Dr L. Miguel Martins

  • MRC Toxicology Unit
  • Reader, Medicine And Medical Sciences
  • United Kingdom

My co-authors include

Prof. Herbert Budka
Dr Ana C Costa
Dr Juan Garrido-Maraver

My Publications

In fruit flies, a diet containing folic acid could improve the function of mitochondria.

  • Cell Death and Disease
  • March 2019

This research suggests a simple blood test could improve the early detection of lung ca...

  • Disease Models & Mechanisms
  • February 2019

A method to improve the detection of cancer-associated mutations in the KRAS gene

  • Matters
  • July 2017

Folinic acid protects neurons

  • Matters
  • March 2017

dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

  • Cell Death and Differentiation
  • February 2017

The neurodegeneration that occurs in Parkinson’s disease can be prevented with a form o...

  • Biology Open
  • December 2016

Paraquat-induced metabolic stress signature in human foetal mesencephalic cells

  • Matters
  • December 2016

Mitochondrial dysfunction triggers ER stress in Parkinson's models

  • Cell Death and Disease
  • June 2016

Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PAR...

  • Cell Death and Disease
  • March 2016

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism throug...

  • Nature Communications
  • July 2014

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Par...

  • Cell Death and Disease
  • April 2014

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease trigge...

  • Neuropharmacology
  • February 2014

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodeg...

  • Nature
  • January 2014

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Par...

  • PLoS ONE
  • December 2013

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dys...

  • Cell Death and Disease
  • October 2013

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of ...

  • Cell Death and Disease
  • January 2013

HtrA2 Peptidase

  • January 2013

The Drosophila inner-membrane protein PMI controls crista biogenesis and mitochondrial ...

  • Journal of Cell Science
  • December 2012

HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and cons...

  • Cell Death and Disease
  • June 2012

Neurodegeneration

  • April 2012

Emerging Concepts Linking Mitochondrial Stress Signalling and Parkinson's Disease

  • April 2012

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

  • Cell Death and Differentiation
  • February 2012

Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease

  • International Journal of Cell Biology
  • January 2012

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout ...

  • PLoS ONE
  • December 2011

Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial fu...

  • Cell Death and Differentiation
  • June 2011

PINK1 cleavage at position A103 by the mitochondrial protease PARL

  • Human Molecular Genetics
  • December 2010

Drosophila happyhour modulates JNK-dependent apoptosis

  • Cell Death and Disease
  • August 2010

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with th...

  • Experimental Cell Research
  • April 2010

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independentl...

  • Cell Death and Differentiation
  • March 2009

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a bra...

  • Cell Death and Differentiation
  • November 2008

Accumulation of HtrA2/Omi in Neuronal and Glial Inclusions in Brains With α-Synucleinop...

  • Journal of Neuropathology & Experimental Neurology
  • October 2008

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase ...

  • Nature
  • September 2007

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

  • Human Molecular Genetics
  • June 2005

The Tumor Suppressor RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformatio...

  • Molecular Cell
  • June 2005

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Target...

  • Molecular and Cellular Biology
  • November 2004

Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi

  • Journal of Biological Chemistry
  • September 2003

The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function

  • Cell Death and Differentiation
  • July 2002

Analysis of Caspase Activation During Apoptosis

  • Current Protocols in Cell Biology
  • July 2001

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

  • Current Biology
  • September 1999

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

  • Annual Review of Biochemistry
  • June 1999

Methods Used to Study Protease Activation During Apoptosis

  • December 1998