Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

What is it about?

We show that vitamin B9 (folic acid) protects neurons in models (flies and human cells) of Parkinson's disease

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Why is it important?

By enhancing nucleotide synthesis pathways it is possible to reverse mitochondrial dysfunction and rescue neurodegeneration in Parkinson's disease models and, potentially, other diseases linked to mitochondrial impairment