All Stories

  1. Structure–Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers

    Article • Journal of Medicinal Chemistry, July 2026, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  2. Complex coacervation reshapes the aggregation landscape of tau

    Article • July 2026, openRxiv

    Professor Michele Vendruscolo

  3. Prediction of antibody non-specificity using protein language models and biophysical parameters

    Article • mAbs, May 2026, Taylor & Francis

    Professor Michele Vendruscolo

  4. Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations

    Article • May 2026, openRxiv

    Professor Michele Vendruscolo

  5. Does the sequence of a disordered protein encode small molecule binding paths?

    Article • May 2026, openRxiv

    Professor Michele Vendruscolo

  6. Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals

    Article • April 2026, openRxiv

    Professor Michele Vendruscolo

  7. Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin

    Article • Communications Chemistry, April 2026, Springer Science + Business Media

    Professor Michele Vendruscolo

  8. Systems-level organization of extracellular proteostasis

    Article • Science, March 2026, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  9. OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening

    Article • March 2026, openRxiv

    Professor Michele Vendruscolo

  10. The α-synuclein proteostasis network and its translational applications in Parkinson’s disease

    Article • Proceedings of the National Academy of Sciences, March 2026, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  11. FuzDrop: sequence-based prediction of the propensity of proteins for liquid–liquid phase separation and aggregation

    Article • Nature Protocols, March 2026, Springer Science + Business Media

    Professor Michele Vendruscolo

  12. Metadiffusion: inference-time meta-energy biasing of biomolecular diffusion models

    Article • February 2026, openRxiv

    Professor Michele Vendruscolo

  13. Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds

    Article • Chemical Science, January 2026, Royal Society of Chemistry

    Professor Michele Vendruscolo

  14. In vitro and in vivo inhibition of amyloid β aggregation by a Ru( ii )–naphthalene diimide complex

    Article • Dalton Transactions, January 2026, Royal Society of Chemistry

    Professor Michele Vendruscolo

  15. Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core

    Article • The Journal of Physical Chemistry Letters, December 2025, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  16. Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via Markov State Models

    Article • November 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  17. Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking

    Article • Molecular Systems Biology, November 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  18. Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

    Article • FEBS Letters, September 2025, Wiley

    Professor Michele Vendruscolo

  19. Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

    Article • Communications Chemistry, September 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  20. Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid

    Article • August 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  21. Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  22. Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  23. Recruitment of Aβ into α-Synuclein Condensates Catalyzes Primary Nucleation of α-Synuclein Aggregation

    Article • ACS Central Science, July 2025, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  24. Sequence-based virtual screening using transformers

    Article • Nature Communications, July 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  25. Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

    Article • FEBS Letters, July 2025, Wiley

    Professor Michele Vendruscolo

  26. Amyloid-β modulates the phase separation and aggregation of α-synuclein

    Article • Proceedings of the National Academy of Sciences, July 2025, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  27. Targeted Protein Modification with an Antibody-Based System

    Article • ACS Central Science, July 2025, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  28. Proteostasis signatures in human diseases

    Article • PLoS Computational Biology, June 2025, PLOS

    Professor Michele Vendruscolo

  29. The thermodynamic hypothesis of protein aggregation

    Article • Molecular Aspects of Medicine, June 2025, Elsevier

    Professor Michele Vendruscolo

  30. Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  31. Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  32. Aggregation of α-synuclein splice isoforms through a phase separation pathway

    Article • Science Advances, April 2025, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  33. Linking Aβ and tau in the amyloid cascade through the intersection of their proteostasis networks

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  34. Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tau

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  35. Natural aminosterols inhibit NMDA receptors with low nanomolar potency

    Article • European Journal of Biochemistry, March 2025, Wiley

    Professor Michele Vendruscolo

  36. The α-Synuclein Proteostasis Network and its Translational Applications in Parkinson’s disease

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  37. Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  38. Detection of protein oligomers with nanopores 

    Article • Nature Reviews Chemistry, March 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  39. AlphaFold prediction of structural ensembles of disordered proteins

    Article • Nature Communications, February 2025, Springer Science + Business Media

    Professor Michele Vendruscolo

  40. Design of Protein Sequences with Precisely Tuned Kinetic Properties

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  41. Lipid-induced condensate formation from the Alzheimer’s Aβ peptide triggers amyloid aggregation

    Article • Proceedings of the National Academy of Sciences, January 2025, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  42. Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

    Article • Macromolecules, January 2025, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  43. Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

    Article • Science Advances, January 2025, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  44. Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins

    Article • Biochemical Journal, January 2025, Portland Press Ltd.

    Professor Michele Vendruscolo, Salvador Ventura

  45. Estimation of Ligand Binding Free Energy Using Multi-eGO

    Article • Journal of Chemical Information and Modeling, December 2024, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  46. Proteostasis Signatures in Human Diseases

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  47. Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo, Professor Fulvio D'Acquisto

  48. Estimation of ligand binding free energy using multi-eGO.

    Article • December 2024, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  49. Language Models for Molecular Dynamics

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  50. A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    Article • eLife, November 2024, eLife

    Professor Michele Vendruscolo

  51. A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    Article • eLife, November 2024, eLife

    Professor Michele Vendruscolo

  52. Organization of the Proteostasis Network of Membraneless Organelles

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  53. AlphaFold-Metainference: Prediction of Structural Ensembles of Disordered Proteins

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  54. Global kinetic model of lipid-inducedα-synuclein aggregation and its inhibition by small molecules

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  55. A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation

    Article • Nature Communications, September 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  56. TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  57. AlphaFold2-based prediction of the co-condensation propensity of proteins

    Article • Proceedings of the National Academy of Sciences, August 2024, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  58. Estimation of ligand binding free energy using multi-eGO.

    Article • July 2024, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  59. Preparation and Characterization of Zn(II)-Stabilized Aβ42 Oligomers

    Article • ACS Chemical Neuroscience, July 2024, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  60. Step Forward Cross Validation for Bioactivity Prediction: Out of Distribution Validation in Drug Discovery

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  61. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

    Article • eLife, June 2024, eLife

    Professor Michele Vendruscolo

  62. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

    Article • eLife, June 2024, eLife

    Professor Michele Vendruscolo

  63. Identification of high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking

    Article • June 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  64. Pharmacological inhibition of α-synuclein aggregation within liquid condensates

    Article • Nature Communications, May 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  65. Targeted protein editing with an antibody-based system

    Article • February 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  66. Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms

    Article • Proceedings of the National Academy of Sciences, February 2024, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  67. Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils

    Article • Communications Biology, February 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  68. Sequence-Based Drug Design Using Transformers

    Article • February 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  69. Imaging Aβ aggregation by liquid-phase transmission electron microscopy

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  70. Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

    Article • January 2024, Springer Science + Business Media

    Professor Michele Vendruscolo

  71. Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity

    Article • Journal of Chemical Information and Modeling, January 2024, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  72. Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  73. Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  74. Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  75. Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors

    Article • Journal of Chemical Theory and Computation, December 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  76. CryoENsemble - a Bayesian approach for reweighting biomolecular structural ensembles using heterogeneous cryo-EM maps

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  77. Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation

    Article • Proceedings of the National Academy of Sciences, September 2023, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  78. Pharmacological inhibition of α-synuclein aggregation within liquid condensates

    Article • September 2023, Springer Science + Business Media

    Professor Michele Vendruscolo

  79. Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts

    Article • ACS Chemical Neuroscience, August 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  80. Targeted protein modification with an antibody-based system

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  81. Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy

    Article • Biochemistry, July 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  82. Amyloid formation as a protein phase transition

    Article • Nature Reviews Physics, June 2023, Springer Science + Business Media

    Professor Michele Vendruscolo

  83. Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation

    Article • Expert Opinion on Drug Discovery, June 2023, Taylor & Francis

    Professor Michele Vendruscolo

  84. Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

    Article • Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  85. Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

    Article • Accounts of Chemical Research, April 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  86. FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins

    Article • Nucleic Acids Research, March 2023, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  87. Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation

    Article • Journal of Chemical Theory and Computation, March 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  88. AlphaFold Prediction of Structural Ensembles of Disordered Proteins

    Article • March 2023, Springer Science + Business Media

    Professor Michele Vendruscolo

  89. Extracellular protein homeostasis in neurodegenerative diseases

    Article • Nature Reviews Neurology, February 2023, Springer Science + Business Media

    Professor Michele Vendruscolo

  90. Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH

    Article • Proceedings of the National Academy of Sciences, February 2023, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  91. Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation

    Article • ACS Chemical Neuroscience, February 2023, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  92. Sequence-based prediction of pH-dependent protein solubility using CamSol

    Article • Briefings in Bioinformatics, January 2023, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  93. AlphaFold Prediction of Structural Ensembles of Disordered Proteins

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  94. Enhanced surface nanoanalytics of transient biomolecular processes

    Article • Science Advances, January 2023, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  95. Fragment-based computational design of antibodies targeting structured epitopes

    Article • Science Advances, November 2022, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  96. Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates

    Article • Biochemistry, November 2022, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  97. Protein condensation diseases: therapeutic opportunities

    Article • Nature Communications, September 2022, Springer Science + Business Media

    Professor Michele Vendruscolo

  98. ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy

    Article • Science Advances, July 2022, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  99. Adsorption free energy predicts amyloid protein nucleation rates

    Article • Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  100. π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation

    Article • Journal of the American Chemical Society, July 2022, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  101. Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?

    Article • FEBS Letters, July 2022, Wiley

    Professor Michele Vendruscolo

  102. A Small Molecule Stabilizes the Disordered Native State of the Alzheimer’s Aβ Peptide

    Article • ACS Chemical Neuroscience, June 2022, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  103. Determination of the structure and dynamics of the fuzzy coat of an amyloid fibril of IAPP using cryo-electron microscopy

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  104. FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid–liquid phase separation and aggregation of proteins

    Article • Nucleic Acids Research, May 2022, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  105. Conformational Entropy as a Potential Liability of Computationally Designed Antibodies

    Article • Biomolecules, May 2022, MDPI AG

    Professor Michele Vendruscolo

  106. Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers

    Article • The Journal of Chemical Physics, April 2022, American Institute of Physics

    Professor Michele Vendruscolo

  107. A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation

    Article • January 2022, Springer Science + Business Media

    Professor Michele Vendruscolo

  108. Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation

    Article • Journal of Molecular Biology, January 2022, Elsevier

    Professor Michele Vendruscolo

  109. Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

    Article • Natural Product Reports, January 2022, Royal Society of Chemistry

    Professor Michele Vendruscolo

  110. Common sequence motifs of nascent chains engage the ribosome surface and trigger factor

    Article • Proceedings of the National Academy of Sciences, December 2021, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  111. Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease

    Article • Pharmaceuticals, December 2021, MDPI AG

    Professor Michele Vendruscolo

  112. Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

    Article • Science Advances, December 2021, American Association for the Advancement of Science

    Nicholas Geraghty, Professor Michele Vendruscolo

  113. A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

    Article • ACS Central Science, December 2021, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  114. A small molecule stabilises the disordered native state of the Alzheimer’s Aβ peptide

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  115. Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  116. The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Professor Michele Vendruscolo, Dr. Andreas Bracher

  117. The signal peptide of the amyloid precursor protein forms amyloid-like aggregates and enhances Aβ42 aggregation

    Article • Cell Reports Physical Science, October 2021, Elsevier

    Professor Michele Vendruscolo

  118. A maximum caliber approach for continuum path ensembles

    Article • Zeitschrift für Physik B Condensed Matter and Quanta, September 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  119. The Amyloid-β Pathway in Alzheimer’s Disease

    Article • Molecular Psychiatry, August 2021, Springer Science + Business Media

    Professor George Perry, Professor Michele Vendruscolo

  120. Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine

    Article • ACS Chemical Neuroscience, August 2021, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  121. Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

    Article • Communications Biology, July 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  122. Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

    Article • Communications Biology, July 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  123. Generic nature of the condensed states of proteins

    Article • Nature Cell Biology, June 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  124. A mistranslation-prone transcriptome underlying polyglutamine expansion diseases

    Article • Nature Reviews Molecular Cell Biology, April 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  125. Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

    Article • Proceedings of the National Academy of Sciences, March 2021, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  126. A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms

    Article • February 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  127. Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases

    Article • Nature Reviews Chemistry, February 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  128. The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  129. Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors

    Article • ACS Chemical Neuroscience, February 2021, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  130. Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

    Article • Nature Communications, January 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  131. Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis

    Article • ACS Chemical Neuroscience, January 2021, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  132. A kinetic ensemble of the Alzheimer’s Aβ peptide

    Article • Nature Computational Science, January 2021, Springer Science + Business Media

    Professor Michele Vendruscolo

  133. Computational maturation of a single-domain antibody against Aβ42 aggregation

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Professor Michele Vendruscolo

  134. Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Professor Michele Vendruscolo

  135. A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  136. Environmental Dependence of the Structure of the C-terminal Domain of the SARS-CoV-2 Envelope Protein

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  137. Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

    Article • Communications Chemistry, December 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  138. Widespread occurrence of the droplet state of proteins in the human proteome

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  139. Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  140. Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Professor Michele Vendruscolo

  141. A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  142. An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase

    Article • Proceedings of the National Academy of Sciences, October 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  143. Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

    Article • Nature Structural & Molecular Biology, September 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  144. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

    Article • Proceedings of the National Academy of Sciences, September 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  145. Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  146. Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

    Article • Nature Structural & Molecular Biology, August 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  147. Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

    Article • Nature Communications, June 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  148. Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  149. Sequence-based prediction of protein binding mode landscapes

    Article • PLoS Computational Biology, May 2020, PLOS

    Professor Michele Vendruscolo

  150. Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

    Article • Nature Protocols, May 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  151. A kinetic ensemble of the Alzheimer’s Aβ peptide

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  152. Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

    Article • Nature Chemistry, April 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  153. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

    Article • Nature Chemistry, April 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  154. Complexity in Lipid Membrane Composition Induces Resilience to Aβ42 Aggregation

    Article • ACS Chemical Neuroscience, March 2020, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  155. Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

    Article • Biomacromolecules, February 2020, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  156. Chris Dobson (1949–2019)

    Article • Nature Chemical Biology, January 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  157. Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

    Article • Proceedings of the National Academy of Sciences, January 2020, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  158. The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Professor Michele Vendruscolo

  159. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  160. Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

    Article • Quarterly Reviews of Biophysics, January 2020, Cambridge University Press

    Professor Michele Vendruscolo

  161. Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases – ERRATUM

    Article • Quarterly Reviews of Biophysics, January 2020, Cambridge University Press

    Professor Michele Vendruscolo

  162. Proteome-wide observation of the phenomenon of life on the edge of solubility

    Article • Proceedings of the National Academy of Sciences, December 2019, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  163. Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA

    Article • Biochemistry, December 2019, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  164. Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

    Article • Proceedings of the National Academy of Sciences, October 2019, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  165. Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

    Article • Science Advances, October 2019, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  166. Probing the dynamic stalk region of the ribosome using solution NMR

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  167. Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers

    Article • ACS Chemical Neuroscience, July 2019, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  168. Determination of protein structural ensembles using cryo-electron microscopy

    Article • Current Opinion in Structural Biology, June 2019, Elsevier

    Professor Michele Vendruscolo

  169. Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response

    Article • PLOS One, May 2019, PLOS

    Professor Michele Vendruscolo

  170. Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

    Article • ACS Chemical Biology, May 2019, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  171. Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Professor Michele Vendruscolo

  172. The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions

    Article • Scientific Reports, April 2019, Springer Science + Business Media

    Professor Michele Vendruscolo

  173. Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

    Article • Science Advances, April 2019, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  174. A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Professor Michele Vendruscolo

  175. Atomic force microscopy for single molecule characterisation of protein aggregation

    Article • Archives of Biochemistry and Biophysics, March 2019, Elsevier

    Professor Michele Vendruscolo

  176. A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone

    Article • Proteins Structure Function and Bioinformatics, February 2019, Wiley

    Professor Michele Vendruscolo

  177. Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

    Article • Nature Communications, January 2019, Springer Science + Business Media

    Professor Michele Vendruscolo

  178. Effects of α-tubulin acetylation on microtubule structure and stability

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  179. Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

    Article • Chemical Communications, January 2019, Royal Society of Chemistry

    Professor Michele Vendruscolo

  180. Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

    Article • Structure, January 2019, Elsevier

    Professor Michele Vendruscolo

  181. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

    Article • Nature Neuroscience, December 2018, Springer Science + Business Media

    Professor Michele Vendruscolo

  182. Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  183. In vitro and in silico assessment of the developability of a designed monoclonal antibody library

    Article • mAbs, December 2018, Taylor & Francis

    Professor Michele Vendruscolo

  184. Determination of Structural Ensembles of Proteins: Restraining vs Reweighting

    Article • Journal of Chemical Theory and Computation, November 2018, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  185. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

    Article • Journal of Visualized Experiments, November 2018, MyJove Corporation

    Professor Michele Vendruscolo

  186. SAR by kinetics for drug discovery in protein misfolding diseases

    Article • Proceedings of the National Academy of Sciences, September 2018, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  187. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

    Article • Nature Communications, September 2018, Springer Science + Business Media

    Professor Michele Vendruscolo

  188. Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in C. elegans

    Article • September 2018, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  189. Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans

    Article • September 2018, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  190. Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

    Article • Proceedings of the National Academy of Sciences, September 2018, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  191. Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

    Article • ACS Chemical Neuroscience, August 2018, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  192. Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Professor Michele Vendruscolo

  193. Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

    Article • Journal of Molecular Biology, August 2018, Elsevier

    Professor Michele Vendruscolo

  194. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

    Article • Journal of Neuroscience Methods, August 2018, Elsevier

    Professor Michele Vendruscolo

  195. Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

    Article • PeerJ, July 2018, PeerJ

    Professor Michele Vendruscolo

  196. Determination of the conformational states of strychnine using NMR residual dipolar couplings in a tensor-free approach

    Article • Methods, July 2018, Elsevier

    Professor Michele Vendruscolo

  197. Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

    Article • Protein Science, July 2018, Wiley

    Professor Michele Vendruscolo

  198. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

    Article • ACS Chemical Biology, June 2018, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  199. Reversible inhibition of the ClpP protease via an N-terminal conformational switch

    Article • Proceedings of the National Academy of Sciences, June 2018, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  200. Cooperative Assembly of Hsp70 Subdomain Clusters

    Article • Biochemistry, May 2018, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  201. A method for partitioning the information contained in a protein sequence between its structure and function

    Article • Proteins Structure Function and Bioinformatics, May 2018, Wiley

    Professor Michele Vendruscolo

  202. A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells

    Article • International Journal of Molecular Sciences, May 2018, MDPI AG

    Professor Michele Vendruscolo

  203. Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamical regions of the ribosome

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  204. Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

    Article • Nature Chemistry, May 2018, Springer Science + Business Media

    Professor Michele Vendruscolo

  205. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation

    Article • Annual Review of Physical Chemistry, April 2018, Annual Reviews

    Professor Michele Vendruscolo

  206. Parapred: antibody paratope prediction using convolutional and recurrent neural networks

    Article • Bioinformatics, April 2018, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  207. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Article • Cell, April 2018, Elsevier

    Professor Michele Vendruscolo

  208. Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy

    Article • Biophysical Journal, April 2018, Elsevier

    Professor Michele Vendruscolo

  209. Molecular determinants of the interaction of EGCG with ordered and disordered proteins

    Article • Biopolymers, March 2018, Wiley

    Professor Michele Vendruscolo

  210. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

    Article • Nature Chemistry, March 2018, Springer Science + Business Media

    Professor Michele Vendruscolo

  211. Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

    Article • February 2018, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  212. Third generation antibody discovery methods:in silicorational design

    Article • Chemical Society Reviews, January 2018, Royal Society of Chemistry

    Professor Michele Vendruscolo

  213. Structural differences between toxic and nontoxic HypF-N oligomers

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Michele Vendruscolo

  214. Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

    Article • Science, December 2017, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  215. Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy

    Article • November 2017, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  216. MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins

    Article • Nucleic Acids Research, November 2017, Oxford University Press (OUP)

    Professor Michele Vendruscolo, Lisanna Paladin

  217. Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  218. Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

    Article • Angewandte Chemie, October 2017, Wiley

    Professor Michele Vendruscolo

  219. In Vitro and In Silico Activity of Iridoids Against Leishmania ama-zonensis

    Article • Current Drug Discovery Technologies, October 2017, Bentham Science Publishers

    Professor Michele Vendruscolo

  220. Influence of Harvest Season and Cultivar on the Variation of Phenolic Compounds Composition and Antioxidant Properties in Vaccinium ashei Leaves

    Article • Molecules, September 2017, MDPI AG

    Professor Michele Vendruscolo

  221. Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  222. Paratope Prediction using Convolutional and Recurrent Neural Networks

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  223. Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

    Article • Journal of Molecular Biology, September 2017, Elsevier

    Professor Michele Vendruscolo

  224. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  225. Rapid and accurate in silico solubility screening of a monoclonal antibody library

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  226. Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

    Article • Proceedings of the National Academy of Sciences, July 2017, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  227. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

    Article • BMC Biology, July 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  228. Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

    Article • Proceedings of the National Academy of Sciences, June 2017, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  229. Methods of probing the interactions between small molecules and disordered proteins

    Article • Cellular and Molecular Life Sciences, June 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  230. Amyloid-like Fibrils from an α-Helical Transmembrane Protein

    Article • Biochemistry, June 2017, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  231. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

    Article • Proceedings of the National Academy of Sciences, June 2017, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  232. Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

    Article • Science Advances, June 2017, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  233. Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  234. Structural Characterization of the Early Events in the Nucleation–Condensation Mechanism in a Protein Folding Process

    Article • Journal of the American Chemical Society, May 2017, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  235. The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

    Article • eLife, April 2017, eLife

    Professor Michele Vendruscolo

  236. Emergence and evolution of an interaction between intrinsically disordered proteins

    Article • eLife, April 2017, eLife

    Professor Michele Vendruscolo

  237. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

    Article • Proceedings of the National Academy of Sciences, April 2017, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  238. MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions

    Article • Journal of Biological Chemistry, March 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Michele Vendruscolo

  239. Simultaneous quantification of protein order and disorder

    Article • Nature Chemical Biology, March 2017, Springer Science + Business Media

    Professor Michele Vendruscolo

  240. Bayesian weighing of electron cryo-microscopy data for integrative structural modeling

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  241. Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

    Article • Molecular Cell, March 2017, Elsevier

    Professor Michele Vendruscolo

  242. Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

    Article • Biochemistry, February 2017, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  243. Widespread Proteome Remodeling and Aggregation in Aging C. elegans

    Article • Cell, February 2017, Elsevier

    Professor Michele Vendruscolo

  244. Networks of Dynamic Allostery Regulate Enzyme Function

    Article • Structure, February 2017, Elsevier

    Professor Michele Vendruscolo

  245. Principles of protein structural ensemble determination

    Article • Current Opinion in Structural Biology, February 2017, Elsevier

    Professor Michele Vendruscolo

  246. A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

    Article • Proceedings of the National Academy of Sciences, January 2017, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  247. Scaling behaviour and rate-determining steps in filamentous self-assembly

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Professor Michele Vendruscolo

  248. Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop

    Article • Physical Chemistry Chemical Physics, January 2017, Royal Society of Chemistry

    Professor Michele Vendruscolo

  249. Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

    Article • Proceedings of the National Academy of Sciences, December 2016, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  250. β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

    Article • Scientific Reports, November 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  251. Simultaneous Production of Amyloglucosidase and Exo-Polygalacturonase by Aspergillus niger in a Rotating Drum Reactor

    Article • Applied Biochemistry and Biotechnology, October 2016, Springer Science + Business Media

    Professor Michele Vendruscolo, Lucielen Oliveira Santos

  252. Structural basis of synaptic vesicle assembly promoted by α-synuclein

    Article • Nature Communications, September 2016, Nature

    Professor Michele Vendruscolo

  253. Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

    Article • Proceedings of the National Academy of Sciences, August 2016, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  254. Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  255. A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimers disease

    Article • Science Advances, August 2016, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  256. Towards a structural biology of the hydrophobic effect in protein folding

    Article • Scientific Reports, July 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  257. Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  258. Structure of a low-population binding intermediate in protein-RNA recognition

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  259. Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  260. Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

    Article • Biochemistry, June 2016, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  261. Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

    Article • Scientific Reports, May 2016, Nature

    Professor Martino Bolognesi, Professor Michele Vendruscolo

  262. Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

    Article • Proceedings of the National Academy of Sciences, April 2016, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  263. A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

    Article • Proceedings of the National Academy of Sciences, April 2016, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  264. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

    Article • Nature Communications, March 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  265. Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain

    Article • Journal of Biological Chemistry, March 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Michele Vendruscolo

  266. A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

    Article • Nature Structural & Molecular Biology, February 2016, Nature

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  267. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

    Article • ACS Combinatorial Science, February 2016, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  268. Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  269. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic A 42 aggregates linked with Alzheimers disease

    Article • Science Advances, February 2016, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  270. Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

    Article • ACS Nano, January 2016, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  271. Metainference: A Bayesian inference method for heterogeneous systems

    Article • Science Advances, January 2016, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  272. Hamiltonian Dynamics of Protein Filament Formation

    Article • Physical Review Letters, January 2016, American Physical Society (APS)

    Professor Michele Vendruscolo

  273. Molecular mechanisms of protein aggregation from global fitting of kinetic models

    Article • Nature Protocols, January 2016, Springer Science + Business Media

    Professor Michele Vendruscolo

  274. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Péclet Numbers

    Article • International Journal of Nonlinear Sciences and Numerical Simulation, January 2016, De Gruyter

    Professor Michele Vendruscolo

  275. Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements

    Article • Biochemistry, December 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  276. Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles

    Article • Biochemistry, December 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  277. Parmbsc1: a refined force field for DNA simulations

    Article • Nature Chemical Biology, November 2015, Nature

    Professor Josep Ll. Gelpi, Dr Alberto Perez, Professor Michele Vendruscolo

  278. Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins

    Article • Biochemistry, November 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  279. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

    Article • Neuron, November 2015, Elsevier

    Professor Michele Vendruscolo

  280. Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations

    Article • PLoS Computational Biology, October 2015, PLOS

    Dr. Sanne Abeln, Professor Michele Vendruscolo

  281. The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  282. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

    Article • Current Alzheimer Research, October 2015, Bentham Science Publishers

    Professor Michele Vendruscolo

  283. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

    Article • Nature Chemistry, September 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  284. Targeting disordered proteins with small molecules using entropy

    Article • Trends in Biochemical Sciences, September 2015, Elsevier

    Professor Michele Vendruscolo

  285. Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study

    Article • Journal of the American Chemical Society, August 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  286. A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

    Article • Biochemistry, August 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  287. Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

    Article • Proceedings of the National Academy of Sciences, July 2015, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  288. Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy

    Article • Biochemistry, July 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  289. Reply to “Comment on ‘A Tensor-Free Method for the Structural and Dynamic Refinement of Proteins using Residual Dipolar Couplings’”

    Article • The Journal of Physical Chemistry B, June 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  290. Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

    Article • Nature Structural & Molecular Biology, June 2015, Springer Science + Business Media

    Dr. Alexandre M.J.J. Bonvin, Professor Michele Vendruscolo, Professor Diana R. Tomchick

  291. Analysis of the performance of the CHESHIRE and YAPP methods at CASD-NMR round 3

    Article • Journal of Biomolecular NMR, May 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  292. Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures

    Article • Biochemistry, May 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  293. Widespread Proteome Remodeling and Aggregation in Aging C. elegans

    Article • Cell, May 2015, Elsevier

    Professor Michele Vendruscolo

  294. Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms

    Article • Structure, April 2015, Elsevier

    Professor Michele Vendruscolo

  295. The physical basis of protein misfolding disorders

    Article • Physics Today, March 2015, American Institute of Physics

    Professor Michele Vendruscolo

  296. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

    Article • Nature Structural & Molecular Biology, February 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  297. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

    Article • Nature Chemical Biology, February 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  298. The s2D Method: Simultaneous Sequence-Based Prediction of the Statistical Populations of Ordered and Disordered Regions in Proteins

    Article • Journal of Molecular Biology, February 2015, Elsevier

    Professor Michele Vendruscolo

  299. Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

    Article • Trends in Pharmacological Sciences, February 2015, Elsevier

    Professor Michele Vendruscolo

  300. A Tensor-Free Method for the Structural and Dynamical Refinement of Proteins using Residual Dipolar Couplings

    Article • The Journal of Physical Chemistry B, January 2015, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  301. Structure of a low-population intermediate state in the release of an enzyme product

    Article • eLife, January 2015, eLife

    Professor Michele Vendruscolo

  302. The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

    Article • Journal of Molecular Biology, January 2015, Elsevier

    Professor Michele Vendruscolo

  303. Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Professor Michele Vendruscolo

  304. The Computational Studies of Co-Translational Protein Folding

    Article • Biophysical Journal, January 2015, Elsevier

    Professor Michele Vendruscolo

  305. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Michele Vendruscolo

  306. Druggability of Intrinsically Disordered Proteins

    Article • January 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  307. Structure and Dynamics of Intrinsically Disordered Proteins

    Article • January 2015, Springer Science + Business Media

    Professor Michele Vendruscolo

  308. The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  309. Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3

    Article • Biophysical Journal, December 2014, Elsevier

    Professor Michele Vendruscolo

  310. A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein

    Article • Biochemistry, November 2014, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  311. ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

    Article • Journal of Cell Biology, November 2014, Rockefeller University Press

    Professor Michele Vendruscolo

  312. Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

    Article • Proceedings of the National Academy of Sciences, September 2014, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  313. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein

    Article • Human Molecular Genetics, September 2014, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  314. NMR characterization of the conformational fluctuations of the human lymphocyte function‐associated antigen‐1 I‐domain

    Article • Protein Science, September 2014, Wiley

    Professor Michele Vendruscolo

  315. Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts

    Article • Proceedings of the National Academy of Sciences, September 2014, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  316. Archaeal MBF1 binds to 30S and 70S ribosomes via its helix–turn–helix domain

    Article • Biochemical Journal, September 2014, Portland Press Ltd.

    Professor Michele Vendruscolo

  317. Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism

    Article • Proceedings of the National Academy of Sciences, June 2014, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  318. Statistical Mechanics of the Denatured State of a Protein Using Replica-Averaged Metadynamics

    Article • Journal of the American Chemical Society, June 2014, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  319. A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings

    Article • June 2014, Protein Data Bank, Rutgers University

    Professor Michele Vendruscolo

  320. Flexible anchoring of archaeal MBF1 on ribosomes suggests role as recruitment factor

    Article • June 2014, Protein Data Bank, Rutgers University

    Professor Michele Vendruscolo

  321. Erratum: The amyloid state and its association with protein misfolding diseases

    Article • Nature Reviews Molecular Cell Biology, June 2014, Springer Science + Business Media

    Professor Michele Vendruscolo

  322. Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

    Article • Nature Communications, May 2014, Springer Science + Business Media

    Professor Michele Vendruscolo

  323. The amyloid state and its association with protein misfolding diseases

    Article • Nature Reviews Molecular Cell Biology, May 2014, Springer Science + Business Media

    Professor Michele Vendruscolo

  324. Understanding the Influence of Codon Translation Rates on Cotranslational Protein Folding

    Article • Accounts of Chemical Research, May 2014, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  325. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

    Article • Proceedings of the National Academy of Sciences, May 2014, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  326. Determination of the Individual Roles of the Linker Residues in the Interdomain Motions of Calmodulin Using NMR Chemical Shifts

    Article • Journal of Molecular Biology, April 2014, Elsevier

    Professor Michele Vendruscolo

  327. ALMOST: An all atom molecular simulation toolkit for protein structure determination

    Article • Journal of Computational Chemistry, March 2014, Wiley

    Professor Michele Vendruscolo

  328. Spatial Propagation of Protein Polymerization

    Article • Physical Review Letters, March 2014, American Physical Society (APS)

    Professor Michele Vendruscolo

  329. Chemical kinetics for drug discovery to combat protein aggregation diseases

    Article • Trends in Pharmacological Sciences, March 2014, Elsevier

    Professor Michele Vendruscolo

  330. Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

    Article • PLOS One, February 2014, PLOS

    Professor Michele Vendruscolo

  331. The dynamics of interleukin‐8 and its interaction with human CXC receptor I peptide

    Article • Protein Science, February 2014, Wiley

    Professor Michele Vendruscolo

  332. A Conformational Ensemble Derived Using NMR Methyl Chemical Shifts Reveals a Mechanical Clamping Transition That Gates the Binding of the HU Protein to DNA

    Article • Journal of the American Chemical Society, February 2014, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  333. New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics

    Article • Journal of Biomolecular NMR, January 2014, Springer Science + Business Media

    Professor Michele Vendruscolo

  334. A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation

    Article • PLOS One, January 2014, PLOS

    Professor Michele Vendruscolo, Dr. Sanne Abeln

  335. Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates

    Article • Nature Communications, January 2014, Springer Science + Business Media

    Professor Michele Vendruscolo

  336. Structure of a Misfolded Intermediate of a PDZ Domain

    Article • January 2014, Elsevier

    Professor Michele Vendruscolo

  337. Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy

    Article • Journal of the American Chemical Society, December 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  338. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation

    Article • ACS Nano, December 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  339. Replica-Averaged Metadynamics

    Article • Journal of Chemical Theory and Computation, December 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  340. Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

    Article • Cell Reports, November 2013, Elsevier

    Professor Michele Vendruscolo

  341. pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

    Article • Nucleic Acids Research, October 2013, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  342. Erratum: “Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle” [J. Chem. Phys. 138, 094112 (2013)]

    Article • The Journal of Chemical Physics, October 2013, American Institute of Physics

    Carlo Camilloni, Professor Michele Vendruscolo

  343. Subdomain Architecture and Stability of a Giant Repeat Protein

    Article • The Journal of Physical Chemistry B, October 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  344. Cucurbit[8]uril and Blue-Box: High-Energy Water Release Overwhelms Electrostatic Interactions

    Article • Journal of the American Chemical Society, September 2013, American Chemical Society (ACS)

    Dr Frank Biedermann, Professor Michele Vendruscolo

  345. A Relationship between the Aggregation Rates of α-Synuclein Variants and the β-Sheet Populations in Their Monomeric Forms

    Article • The Journal of Physical Chemistry B, September 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  346. Characterization of the Interdomain Motions in Hen Lysozyme Using Residual Dipolar Couplings as Replica-Averaged Structural Restraints in Molecular Dynamics Simulations

    Article • Biochemistry, September 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  347. Structures of the Excited States of Phospholamban and Shifts in Their Populations upon Phosphorylation

    Article • Biochemistry, September 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  348. In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

    Article • PLOS One, August 2013, PLOS

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  349. A geometrical parametrization of C1′-C5′ RNA ribose chemical shifts calculated by density functional theory

    Article • The Journal of Chemical Physics, July 2013, American Institute of Physics

    Professor Michele Vendruscolo

  350. Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

    Article • The Journal of Chemical Physics, July 2013, American Institute of Physics

    Professor Michele Vendruscolo

  351. Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

    Article • Journal of Molecular Biology, July 2013, Elsevier

    Professor Michele Vendruscolo

  352. Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution

    Article • Analytical Chemistry, June 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  353. A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings

    Article • The Journal of Chemical Physics, June 2013, American Institute of Physics

    Professor Michele Vendruscolo

  354. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  355. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step

    Article • Applied Physics Letters, May 2013, American Institute of Physics

    Professor Michele Vendruscolo

  356. The codon information index: a quantitative measure of the information provided by the codon bias

    Article • Journal of Statistical Mechanics Theory and Experiment, April 2013, Institute of Physics Publishing

    Professor Michele Vendruscolo

  357. Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  358. Atomic structure and hierarchical assembly of a cross-β amyloid fibril

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  359. Protein self-assembly intermediates

    Article • Nature Chemical Biology, March 2013, Springer Science + Business Media

    Professor Michele Vendruscolo

  360. Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle

    Article • The Journal of Chemical Physics, March 2013, American Institute of Physics

    Carlo Camilloni, Professor Michele Vendruscolo

  361. Erratum: Prediction of variable translation rate effects on cotranslational protein folding

    Article • Nature Communications, February 2013, Springer Science + Business Media

    Professor Michele Vendruscolo

  362. Analysis of the Contributions of Ring Current and Electric Field Effects to the Chemical Shifts of RNA Bases

    Article • The Journal of Physical Chemistry B, February 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  363. Assessment of the Use of NMR Chemical Shifts as Replica-Averaged Structural Restraints in Molecular Dynamics Simulations to Characterize the Dynamics of Proteins

    Article • The Journal of Physical Chemistry B, February 2013, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  364. R state structure of monomeric phospholamban (C36A, C41F, C46A)

    Article • February 2013, Protein Data Bank, Rutgers University

    Professor Michele Vendruscolo

  365. Sequence-Based Prediction of Protein Behavior

    Article • January 2013, Wiley

    Professor Michele Vendruscolo

  366. The Kinetics and Mechanisms of Amyloid Formation

    Article • January 2013, Wiley

    Professor Michele Vendruscolo

  367. Characterization of Free Energy Landscapes of Proteins using NMR Spectroscopy

    Article • Biophysical Journal, January 2013, Elsevier

    Professor Michele Vendruscolo

  368. In Vivo Translation Rates Can Substantially Delay the Co-Translational Folding of the E. Coli Cytosolic Proteome

    Article • Biophysical Journal, January 2013, Elsevier

    Professor Michele Vendruscolo

  369. Thermodynamics of an Intrinsically Disordered Protein by Atomistic Simulations

    Article • Biophysical Journal, January 2013, Elsevier

    Professor Michele Vendruscolo

  370. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  371. A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

    Article • Biochemistry, November 2012, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  372. Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides

    Article • Physical Review Letters, October 2012, American Physical Society (APS)

    Professor Michele Vendruscolo

  373. In support of the BMRB

    Article • Nature Structural & Molecular Biology, September 2012, Springer Science + Business Media

    Dr Patrick C A van der Wel, Dr. Alexandre M.J.J. Bonvin, Professor Michele Vendruscolo, Rolf Boelens

  374. ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

    Article • Journal of Cell Biology, August 2012, Rockefeller University Press

    Professor Michele Vendruscolo

  375. From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

    Article • Journal of Molecular Biology, August 2012, Elsevier

    Professor Michele Vendruscolo

  376. Sequence-Based Prediction of Protein Solubility

    Article • Journal of Molecular Biology, August 2012, Elsevier

    Professor Michele Vendruscolo

  377. Trigger Factor Slows Co-translational Folding through Kinetic Trapping while Sterically Protecting the Nascent Chain from Aberrant Cytosolic Interactions

    Article • Journal of the American Chemical Society, July 2012, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  378. Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings

    Article • Journal of Biomolecular NMR, June 2012, Springer Science + Business Media

    Professor Michele Vendruscolo

  379. Protein Structure Validation Using Side-Chain Chemical Shifts

    Article • The Journal of Physical Chemistry B, April 2012, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  380. Structure of an Intermediate State in Protein Folding and Aggregation

    Article • Science, April 2012, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  381. Proteome folding and aggregation

    Article • Current Opinion in Structural Biology, April 2012, Elsevier

    Professor Michele Vendruscolo

  382. Fibrillogenic propensity of the GroEL apical domain: A Janus-faced minichaperone

    Article • FEBS Letters, March 2012, Wiley

    Professor Michele Vendruscolo

  383. Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

    Article • Biochemistry, March 2012, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  384. Characterization of the Conformational Equilibrium between the Two Major Substates of RNase A Using NMR Chemical Shifts

    Article • Journal of the American Chemical Society, March 2012, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  385. Blind Testing of Routine, Fully Automated Determination of Protein Structures from NMR Data

    Article • Structure, February 2012, Elsevier

    Professor Michele Vendruscolo, Professor Geerten W. Vuister, Dr. Alexandre M.J.J. Bonvin

  386. Prediction of variable translation rate effects on cotranslational protein folding

    Article • Nature Communications, January 2012, Springer Science + Business Media

    Professor Michele Vendruscolo

  387. Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings

    Article • Journal of Chemical Theory and Computation, December 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  388. Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  389. Coarse-grained model for protein folding based on structural profiles

    Article • Physical Review E, October 2011, American Physical Society (APS)

    Professor Michele Vendruscolo

  390. Inversion of the Balance between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation

    Article • PLoS Computational Biology, October 2011, PLOS

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  391. ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

    Article • Human Molecular Genetics, September 2011, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  392. Metastability of Native Proteins and the Phenomenon of Amyloid Formation

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  393. Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments

    Article • International Journal of Molecular Sciences, September 2011, MDPI AG

    Professor Michele Vendruscolo

  394. Using Side-Chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures

    Article • Angewandte Chemie, September 2011, Wiley

    Professor Michele Vendruscolo

  395. Using Side-Chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures

    Article • Angewandte Chemie, September 2011, Wiley

    Professor Michele Vendruscolo

  396. Excited-State Control of Protein Activity

    Article • Journal of Molecular Biology, September 2011, Elsevier

    Professor Michele Vendruscolo

  397. The A53T Mutation is Key in Defining the Differences in the Aggregation Kinetics of Human and Mouse α-Synuclein

    Article • Journal of the American Chemical Society, August 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  398. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

    Article • The Journal of Chemical Physics, August 2011, American Institute of Physics

    Professor Michele Vendruscolo

  399. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

    Article • The Journal of Chemical Physics, August 2011, American Institute of Physics

    Professor Michele Vendruscolo

  400. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations

    Article • The Journal of Chemical Physics, August 2011, American Institute of Physics

    Professor Michele Vendruscolo

  401. Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

    Article • Cold Spring Harbor Perspectives in Biology, August 2011, Cold Spring Harbor Laboratory Press

    Professor Michele Vendruscolo

  402. Using Chemical Shifts to Determine Structural Changes in Proteins upon Complex Formation

    Article • The Journal of Physical Chemistry B, August 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  403. Structure-based prediction of methyl chemical shifts in proteins

    Article • Journal of Biomolecular NMR, July 2011, Springer Science + Business Media

    Professor Michele Vendruscolo

  404. The statistical theory of allostery

    Article • Nature Chemical Biology, June 2011, Springer Science + Business Media

    Professor Michele Vendruscolo

  405. 1H, 13C and 15N resonance assignments of human muscle acylphosphatase

    Article • Biomolecular NMR Assignments, June 2011, Springer Science + Business Media

    Professor Michele Vendruscolo

  406. Asymmetric folding pathways and transient misfolding in a coarse-grained model of proteins

    Article • EPL (Europhysics Letters), May 2011, Institute of Physics Publishing

    Professor Michele Vendruscolo

  407. Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

    Article • Journal of Molecular Biology, April 2011, Elsevier

    Professor Michele Vendruscolo

  408. Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

    Article • Journal of Neuroscience Methods, April 2011, Elsevier

    Professor Michele Vendruscolo

  409. Faculty Opinions recommendation of A transient and low-populated protein-folding intermediate at atomic resolution.

    Article • March 2011, F1000Research

    Professor Michele Vendruscolo

  410. On the Effect of the Ribosome and Trigger Factor on Nascent Chain Protein Folding

    Article • Biophysical Journal, February 2011, Elsevier

    Professor Michele Vendruscolo

  411. New Scenarios of Protein Folding Can Occur on the Ribosome

    Article • Journal of the American Chemical Society, January 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  412. The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

    Article • Integrative Biology, January 2011, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  413. Interactions in the native state of monellin, which play a protective role against aggregation

    Article • Molecular BioSystems, January 2011, Royal Society of Chemistry

    Professor Michele Vendruscolo

  414. Protein Dynamics: Moore's Law in Molecular Biology

    Article • Current Biology, January 2011, Elsevier

    Professor Michele Vendruscolo

  415. Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

    Article • Cell, January 2011, Elsevier

    Professor Michele Vendruscolo

  416. Transient Tertiary Structure Formation within the Ribosome Exit Port

    Article • Journal of the American Chemical Society, December 2010, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  417. Focus on Physical Principles of Protein Behavior in the Cell

    Article • PROTEOMICS, November 2010, Wiley

    Professor Michele Vendruscolo

  418. Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

    Article • Nature Structural & Molecular Biology, November 2010, Springer Science + Business Media

    Professor Michele Vendruscolo

  419. Translationally optimal codons associate with aggregation-prone sites in proteins

    Article • PROTEOMICS, November 2010, Wiley

    Professor Michele Vendruscolo

  420. Accurate Determination of Interstrand Distances and Alignment in Amyloid Fibrils by Magic Angle Spinning NMR

    Article • The Journal of Physical Chemistry B, October 2010, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  421. Proteome-Level Interplay between Folding and Aggregation Propensities of Proteins

    Article • Journal of Molecular Biology, October 2010, Elsevier

    Professor Michele Vendruscolo

  422. Enzymatic activity in disordered states of proteins

    Article • Current Opinion in Chemical Biology, October 2010, Elsevier

    Professor Michele Vendruscolo

  423. Functional interactions as a survival strategy against abnormal aggregation

    Article • The FASEB Journal, September 2010, Federation of American Societies For Experimental Biology (FASEB)

    Professor Michele Vendruscolo

  424. Faculty Opinions recommendation of Widespread protein aggregation as an inherent part of aging in C. elegans.

    Article • August 2010, F1000Research

    Professor Michele Vendruscolo

  425. Using NMR Chemical Shifts as Structural Restraints in Molecular Dynamics Simulations of Proteins

    Article • Structure, August 2010, Elsevier

    Professor Michele Vendruscolo

  426. Physicochemical Determinants of Chaperone Requirements

    Article • Journal of Molecular Biology, July 2010, Elsevier

    Professor Michele Vendruscolo

  427. Time Averaging of NMR Chemical Shifts in the MLF Peptide in the Solid State

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Patrick C A van der Wel

  428. Intrinsic Determinants of Neurotoxic Aggregate Formation by the Amyloid β Peptide

    Article • Biophysical Journal, April 2010, Elsevier

    Professor Michele Vendruscolo

  429. Faculty Opinions recommendation of NMR spectroscopy brings invisible protein states into focus.

    Article • March 2010, F1000Research

    Professor Michele Vendruscolo

  430. Efficient identification of near-native conformations in ab initio protein structure prediction using structural profiles

    Article • Proteins Structure Function and Bioinformatics, February 2010, Wiley

    Professor Michele Vendruscolo

  431. Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation

    Article • Molecular BioSystems, January 2010, Royal Society of Chemistry

    Professor Michele Vendruscolo

  432. Determination of the Free Energy Landscape of α-Synuclein Using Spin Label Nuclear Magnetic Resonance Measurements

    Article • Journal of the American Chemical Society, December 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  433. An Analytical Solution to the Kinetics of Breakable Filament Assembly

    Article • Science, December 2009, American Association for the Advancement of Science

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  434. Accurate Random Coil Chemical Shifts from an Analysis of Loop Regions in Native States of Proteins

    Article • Journal of the American Chemical Society, November 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  435. Analysis of Sub-τc and Supra-τc Motions in Protein Gβ1 Using Molecular Dynamics Simulations

    Article • Biophysical Journal, November 2009, Elsevier

    Professor Michele Vendruscolo

  436. Fast and Accurate Predictions of Protein NMR Chemical Shifts from Interatomic Distances

    Article • Journal of the American Chemical Society, October 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  437. On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

    Article • Biochemistry, September 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  438. A Condensation-Ordering Mechanism in Nanoparticle-Catalyzed Peptide Aggregation

    Article • PLoS Computational Biology, August 2009, PLOS

    Professor Michele Vendruscolo

  439. Factors That Affect the Degree of Twist in β-Sheet Structures: A Molecular Dynamics Simulation Study of a Cross-β Filament of the GNNQQNY Peptide

    Article • The Journal of Physical Chemistry B, July 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  440. Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

    Article • Proceedings of the National Academy of Sciences, June 2009, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  441. Physical Principles of Protein Behavior in the Cell

    Article • Journal of Proteome Research, June 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  442. Folding of Small Proteins by Monte Carlo Simulations with Chemical Shift Restraints without the Use of Molecular Fragment Replacement or Structural Homology

    Article • The Journal of Physical Chemistry B, June 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  443. Competition between Intramolecular and Intermolecular Interactions in an Amyloid-Forming Protein

    Article • Journal of Molecular Biology, June 2009, Elsevier

    Professor Michele Vendruscolo

  444. Position-Dependent Electrostatic Protection against Protein Aggregation

    Article • ChemBioChem, May 2009, Wiley

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  445. A Relationship between mRNA Expression Levels and Protein Solubility in E. coli

    Article • Journal of Molecular Biology, May 2009, Elsevier

    Professor Michele Vendruscolo

  446. Mutational Analysis of the Aggregation-Prone and Disaggregation-Prone Regions of Acylphosphatase

    Article • Journal of Molecular Biology, April 2009, Elsevier

    Professor Michele Vendruscolo

  447. Toward an Accurate Determination of Free Energy Landscapes in Solution States of Proteins

    Article • Journal of the American Chemical Society, March 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  448. The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints

    Article • Nature Structural & Molecular Biology, March 2009, Springer Science + Business Media

    Professor Michele Vendruscolo

  449. Factors That Affect the Degree of Twist in β-Sheet Structures: A Molecular Dynamics Simulation Study of a Cross-β Filament of the GNNQQNY Peptide

    Article • The Journal of Physical Chemistry B, February 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  450. Competition between Folding, Native-State Dimerisation and Amyloid Aggregation in β-Lactoglobulin

    Article • Journal of Molecular Biology, February 2009, Elsevier

    Professor Michele Vendruscolo

  451. Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations

    Article • Molecular BioSystems, January 2009, Royal Society of Chemistry

    Professor Michele Vendruscolo

  452. Quantitative approaches to defining normal and aberrant protein homeostasis

    Article • Faraday Discussions, January 2009, Royal Society of Chemistry

    Professor Michele Vendruscolo

  453. Networks in Cell Biology

    Article • January 2009, Cambridge University Press

    Professor Michele Vendruscolo

  454. Self-Templated Nucleation in Peptide and Protein Aggregation

    Article • Physical Review Letters, December 2008, American Physical Society (APS)

    Professor Michele Vendruscolo

  455. Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  456. Determination of Protein Structures in the Solid State from NMR Chemical Shifts

    Article • Structure, December 2008, Elsevier

    Professor Michele Vendruscolo

  457. Structure Determination of Protein−Protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicin−Immunity Protein Complex

    Article • Journal of the American Chemical Society, November 2008, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  458. A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates

    Article • PLoS Computational Biology, November 2008, PLOS

    Professor Michele Vendruscolo

  459. Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

    Article • PLOS One, October 2008, PLOS

    Professor Michele Vendruscolo

  460. Introduction to the special issue of GENE

    Article • Gene, October 2008, Elsevier

    Professor Michele Vendruscolo

  461. A stochastic method for the reconstruction of protein structures from one-dimensional structural profiles

    Article • Gene, October 2008, Elsevier

    Professor Michele Vendruscolo

  462. Competition between protein aggregation and protein complex formation

    Article • BMC Bioinformatics, October 2008, Springer Science + Business Media

    Professor Michele Vendruscolo

  463. Structure and Dynamics of a Partially Folded Protein Are Decoupled from Its Mechanism of Aggregation

    Article • Journal of the American Chemical Society, October 2008, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  464. ChemInform Abstract: The Zyggregator Method for Predicting Protein Aggregation Propensities

    Article • ChemInform, September 2008, Wiley

    Professor Michele Vendruscolo

  465. Protein dynamics under light control

    Article • Nature Chemical Biology, August 2008, Springer Science + Business Media

    Professor Michele Vendruscolo

  466. Characterizing the First Steps of Amyloid Formation for the ccβ Peptide

    Article • The Journal of Physical Chemistry B, August 2008, American Chemical Society (ACS)

    Professor Michele Vendruscolo, David Wales

  467. Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-Synonymous Single Nucleotide Polymorphisms

    Article • PLoS Computational Biology, July 2008, PLOS

    Professor Michele Vendruscolo

  468. Prediction of Aggregation-Prone Regions in Structured Proteins

    Article • Journal of Molecular Biology, July 2008, Elsevier

    Professor Michele Vendruscolo

  469. Mapping of Two Networks of Residues That Exhibit Structural and Dynamical Changes upon Binding in a PDZ Domain Protein

    Article • Journal of the American Chemical Society, July 2008, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  470. Biological function in a non-native partially folded state of a protein

    Article • The EMBO Journal, May 2008, Wiley

    Professor Michele Vendruscolo

  471. A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

    Article • Structure, May 2008, Elsevier

    Professor Michele Vendruscolo

  472. Molecular determinants of the aggregation behavior of α- and β-synuclein

    Article • Protein Science, May 2008, Wiley

    Professor Michele Vendruscolo

  473. Determination of the Transition State Ensemble for the Folding of Ubiquitin from a Combination of Φ and Ψ Analyses

    Article • Journal of Molecular Biology, March 2008, Elsevier

    Professor Michele Vendruscolo

  474. Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low'  -values

    Article • Protein Engineering Design and Selection, January 2008, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  475. Towards quantitative predictions in cell biology using chemical properties of proteins

    Article • Molecular BioSystems, January 2008, Royal Society of Chemistry

    Professor Michele Vendruscolo

  476. The Zyggregator method for predicting protein aggregation propensities

    Article • Chemical Society Reviews, January 2008, Royal Society of Chemistry

    Professor Michele Vendruscolo

  477. Stochastic reconstruction of protein structures from effective connectivity profiles

    Article • PMC Biophysics, January 2008, Springer Science + Business Media

    Professor Michele Vendruscolo

  478. Calculation of the free energy barriers in the oligomerisation of Ab

    Article • Frontiers in Bioscience, January 2008, Frontiers in Bioscience

    Professor Michele Vendruscolo

  479. Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils

    Article • Science, December 2007, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  480. The Distribution of Residues in a Polypeptide Sequence Is a Determinant of Aggregation Optimized by Evolution

    Article • Biophysical Journal, December 2007, Elsevier

    Professor Michele Vendruscolo

  481. Influence of the fluctuations of the alignment tensor on the analysis of the structure and dynamics of proteins using residual dipolar couplings

    Article • Journal of Biomolecular NMR, November 2007, Springer Science + Business Media

    Professor Michele Vendruscolo

  482. Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

    Article • PLoS Biology, October 2007, PLOS

    Professor Michele Vendruscolo

  483. Importance of Metastable States in the Free Energy Landscapes of Polypeptide Chains

    Article • Physical Review Letters, October 2007, American Physical Society (APS)

    Professor Michele Vendruscolo

  484. More charges against aggregation

    Article • Nature, October 2007, Springer Science + Business Media

    Professor Michele Vendruscolo

  485. Characterisation of Amyloid Fibril Formation by Small Heat-shock Chaperone Proteins Human αA-, αB- and R120G αB-Crystallins

    Article • Journal of Molecular Biology, September 2007, Elsevier

    Professor Michele Vendruscolo

  486. Molecular dynamics simulations from putative transition states of α-spectrin SH3 domain

    Article • Proteins Structure Function and Bioinformatics, July 2007, Wiley

    Professor Michele Vendruscolo

  487. Characterization of the nucleation barriers for protein aggregation and amyloid formation

    Article • HFSP Journal, July 2007, Taylor & Francis

    Professor Michele Vendruscolo

  488. Protein structure determination from NMR chemical shifts

    Article • Proceedings of the National Academy of Sciences, June 2007, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  489. Similarities in the thermodynamics and kinetics of aggregation of disease-related Aβ(1-40) peptides

    Article • Protein Science, June 2007, Wiley

    Professor Michele Vendruscolo

  490. Life on the edge: a link between gene expression levels and aggregation rates of human proteins

    Article • Trends in Biochemical Sciences, May 2007, Elsevier

    Professor Michele Vendruscolo

  491. Determination of conformationally heterogeneous states of proteins

    Article • Current Opinion in Structural Biology, February 2007, Elsevier

    Professor Michele Vendruscolo

  492. Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

    Article • Structure, February 2007, Elsevier

    Professor Michele Vendruscolo

  493. The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native state ensembles of proteins

    Article • Journal of Biomolecular NMR, January 2007, Springer Science + Business Media

    Professor Michele Vendruscolo

  494. A PDZ domain recapitulates a unifying mechanism for protein folding

    Article • Proceedings of the National Academy of Sciences, January 2007, Proceedings of the National Academy of Sciences

    Professor Geerten W. Vuister, Professor Michele Vendruscolo

  495. The Structurally Constrained Neutral Model of Protein Evolution

    Article • January 2007, Springer Science + Business Media

    Professor Michele Vendruscolo

  496. Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

    Article • PLoS Computational Biology, January 2007, PLOS

    Professor Michele Vendruscolo

  497. BPPred: A Web-based computational tool for predicting biophysical parameters of proteins

    Article • Protein Science, November 2006, Wiley

    Professor Michele Vendruscolo

  498. Geometry, Energetics, and Dynamics of Hydrogen Bonds in Proteins:  Structural Information Derived from NMR Scalar Couplings

    Article • Journal of the American Chemical Society, November 2006, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  499. STRUCTURAL BIOLOGY: Dynamic Visions of Enzymatic Reactions

    Article • Science, September 2006, American Association for the Advancement of Science

    Professor Michele Vendruscolo

  500. Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease

    Article • Proteins Structure Function and Bioinformatics, July 2006, Wiley

    Professor Michele Vendruscolo

  501. Relation between native ensembles and experimental structures of proteins

    Article • Proceedings of the National Academy of Sciences, July 2006, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  502. Structural Comparison of the Two Alternative Transition States for Folding of TI I27

    Article • Biophysical Journal, July 2006, Elsevier

    Professor Michele Vendruscolo

  503. Theoretical Approaches to Protein Aggregation

    Article • Protein & Peptide Letters, March 2006, Bentham Science Publishers

    Professor Michele Vendruscolo

  504. Structural Interpretation of Hydrogen Exchange Protection Factors in Proteins: Characterization of the Native State Fluctuations of CI2

    Article • Structure, January 2006, Elsevier

    Professor Michele Vendruscolo

  505. Article • BMC Evolutionary Biology, January 2006, Springer Science + Business Media

    Professor Michele Vendruscolo

  506. Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7

    Article • Proceedings of the National Academy of Sciences, December 2005, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  507. Effective interactions between chaotropic agents and proteins

    Article • Proteins Structure Function and Bioinformatics, September 2005, Wiley

    Professor Michele Vendruscolo

  508. Transition State Contact Orders Correlate with Protein Folding Rates

    Article • Journal of Molecular Biology, September 2005, Elsevier

    Professor Michele Vendruscolo

  509. Form of Growing Strings

    Article • Physical Review Letters, August 2005, American Physical Society (APS)

    Professor Michele Vendruscolo

  510. Determination of the folding transition states of barnase by using Φ I -value-restrained simulations validated by double mutant Φ IJ -values

    Article • Proceedings of the National Academy of Sciences, August 2005, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  511. Interpreting Dynamically-Averaged Scalar Couplings in Proteins

    Article • Journal of Biomolecular NMR, August 2005, Springer Science + Business Media

    Professor Michele Vendruscolo

  512. Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Professor Michele Vendruscolo

  513. Comparison of Sequence-Based and Structure-Based Energy Functions for the Reversible Folding of a Peptide

    Article • Biophysical Journal, May 2005, Elsevier

    Professor Michele Vendruscolo

  514. Detection of non-native hydrophobic interactions in the denatured state of lysozyme by molecular dynamics simulations

    Article • Journal of Physics Condensed Matter, April 2005, Institute of Physics Publishing

    Professor Michele Vendruscolo

  515. A glimpse at the organization of the protein universe

    Article • Proceedings of the National Academy of Sciences, April 2005, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  516. Formation of Native and Non-native Interactions in Ensembles of Denatured ACBP Molecules from Paramagnetic Relaxation Enhancement Studies

    Article • Journal of Molecular Biology, April 2005, Elsevier

    Professor Michele Vendruscolo

  517. Looking at structure, stability, and evolution of proteins through the principal eigenvector of contact matrices and hydrophobicity profiles

    Article • Gene, March 2005, Elsevier

    Professor Michele Vendruscolo

  518. Towards complete descriptions of the free–energy landscapes of proteins

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, February 2005, Royal Society Publishing

    Professor Michele Vendruscolo

  519. Simultaneous determination of protein structure and dynamics

    Article • January 2005, Nature

    Professor Michele Vendruscolo

  520. Protein folding and the organization of the protein topology universe

    Article • Trends in Biochemical Sciences, January 2005, Elsevier

    Professor Michele Vendruscolo

  521. Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

    Article • Journal of the American Chemical Society, January 2005, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  522. Prediction of Site-Specific Amino Acid Distributions and Limits of Divergent Evolutionary Changes in Protein Sequences

    Article • Molecular Biology and Evolution, November 2004, Oxford University Press (OUP)

    Professor Michele Vendruscolo

  523. Principal eigenvector of contact matrices and hydrophobicity profiles in proteins

    Article • Proteins Structure Function and Bioinformatics, November 2004, Wiley

    Professor Michele Vendruscolo

  524. Comparison of the Transition States for Folding of Two Ig-like Proteins from Different Superfamilies

    Article • Journal of Molecular Biology, October 2004, Elsevier

    Professor Michele Vendruscolo

  525. Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

    Article • Journal of Molecular Biology, August 2004, Elsevier

    Professor Michele Vendruscolo

  526. Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR

    Article • July 2004, Nature

    Professor Michele Vendruscolo

  527. Molecular Dynamics Studies of the Process of Amyloid Aggregation of Peptide Fragments of Transthyretin

    Article • Journal of Molecular Biology, July 2004, Elsevier

    Professor Michele Vendruscolo

  528. Determination of Protein Structures Consistent with NMR Order Parameters

    Article • Journal of the American Chemical Society, July 2004, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  529. Reconstruction of Protein Structures from a Vectorial Representation

    Article • Physical Review Letters, May 2004, American Physical Society (APS)

    Professor Michele Vendruscolo

  530. Transition states for protein folding have native topologies despite high structural variability

    Article • Nature Structural & Molecular Biology, April 2004, Springer Science + Business Media

    Professor Michele Vendruscolo

  531. Determination of an Ensemble of Structures Representing the Denatured State of the Bovine Acyl-Coenzyme A Binding Protein

    Article • Journal of the American Chemical Society, March 2004, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  532. Inhibition of protein crystallization by evolutionary negative design

    Article • Physical Biology, February 2004, Institute of Physics Publishing

    Jonathan Doye, Professor Michele Vendruscolo

  533. Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with ϕ value restraints

    Article • Proteins Structure Function and Bioinformatics, December 2003, Wiley

    Professor Michele Vendruscolo

  534. Rare Fluctuations of Native Proteins Sampled by Equilibrium Hydrogen Exchange

    Article • Journal of the American Chemical Society, December 2003, American Chemical Society (ACS)

    Professor Michele Vendruscolo

  535. Structures and relative free energies of partially folded states of proteins

    Article • Proceedings of the National Academy of Sciences, December 2003, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  536. Statistical Properties of Neutral Evolution

    Article • Journal of Molecular Evolution, August 2003, Springer Science + Business Media

    Professor Michele Vendruscolo

  537. Calculation of Mutational Free Energy Changes in Transition States for Protein Folding

    Article • Biophysical Journal, August 2003, Elsevier

    Professor Michele Vendruscolo

  538. Analysis of the distributed computing approach applied to the folding of a small β peptide

    Article • Proceedings of the National Academy of Sciences, June 2003, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  539. Protein folding and misfolding: a paradigm of self–assembly and regulation in complex biological systems

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, June 2003, Royal Society Publishing

    Professor Michele Vendruscolo

  540. Connectivity of Neutral Networks, Overdispersion, and Structural Conservation in Protein Evolution

    Article • Journal of Molecular Evolution, March 2003, Springer Science + Business Media

    Professor Michele Vendruscolo

  541. Protein folding: bringing theory and experiment closer together

    Article • Current Opinion in Structural Biology, February 2003, Elsevier

    Professor Michele Vendruscolo

  542. Self-consistent determination of the transition state for protein folding: Application to a fibronectin type III domain

    Article • Proceedings of the National Academy of Sciences, January 2003, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  543. Validity of Gō Models: Comparison with a Solvent-Shielded Empirical Energy Decomposition

    Article • Biophysical Journal, December 2002, Elsevier

    Professor Michele Vendruscolo

  544. Determination of the structures of distinct transition state ensembles for a β-sheet peptide with parallel folding pathways

    Article • The Journal of Chemical Physics, November 2002, American Institute of Physics

    Professor Michele Vendruscolo

  545. Determination of a Transition State at Atomic Resolution from Protein Engineering Data

    Article • Journal of Molecular Biology, November 2002, Elsevier

    Professor Michele Vendruscolo

  546. Lack of Self-Averaging in Neutral Evolution of Proteins

    Article • Physical Review Letters, October 2002, American Physical Society (APS)

    Professor Michele Vendruscolo

  547. Small-world view of the amino acids that play a key role in protein folding

    Article • June 2002, American Physical Society (APS)

    Professor Michele Vendruscolo

  548. Native and non-native interactions along protein folding and unfolding pathways

    Article • Proteins Structure Function and Bioinformatics, April 2002, Wiley

    Professor Michele Vendruscolo

  549. Statistical properties of contact vectors

    Article • March 2002, American Physical Society (APS)

    Professor Michele Vendruscolo

  550. Automated assignment of SCOP and CATH protein structure classifications from FSSP scores

    Article • Proteins Structure Function and Bioinformatics, February 2002, Wiley

    Professor Michele Vendruscolo

  551. Energetics of enzyme stability

    Article • Trends in Biotechnology, January 2002, Elsevier

    Professor Michele Vendruscolo

  552. Three key residues form a critical contact network in a protein folding transition state

    Article • Nature, February 2001, Springer Science + Business Media

    Professor Michele Vendruscolo

  553. How to guarantee optimal stability for most representative structures in the protein data bank

    Article • Proteins Structure Function and Bioinformatics, January 2001, Wiley

    Professor Michele Vendruscolo

  554. Article • Journal of Biological Physics, January 2001, Springer Science + Business Media

    Professor Michele Vendruscolo

  555. Comparison of two optimization methods to derive energy parameters for protein folding: Perceptron and Z score

    Article • Proteins Structure Function and Bioinformatics, November 2000, Wiley

    Professor Michele Vendruscolo

  556. Toward an energy function for the contact map representation of proteins

    Article • Proteins Structure Function and Bioinformatics, August 2000, Wiley

    Professor Michele Vendruscolo

  557. Toward an energy function for the contact map representation of proteins

    Article • Proteins Structure Function and Bioinformatics, August 2000, Wiley

    Professor Michele Vendruscolo

  558. Structurally constrained protein evolution: results from a lattice simulation

    Article • Zeitschrift für Physik B Condensed Matter and Quanta, May 2000, Springer Science + Business Media

    Professor Michele Vendruscolo

  559. A statistical mechanical method to optimize energy functions for protein folding

    Article • Proceedings of the National Academy of Sciences, April 2000, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo

  560. Can a pairwise contact potential stabilize native protein folds against decoys obtained by threading?

    Article • Proteins Structure Function and Bioinformatics, February 2000, Wiley

    Professor Michele Vendruscolo

  561. Protein folding using contact maps

    Article • January 2000, Elsevier

    Professor Michele Vendruscolo

  562. Comparison of two optimization methods to derive energy parameters for protein folding: Perceptron andZ score

    Article • Proteins Structure Function and Bioinformatics, January 2000, Wiley

    Professor Michele Vendruscolo

  563. Folding Lennard-Jones proteins by a contact potential

    Article • Proteins Structure Function and Bioinformatics, December 1999, Wiley

    Professor Michele Vendruscolo

  564. Neutral Evolution of Model Proteins: Diffusion in Sequence Space and Overdispersion

    Article • Journal of Theoretical Biology, September 1999, Elsevier

    Professor Michele Vendruscolo

  565. Hydrophobicity and unique folding of selected polymers

    Article • Zeitschrift für Physik B Condensed Matter and Quanta, March 1999, Springer Science + Business Media

    Professor Michele Vendruscolo

  566. Protein Folding in Contact Map Space

    Article • Physical Review Letters, January 1999, American Physical Society (APS)

    Professor Michele Vendruscolo

  567. Statistical properties of contact maps

    Article • January 1999, American Physical Society (APS)

    Professor Michele Vendruscolo

  568. An optimal derivation of a potential for protein folding

    Article • Physica A Statistical Mechanics and its Applications, January 1999, Elsevier

    Professor Michele Vendruscolo

  569. Pairwise contact potentials are unsuitable for protein folding

    Article • The Journal of Chemical Physics, December 1998, American Institute of Physics

    Professor Michele Vendruscolo

  570. Efficient dynamics in the space of contact maps

    Article • Folding and Design, October 1998, Elsevier

    Professor Michele Vendruscolo

  571. High-Dimensional Bak-Sneppen Model

    Article • Physical Review Letters, June 1998, American Physical Society (APS)

    Professor Michele Vendruscolo

  572. Protein stability and foldability–designability complementarity

    Article • Physica A Statistical Mechanics and its Applications, January 1998, Elsevier

    Professor Michele Vendruscolo

  573. Recovery of protein structure from contact maps

    Article • Folding and Design, October 1997, Elsevier

    Professor Michele Vendruscolo

  574. Stability Threshold as a Selection Principle for Protein Design

    Article • Physical Review Letters, May 1997, American Physical Society (APS)

    Professor Michele Vendruscolo

  575. Growth with memory

    Article • EPL (Europhysics Letters), March 1997, Institute of Physics Publishing

    Professor Michele Vendruscolo

  576. Modified configurational bias Monte Carlo method for simulation of polymer systems

    Article • The Journal of Chemical Physics, February 1997, American Institute of Physics

    Professor Michele Vendruscolo

  577. Model of correlated evolution

    Article • December 1996, American Physical Society (APS)

    Professor Michele Vendruscolo

  578. Hot sandpiles

    Article • EPL (Europhysics Letters), September 1996, Institute of Physics Publishing

    Professor Michele Vendruscolo

  579. Optimal Protein Design Procedure

    Article • Physical Review Letters, August 1996, American Physical Society (APS)

    Professor Michele Vendruscolo

  580. Diffusion in disordered media as a process with memory

    Article • August 1996, American Physical Society (APS)

    Professor Michele Vendruscolo

  581. Disordered flat phase and phase diagram for restricted solid-on-solid models of fcc (110) surfaces

    Article • May 1996, American Physical Society (APS)

    Professor Michele Vendruscolo

  582. Quenched disorder, memory, and self-organization

    Article • January 1996, American Physical Society (APS)

    Professor Michele Vendruscolo

  583. Evolution of the missing row deconstruction on Rh (110)

    Article • Surface Science, October 1994, Elsevier

    Dr Alberto Morgante, Professor Michele Vendruscolo

  584. A mean-field study of the temperature dependence of the layer magnetizations in a semi-infinite ising model

    Article • Il Nuovo Cimento D, February 1993, Springer Science + Business Media

    Professor Michele Vendruscolo

  585. Magnetic-Phase Transitions of Ising Surfaces with Modified Surface-Bulk Coupling: a Monte Carlo Study

    Article • EPL (Europhysics Letters), November 1992, Institute of Physics Publishing

    Professor Michele Vendruscolo

  586. Network views of the cell

    Article • Cambridge University Press

    Professor Michele Vendruscolo

  587. Introduction

    Article • Cambridge University Press

    Professor Michele Vendruscolo

  588. Protein folding using inter-residue contact

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Professor Michele Vendruscolo