Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease

  • S Lehmann, A C Costa, I Celardo, S H Y Loh, L M Martins
  • Cell Death and Disease, March 2016, Nature Publishing Group
  • DOI: 10.1038/cddis.2016.72

What is it about?

We show that flies kept on a diet supplemented with vitamin B3 are protected from the neurotoxic consequences of mitochondrial defects in a model of Parkinson's disease

Why is it important?

This strengthens the therapeutic potential for a vitamin B3/niacin-supplemented diet and PARP inhibition for Parkinson's disease

Perspectives

Dr L. Miguel Martins
MRC Toxicology Unit

This study used Parkin mutant flies as an in vivo model of mitochondrial dysfunction associated with Parkinson's disease. We published a very similar study in Biology Open replicating most of these findings in flies mutant for another gene involved in Parkinson's disease (Pink1)

Read Publication

http://dx.doi.org/10.1038/cddis.2016.72

The following have contributed to this page: Dr L. Miguel Martins and Dr Susann Lehmann