Immunology, September 2019, Frontiers

    Professor Werner Muller

  27. Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

    Article • Stem Cell Research, March 2019, Elsevier

    Professor Werner Muller

  28. The essential role played by B cells in supporting protective immunity against Trichuris muris infection is dependent on host genetic background and is independent of antibody

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Professor Werner Muller

  29. Macrophage-specific NF-kappa B activation dynamics can segregate inflammatory bowel disease patients: Supplementary information

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Professor Werner Muller, Michael Burkitt

  30. Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses

    Article • Scientific Reports, January 2019, Springer Science + Business Media

    Professor Werner Muller

  31. Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

    Article • PLoS Pathogens, January 2019, PLOS

    Professor Werner Muller, Timothy Jenkins

  32. IL‐10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation

    Article • European Journal of Immunology, January 2019, Wiley

    Professor Werner Muller

  33. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

    Article • Cell Reports, January 2019, Elsevier

    Professor Werner Muller

  34. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

    Article • Brain Behavior and Immunity, November 2018, Elsevier

    Professor Werner Muller

  35. Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10–Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani

    Article • The Journal of Immunology, October 2018, The American Association of Immunologists

    Professor Werner Muller

  36. Evaluating the IgMi mouse as a novel tool to study B cell biology

    Article • European Journal of Immunology, October 2018, Wiley

    Professor Werner Muller

  37. Ribonucleotide excision repair is essential to prevent squamous cell carcinoma of the skin.

    Article • Cancer Research, August 2018, American Association for Cancer Research (AACR)

    Professor Werner Muller

  38. Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency

    Article • Frontiers in Immunology, August 2018, Frontiers

    Professor Werner Muller

  39. Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

    Article • Science Signaling, July 2018, American Association for the Advancement of Science

    Professor Werner Muller

  40. Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

    Article • Nature Medicine, July 2018, Springer Science + Business Media

    Professor Werner Muller

  41. Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors

    Article • Cell Reports, January 2018, Elsevier

    Professor Werner Muller

  42. IL-6–Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion

    Article • Diabetes, October 2017, American Diabetes Association

    Professor Werner Muller, Daniel Konrad

  43. Gamma Interferon Mediates Experimental Cerebral Malaria by Signaling within Both the Hematopoietic and Nonhematopoietic Compartments

    Article • Infection and Immunity, September 2017, ASM Journals

    Professor Werner Muller

  44. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

    Article • eLife, July 2017, eLife

    Professor Werner Muller

  45. Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses

    Article • Brain Behavior and Immunity, June 2017, Elsevier

    Professor Werner Muller

  46. IL‐1 signaling is critical for expansion but not generation of autoreactive GM‐CSF + Th17 cells

    Article • The EMBO Journal, November 2016, EMBO

    Professor Werner Muller

  47. Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease

    Article • Gut, September 2016, BMJ

    Professor Werner Muller

  48. Making sense of big data in health research: Towards an EU action plan

    Article • Genome Medicine, June 2016, Springer Science + Business Media

    Professor Werner Muller, DR Juan Antonio Vizcaino, Dr Christoph Bock, Dr Niklas U Blomberg

  49. CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation

    Article • Mucosal Immunology, May 2016, Nature

    Professor Werner Muller, Dr Riccardo RG Guidi

  50. Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR-/- mice

    Article • Atherosclerosis, March 2016, Elsevier

    Professor Werner Muller

  51. Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

    Article • PLoS Pathogens, February 2016, PLOS

    Professor Werner Muller

  52. Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system

    Article • European Journal of Immunology, January 2016, Wiley

    Professor Werner Muller

  53. Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

    Article • PLoS Pathogens, January 2016, PLOS

    Professor Werner Muller

  54. Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo

    Article • Journal of Controlled Release, January 2016, Elsevier

    Professor Werner Muller

  55. Mesenteric Fat Lipolysis Mediates Obesity-associated Hepatic Steatosis and Insulin Resistance

    Article • Diabetes, September 2015, American Diabetes Association

    Professor Werner Muller

  56. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

    Article • Nature Genetics, July 2015, Nature

    Professor Werner Muller, Dr John M Hancock

  57. Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

    Article • Immunity, July 2015, Elsevier

    Professor Werner Muller

  58. IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells

    Article • PLoS Pathogens, February 2015, PLOS

    Professor Werner Muller

  59. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

    Article • Molecular Cell, November 2014, Elsevier

    Professor Werner Muller

  60. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

    Article • Molecular Cell, October 2014, Elsevier

    Professor Werner Muller

  61. Regulatory T cells and T‐cell‐derived IL‐10 interfere with effective anti‐cytomegalovirus immune response

    Article • Immunology and Cell Biology, July 2014, Wiley

    Professor Tim D Sparwasser, Professor Werner Muller

  62. Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer

    Article • Cancer Research, June 2014, American Association for Cancer Research (AACR)

    Professor Werner Muller, Professor Tim D Sparwasser

  63. Glycoprotein 130 Receptor Signaling Mediates  -Cell Dysfunction in a Rodent Model of Type 2 Diabetes

    Article • Diabetes, May 2014, American Diabetes Association

    Professor Werner Muller

  64. Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function

    Article • PLoS Pathogens, May 2014, PLOS

    Professor Werner Muller

  65. Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

    Article • Immunity, May 2014, Elsevier

    Professor Werner Muller

  66. Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

    Article • Immunity, May 2014, Elsevier

    Professor Werner Muller

  67. Protective mucosal immunity mediated by epithelial CD1d and IL-10

    Article • Nature, April 2014, Nature

    Professor Werner Muller

  68. Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days

    Article • mBio, January 2014, ASM Journals

    Professor Werner Muller

  69. IFN- -Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia

    Article • The Journal of Immunology, December 2013, The American Association of Immunologists

    Professor Werner Muller

  70. TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

    Article • PLoS Biology, October 2013, PLOS

    Professor Werner Muller

  71. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

    Article • Journal of Clinical Investigation, October 2013, American Society for Clinical Investigation

    Professor Werner Muller

  72. Neuroprotective intervention by interferon-γ blockade prevents CD8 + T cell–mediated dendrite and synapse loss

    Article • The Journal of Experimental Medicine, September 2013, Rockefeller University Press

    Professor Werner Muller

  73. Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

    Article • Immunity, September 2013, Elsevier

    Professor Werner Muller

  74. Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

    Article • Cell Reports, August 2013, Elsevier

    Professor Werner Muller

  75. T Cell-Derived IL-10 Determines Leishmaniasis Disease Outcome and Is Suppressed by a Dendritic Cell Based Vaccine

    Article • PLoS Pathogens, June 2013, PLOS

    Professor Werner Muller

  76. CD4+ T Cell-derived IL-10 Promotes Brucella abortus Persistence via Modulation of Macrophage Function

    Article • PLoS Pathogens, June 2013, PLOS

    Professor Werner Muller, Dr Renato Lima Santos

  77. T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses inLitomosoides sigmodontis-infected mice

    Article • European Journal of Immunology, May 2013, Wiley

    Professor Werner Muller

  78. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

    Article • Genome Biology, January 2013, Springer Science + Business Media

    Professor Werner Muller, Dr John M Hancock

  79. Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

    Article • British Journal of Dermatology, October 2012, Wiley

    Professor Werner Muller

  80. IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection

    Article • The Journal of Immunology, August 2012, The American Association of Immunologists

    Professor Werner Muller

  81. β7 integrin controls immunogenic and tolerogenic mucosal B cell responses

    Article • Clinical Immunology, August 2012, Elsevier

    Professor Werner Muller

  82. Neuronal gp130 Expression Is Crucial to Prevent Neuronal Loss, Hyperinflammation, and Lethal Course of Murine Toxoplasma Encephalitis

    Article • American Journal Of Pathology, July 2012, Elsevier

    Professor Werner Muller

  83. Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection

    Article • The Journal of Immunology, April 2012, The American Association of Immunologists

    Professor Werner Muller, Professor Tim D Sparwasser

  84. Studying Immunology in Mice

    Article • January 2012, Elsevier

    Professor Werner Muller

  85. Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation ThresholdsIn Vivo

    Article • Developmental Immunology, January 2012, Hindawi Publishing Corporation

    Professor Werner Muller

  86. IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Werner Muller

  87. Induction of Regulatory T Cells by a Murine  -Defensin

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Tim D Sparwasser, Professor Werner Muller

  88. B Cell-Derived IL-10 Does Not Regulate Spontaneous Systemic Autoimmunity in MRL.Faslpr Mice

    Article • The Journal of Immunology, December 2011, The American Association of Immunologists

    Professor Werner Muller

  89. Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-101

    Article • Inflammatory Bowel Diseases, October 2011, Wolters Kluwer Health

    Professor Werner Muller, Dr Mariela Bollati-Fogolin

  90. Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus

    Article • PLoS Pathogens, August 2011, PLOS

    Professor Werner Muller

  91. Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

    Article • Proceedings of the National Academy of Sciences, June 2011, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  92. Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

    Article • Immunity, June 2011, Elsevier

    Dr Anne Dudeck, Professor Werner Muller, Anne Dudeck

  93. gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis

    Article • European Journal of Cell Biology, June 2011, Elsevier

    Professor Werner Muller

  94. Gp130-Dependent Release of Acute Phase Proteins Is Linked to the Activation of Innate Immune Signaling Pathways

    Article • PLoS ONE, May 2011, PLOS

    Professor Werner Muller, Prof. Dr. Karsten Grote

  95. Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

    Article • The Journal of Immunology, April 2011, The American Association of Immunologists

    Professor Werner Muller

  96. Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

    Article • Immunity, April 2011, Elsevier

    Professor Werner Muller

  97. High-throughput mouse phenotyping

    Article • Methods, April 2011, Elsevier

    Professor Werner Muller

  98. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

    Article • Immunity, February 2011, Elsevier

    Professor Tim D Sparwasser, Professor Werner Muller

  99. TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

    Article • The Journal of Immunology, December 2010, The American Association of Immunologists

    Professor Werner Muller

  100. Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit

    Article • Blood, December 2010, American Society of Hematology

    Professor Werner Muller

  101. Transgenic mice with a diverse human T cell antigen receptor repertoire

    Article • Nature Medicine, August 2010, Nature

    Professor Werner Muller

  102. Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

    Article • Circulation, July 2010, Wolters Kluwer Health

    Professor Werner Muller

  103. Differential Roles of Macrophages in Diverse Phases of Skin Repair

    Article • The Journal of Immunology, February 2010, The American Association of Immunologists

    Professor Werner Muller

  104. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

    Article • European Journal of Immunology, February 2010, Wiley

    Professor Werner Muller

  105. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  106. EuroPhenome: a repository for high-throughput mouse phenotyping data

    Article • Nucleic Acids Research, November 2009, Oxford University Press (OUP)

    Professor Werner Muller, Dr John M Hancock

  107. Hepatocyte gp130 Deficiency Reduces Vascular Remodeling After Carotid Artery Ligation

    Article • Hypertension, November 2009, Wolters Kluwer Health

    Professor Werner Muller, Prof. Dr. Karsten Grote

  108. A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain

    Article • Journal of Neuroscience, October 2009, Society for Neuroscience

    Professor Werner Muller

  109. Langerhans Cells Suppress Contact Hypersensitivity Responses Via Cognate CD4 Interaction and Langerhans Cell-Derived IL-10

    Article • The Journal of Immunology, October 2009, The American Association of Immunologists

    Professor Werner Muller

  110. Charles River altered Schaedler flora (CRASF®) remained stable for four years in a mouse colony housed in individually ventilated cages

    Article • Laboratory Animals, October 2009, SAGE Publications

    Professor Werner Muller

  111. Mucosal Addressin Cell-Adhesion Molecule-1 Controls Plasma-Cell Migration and Function in the Small Intestine of Mice

    Article • Gastroenterology, September 2009, Elsevier

    Professor Werner Muller

  112. Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

    Article • The Journal of Immunology, August 2009, The American Association of Immunologists

    Professor Werner Muller

  113. T‐cell‐specific deletion of gp130 renders the highly susceptible IL‐10‐deficient mouse resistant to intestinal nematode infection

    Article • European Journal of Immunology, August 2009, Wiley

    Professor Werner Muller, Dr Mariela Bollati-Fogolin

  114. Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

    Article • Proceedings of the National Academy of Sciences, February 2009, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  115. The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models

    Article • Current Pharmaceutical Biotechnology, February 2009, Bentham Science Publishers

    Professor Werner Muller

  116. Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies

    Article • Journal of Immunological Methods, February 2009, Elsevier

    Professor Werner Muller

  117. IL-20 Receptor 2 Signaling Down-Regulates Antigen-Specific T Cell Responses

    Article • The Journal of Immunology, January 2009, The American Association of Immunologists

    Professor Werner Muller

  118. Excessive CpG 1668 stimulation triggers IL‐10 production by cDC that inhibits IFN‐α responses by pDC

    Article • European Journal of Immunology, November 2008, Wiley

    Professor Werner Muller

  119. Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis

    Article • The Journal of Immunology, August 2008, The American Association of Immunologists

    Professor Werner Muller

  120. Conditional gp130 deficient mouse mutants

    Article • Seminars in Cell and Developmental Biology, August 2008, Elsevier

    Professor Werner Muller

  121. Role of β7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease

    Article • Gastroenterology, June 2008, Elsevier

    Professor Werner Muller

  122. GP130-STAT3 Regulates Epithelial Cell Migration and Is Required for Repair of the Bronchiolar Epithelium

    Article • American Journal Of Pathology, June 2008, Elsevier

    Professor Werner Muller

  123. Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

    Article • The Journal of Experimental Medicine, May 2008, Rockefeller University Press

    Professor Werner Muller

  124. Susceptibility of four inbred mouse strains to a low-pathogenic isolate of Yersinia enterocolitica

    Article • Mammalian Genome, April 2008, Springer Science + Business Media

    Professor Werner Muller

  125. Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

    Article • Immunity, April 2008, Elsevier

    Professor Werner Muller

  126. Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6-gp130 Interaction

    Article • Chemical Biology & Drug Design, March 2008, Wiley

    Professor Werner Muller, Dr Mariela Bollati-Fogolin

  127. Distinct Functions of Interleukin-10 Derived from Different Cellular Sources

    Article • Current Immunology Reviews, February 2008, Bentham Science Publishers

    Professor Werner Muller

  128. Astrocyte gp130-expression is critical for the control of Toxoplasma encephalitis

    Article • BMC Proceedings, January 2008, Springer Science + Business Media

    Professor Werner Muller

  129. Mast cell-specific Cre/loxP-mediated recombination in vivo

    Article • Transgenic Research, October 2007, Springer Science + Business Media

    Professor Werner Muller

  130. LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1

    Article • Blood, October 2007, American Society of Hematology

    Professor Werner Muller

  131. Contribution of Interleukin‐6/gp130 Signaling in Hepatocytes to the Inflammatory Response in Mice Infected with Streptococcus pyogenes

    Article • The Journal of Infectious Diseases, September 2007, Oxford University Press (OUP)

    Professor Werner Muller

  132. Reply to “TSLP-mediated fetal B lymphopoiesis?”

    Article • Nature Immunology, September 2007, Nature

    Professor Werner Muller

  133. The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens

    Article • European Journal of Immunology, August 2007, Wiley

    Professor Werner Muller

  134. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

    Article • The Journal of Experimental Medicine, July 2007, Rockefeller University Press

    Professor Werner Muller, Prof. Dr. Karsten Grote

  135. Serum Response Factor Contributes Selectively to Lymphocyte Development

    Article • Journal of Biological Chemistry, June 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Werner Muller

  136. Integration of mouse phenome data resources

    Article • Mammalian Genome, April 2007, Springer Science + Business Media

    Professor Werner Muller, Dr John M Hancock

  137. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA

    Article • European Journal of Immunology, December 2006, Wiley

    Professor Werner Muller, Dr Mariela Bollati-Fogolin

  138. Dissecting the cytokine network

    Article • Cellular Immunology, December 2006, Elsevier

    Professor Werner Muller

  139. Adult murine hematopoiesis can proceed without beta1 and beta7 integrins

    Article • Blood, September 2006, American Society of Hematology

    Professor Werner Muller

  140. A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus

    Article • Journal of Evolutionary Biology, September 2006, Wiley

    Professor Werner Muller

  141. Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in  2 integrin-deficient mice

    Article • Journal of Leukocyte Biology, July 2006, Society for Leukocyte Biology

    Professor Werner Muller

  142. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor

    Article • Proceedings of the National Academy of Sciences, July 2006, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  143. Enhanced FTY720-Mediated Lymphocyte Homing Requires G i Signaling and Depends on  2 and  7 Integrin

    Article • The Journal of Immunology, January 2006, The American Association of Immunologists

    Professor Werner Muller

  144. Nine fluorescence parameter analysis on a four-color fluorescence activated flow cytometer

    Article • Cytometry Part A, January 2006, Wiley

    Professor Werner Muller

  145. Corrigendum to “Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo” [Free Radic. Biol. Med. 38:1458–1470; 2005]

    Article • Free Radical Biology and Medicine, January 2006, Elsevier

    Professor Werner Muller

  146. EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

    Article • Nature Genetics, November 2005, Nature

    Professor Werner Muller

  147. Virus free, cell-based assay for the quantification of murine type I interferons

    Article • Journal of Immunological Methods, November 2005, Elsevier

    Professor Werner Muller, Dr Mariela Bollati-Fogolin

  148. Introducing the German Mouse Clinic: open access platform for standardized phenotyping

    Article • Nature Methods, June 2005, Nature

    Professor Werner Muller

  149. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo

    Article • Free Radical Biology and Medicine, June 2005, Elsevier

    Professor Werner Muller

  150. VBASE2, an integrative V gene database

    Article • Nucleic Acids Research, December 2004, Oxford University Press (OUP)

    Professor Werner Muller

  151. T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation

    Article • The Journal of Experimental Medicine, November 2004, Rockefeller University Press

    Professor Werner Muller

  152. The European dimension for the mouse genome mutagenesis program

    Article • Nature Genetics, September 2004, Nature

    Dr Marcos Malumbres, Professor Werner Muller

  153. Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment

    Article • Proceedings of the National Academy of Sciences, July 2004, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  154. Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein

    Article • genesis, April 2004, Wiley

    Professor Werner Muller

  155. Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis

    Article • January 2004, Elsevier

    Professor Werner Muller

  156. CD4+ T Cell-Associated Pathophysiology Critically Depends on CD18 Gene Dose Effects in a Murine Model of Psoriasis

    Article • The Journal of Immunology, November 2003, The American Association of Immunologists

    Professor Werner Muller

  157. Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.

    Article • Gastroenterology, August 2003, Elsevier

    Professor Werner Muller

  158. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

    Article • Proceedings of the National Academy of Sciences, July 2003, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  159. Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development

    Article • Nature Immunology, July 2003, Nature

    Professor Werner Muller

  160. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases

    Article • Hepatology, July 2003, Wiley

    Professor Werner Muller

  161. Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis

    Article • European Journal of Immunology, May 2003, Wiley

    Professor Werner Muller

  162. IL-15 is an essential mediator of peripheral NK-cell homeostasis

    Article • Blood, February 2003, American Society of Hematology

    Professor Werner Muller

  163. Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration

    Article • Journal of Biological Chemistry, December 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Werner Muller

  164. ??7 integrins contribute to skin graft rejection

    Article • Transplantation, October 2002, Wolters Kluwer Health

    Professor Werner Muller

  165. β 7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis

    Article • Clinical & Experimental Immunology, June 2002, Wiley

    Professor Werner Muller

  166. Integrin  2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Werner Muller

  167. Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons

    Article • Molecular and Cellular Neuroscience, September 2001, Elsevier

    Professor Werner Muller

  168. Neonatally Induced Inactivation of the Vascular Cell Adhesion Molecule 1 Gene Impairs B Cell Localization and T Cell–Dependent Humoral Immune Response

    Article • The Journal of Experimental Medicine, March 2001, Rockefeller University Press

    Professor Werner Muller

  169. α4β7 independent pathway for CD8+ T cell–mediated intestinal immunity to rotavirus

    Article • Journal of Clinical Investigation, December 2000, American Society for Clinical Investigation

    Professor Werner Muller

  170. Despite high levels of lymphocyte homing receptor α4β7 integrin after small bowel allotransplantation, it is not critical for rejection

    Article • Transplantation Proceedings, September 2000, Elsevier

    Professor Werner Muller

  171. Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

    Article • The Journal of Experimental Medicine, August 2000, Rockefeller University Press

    Professor Werner Muller

  172. Blockade of the integrin alpha Lbeta 2 but not of integrins alpha 4 and/or beta 7 significantly prolongs intestinal allograft survival in mice

    Article • Gut, July 2000, BMJ

    Professor Werner Muller

  173. β7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection

    Article • European Journal of Immunology, June 2000, Wiley

    Professor Werner Muller

  174. Common cytokine receptor γ chain (γc)-deficient B cells persist in T cell-deficient γc mice and respond to a T-independent antigen

    Article • European Journal of Immunology, June 2000, Wiley

    Professor Werner Muller

  175. Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

    Article • Proceedings of the National Academy of Sciences, February 2000, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  176. β7 integrins contribute to demyelinating disease of the central nervous system

    Article • Journal of Neuroimmunology, January 2000, Elsevier

    Professor Werner Muller

  177. Chronic Colitis in IL-10-/-Mice: Insufficient Counter Regulation of a Th1 Response

    Article • International Reviews of Immunology, January 2000, Taylor & Francis

    Professor Werner Muller

  178. The Role of β7 Integrins in CD8 T Cell Trafficking During an Antiviral Immune Response

    Article • The Journal of Experimental Medicine, May 1999, Rockefeller University Press

    Professor Werner Muller

  179. Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

    Article • Cell, April 1999, Elsevier

    Professor Werner Muller

  180. Rearrangement and Expression of Immunoglobulin Light Chain Genes Can Precede Heavy Chain Expression during Normal B Cell Development in Mice

    Article • The Journal of Experimental Medicine, January 1999, Rockefeller University Press

    Professor Werner Muller

  181. IMGT, the international ImMunoGeneTics database

    Article • Nucleic Acids Research, January 1999, Oxford University Press (OUP)

    Professor Werner Muller

  182. Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects

    Article • The Journal of Experimental Medicine, November 1998, Rockefeller University Press

    Professor Werner Muller

  183. L-selectin and β7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes

    Article • European Journal of Immunology, November 1998, Wiley

    Professor Werner Muller

  184. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation

    Article • International Immunology, August 1998, Oxford University Press (OUP)

    Professor Werner Muller

  185. Efficient homing of CD4+ cells to the gut mucosa is necessary for colitis pathogenesis, but may not be required for the down regulation of pathogenic T cells

    Article • Gastroenterology, April 1998, Elsevier

    Professor Werner Muller

  186. IMGT, the International ImMunoGeneTics database

    Article • Nucleic Acids Research, January 1998, Oxford University Press (OUP)

    Professor Werner Muller

  187. Functions of α4- and β7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development

    Article • January 1998, Springer Science + Business Media

    Professor Werner Muller

  188. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

    Article • Journal of Reproductive Immunology, November 1997, Elsevier

    Professor Werner Muller

  189. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains

    Article • Journal of Immunological Methods, September 1997, Elsevier

    Professor Werner Muller

  190. On the role of the common cytokine receptor γ chain in B-cell vs. T-cell development

    Article • Research in Immunology, September 1997, Elsevier

    Professor Werner Muller

  191. Conditional inactivation of gp130 in mice

    Article • Immunology Letters, May 1997, Elsevier

    Professor Werner Muller

  192. Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome

    Article • The Journal of Experimental Medicine, January 1997, Rockefeller University Press

    Professor Werner Muller

  193. IMGT, the international ImMunoGeneTics database

    Article • Nucleic Acids Research, January 1997, Oxford University Press (OUP)

    Professor Werner Muller

  194. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse

    Article • The Journal of Experimental Medicine, November 1996, Rockefeller University Press

    Professor Werner Muller

  195. Plasmodium chabaudi chabaudi:Differential Susceptibility of Gene-Targeted Mice Deficient in IL-10 to an Erythrocytic-Stage Infection

    Article • Experimental Parasitology, November 1996, Elsevier

    Professor Werner Muller

  196. Impaired Immunosuppressive Response to Ultraviolet Radiation in Interleukin-10–Deficient Mice

    Article • Journal of Investigative Dermatology, October 1996, Elsevier

    Professor Werner Muller

  197. Bypass of lethality with mosaic mice generated by Cre–loxP-mediated recombination

    Article • Current Biology, October 1996, Elsevier

    Professor Werner Muller

  198. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

    Article • Journal of Clinical Investigation, August 1996, American Society for Clinical Investigation

    Professor Werner Muller

  199. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

    Article • European Journal of Immunology, August 1996, Wiley

    Professor Werner Muller

  200. Conditional gene targeting.

    Article • Journal of Clinical Investigation, August 1996, American Society for Clinical Investigation

    Professor Werner Muller

  201. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

    Article • Nature, July 1996, Nature

    Professor Werner Muller

  202. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice

    Article • The Journal of Experimental Medicine, July 1996, Rockefeller University Press

    Professor Werner Muller

  203. Prolonged islet allograft acceptance in the absence of interleukin 4 expression

    Article • Transplant Immunology, March 1996, Elsevier

    Professor Werner Muller

  204. Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

    Article • Immunity, February 1996, Elsevier

    Professor Werner Muller

  205. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

    Article • The Journal of Experimental Medicine, February 1996, Rockefeller University Press

    Professor Werner Muller

  206. Common Cytokine Receptor gamma chain (gammac)-Dependent Cytokines: Understanding in vivo Functions by Gene Targeting

    Article • Immunological Reviews, December 1995, Wiley

    Professor Werner Muller

  207. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

    Article • Journal of Clinical Investigation, November 1995, American Society for Clinical Investigation

    Professor Werner Muller

  208. A role for CD5 in TCR-mediated signal transduction and thymocyte selection

    Article • Science, July 1995, American Association for the Advancement of Science

    Professor Werner Muller

  209. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

    Article • The Journal of Experimental Medicine, July 1995, Rockefeller University Press

    Professor Werner Muller

  210. Altered immune responses in mice lacking inducible nitric oxide synthase

    Article • Nature, June 1995, Nature

    Professor Werner Muller

  211. Immunological techniques

    Article • Current Opinion in Immunology, April 1995, Elsevier

    Professor Werner Muller

  212. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

    Article • Proceedings of the National Academy of Sciences, January 1995, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  213. Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

    Article • Current Biology, December 1994, Elsevier

    Professor Werner Muller

  214. Lymphocyte populations and immune responses in CD5-deficient mice

    Article • European Journal of Immunology, July 1994, Wiley

    Professor Werner Muller

  215. Analysis of the B-cell progenitor compartment at the level of single cells

    Article • Current Biology, July 1994, Elsevier

    Professor Werner Muller

  216. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells

    Article • The Journal of Experimental Medicine, April 1994, Rockefeller University Press

    Professor Werner Muller

  217. Early B-Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting

    Article • Immunological Reviews, February 1994, Wiley

    Professor Werner Muller

  218. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

    Article • European Journal of Immunology, January 1994, Wiley

    Professor Werner Muller

  219. Interleukin-10-deficient mice develop chronic enterocolitis

    Article • Cell, October 1993, Elsevier

    Professor Werner Muller

  220. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

    Article • Cell, March 1993, Elsevier

    Professor Werner Muller

  221. Interleukin-4-deficient mice

    Article • Research in Immunology, January 1993, Elsevier

    Professor Werner Muller

  222. Allelic exclusion model questioned

    Article • Nature, October 1992, Nature

    Professor Werner Muller

  223. Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction

    Article • European Journal of Immunology, May 1992, Wiley

    Professor Werner Muller

  224. A critical role of λ5 protein in B cell development

    Article • Cell, May 1992, Elsevier

    Professor Werner Muller

  225. Generation and analysis of interleukin-4 deficient mice

    Article • Science, November 1991, American Association for the Advancement of Science

    Professor Werner Muller

  226. Generation of long-lived B cells in germ-free mice

    Article • European Journal of Immunology, July 1991, Wiley

    Professor Werner Muller

  227. Most peripheral B cells in mice are ligand selected

    Article • The Journal of Experimental Medicine, June 1991, Rockefeller University Press

    Professor Werner Muller

  228. Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer

    Article • The Journal of Experimental Medicine, May 1991, Rockefeller University Press

    Professor Werner Muller

  229. Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia

    Article • European Journal of Immunology, April 1991, Wiley

    Professor Werner Muller

  230. CD5 B Cells in the Mouse

    Article • January 1991, Springer Science + Business Media

    Professor Werner Muller

  231. Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity

    Article • European Journal of Immunology, April 1990, Wiley

    Professor Werner Muller

  232. High gradient magnetic cell separation with MACS

    Article • Cytometry, January 1990, Wiley

    Professor Werner Muller

  233. A retroviral expression vector containing murine immunoglobullin heavy chain promoter/enhancer

    Article • Nucleic Acids Research, November 1988, Oxford University Press (OUP)

    Professor Werner Muller

  234. c-fos expression interferes with thymus development in transgenic mice

    Article • Cell, June 1988, Elsevier

    Professor Werner Muller

  235. A new V gene expressed in lambda-2 light chains of the mouse

    Article • European Journal of Immunology, January 1987, Wiley

    Professor Werner Muller

  236. A T cell clone which responds to interkeukin 2 but not to interleukin 4

    Article • European Journal of Immunology, January 1987, Wiley

    Professor Werner Muller

  237. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.

    Article • Proceedings of the National Academy of Sciences, June 1986, Proceedings of the National Academy of Sciences

    Professor Werner Muller

  238. Control of Immunoglobulin Class Switch Recombination

    Article • Immunological Reviews, February 1986, Wiley

    Professor Werner Muller

  239. Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin

    Article • The Science of Nature, June 1985, Springer Science + Business Media

    Professor Werner Muller

  240. Intercellular communication and cell cooperation in growth control of T-lymphocytes

    Article • January 1982, Springer Science + Business Media

    Professor Werner Muller