Peptide nucleic acid clamping to improve the sensitivity of Ion Torrent-based detection of an oncogenic mutation in KRAS

  • Callum Rakhit, Barbara Ottolini, Carolyn Jones, James Pringle, Jacqueline Shaw, L. Miguel Martins
  • Matters, July 2017, Sciencematters
  • DOI: 10.19185/matters.201706000001

A method to improve the detection of cancer-associated mutations in the KRAS gene

What is it about?

We used a chemical method (a PNA clamp) to improve the detection of mutations in KRAS. Mutations in KRAS are associated with cancers that are difficult to treat such as lung cancer.

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http://dx.doi.org/10.19185/matters.201706000001

The following have contributed to this page: Dr L. Miguel Martins