All Stories

  1. Advancing biological understanding of cellular senescence with computational multiomics

    Article • Nature Genetics, September 2025, Springer Science + Business Media

    Dr Paul Robson

  2. Evidence for coopetition at the maternal–fetal interface shaping placental invasion

    Article • Proceedings of the National Academy of Sciences, September 2025, Proceedings of the National Academy of Sciences

    Gunter Wagner, Dr Paul Robson

  3. Immunosuppressive Tumor Microenvironment of Osteosarcoma

    Article • Cancers, June 2025, MDPI AG

    Dr Paul Robson

  4. HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs

    Article • Cell Reports, April 2025, Elsevier

    Dr Paul Robson

  5. Extravillous trophoblasts reverse the decidualization induced increase in matrix production by secreting TGFβ antagonists Emilin-1 and Gremlin-1

    Article • Cells and Development, March 2025, Elsevier

    Dr Paul Robson

  6. MorPhiC Consortium: towards functional characterization of all human genes

    Article • Nature, February 2025, Springer Science + Business Media

    Dr Paul Robson

  7. Development of an automated 3D high content cell screening platform for organoid phenotyping

    Article • SLAS DISCOVERY, October 2024, Elsevier

    Dr Paul Robson

  8. SenNet recommendations for detecting senescent cells in different tissues

    Article • Nature Reviews Molecular Cell Biology, June 2024, Springer Science + Business Media

    Dr Ruth R Montgomery, Dr Paul Robson

  9. Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

    Article • Nature Cell Biology, July 2023, Springer Science + Business Media

    Dr Paul Robson

  10. Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold

    Article • Nucleic Acids Research, July 2023, Oxford University Press (OUP)

    Dr Paul Robson

  11. Single-cell Transcriptome Landscape of DNA Methylome Regulators Associated with Orofacial Clefts in the Mouse Dental Pulp

    Article • The Cleft Palate-Craniofacial Journal, May 2023, SAGE Publications

    Dr Paul Robson

  12. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

    Article • Nature Aging, December 2022, Springer Science + Business Media

    Dr Paul Robson

  13. A path to translation: How 3D patient tumor avatars enable next generation precision oncology

    Article • Cancer Cell, December 2022, Elsevier

    Dr Paul Robson

  14. Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners

    Article • Stem Cells International, August 2022, Wiley

    Dr Paul Robson

  15. Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

    Article • Nature Cell Biology, July 2022, Springer Science + Business Media

    Dr Paul Robson

  16. The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation

    Article • AJP Regulatory Integrative and Comparative Physiology, July 2022, American Physiological Society

    Dr Paul Robson

  17. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function

    Article • Cell Reports Medicine, May 2022, Elsevier

    Dr Paul Robson

  18. Single-cell transcriptome analysis defines mesenchymal stromal cells in the mouse incisor dental pulp

    Article • Gene Expression Patterns, March 2022, Elsevier

    Dr Paul Robson

  19. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

    Article • Cell Metabolism, January 2022, Elsevier

    Dr Paul Robson

  20. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

    Article • Nature Genetics, September 2021, Springer Science + Business Media

    Dr Paul Robson

  21. RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

    Article • Biology Open, June 2021, The Company of Biologists

    Dr Paul Robson

  22. Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Article • eLife, May 2021, eLife

    Dr Paul Robson

  23. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

    Article • Cell Reports, May 2021, Elsevier

    Dr Paul Robson

  24. Human KIT+ myeloid cells facilitate visceral metastasis by melanoma

    Article • Journal of Experimental Medicine, April 2021, Rockefeller University Press

    Dr Paul Robson

  25. Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

    Article • Cancer Cell, March 2021, Elsevier

    Dr Paul Robson

  26. Corneal nonmyelinating Schwann cells illuminated by single‐cell transcriptomics and visualized by protein biomarkers

    Article • Journal of Neuroscience Research, November 2020, Wiley

    Dr Paul Robson

  27. Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Article • eLife, October 2020, eLife

    Dr Paul Robson

  28. Cellular taxonomy and spatial organization of the ventral posterior hypothalamus reveals neuroanatomical parcellation of the mammillary bodies

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  29. Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

    Article • Nature Cancer, February 2020, Springer Science + Business Media

    Dr Paul Robson

  30. Transplanting cells from old but not young donors causes physical dysfunction in older recipients

    Article • Aging Cell, January 2020, Wiley

    Dr Paul Robson

  31. Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma

    Article • OncoImmunology, January 2020, Taylor & Francis

    Dr Paul Robson

  32. Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts

    Article • Cancer Discovery, June 2019, American Association for Cancer Research (AACR)

    Dr Paul Robson

  33. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

    Article • Proceedings of the National Academy of Sciences, March 2019, Proceedings of the National Academy of Sciences

    Dr Paul Robson

  34. Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

    Article • Nature Neuroscience, March 2019, Springer Science + Business Media

    Dr Paul Robson

  35. Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

    Article • Cell Stem Cell, March 2019, Elsevier

    Dr Paul Robson

  36. Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer

    Article • Cell Reports, November 2018, Elsevier

    Dr Paul Robson

  37. Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

    Article • Nature Communications, July 2018, Springer Science + Business Media

    Dr Paul Robson

  38. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Dr Paul Robson, Dr Christoph Bock

  39. Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signalling in preimplantation mouse embryos

    Article • Biochemical Journal, February 2018, Portland Press Ltd.

    Dr Paul Robson

  40. Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

    Article • Cell Reports, January 2018, Elsevier

    Dr Paul Robson

  41. Comprehensive Cell Type Specific Transcriptomics of the Human Kidney

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  42. The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

    Article • Scientific Reports, December 2017, Nature

    Dr Paul Robson

  43. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

    Article • Nature Genetics, March 2017, Nature

    Dr Paul Robson

  44. Single cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes

    Article • Genome Research, November 2016, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  45. Single-cell multimodal profiling reveals cellular epigenetic heterogeneity

    Article • Nature Chemical Biology, August 2016, Nature

    Dr Paul Robson

  46. Tumor-derived circulating endothelial cell clusters in colorectal cancer

    Article • Science Translational Medicine, June 2016, American Association for the Advancement of Science

    Dr Paul Robson, Dr Ciprian Iliescu

  47. Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

    Article • Scientific Reports, June 2016, Nature

    Dr Paul Robson

  48. Dynamic changes in Sox2 spatio-temporal expression direct the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos

    Article • June 2016, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  49. Human blastocyst biology

    Article • Development, August 2015, The Company of Biologists

    Dr Paul Robson

  50. Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells

    Article • EMBO Reports, August 2015, EMBO

    Dr Paul Robson

  51. Transcriptional Intricacies of Stem Cells

    Article • Cell Systems, August 2015, Elsevier

    Dr Paul Robson

  52. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

    Article • Nature Immunology, June 2015, Nature

    Dr Paul Robson, Shalin Naik

  53. BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

    Article • Nature Communications, December 2014, Nature

    Dr Paul Robson

  54. Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Dr Paul Robson

  55. The importance of study design for detecting differentially abundant features in high-throughput experiments

    Article • December 2014, Springer Science + Business Media

    Dr Paul Robson

  56. Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development

    Article • Bioinformatics, November 2014, Oxford University Press (OUP)

    Dr Paul Robson

  57. Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

    Article • Genome Research, October 2014, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  58. Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer

    Article • Cell Death and Disease, July 2014, Nature

    Dr Paul Robson

  59. Deciphering Developmental Processes from Single-Cell Transcriptomes

    Article • Developmental Cell, May 2014, Elsevier

    Dr Paul Robson

  60. The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

    Article • eLife, March 2014, eLife

    Hongyan Wang, Professor Cayetano Gonzalez, Dr Song Li, Dr Paul Robson, Dr Sherry S Aw

  61. BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures

    Article • Stem Cell Reports, November 2013, Elsevier

    Dr Paul Robson

  62. High Throughput Gene Expression Analysis Identifies Reliable Expression Markers of Human Corneal Endothelial Cells

    Article • PLOS One, July 2013, PLOS

    Dr Paul Robson

  63. A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo

    Article • Genes & Development, June 2013, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  64. Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst

    Article • Developmental Cell, June 2013, Elsevier

    Dr Paul Robson

  65. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

    Article • The EMBO Journal, March 2013, Springer Science + Business Media

    Dr Paul Robson

  66. Co‐Motif Discovery Identifies an Esrrb‐Sox2‐DNA Ternary Complex as a Mediator of Transcriptional Differences Between Mouse Embryonic and Epiblast Stem Cells

    Article • Stem Cells, February 2013, Oxford University Press (OUP)

    Dr Paul Robson

  67. Single-Cell mRNA Profiling Identifies Progenitor Subclasses in Neurospheres

    Article • Stem Cells and Development, December 2012, Mary Ann Liebert Inc

    Dr Paul Robson

  68. DNA-dependent Oct4–Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy

    Article • Biochemical Journal, November 2012, Portland Press Ltd.

    Dr Paul Robson

  69. Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

    Article • Cell, January 2012, Elsevier

    Dr Paul Robson, Shivshankar Umashankar, Dr. Amit Rai, Dr Philipp Kaldis

  70. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

    Article • Nature Biotechnology, November 2011, Springer Science + Business Media

    Dr Paul Robson, Dr Tetsuya Ishii

  71. Conversion of Sox17 into a Pluripotency Reprogramming Factor by Reengineering Its Association with Oct4 on DNA

    Article • Stem Cells, May 2011, Oxford University Press (OUP)

    Dr Paul Robson

  72. Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

    Article • Developmental Cell, April 2010, Elsevier

    Dr Paul Robson

  73. Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Dr Paul Robson

  74. Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

    Article • Development, January 2010, The Company of Biologists

    Dr Paul Robson

  75. Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells

    Article • RNA, December 2009, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  76. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

    Article • Genes & Development, November 2009, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  77. Unraveling the Human Embryonic Stem Cell Phosphoproteome

    Article • Cell Stem Cell, August 2009, Elsevier

    Dr Paul Robson

  78. Sall4 Regulates Distinct Transcription Circuitries in Different Blastocyst-Derived Stem Cell Lineages

    Article • Cell Stem Cell, November 2008, Elsevier

    Dr Paul Robson

  79. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

    Article • Genes & Development, October 2008, Cold Spring Harbor Laboratory Press

    Dr Paul Robson

  80. A core Klf circuitry regulates self-renewal of embryonic stem cells

    Article • Nature Cell Biology, February 2008, Springer Science + Business Media

    Dr Paul Robson

  81. Zfp206 Is a Transcription Factor That Controls Pluripotency of Embryonic Stem Cells

    Article • Stem Cells, September 2007, Oxford University Press (OUP)

    Dr Paul Robson

  82. Oct4 and Sox2 Directly Regulate Expression of Another Pluripotency Transcription Factor, Zfp206, in Embryonic Stem Cells

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paul Robson

  83. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

    Article • Nature Cell Biology, September 2006, Springer Science + Business Media

    Dr Paul Robson

  84. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

    Article • Nature Genetics, March 2006, Springer Science + Business Media

    Dr Paul Robson

  85. Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures

    Article • Tissue and Cell, August 2005, Elsevier

    Dr Paul Robson

  86. Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells

    Article • Molecular and Cellular Biology, June 2005, ASM Journals

    Dr Paul Robson

  87. Transcriptional Regulation of Nanog by OCT4 and SOX2

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paul Robson

  88. Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State

    Article • Stem Cells, February 2005, Oxford University Press (OUP)

    Dr Paul Robson

  89. The maturing of the human embryonic stem cell transcriptome profile

    Article • Trends in Biotechnology, December 2004, Elsevier

    Dr Paul Robson

  90. Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro

    Article • Journal of Bone and Mineral Research, September 2004, Oxford University Press (OUP)

    Dr Paul Robson

  91. Regulation of the Murine Nfatc1 Gene by NFATc2

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paul Robson

  92. Self-aggregation characteristics of recombinantly expressed human elastin polypeptides

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, November 2001, Elsevier

    Dr Paul Robson

  93. Inner Cell Mass-Specific Expression of a Cell Adhesion Molecule (PECAM-1/CD31) in the Mouse Blastocyst

    Article • Developmental Biology, June 2001, Elsevier

    Dr Paul Robson

  94. The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates

    Article • Cell and Tissue Research, May 2001, Springer Science + Business Media

    Dr Paul Robson

  95. The Structure and Organization of Lamprin Genes: Multiple-Copy Genes with Alternative Splicing and Convergent Evolution with Insect Structural Proteins

    Article • Molecular Biology and Evolution, November 2000, Oxford University Press (OUP)

    Dr Paul Robson

  96. Distinct non-collagen based cartilages comprising the endoskeleton of the Atlantic hagfish, Myxine glutinosa

    Article • Brain Structure and Function, September 2000, Springer Science + Business Media

    Dr Paul Robson

  97. Partial clone of the gene for AS protein of the lampreyPetromyzon marinus, a member of the albumin supergene family whose expression is restricted to the larval and metamorphic phases of the life cycle

    Article • The Journal of Experimental Zoology, October 1998, Wiley

    Dr Paul Robson

  98. Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey

    Article • Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, June 1998, Elsevier

    Dr Paul Robson

  99. A Family of Non–Collagen-Based Cartilages in the Skeleton of the Sea Lamprey, Petromyzon marinus

    Article • Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, September 1997, Elsevier

    Dr Paul Robson

  100. Decreased Elastin Synthesis in Normal Development and in Long-term Aortic Organ and Cell Cultures Is Related to Rapid and Selective Destabilization of mRNA for Elastin

    Article • Circulation Research, December 1995, Wolters Kluwer Health

    Dr Paul Robson

  101. The Appearance of Proopiomelanocortin Early in Vertebrate Evolution: Cloning and Sequencing of POMC from a Lamprey Pituitary cDNA Library

    Article • General and Comparative Endocrinology, August 1995, Elsevier

    Dr Paul Robson