What is it about?
We show that fly food with increased levels of vitamin B3 rescues mitochondrial defects and has neuroprotective effects in a fly model of Parkinson's disease.
Featured Image
Why is it important?
This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions and PARP inhibition in the treatment of Parkinson’s disease.
Perspectives
This study shows the neuroprotective potential of a dietary intervention with niacin (vitamin B3) in a fly model of Parkinson's disease.
Dr L. Miguel Martins
MRC Toxicology Unit
Read the Original
This page is a summary of:
Enhancing NAD
+
salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease
, Biology Open, December 2016, The Company of Biologists,
DOI: 10.1242/bio.022186.
You can read the full text:
Resources
Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease
A related publication where we describe the protective effects of Vitamin B3 in another model of Parkinson's diseases
Niacin is neuroprotective in a fly model of Parkinson’s disease
A video abstract summarising our findings
Contributors
The following have contributed to this page
