dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

  • Ivana Celardo, Susann Lehmann, Ana C Costa, Samantha HY Loh, L Miguel Martins
  • Cell Death and Differentiation, February 2017, Nature Publishing Group
  • DOI: 10.1038/cdd.2016.158

What is it about?

Boosting genes that affect the metabolism of nucleotides in mitochondria can protect neurons that are affected in Parkinson’s disease.

Why is it important?

These findings highlight the importance of mitochondrial metabolism for neuron health. By discovering the gene networks that orchestrate this process, the researchers have singled out new therapeutic targets that could prevent neuron loss. Studying the roles of these genes in human neurons could lead to tailored interventions that could one day prevent or delay the neuronal loss seen in Parkinson’s.

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The following have contributed to this page: Dr L. Miguel Martins, Dr Ana C Costa, and Dr Susann Lehmann