Enhancing NAD + salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

  • Susann Lehmann, Samantha H. Y. Loh, L. Miguel Martins
  • Biology Open, December 2016, The Company of Biologists
  • DOI: 10.1242/bio.022186

The neurodegeneration that occurs in Parkinson’s disease can be prevented with a form of vitamin B3

What is it about?

We show that fly food with increased levels of vitamin B3 rescues mitochondrial defects and has neuroprotective effects in a fly model of Parkinson's disease.

Why is it important?

This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions and PARP inhibition in the treatment of Parkinson’s disease.

Perspectives

Dr L. Miguel Martins
MRC Toxicology Unit

This study shows the neuroprotective potential of a dietary intervention with niacin (vitamin B3) in a fly model of Parkinson's disease.

Read Publication

http://dx.doi.org/10.1242/bio.022186

The following have contributed to this page: Dr L. Miguel Martins and Dr Susann Lehmann