All Stories

  1. Crosslinking, salt-induced aging, and secondary structure formation in Peptide-containing coacervates inspired by spider silk

    Article • Communications Chemistry, August 2025, Springer Science + Business Media

    Dr Patrick C A van der Wel

  2. Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation.

    Article • August 2025, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  3. Probing How Anti‐huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid‐State NMR

    Article • Chemistry - A European Journal, July 2025, Wiley

    Dr Patrick C A van der Wel

  4. Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy

    Article • Journal of the American Chemical Society, June 2025, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  5. Editorial: Solid-state NMR and DNP of heterogeneous biomaterials and cellular systems

    Article • Solid State Nuclear Magnetic Resonance, June 2025, Elsevier

    Dr Patrick C A van der Wel

  6. Departure from randomness: Evolution of self-replicators that can self-sort through steric zipper formation

    Article • Chem, May 2025, Elsevier

    Dr Patrick C A van der Wel

  7. Probing How Anti-Huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State NMR

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  8. Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress

    Article • Nature Communications, April 2025, Springer Science + Business Media

    Dr Patrick C A van der Wel

  9. Solid‐state NMR protocols for unveiling dynamics and (drug) interactions of membrane‐bound proteins

    Article • Protein Science, March 2025, Wiley

    Dr Patrick C A van der Wel

  10. Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease

    Article • Nature Communications, December 2024, Springer Science + Business Media

    Dr Patrick C A van der Wel

  11. Direct observation of secondary nucleation in huntingtin amyloid formation by High-Speed Atomic Force Microscopy

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  12. Resolving Atomic-Level Dynamics and Interactions of High-Molecular-Weight Hyaluronic Acid by Multidimensional Solid-State NMR

    Article • ACS Applied Materials & Interfaces, August 2024, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  13. Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation

    Article • Biochemical Society Transactions, April 2024, Portland Press Ltd.

    Dr Patrick C A van der Wel

  14. Resolving atomic-level dynamics and interactions of high molecular weight hyaluronic acid by multidimensional solid-state NMR

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  15. Photocontrol of the β-Hairpin Polypeptide Structure through an Optimized Azobenzene-Based Amino Acid Analogue

    Article • Journal of the American Chemical Society, January 2024, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  16. Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington’s disease

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  17. Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  18. A Universal Nanogel‐Based Coating Approach for Medical Implant Materials

    Article • Advanced NanoBiomed Research, April 2023, Wiley

    Dr Patrick C A van der Wel

  19. Production of isotopically enriched high molecular weight hyaluronic acid and characterization by solid-state NMR

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  20. New insights in polydopamine formation via surface adsorption

    Article • Nature Communications, February 2023, Springer Science + Business Media

    Dr Patrick C A van der Wel

  21. Fast magic angle spinning for the characterization of milligram quantities of organic and biological solids at natural isotopic abundance by 13C–13C correlation DNP-enhanced NMR

    Article • Solid State Nuclear Magnetic Resonance, February 2023, Elsevier

    Dr Patrick C A van der Wel

  22. In situ SnSe deposition as passivation for scalable and stable quasi-2D lead–tin perovskite solar cells

    Article • Energy & Environmental Science, January 2023, Royal Society of Chemistry

    Dr Patrick C A van der Wel

  23. Binder‐free Zeolite Beta Beads with Hierarchical Porosity: Synthesis and Application as Heterogeneous Catalysts for Anisole Acylation

    Article • ChemCatChem, August 2022, Wiley

    Dr Patrick C A van der Wel

  24. Solid-state NMR spectroscopy insights for resolving different water pools in alginate hydrogels

    Article • Food Hydrocolloids, June 2022, Elsevier

    Dr Patrick C A van der Wel

  25. Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  26. New insights in polydopamine formation via surface adsorption

    Article • January 2022, Springer Science + Business Media

    Dr Patrick C A van der Wel

  27. Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils

    Article • Journal of Structural Biology X, January 2022, Elsevier

    Dr Patrick C A van der Wel

  28. Dihedral Angle Measurements for Structure Determination by Biomolecular Solid-State NMR Spectroscopy

    Article • Frontiers in Molecular Biosciences, December 2021, Frontiers

    Dr Patrick C A van der Wel

  29. NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission

    Article • Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences

    Rajesh Ramachandran, Dr Patrick C A van der Wel

  30. Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids

    Article • Journal of Molecular Biology, July 2021, Elsevier

    Dr Patrick C A van der Wel

  31. Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  32. Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Dr Patrick C A van der Wel

  33. Use of solid-state NMR spectroscopy for investigating polysaccharide-based hydrogels: A review

    Article • Carbohydrate Polymers, July 2020, Elsevier

    Dr Patrick C A van der Wel

  34. Auto-regulatory J-domain interactions control Hsp70 recruitment to the DnaJB8 chaperone

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Dr Patrick C A van der Wel

  35. Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s disease

    Article • Experimental Biology and Medicine, June 2019, SAGE Publications

    Dr Patrick C A van der Wel

  36. Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics

    Article • Structure, March 2019, Elsevier

    Dr Patrick C A van der Wel

  37. Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance

    Article • Journal of the American Chemical Society, October 2018, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  38. Hidden motions and motion-induced invisibility: Dynamics-based spectral editing in solid-state NMR

    Article • April 2018, Elsevier

    Dr Patrick C A van der Wel

  39. New applications of solid-state NMR in structural biology

    Article • Emerging Topics in Life Sciences, February 2018, Portland Press Ltd.

    Dr Patrick C A van der Wel

  40. Methionine oxidized apolipoprotein A‐I at the crossroads of HDL biogenesis and amyloid formation

    Article • The FASEB Journal, January 2018, Wiley

    Dr Patrick C A van der Wel

  41. Energetics Underlying Twist Polymorphisms in Amyloid Fibrils

    Article • The Journal of Physical Chemistry B, January 2018, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  42. Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy

    Article • Solid State Nuclear Magnetic Resonance, November 2017, Elsevier

    Dr Patrick C A van der Wel

  43. Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  44. Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  45. On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR

    Article • Journal of Biomolecular NMR, February 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  46. Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

    Article • January 2017, Elsevier

    Dr Patrick C A van der Wel

  47. MAS 1 H NMR Probes Freezing Point Depression of Water and Liquid-Gel Phase Transitions in Liposomes

    Article • November 2016, Elsevier

    Dr Patrick C A van der Wel

  48. Peptide-Directed Assembly of Single-Helical Gold Nanoparticle Superstructures Exhibiting Intense Chiroptical Activity

    Article • Journal of the American Chemical Society, October 2016, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  49. Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Dr Patrick C A van der Wel

  50. Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c

    Article • November 2015, Elsevier

    Dr Patrick C A van der Wel

  51. Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

    Article • Biochemistry, October 2014, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  52. Lipid Dynamics and Protein-Lipid Interactions in Integral Membrane Proteins: Insights from Solid-State NMR

    Article • March 2014, Wiley

    Dr Patrick C A van der Wel

  53. How Amyloid Precursor Protein Protects Itself from Cleavage

    Article • March 2014, Elsevier

    Dr Patrick C A van der Wel

  54. d-Polyglutamine Amyloid Recruits l-Polyglutamine Monomers and Kills Cells

    Article • Journal of Molecular Biology, February 2014, Elsevier

    Dr Patrick C A van der Wel

  55. Spinning-rate encoded chemical shift correlations from rotational resonance solid-state NMR experiments

    Article • May 2013, Elsevier

    Dr Patrick C A van der Wel

  56. β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

    Article • Journal of Molecular Biology, April 2013, Elsevier

    Dr Patrick C A van der Wel

  57. Serine Phosphorylation Suppresses Huntingtin Amyloid Accumulation by Altering Protein Aggregation Properties

    Article • Journal of Molecular Biology, November 2012, Elsevier

    Dr Patrick C A van der Wel

  58. In support of the BMRB

    Article • Nature Structural & Molecular Biology, September 2012, Springer Science + Business Media

    Dr Patrick C A van der Wel, Dr. Alexandre M.J.J. Bonvin, Professor Michele Vendruscolo, Rolf Boelens

  59. Domain swapping and amyloid fibril conformation

    Article • Prion, July 2012, Taylor & Francis

    Dr Patrick C A van der Wel

  60. Lipid Dynamics and Protein–Lipid Interactions in 2D Crystals Formed with the β-Barrel Integral Membrane Protein VDAC1

    Article • Journal of the American Chemical Society, March 2012, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  61. Structural Characterization of the Caveolin Scaffolding Domain in Association with Cholesterol-Rich Membranes

    Article • Biochemistry, December 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  62. Structural Complexity of a Composite Amyloid Fibril

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  63. Amyloid-like Fibrils from a Domain-swapping Protein Feature a Parallel, in-Register Conformation without Native-like Interactions

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Patrick C A van der Wel

  64. The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

    Article • Journal of the American Chemical Society, March 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  65. Structural Characterization of GNNQQNY Amyloid Fibrils by Magic Angle Spinning NMR

    Article • Biochemistry, November 2010, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  66. Time Averaging of NMR Chemical Shifts in the MLF Peptide in the Solid State

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Patrick C A van der Wel

  67. Dynamic nuclear polarization-enhanced solid-state NMR spectroscopy of GNNQQNY nanocrystals and amyloid fibrils

    Article • Physical Chemistry Chemical Physics, January 2010, Royal Society of Chemistry

    Dr Patrick C A van der Wel

  68. High-resolution solid-state NMR structure of Alanyl-Prolyl-Glycine

    Article • September 2009, Elsevier

    Dr Patrick C A van der Wel

  69. Targeted13C-13C Distance Measurements in a Microcrystalline Protein via J-Decoupled Rotational Resonance Width Measurements

    Article • ChemPhysChem, July 2009, Wiley

    Dr Patrick C A van der Wel

  70. Cryogenic sample exchange NMR probe for magic angle spinning dynamic nuclear polarization

    Article • June 2009, Elsevier

    Dr Patrick C A van der Wel

  71. Observation of a Low-Temperature, Dynamically Driven Structural Transition in a Polypeptide by Solid-State NMR Spectroscopy

    Article • Journal of the American Chemical Society, January 2009, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  72. High-Field Dynamic Nuclear Polarization for Solid and Solution Biological NMR

    Article • Applied Magnetic Resonance, August 2008, Springer Science + Business Media

    Dr Patrick C A van der Wel

  73. Dynamic nuclear polarization at high magnetic fields

    Article • The Journal of Chemical Physics, February 2008, American Institute of Physics

    Dr Patrick C A van der Wel

  74. Helical Distortion in Tryptophan- and Lysine-Anchored Membrane-Spanning α-Helices as a Function of Hydrophobic Mismatch: A Solid-State Deuterium NMR Investigation Using the Geometric Analysis of Labeled Alanines Method

    Article • January 2008, Elsevier

    Dr Patrick C A van der Wel

  75. Peptide Influences on Lipids

    Article • September 2007, Wiley

    Dr Patrick C A van der Wel

  76. Orientation and Motion of Tryptophan Interfacial Anchors in Membrane-Spanning Peptides†

    Article • Biochemistry, June 2007, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  77. Solid-State NMR Study of Amyloid Nanocrystals and Fibrils Formed by the Peptide GNNQQNY from Yeast Prion Protein Sup35p

    Article • Journal of the American Chemical Society, April 2007, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  78. Dynamic Nuclear Polarization of Amyloidogenic Peptide Nanocrystals:  GNNQQNY, a Core Segment of the Yeast Prion Protein Sup35p

    Article • Journal of the American Chemical Society, August 2006, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  79. Multipole-multimode Floquet theory of rotational resonance width experiments: C13–C13 distance measurements in uniformly labeled solids

    Article • The Journal of Chemical Physics, June 2006, American Institute of Physics

    Dr Patrick C A van der Wel

  80. Importance of Tensor Asymmetry for the Analysis of2H NMR Spectra from Deuterated Aromatic Rings

    Article • Journal of the American Chemical Society, December 2005, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  81. Complexes obtained by electrophilic attack on a dinitrogen-derived terminal molybdenum nitride: electronic structure analysis by solid state CP/MAS 15N NMR in combination with DFT calculations

    Article • Polyhedron, November 2004, Elsevier

    Dr Patrick C A van der Wel

  82. Tilt Angles of Transmembrane Model Peptides in Oriented and Non-Oriented Lipid Bilayers as Determined by 2 H Solid-State NMR

    Article • June 2004, Elsevier

    Dr Patrick C A van der Wel

  83. Combined Experimental/Theoretical Refinement of Indole Ring Geometry Using Deuterium Magnetic Resonance and ab Initio Calculations

    Article • Journal of the American Chemical Society, October 2003, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  84. Hydrophobic Mismatch between Helices and Lipid Bilayers

    Article • January 2003, Elsevier

    Dr Patrick C A van der Wel

  85. Lipid Dependence of Membrane Anchoring Properties and Snorkeling Behavior of Aromatic and Charged Residues in Transmembrane Peptides†

    Article • Biochemistry, June 2002, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  86. Optimized aminolysis conditions for cleavage of N-protected hydrophobic peptides from solid-phase resins

    Article • Journal of Peptide Research, June 2001, Wiley

    Dr Patrick C A van der Wel

  87. Tryptophan-Anchored Transmembrane Peptides Promote Formation of Nonlamellar Phases in Phosphatidylethanolamine Model Membranes in a Mismatch-Dependent Manner†

    Article • Biochemistry, March 2000, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  88. Modulation of membrane structure and function by hydrophobic mismatch between proteins and lipids

    Article • Pure and Applied Chemistry, January 1998, De Gruyter

    Dr Patrick C A van der Wel