All Stories

  1. Solution structure, dynamics and fragment binding of unbound MERS-CoV nsp10

    Article • September 2026, openRxiv

    Dr Christopher A Waudby

  2. Structures of protein folding intermediates on the ribosome

    Article • Nature Structural & Molecular Biology, June 2026, Springer Science + Business Media

    Dr Christopher A Waudby

  3. An open format for recording sample metadata alongside NMR experiments

    Article • May 2026, American Chemical Society (ACS)

    Dr Christopher A Waudby

  4. Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression

    Article • Nucleic Acids Research, October 2025, Oxford University Press (OUP)

    Dr Christopher A Waudby

  5. Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion

    Article • September 2025, American Chemical Society (ACS)

    Dr Christopher A Waudby

  6. Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors

    Article • Biochemical Journal, September 2025, Portland Press Ltd.

    Dr Christopher A Waudby

  7. Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

    Article • Advanced Science, June 2025, Wiley

    Dr Christopher A Waudby

  8. High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy

    Article • Science Advances, May 2025, American Association for the Advancement of Science

    Dr Christopher A Waudby

  9. Long-range electrostatic forces govern how proteins fold on the ribosome

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  10. Development of hyaluronic acid/β-cyclodextrin semi-interpenetrating network hydrogels for prolonged delivery of water-soluble sunitinib malate

    Article • International Journal of Pharmaceutics, January 2025, Elsevier

    Dr Christopher A Waudby, Gareth Williams

  11. Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  12. Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region

    Article • Nature Communications, August 2024, Springer Science + Business Media

    Dr Christopher A Waudby

  13. The ribosome lowers the entropic penalty of protein folding

    Article • Nature, August 2024, Springer Science + Business Media

    Dr Christopher A Waudby

  14. Dynamic and Assembly Characteristics of Deep‐Cavity Basket Acting as a Host for Inclusion Complexation of Mitoxantrone in Biotic and Abiotic Systems

    Article • Chemistry - A European Journal, November 2023, Wiley

    Dr Christopher A Waudby

  15. Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase

    Article • Nature Communications, October 2023, Springer Science + Business Media

    Dr Christopher A Waudby

  16. Structural Insights into Regulation of Insulin Expression Involving i-Motif DNA Structures in the Insulin-Linked Polymorphic Region

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  17. Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Dr Christopher A Waudby

  18. An introduction to one- and two-dimensional lineshape analysis of chemically exchanging systems

    Article • Journal of Magnetic Resonance Open, March 2023, Elsevier

    Dr Christopher A Waudby

  19. Disordered proteins mitigate the temperature dependence of site-specific binding free energies

    Article • Journal of Biological Chemistry, February 2023, Elsevier

    Dr Christopher A Waudby

  20. An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment

    Article • Nature Communications, October 2022, Springer Science + Business Media

    Dr Christopher A Waudby

  21. Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering

    Article • Nature Communications, September 2022, Springer Science + Business Media

    Dr Christopher A Waudby

  22. Closed Aromatic Tubes—Capsularenes

    Article • Angewandte Chemie, September 2022, Wiley

    Dr Christopher A Waudby

  23. The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

    Article • Nature Chemistry, August 2022, Springer Science + Business Media

    Dr Christopher A Waudby

  24. Modulating co-translational protein folding by rational design and ribosome engineering

    Article • Nature Communications, July 2022, Springer Science + Business Media

    Dr Christopher A Waudby

  25. Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions

    Article • Communications Biology, June 2022, Springer Science + Business Media

    Dr Christopher A Waudby

  26. Thermodynamics of co-translational folding and ribosome–nascent chain interactions

    Article • Current Opinion in Structural Biology, June 2022, Elsevier

    Dr Christopher A Waudby

  27. Common sequence motifs of nascent chains engage the ribosome surface and trigger factor

    Article • Proceedings of the National Academy of Sciences, December 2021, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  28. Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

    Article • Nature Communications, November 2021, Springer Science + Business Media

    Dr Christopher A Waudby

  29. An intrinsic temporal order of c-Jun N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment

    Article • November 2021, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  30. Analysis of conformational exchange processes using methyl-TROSY-based Hahn echo measurements of quadruple-quantum relaxation

    Article • Magnetic Resonance, November 2021, Copernicus GmbH

    Dr Christopher A Waudby

  31. Interactions between nascent proteins and the ribosome surface inhibit co-translational folding

    Article • Nature Chemistry, October 2021, Springer Science + Business Media

    Dr Christopher A Waudby

  32. Analysis of Conformational Exchange Processes using Methyl-TROSY-Based Hahn Echo Measurements of Quadruple-Quantum Relaxation

    Article • September 2021, Copernicus GmbH

    Dr Christopher A Waudby

  33. Supplementary material to "Analysis of Conformational Exchange Processes using Methyl-TROSY-Based Hahn Echo Measurements of Quadruple-Quantum Relaxation"

    Article • September 2021, Copernicus GmbH

    Dr Christopher A Waudby

  34. From Selection to Instruction and Back: Competing Conformational Selection and Induced Fit Pathways in Abiotic Hosts

    Article • Angewandte Chemie, July 2021, Wiley

    Dr Christopher A Waudby

  35. Analysis of Conformational Exchange Processes using Methyl-TROSY-Based Hahn Echo Measurements of Quadruple-Quantum Relaxation

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  36. Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex

    Article • Journal of Magnetic Resonance, February 2021, Elsevier

    Dr Christopher A Waudby

  37. Nascent chain dynamics and ribosome interactions within folded ribosome–nascent chain complexes observed by NMR spectroscopy

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Dr Christopher A Waudby

  38. High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin

    Article • Nature Communications, December 2020, Springer Science + Business Media

    Dr Christopher A Waudby

  39. Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex

    Article • October 2020, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  40. Dynamics of Ligand Binding to a Rigid Glycosidase

    Article • Angewandte Chemie, September 2020, Wiley

    Dr Christopher A Waudby

  41. Dynamics of Ligand Binding to a Rigid Glycosidase

    Article • Angewandte Chemie, September 2020, Wiley

    Dr Christopher A Waudby

  42. Rapid Quantification of Protein-Ligand Binding via 19F NMR Lineshape Analysis

    Article • Biophysical Journal, May 2020, Elsevier

    Dr Christopher A Waudby

  43. NMR Resolution Enhancement and Homonuclear Decoupling Using Non-Uniform Weighted Sampling

    Article • March 2020, American Chemical Society (ACS)

    Dr Christopher A Waudby

  44. Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments

    Article • Journal of Biomolecular NMR, January 2020, Springer Science + Business Media

    Dr Christopher A Waudby

  45. NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions

    Article • January 2020, Springer Science + Business Media

    Dr Christopher A Waudby

  46. Nature and Regulation of Protein Folding on the Ribosome

    Article • Trends in Biochemical Sciences, November 2019, Elsevier

    Dr Christopher A Waudby

  47. Catalysis by a rigid enzyme

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  48. Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  49. Probing the dynamic stalk region of the ribosome using solution NMR

    Article • Scientific Reports, September 2019, Springer Science + Business Media

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  50. Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Dr Christopher A Waudby

  51. Cross-Peaks in Simple Two-Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation

    Article • Angewandte Chemie, May 2019, Wiley

    Dr Christopher A Waudby

  52. Cross‐Peaks in Simple Two‐Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation

    Article • Angewandte Chemie, May 2019, Wiley

    Dr Christopher A Waudby

  53. Cross-Peaks in Simple 2D NMR Experiments from Chemical Exchange of Transverse Magnetization

    Article • March 2019, American Chemical Society (ACS)

    Dr Christopher A Waudby

  54. Cross-Peaks in Simple 2D NMR Experiments from Chemical Exchange of Transverse Magnetization

    Article • March 2019, American Chemical Society (ACS)

    Dr Christopher A Waudby

  55. Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

    Article • Proceedings of the National Academy of Sciences, September 2018, Proceedings of the National Academy of Sciences

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  56. Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamical regions of the ribosome

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  57. Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation

    Article • Scientific Reports, November 2017, Nature

    Dr Christopher A Waudby

  58. Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization

    Article • September 2017, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  59. A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy

    Article • Nature Protocols, July 2016, Springer Science + Business Media

    Dr Christopher A Waudby

  60. TITAN: Two-dimensional lineshape analysis of biomolecular NMR titration experiments

    Article • Scientific Reports, April 2016, Nature

    Dr Christopher A Waudby

  61. Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

    Article • Proceedings of the National Academy of Sciences, April 2016, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  62. A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

    Article • Nature Structural & Molecular Biology, February 2016, Nature

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  63. Two-Dimensional NMR Lineshape Analysis

    Article • February 2016, Cold Spring Harbor Laboratory Press

    Dr Christopher A Waudby

  64. D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

    Article • Nature Communications, January 2016, Nature

    Dr Christopher A Waudby

  65. Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome–nascent chain complexes

    Article • Journal of Biomolecular NMR, August 2015, Springer Science + Business Media

    Dr Christopher A Waudby

  66. The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  67. Hsp90 Inhibits α-Synuclein Aggregation by Interacting with Soluble Oligomers

    Article • Journal of Molecular Biology, November 2013, Elsevier

    Dr Christopher A Waudby

  68. Protein folding on the ribosome studied using NMR spectroscopy

    Article • Progress in Nuclear Magnetic Resonance Spectroscopy, October 2013, Elsevier

    Dr Christopher A Waudby

  69. In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

    Article • PLOS One, August 2013, PLOS

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  70. Atomic structure and hierarchical assembly of a cross-β amyloid fibril

    Article • Proceedings of the National Academy of Sciences, March 2013, Proceedings of the National Academy of Sciences

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  71. Rapid Distinction of Intracellular and Extracellular Proteins Using NMR Diffusion Measurements

    Article • Journal of the American Chemical Society, July 2012, American Chemical Society (ACS)

    Dr Christopher A Waudby

  72. An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR

    Article • Journal of Magnetic Resonance, June 2012, Elsevier

    Dr Christopher A Waudby

  73. Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

    Article • Structure, March 2012, Elsevier

    Dr Bibek Gooptu, Dr Christopher A Waudby

  74. Inversion of the Balance between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation

    Article • PLoS Computational Biology, October 2011, PLOS

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  75. Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

    Article • Biophysical Journal, October 2011, Elsevier

    Dr Christopher A Waudby

  76. Metastability of Native Proteins and the Phenomenon of Amyloid Formation

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  77. GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments

    Article • Journal of Magnetic Resonance, July 2011, Elsevier

    Dr Christopher A Waudby

  78. Solution-State Nuclear Magnetic Resonance Spectroscopy and Protein Folding

    Article • January 2011, Springer Science + Business Media

    Dr Christopher A Waudby

  79. Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

    Article • PLOS One, October 2010, PLOS

    Dr Christopher A Waudby

  80. Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody

    Article • Journal of Molecular Biology, September 2010, Elsevier

    Dr Christopher A Waudby

  81. Mechanosensitive Self-Replication Driven by Self-Organization

    Article • Science, March 2010, American Association for the Advancement of Science

    Dr Christopher A Waudby

  82. The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

    Article • Biophysical Journal, March 2010, Elsevier

    Dr Christopher A Waudby

  83. An Analytical Solution to the Kinetics of Breakable Filament Assembly

    Article • Science, December 2009, American Association for the Advancement of Science

    Dr Christopher A Waudby, Professor Michele Vendruscolo

  84. On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

    Article • Biochemistry, September 2009, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  85. Position-Dependent Electrostatic Protection against Protein Aggregation

    Article • ChemBioChem, May 2009, Wiley

    Professor Michele Vendruscolo, Dr Christopher A Waudby

  86. Chemical documents: machine understanding and automated information extraction

    Article • Organic & Biomolecular Chemistry, January 2004, Royal Society of Chemistry

    Dr Christopher A Waudby

  87. Experimental data checker: better information for organic chemists

    Article • Organic & Biomolecular Chemistry, January 2004, Royal Society of Chemistry

    Dr Christopher A Waudby, Rich Kidd