All Stories

  1. A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

    Article • Cell, September 2019, Elsevier

    Professor Diana R. Tomchick

  2. Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

    Article • Science, May 2019, American Association for the Advancement of Science

    Professor Diana R. Tomchick

  3. High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

    Article • PLoS ONE, May 2019, PLOS

    Professor Diana R. Tomchick, Kim Orth

  4. Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Article • eLife, March 2019, eLife

    Professor Diana R. Tomchick

  5. Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

    Article • Cell, February 2019, Elsevier

    Professor Diana R. Tomchick

  6. Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

    Article • Structure, November 2018, Elsevier

    Professor Diana R. Tomchick

  7. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

    Article • ACS Infectious Diseases, October 2018, American Chemical Society (ACS)

    Professor David A Fidock, Professor Diana R. Tomchick

  8. Protein AMPylation by an Evolutionarily Conserved Pseudokinase

    Article • Cell, October 2018, Elsevier

    Professor Diana R. Tomchick

  9. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

    Article • eLife, October 2017, eLife

    Professor Diana R. Tomchick

  10. Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C 2 A domain in asynchronous neurotransmitter release

    Article • Proceedings of the National Academy of Sciences, September 2017, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  11. Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein fromTreponema pallidum

    Article • Protein Science, March 2017, Wiley

    Professor Diana R. Tomchick

  12. Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

    Article • eLife, February 2017, eLife

    Professor Diana R. Tomchick

  13. Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

    Article • eLife, December 2016, eLife

    Professor Diana R. Tomchick

  14. Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy

    Article • Proceedings of the National Academy of Sciences, October 2016, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  15. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

    Article • ACS Infectious Diseases, October 2016, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  16. Bile salt receptor complex activates a pathogenic type III secretion system

    Article • eLife, July 2016, eLife

    Professor Diana R. Tomchick

  17. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

    Article • Journal of Medicinal Chemistry, May 2016, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  18. Phosphorylation of spore coat proteins by a family of atypical protein kinases

    Article • Proceedings of the National Academy of Sciences, May 2016, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  19. Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

    Article • Molecular Cell, April 2016, Elsevier

    Professor Diana R. Tomchick

  20. Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

    Article • Biochemistry, February 2016, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  21. Molecular insights into the enzymatic diversity of flavin‐trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm

    Article • MicrobiologyOpen, December 2015, Wiley

    Professor Diana R. Tomchick

  22. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    Article • Science Translational Medicine, July 2015, American Association for the Advancement of Science

    Professor David A Fidock, Professor Diana R. Tomchick

  23. Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

    Article • Nature Structural & Molecular Biology, June 2015, Springer Science + Business Media

    Dr. Alexandre M.J.J. Bonvin, Professor Michele Vendruscolo, Professor Diana R. Tomchick

  24. Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein

    Article • mBio, May 2015, ASM Journals

    Professor Diana R. Tomchick

  25. Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization

    Article • Journal of Biological Chemistry, January 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  26. Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  27. Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

    Article • Structure, November 2014, Elsevier

    Professor Diana R. Tomchick

  28. Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

    Article • Nature Structural & Molecular Biology, August 2014, Springer Science + Business Media

    Professor Diana R. Tomchick

  29. Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection

    Article • Infection and Immunity, May 2014, ASM Journals

    Dr Jon S Blevins, Professor Diana R. Tomchick

  30. Re-examining how complexin inhibits neurotransmitter release

    Article • eLife, May 2014, eLife

    Christian Rosenmund, Professor Diana R. Tomchick

  31. Structure and Ca2+-Binding Properties of the Tandem C2 Domains of E-Syt2

    Article • Structure, February 2014, Elsevier

    Professor Diana R. Tomchick

  32. Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

    Article • Structure, October 2013, Elsevier

    Professor Diana R. Tomchick

  33. The Bacterial Effector VopL Organizes Actin into Filament-like Structures

    Article • Cell, October 2013, Elsevier

    Professor Diana R. Tomchick

  34. Structure of the human cohesin inhibitor Wapl

    Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  35. The TP0796 Lipoprotein ofTreponema pallidumIs a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis

    Article • Journal of Biological Chemistry, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  36. Biophysical and Bioinformatic Analyses Implicate the Treponema pallidum Tp34 Lipoprotein (Tp0971) in Transition Metal Homeostasis

    Article • Journal of Bacteriology, October 2012, ASM Journals

    Professor Diana R. Tomchick

  37. Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

    Article • Proceedings of the National Academy of Sciences, October 2012, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  38. Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT)

    Article • Journal of Molecular Biology, June 2012, Elsevier

    Professor Diana R. Tomchick

  39. Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  40. Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter

    Article • Journal of Molecular Biology, March 2012, Elsevier

    Professor Diana R. Tomchick

  41. Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

    Article • Proceedings of the National Academy of Sciences, February 2012, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  42. Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  43. A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation

    Article • Biochemistry, October 2011, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  44. The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

    Article • Structure, October 2011, Elsevier

    Professor Diana R. Tomchick

  45. Mechanism of actin filament nucleation by the bacterial effector VopL

    Article • Nature Structural & Molecular Biology, August 2011, Springer Science + Business Media

    Professor Diana R. Tomchick

  46. The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

    Article • Nature, December 2010, Springer Science + Business Media

    Professor Diana R. Tomchick

  47. Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

    Article • PLoS ONE, September 2010, PLOS

    Professor Diana R. Tomchick

  48. Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7

    Article • PLoS ONE, September 2010, PLOS

    Professor Diana R. Tomchick

  49. Evolution of Substrate Specificity within a Diverse Family of β/α-Barrel-fold Basic Amino Acid Decarboxylases

    Article • Journal of Biological Chemistry, June 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  50. Kinetic and Structural Insights into the Mechanism of AMPylation by VopS Fic Domain

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  51. Structural and functional analysis of the YAP-binding domain of human TEAD2

    Article • Proceedings of the National Academy of Sciences, April 2010, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  52. Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

    Article • Nature Structural & Molecular Biology, February 2010, Springer Science + Business Media

    Professor Diana R. Tomchick

  53. Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

    Article • Cell, January 2010, Elsevier

    Professor Diana R. Tomchick

  54. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

    Article • Proceedings of the National Academy of Sciences, January 2009, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  55. Localization and Structure of the Ankyrin-binding Site on β2-Spectrin

    Article • Journal of Biological Chemistry, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  56. Correction for Meyer et al. , Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  57. Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

    Article • Molecular Cell, November 2008, Elsevier

    Professor Diana R. Tomchick

  58. Changes at the KinA PAS-A Dimerization Interface Influence Histidine Kinase Function†,‡

    Article • Biochemistry, April 2008, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  59. Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

    Article • PLoS Biology, March 2008, PLOS

    Professor Diana R. Tomchick

  60. Crystal Structure of Inhibitor-Bound P450BM-3 Reveals Open Conformation of Substrate Access Channel†,‡

    Article • Biochemistry, March 2008, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  61. Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

    Article • Proceedings of the National Academy of Sciences, January 2008, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  62. Interactions of Substrates at the Surface of P450s Can Greatly Enhance Substrate Potency†,‡

    Article • Biochemistry, December 2007, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  63. p31comet Blocks Mad2 Activation through Structural Mimicry

    Article • Cell, November 2007, Elsevier

    Professor Diana R. Tomchick

  64. Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor

    Article • Journal of Molecular Biology, October 2007, Elsevier

    Professor Diana R. Tomchick

  65. Crystal Structure of the RIM1α C2B Domain at 1.7 Å Resolution†,‡

    Article • Biochemistry, August 2007, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  66. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

    Article • Nature Structural & Molecular Biology, May 2007, Springer Science + Business Media

    Professor Diana R. Tomchick

  67. Structural Analysis ofXanthomonasXopD Provides Insights into Substrate Specificity of Ubiquitin-like Protein Proteases

    Article • Journal of Biological Chemistry, January 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  68. Crystal Structure of the Tp34 (TP0971) Lipoprotein ofTreponema pallidum

    Article • Journal of Biological Chemistry, December 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  69. Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria

    Article • Journal of Bacteriology, August 2006, ASM Journals

    Professor Diana R. Tomchick, Professor Erick Strauss

  70. Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

    Article • Molecular Cell, August 2006, Elsevier

    Professor Diana R. Tomchick

  71. Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

    Article • PLoS Biology, June 2006, PLOS

    Professor Diana R. Tomchick

  72. A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium japonicum FixL Oxygen Sensor

    Article • Journal of Molecular Biology, June 2006, Elsevier

    Professor Eduardo Henrique Silva Sousa, Professor Diana R. Tomchick

  73. A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

    Article • Structure, March 2006, Elsevier

    Professor Diana R. Tomchick

  74. Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex

    Article • Structure, March 2006, Elsevier

    Professor Diana R. Tomchick

  75. Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef

    Article • Journal of Virology, February 2006, ASM Journals

    Professor Diana R. Tomchick

  76. A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

    Article • Structure, February 2006, Elsevier

    Professor Diana R. Tomchick

  77. The PnrA (Tp0319; TmpC) Lipoprotein Represents a New Family of Bacterial Purine Nucleoside Receptor Encoded within an ATP-binding Cassette (ABC)-like Operon inTreponema pallidum

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  78. Crystal Structure of the RIM2 C2A-Domain at 1.4 Å Resolution,

    Article • Biochemistry, September 2005, American Chemical Society (ACS)

    Dr Jesus Garcia, Professor Diana R. Tomchick

  79. Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD+/NADH Binding and the Structural Basis of Disease-causing Mutations

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Professor Diana R. Tomchick

  80. Structural Basis of Rho GTPase-Mediated Activation of the Formin mDia1

    Article • Molecular Cell, April 2005, Elsevier

    Professor Diana R. Tomchick

  81. Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

    Article • Nature, January 2005, Springer Science + Business Media

    Professor Diana R. Tomchick

  82. Molecular Mechanism for Regulation of the Human Mitochondrial Branched-Chain α-Ketoacid Dehydrogenase Complex by Phosphorylation

    Article • Structure, December 2004, Elsevier

    Professor Diana R. Tomchick

  83. Structural Evidence That the 32-Kilodalton Lipoprotein (Tp32) ofTreponema pallidumIs an l-Methionine-binding Protein

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  84. Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

    Article • Nature Structural & Molecular Biology, August 2004, Springer Science + Business Media

    Professor Diana R. Tomchick

  85. Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana

    Article • Proceedings of the National Academy of Sciences, August 2004, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  86. Cross-talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-chain α-Keto Acid Decarboxylase/Dehydrogenase

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  87. Roles of His291-α and His146-β′ in the Reductive Acylation Reaction Catalyzed by Human Branched-chain α-Ketoacid Dehydrogenase

    Article • Journal of Biological Chemistry, August 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  88. The Purine Repressor of Bacillus subtilis: a Novel Combination of Domains Adapted for Transcription Regulation

    Article • Journal of Bacteriology, July 2003, ASM Journals

    Professor Diana R. Tomchick

  89. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

    Article • The EMBO Journal, March 2003, Wiley

    Professor Diana R. Tomchick

  90. Crystal structure of a 12 ANK repeat stack from human ankyrinR

    Article • The EMBO Journal, December 2002, Wiley

    Professor Diana R. Tomchick

  91. Crystal Structure of the 47-kDa Lipoprotein of Treponema pallidum Reveals a Novel Penicillin-binding Protein

    Article • Journal of Biological Chemistry, August 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  92. Structure of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  93. Three-Dimensional Structure of the Complexin/SNARE Complex

    Article • Neuron, January 2002, Elsevier

    Professor Diana R. Tomchick

  94. Pivotal Role of Water in the Mechanism of P450BM-3†

    Article • Biochemistry, November 2001, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  95. Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase

    Article • Proceedings of the National Academy of Sciences, September 2001, Proceedings of the National Academy of Sciences

    Professor Diana R. Tomchick

  96. Structural and Functional Characterization of Second-Coordination Sphere Mutants of Soybean Lipoxygenase-1†

    Article • Biochemistry, June 2001, American Chemical Society (ACS)

    Dr Wladek Minor, Professor Diana R. Tomchick

  97. Strategies for macromolecular synchrotron crystallography

    Article • Structure, May 2000, Elsevier

    Dr Wladek Minor, Professor Diana R. Tomchick

  98. Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase

    Article • Structure, March 1998, Elsevier

    Professor Diana R. Tomchick

  99. Mechanism of the Synergistic End-Product Regulation ofBacillus subtilisGlutamine Phosphoribosylpyrophosphate Amidotransferase by Nucleotides†,‡

    Article • Biochemistry, September 1997, American Chemical Society (ACS)

    Professor Diana R. Tomchick

  100. Structure and Function of the Glutamine Phosphoribosylpyrophosphate Amidotransferase Glutamine Site and Communication with the Phosphoribosylpyrophosphate Site

    Article • Journal of Biological Chemistry, June 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Diana R. Tomchick

  101. A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

    Article • Nature, November 1995, Springer Science + Business Media

    Professor Diana R. Tomchick

  102. Crystallization and preliminary X-ray crystallographic analysis of carbamoyl phosphate synthetase fromEscherichia coli

    Article • Acta Crystallographica Section D Biological Crystallography, September 1995, International Union of Crystallography

    Professor Diana R. Tomchick

  103. Three-dimensional structure of myosin subfragment-1: a molecular motor

    Article • Science, July 1993, American Association for the Advancement of Science

    Professor Diana R. Tomchick

  104. Photochemical synthesis and structural characterization of (η5-C5Me5)3Mo3(CO)4(μ2-H)(μ3-O): an unprecedented 46-electron trimolybdenum cluster containing a localized monoprotonated MoMo double bond

    Article • Journal of Organometallic Chemistry, February 1988, Elsevier

    Professor Diana R. Tomchick