What is it about?
We show that flies kept on a diet supplemented with vitamin B3 are protected from the neurotoxic consequences of mitochondrial defects in a model of Parkinson's disease
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Why is it important?
This strengthens the therapeutic potential for a vitamin B3/niacin-supplemented diet and PARP inhibition for Parkinson's disease
Perspectives
This study used Parkin mutant flies as an in vivo model of mitochondrial dysfunction associated with Parkinson's disease. We published a very similar study in Biology Open replicating most of these findings in flies mutant for another gene involved in Parkinson's disease (Pink1)
Dr L. Miguel Martins
MRC Toxicology Unit
Read the Original
This page is a summary of: Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease, Cell Death and Disease, March 2016, Nature,
DOI: 10.1038/cddis.2016.72.
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