Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

  • Roberta Tufi, Sonia Gandhi, Inês P. de Castro, Susann Lehmann, Plamena R. Angelova, David Dinsdale, Emma Deas, Hélène Plun-Favreau, Pierluigi Nicotera, Andrey Y. Abramov, Anne E. Willis, Giovanna R. Mallucci, Samantha H. Y. Loh, L. Miguel Martins
  • Nature, January 2014, Nature Publishing Group
  • DOI: 10.1038/ncb2901

What is it about?

We show that vitamin B9 (folic acid) protects neurons in models (flies and human cells) of Parkinson's disease

Why is it important?

By enhancing nucleotide synthesis pathways it is possible to reverse mitochondrial dysfunction and rescue neurodegeneration in Parkinson's disease models and, potentially, other diseases linked to mitochondrial impairment

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The following have contributed to this page: Dr L. Miguel Martins and Dr Susann Lehmann