Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA

  • Callum P. Rakhit, Ricky M. Trigg, John Le Quesne, Michael Kelly, Jacqueline A. Shaw, Catrin Pritchard, L. Miguel Martins
  • Disease Models & Mechanisms, February 2019, The Company of Biologists
  • DOI: 10.1242/dmm.036863

This research suggests a simple blood test could improve the early detection of lung cancer

What is it about?

The study, published in the journal Disease Models and Mechanisms, found that in preliminary tests using mice, a blood test could measure the circulating levels of DNA in the blood which cancer cells shed as they grow and multiply, and could even predict the presence of tumours in the lungs before they became cancerous

Why is it important?

This observation is exciting because it suggests that tumour-causing mutations may be detectable in circulating DNA from patients with early-stage cancers or with pre-cancerous tumours

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The following have contributed to this page: Dr L. Miguel Martins