Folinic acid is neuroprotective in a fly model of Parkinson’s disease associated with pink1 mutations

  • Susann Lehmann, Jane Jardine, Juan Garrido - Maraver, Samantha Loh, L. Miguel Martins
  • Matters, March 2017, Sciencematters
  • DOI: 10.19185/matters.201702000009

Folinic acid protects neurons

What is it about?

The study suggests that folinic acid, which is used in medications to treat bowel cancer, can also protect dying neurons associated with Parkinson’s disease in fruit flies.

Why is it important?

Folinic acid is already approved and used for applications in the clinic as an adjuvant during chemotherapy and can be administered orally, as a dietary supplement, or intravenously. Thus, the drug safety risk is low, and drug development for repurposing folinic acid as a treatment for Parkinson’s disease would be faster than for a novel drug.

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http://dx.doi.org/10.19185/matters.201702000009

The following have contributed to this page: Dr L. Miguel Martins, Dr Susann Lehmann, and Dr Juan Garrido-Maraver