All Stories

  1. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine
  2. Sur les épaules des géants qui nous ont précédés
  3. The ethics of genomic medicine: redefining values and norms in the UK and France
  4. The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation
  5. Global citizen deliberation on genome editing
  6. LifeTime and improving European healthcare through cell-based interceptive medicine
  7. ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
  8. Covid-19 : protocoles de soins ou protocoles de recherche ?
  9. Organoïdes : nouvelles perspectives et nouvelles questions éthiques
  10. Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells
  11. Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells
  12. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
  13. The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity
  14. Genome Editing: Promoting Responsible Research
  15. De retour de Hong Kong ou l’éthique à l’heure d’une génétique d’« augmentation » de la personne humaine
  16. Éléments pour une éthique de la communication des faits scientifiques
  17. ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition
  18. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3– cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
  19. The tsunami named CRISPR/Cas9
  20. Could Failure in Preimplantation Genetic Diagnosis Justify Editing the Human Embryo Genome?
  21. ARRIGE Arrives: Toward the Responsible Use of Genome Editing
  22. Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation
  23. Les états généraux de la bioéthique de 2018
  24. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma
  25. Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness
  26. Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma
  27. Commentary: Just Say “No”
  28. DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression
  29. Fostering responsible research with genome editing technologies: a European perspective
  30. Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling
  31. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth
  32. Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
  33. Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System
  34. A European position on genome editing
  35. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma
  36. CHD7 promotes proliferation of neural stem cells mediated by MIF
  37. EXTH-09. LOOKING FOR A CURE: DELTA-24-RDG AND RADIOTHERAPY FOR DIPG TREATMENT
  38. Nos jeunes pousses ont du talent !
  39. HG-51DELTA-24-RDG IN COMBINATION WITH RADIOTHERAPY FOR DIPG: OPENING NEW THERAPEUTIC AVENUES
  40. Calcium signaling orchestrates glioblastoma development: Facts and conjunctures
  41. The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway
  42. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells
  43. La recherche biomédicale pensée en français : Nouvelle année, nouveaux concepts
  44. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression
  45. Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo
  46. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells
  47. Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro
  48. Une éthique de dialogue science-société
  49. Les années 2010
  50. Les années 2000
  51. Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
  52. 30 ans déjà, et demain ?
  53. Depuis 30 ans, aujourd’hui et demain : transmettre la science biomédicale en langue française
  54. Metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
  55. A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)
  56. Lamarck en invité spécial du 30eanniversaire dem/s
  57. SIRT2, une déacétylase aux multiples talents
  58. Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells
  59. Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets
  60. À quoi sert donc une revue scientifique en langue française ?
  61. A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype
  62. The relationship between brain tumor cell invasion of engineered neural tissues and in vivo features of glioblastoma
  63. Sirtuin-2 Activity is Required for Glioma Stem Cell Proliferation Arrest but not Necrosis Induced by Resveratrol
  64. Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis and favors glioblastoma resistance to etoposide
  65. Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling
  66. Critical multiple angiogenic factors secreted by glioblastoma stem-like cells underline the need for combinatorial anti-angiogenic therapeutic strategies
  67. médecine/sciences2013
  68. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation
  69. Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor
  70. Antiproliferative Activity of trans- Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells
  71. Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells
  72. médecine/sciencesacteur de la bioéconomie responsable
  73. Proteomic analysis of oligodendrogliomas expressing a mutant isocitrate dehydrogenase-1
  74. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
  75. Does Cognitive Enhancement Fit with the Physiology of Our Cognition?
  76. Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway
  77. Alternative Lengthening of Telomeres in Human Glioma Stem Cells
  78. Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors
  79. Cerveau préservé, réparé, amélioré
  80. Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells
  81. médecine/sciences2011
  82. Plasticité du phénotype cellulaire ou une certaine fin de l’insouciance du déterminisme
  83. NG2+/Olig2+Cells are the Major Cycle-Related Cell Population of the Adult Human Normal Brain
  84. CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
  85. An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
  86. Neurosciences et neuroéthique
  87. Astrocytes Reverted to a Neural Progenitor-like State with Transforming Growth Factor Alpha Are Sensitized to Cancerous Transformation
  88. Calcium fingerprints induced by Calmodulin interactors in eukaryotic cells
  89. Development of Human Nervous Tissue upon Differentiation of Embryonic Stem Cells in Three-Dimensional Culture
  90. DLG1/SAP97 modulates transforming growth factor α bioavailability
  91. GFAPδ immunostaining improves visualization of normal and pathologic astrocytic heterogeneity
  92. Médecine/Scienceset les passerelles du temps
  93. Dans la lumière et les ombres
  94. Trop court traité de l’âme :Court Traité de l’âme(Philippe Lazar)
  95. Voyage autour du monde dans le regard de l’autre :L’homme pluriel
  96. Quand l’art rencontre la science
  97. The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway
  98. Une dimension de plus en plus individualisée du rapport bénéfice/risque
  99. Contrats et vivant  : le droit de la circulation des ressources biologiques Florence Bellivier, Christine Noiville
  100. PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic  -Cells
  101. Phosphoprotein Enriched in Astrocytes-15 kDa Expression Inhibits Astrocyte Migration by a Protein Kinase Cδ-dependent Mechanism
  102. Transforming growth factor α promotes sequential conversion of mature astrocytes into neural progenitors and stem cells
  103. Do Secretin and Vasoactive Intestinal Peptide Have Independent Receptors on Striatal Neurons and Glial Cells in Primary Cultures?
  104. Akt Down-Regulates ERK1/2 Nuclear Localization and Angiotensin II-induced Cell Proliferation through PEA-15
  105. Transforming growth factor alpha acts as a gliatrophin for mouse and human astrocytes
  106. Chroniques bioéthiques (13) : Enfin, les cellules souches embryonnaires humaines françaises ont leur décret d’application !
  107. Cloningate? La publication scientifique et le clonage thérapeutique face à la mystification Hwang
  108. Et l’épilepsie devint une maladie de l’astrocyte
  109. Mise en évidence de cellules souches tumorales au sein des tumeurs glio-neuronales malignes (TGNM)
  110. Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
  111. Brève esquisse neurophysiologique de l'excitation : des neurones, des astrocytes et des images
  112. New Variants of Malignant Glioneuronal Tumors: A Clinicopathological Study of 40 Cases
  113. p38/SAPK2 controls gap junction closure in astrocytes
  114. The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain
  115. PEA-15 Modulates TNFα Intracellular Signaling in Astrocytes
  116. The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes
  117. Sur les rivages de la misère
  118. Sur les sentiers escarpés des montagnes de bioéthique
  119. Dans les grandes plaines de la génomique
  120. Sur les sentiers escarpés des montagnes de bioéthique
  121. Sur les sentiers escarpés des montagnes de bioéthique
  122. Cellular Expression, Developmental Regulation, and Phylogenic Conservation of PEA-15, the Astrocytic Major Phosphoprotein and Protein Kinase C Substrate
  123. Endothelin Induces a Calcium-Dependent Phosphorylation of PEA-15 in Intact Astrocytes: Identification of Ser104 and Ser116 Phosphorylated, Respectively, by Protein Kinase C and Calcium/Calmodulin Kinase II In Vitro
  124. Les astrocytes contrôlent la neurogenèse dans le système nerveux central adulte
  125. PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase
  126. Keeping TNF-induced apoptosis under control in astrocytes: PEA-15 as a ‘double key’ on caspase-dependent and MAP-kinase-dependent pathways
  127. Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent Mechanism
  128. Regulation of Expression of Phospholipase D1 and D2 by PEA-15, a Novel Protein That Interacts with Them
  129. Knock-Out of the Neural Death Effector Domain Protein PEA-15 Demonstrates That Its Expression Protects Astrocytes from TNFα-Induced Apoptosis
  130. Polyneuropathy in autosomal dominant cerebellar ataxias: Phenotype-genotype correlation
  131. Molecular and Clinical Correlations in Spinocerebellar Ataxia 2: A Study of 32 Families
  132. Percevoir n'est pas voir.
  133. The Major Astrocytic Phosphoprotein PEA-15 Is Encoded by Two mRNAs Conserved on Their Full Length in Mouse and Human
  134. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies): Genetic analysis of three unrelated SCA2 families
  135. Spinocerebellar ataxia 3 and machado-joseph disease: Clinical, molecular, and neuropathological features
  136. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies): genetic analysis of three unrelated SCA2 families
  137. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse
  138. SCA2 is not a major locus for ADCA type I in French families
  139. Gender equality in Machado–Joseph disease
  140. Analysis of the SCAI CAG repeat in a large number of families with dominant ataxia: Clinical and molecular correlations
  141. Autosomal dominant cerebellar ataxia type I in Martinique (French West Indies)
  142. Is DRPLA also linked to 14q?
  143. Phenotypic variability in autosomal dominant cerebellar ataxia type I is unrelated to genetic heterogeneity
  144. Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23–24.1
  145. Expression of transfected stathmin cDNA reveals novel phosphorylated forms associated with developmental and functional cell regulation
  146. Stathmin Phosphorylation Is Regulated in Striatal Neurons by Vasoactive Intestinal Peptide and Monoamines via Multiple Intracellular Pathways
  147. Cyclic AMP Accumulation Induces a Rapid Desensitization of the Cyclic AMP-Dependent Protein Kinase in Mouse Striatal Neurons
  148. Stathmin phosphorylation patterns discriminate between distinct transduction pathways of human T lymphocyte activation through CD2 triggering
  149. Dopamine-induced homologous and heterologous desensitizations of adenylate cyclase-coupled receptors on striatal neurons
  150. CD2 triggers protein phosphorylations related to proliferation in PKC-down regulated human T lymphocytes
  151. Stathmin Is a Major Phosphoprotein and Cyclic AMP-Dependent Protein Kinase Substrate in Mouse Brain Neurons but Not in Astrocytes in Culture: Regulation During Ontogenesis
  152. Cyclic AMP reduces adhesion of isolated neuronal growth cones from developing rat forebrain to an astrocytic cell line from embryonic mouse striatum
  153. Cyclic-amp dependent protein kinase in mouse striatal neurones and astrocytes in primary culture: development, subcellular distribution and stimulation of endogenous phosphorylation
  154. Somatostatin receptors on cortical neurones and adenohypophysis: comparison between specific binding and adenylate cyclase inhibition
  155. Two simian virus 40 (SV40)-transformed cell lines from the mouse striatum and mesencephalon presenting astrocytic characters. I. Immunological and pharmacological properties
  156. Modulation by Monoamines of Somatostatin-Sensitive Adenylate Cyclase on Neuronal and Glial Cells from the Mouse Brain in Primary Cultures
  157. Vasoactive Intestinal Polypeptide Receptors Linked to an Adenylate Cyclase, and Their Relationship with Biogenic Amine- and Somatostatin-Sensitive Adenylate Cyclases on Central Neuronal and Glial Cells in Primary Cultures
  158. VIP and secretin receptors linked to an adenylate cyclase on central neuronal and glial cells in primary cultures
  159. Biogenic amine-sensitive adenylate cyclases in primary culture of neuronal or glial cells from mesencephalon