Professor Zeno Földes-Papp [Biochemist, Gerontologist (Biochemiker, Geriater)]: Single-Molecule Biophysics & Biochemistry Based On the Stochastic Nature of Diffusion. -- I hope that my humble scientific work will be well received by the communities of single-molecule imaging and spectroscopy and by all users of these technologies as well as biotechnologies in the various and different disciplines:

  • Head of Geriatric Medicine (Medical Director of the Geriatric Service: Sektionsleitung Geriatrie) at Asklepios Klinikum Lindau (Bodensee), Bavaria, Germany
  • Professor, Medicine And Medical Sciences
  • Germany

My co-authors include

Prof. Dr. Karsten Koenig
Dr Michael Krachler
Professor Noel F. Lowndes

Find me at

My Publications

The FUNDAMENTAL NATURAL LAWS OF SINGLE-MOLECULE TIME RESOLUTION of freely diffusing mol...

  • Current Pharmaceutical Biotechnology
  • April 2013
  • The natural laws of single-molecule detection in dilute liquids and live cells depends on the Stochastic Nature of Diffusion and was found by Zeno Földes-Papp for the first time. The meaningful tim...

Basic theory of anomalous subdiffusive motion (transport without significant hydrodynam...

  • Current Pharmaceutical Biotechnology
  • August 2010
  • The 'SINGLE-MOLECULE DEMON' (single-molecule ratchet) in IMAGING/MICROSCOPY/SUPER-RESOLUTION MICROSCOPY (NANOSCOPY) and SPECTROSCOPY: Dilute Liquids and Live Cells https://www.growkudos.com/public...

Molecule Counting in Crowded Environment of Living Cells without and with Broken Ergodi...

  • Current Pharmaceutical Biotechnology
  • May 2011
  • Getting High on Single Molecule Biophysics: We first provide solutions to the problems : - how bulk egodicity behaves for subpopulations of biomacromolecules and - in what ways and how much the in...

Observing the Same Molecule in Solution and Live Cells.

  • Experimental and Molecular Pathology
  • April 2007
  • The discussion on the detection of single molecules in liquids and live cells is taken place in the Linkedin Group 'Super-Resolution Microscopy (Nanoscopy)' in 2020: One has to put forward the rig...

The Physical Theory of Single-Molecule Measurements in Dilute Liquids and Live Cells

  • Current Pharmaceutical Biotechnology
  • October 2007
  • What do the approaches of Single-Molecule Localization Microscopy/Nanoscopy/ Spectroscopy and Laser Scanning Microscopy or Single-Molecule Image Analysis as well as (temporally unlimited) Single-...

Quantification of the number of molecules in the detection volume

  • Current Pharmaceutical Biotechnology
  • December 2005
  • Abstract: Fluorescence correlation spectroscopy (FCS) and two-color fluorescence cross-correlation spectroscopy (FCCS) are among the cutting-edge technologies for measuring molecule numbers at the ...

Anomalous behavior in length distributions of 3D random Brownian walks and measured pho...

  • Optics Express
  • August 2010
  • Based on classical mean-field approximation using the diffusion equation for ergodic normal motion of single 24-nm and 100-nm nanospheres, we simulated and measured molecule number counting in fluo...

Individual Macromolecule Motion in a Crowded Living Cell

  • Current Pharmaceutical Biotechnology
  • January 2015
  • The 'SINGLE-MOLECULE DEMON' (single-molecule ratchet) in IMAGING/MICROSCOPY/SUPER-RESOLUTION MICROSCOPY (NANOSCOPY) and SPECTROSCOPY: Dilute Liquids and Live Cells https://www.growkudos.com/public...

Separation of the spatial subdiffusion from the temporal subdiffusion

  • Journal of Biological Methods
  • March 2014
  • Until now, characterization of translational diffusion in live cells has relied almost exclusively on measurements of constant translational diffusion coefficients. In live cells there is some evid...

HOW TO USE THE SELF-SAME MOLECULE LIKELIHOOD ESTIMATOR

  • December 2004
  • The physical theory of measuring just one molecule in dilute solutions or live cells without immobilization or hydrodynamic flow, i.e., the self-same molecule, is mainly based on two facts: i) the ...

Individual molecules in chemically solid phase synthesized oligonucleotides and DNA seq...

  • January 1994
  • Our interest was focused on error propagation during the synthesis of single stranded oligonucleotides and DNA sequences. We have modeled the assumed degenerative effects of such 3′→5′-driven synth...

What it means to measure a single molecule in a solution or in a living cell

  • Experimental and Molecular Pathology
  • June 2006
  • Traditional methodologies in micro- and nanofluidics measure biological mechanisms as an average of a population of molecules as only their combined effect can be detected. Fluorescence fluctuation...

New Ideas in Cell Biology: The Single-Molecule Level versus The Many-Molecule Level in ...

  • Journal of Biological Methods
  • January 2021
  • We measured anomalous diffusion in human prostate cancer cells which were transfected with the Alexa633 fluorescent RNA probe and co-transfected with enhanced green fluorescent protein-labeled argo...

Zeno Földes-Papp was in the driving seat

  • Proceedings of the National Academy of Sciences
  • September 2001
  • The question of the observation of fluctuations from the same molecule in dilute liquids at room temperature was put forward by Zeno Földes-Papp in the article for the very first time. This fundame...

Study on Single-Molecule Biophysics and Biochemistry in Liquids and LiveCells:No immobi...

  • Current Pharmaceutical Biotechnology
  • June 2022
  • THE THERMODYNAMIC SINGLE-MOLECULE DEMON (Maxwell's Demon) IS IN YOUR SINGLE-MOLECULE EXPERIMENTS IN DILUTE LIQUDS AND LIVE CELLS WITHOUT IMMOBILIZATION OR HYDRODYNAMIC FLOW: How far apart do two mo...

Personalised Healthcare: The DiMA Clinical Model

  • Current Pharmaceutical Biotechnology
  • April 2017

A Retrospective Study on Advanced Maternal Age and Assisted Reproductive Techniques, Me...

  • Current Pharmaceutical Biotechnology
  • February 2016

Amniotic Fluid Embolism: What Level of Scientific Evidence can be Drawn? A Systematic R...

  • Current Pharmaceutical Biotechnology
  • June 2014

Elimination of autofluorescence in fluorescence correlation spectroscopy using the AzaD...

  • Analytical and Bioanalytical Chemistry
  • April 2013

Preface

  • Current Pharmaceutical Biotechnology
  • January 2013

Preface

  • Current Pharmaceutical Biotechnology
  • January 2013

Detection of hyaluronidase activity using fluorescein labeled hyaluronic acid and Fluor...

  • Journal of Photochemistry and Photobiology B Biology
  • November 2012

Preface

  • Current Pharmaceutical Biotechnology
  • January 2012

An individual actin molecule in live cells

  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • May 2011

Confocal Fluctuation Spectroscopy and Imaging

  • Current Pharmaceutical Biotechnology
  • September 2010

Myocardial Expression of TNF-α, IL-1β, IL-6, IL-8, IL-10 and MCP-1 After a Si...

  • Current Pharmaceutical Biotechnology
  • August 2010

Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity

  • Current Pharmaceutical Biotechnology
  • August 2010

ChemInform Abstract: Fluorescence Correlation Spectroscopy in Nucleic Acid Analysis

  • ChemInform
  • May 2010

Polarized fluorescent nanospheres

  • Optics Express
  • February 2010

Long-term marker-free multiphoton imaging, targeted transfection, optical cleaning of s...

  • February 2010

Comparative Study of the Immunological Marker IL-6 and the Non-Immunological Marker PCT...

  • The Open Pathology Journal
  • November 2009

Trafficking of Mature miRNA-122 into the Nucleus of Live Liver Cells

  • Current Pharmaceutical Biotechnology
  • September 2009

Reducing Background Contributions in Fluorescence Fluctuation Time- Traces for Single-M...

  • Current Pharmaceutical Biotechnology
  • August 2009

Alternatives to diagnostic microarrys: the repertoir of single-molecule microscopy

  • January 2009

Contributors

  • January 2009

An early experimental study indicating anomalous subdiffusive behavior in live cells

  • Experimental and Molecular Pathology
  • April 2007

Exploring the biomedical applications of microscopy and spectroscopy

  • Experimental and Molecular Pathology
  • April 2007

Chronic Obstructive Pulmonary Disease and Oxidative Stress

  • Current Pharmaceutical Biotechnology
  • April 2006

Lack of specific immunological disease pattern in vulvar lichen sclerosus

  • Experimental and Molecular Pathology
  • October 2005

A new ultrasensitive way to circumvent PCR-based allele distinction: Direct probing of ...

  • Experimental and Molecular Pathology
  • June 2005

Aspects and necessity of moderate-altitude research

  • Wiener Medizinische Wochenschrift
  • April 2005

Oxidative stress caused by acute and chronic exposition to altitude

  • Wiener Medizinische Wochenschrift
  • April 2005

Human Herpes Virus Detection by DNA Microarray Technology

  • December 2004

Enhancing sensitivity of human herpes virus diagnosis with DNA microarrays using dendri...

  • Experimental and Molecular Pathology
  • October 2004

Preface [Hot Topic: The Way Down from Single Genes and Proteins to Single Molecules (Gu...

  • Current Pharmaceutical Biotechnology
  • June 2004

Foreword

  • Current Pharmaceutical Biotechnology
  • June 2004

Specifically associated PCR products probed by coincident detection of two-color cross-...

  • Experimental and Molecular Pathology
  • June 2004

Preface [Hot Topic: The Way Down from Single Genes and Proteins to Single Molecules (Gu...

  • Current Pharmaceutical Biotechnology
  • April 2004

Counting and Behavior of an Individual Fluorescent Molecule without Hydrodynamic Flow, ...

  • Current Pharmaceutical Biotechnology
  • April 2004

Foreword

  • Current Pharmaceutical Biotechnology
  • April 2004

Suppression of Exonucleolytic Degradation of Double-Stranded DNA and Inhibition of Exon...

  • ChemInform
  • March 2004

Detection of Multiple Human Herpes Viruses by DNA Microarray Technology

  • Molecular Diagnosis
  • March 2004

A new concept for ultrasensitive fluorescence measurements of molecules in solution and...

  • Journal of Immunological Methods
  • March 2004

A new concept for ultrasensitive fluorescence measurements of molecules in solution and...

  • Journal of Immunological Methods
  • March 2004

Foreword

  • Current Pharmaceutical Biotechnology
  • February 2004

Preface [Hot topic: The Way Down from Single Genes and Proteins to Single Molecules (Gu...

  • Current Pharmaceutical Biotechnology
  • February 2004

Clinical Applicability of Mass Spectrometry for Inhaled Carbon Compounds and the Charac...

  • Current Pharmaceutical Biotechnology
  • February 2004

Foreword

  • Current Pharmaceutical Biotechnology
  • February 2004

Detection of Multiple Human Herpes Viruses by DNA Microarray Technology

  • Molecular Diagnosis
  • January 2004

Foreword

  • Current Pharmaceutical Biotechnology
  • December 2003

Preface [Hot topic: The Way Down from Single Genes and Proteins to Single Molecules (Gu...

  • Current Pharmaceutical Biotechnology
  • December 2003

Virus Diagnostics on Microarrays

  • Current Pharmaceutical Biotechnology
  • December 2003

Laser scanning confocal fluorescence microscopy: an overview

  • International Immunopharmacology
  • December 2003

Reconstructed mass-spectrometric pattern for characterization of carbon compounds in sm...

  • Environmental Science and Pollution Research
  • November 2003

Suppression of Exonucleolytic Degradation of Double-Stranded DNA and Inhibition of Exon...

  • Nucleosides Nucleotides & Nucleic Acids
  • October 2003

A Novel Strategy Using Two-Color Cross-Correlation Fluorescence Spectroscopy

  • Molecular Diagnosis
  • June 2003

Microsecond structural fluctuations in denatured cytochrome c and the mechanism of rapi...

  • Journal of Physics Condensed Matter
  • April 2003

A Novel Strategy Using Two-Color Cross-Correlation Fluorescence Spectroscopy

  • Molecular Diagnosis
  • January 2003

Ligand binding of a ribosome-displayed protein detected in solution at the single molec...

  • European Biophysics Journal
  • June 2002

Ligand binding of a ribosome-displayed protein detected in solution at the single molec...

  • European Biophysics Journal
  • June 2002

TISSUE TRANSGLUTAMINASE ANTIBODY DETERMINATION IN CELIAC DISEASE. ANALYSIS OF DIAGNOSTI...

  • Journal of Immunoassay and Immunochemistry
  • May 2002

A New Dimension for the Development of Fluorescence-Based Assays in Solution

  • Experimental Biology and Medicine
  • May 2002

Prolonged Endurance Challenge at Moderate Altitude

  • CHEST Journal
  • April 2002

Cystatin C of pleural effusion as a novel diagnostic aid in pleural diseases of differe...

  • Clinical Science
  • March 2002

Cystatin C of pleural effusion as a novel diagnostic aid in pleural diseases of differe...

  • Clinical Science
  • March 2002

Single-Molecule Surface-Enhanced Raman and Fluorescence Correlation Spectroscopy of Hor...

  • The Journal of Physical Chemistry
  • February 2002

Detection of single molecules: solution-phase single-molecule fluorescence correlation ...

  • Journal of Immunological Methods
  • February 2002

Sequential Thoracentesis

  • Biological Trace Element Research
  • January 2002

Theory of Measuring the Selfsame Single Fluorescent Molecule in Solution Suited for Stu...

  • Pteridines
  • January 2002

Fluorescence correlation spectroscopy as a method for assessment of interactions betwee...

  • Protein Science
  • August 2001

Fluorescently labeled model DNA sequences for exonucleolytic sequencing

  • Journal of Biotechnology
  • April 2001

Fluorescent high-density labeling of DNA: error-free substitution for a normal nucleotide

  • Journal of Biotechnology
  • April 2001

Towards a general procedure for sequencing single DNA molecules

  • Journal of Biotechnology
  • April 2001

Single molecule DNA sequencing in submicrometer channels: state of the art and future p...

  • Journal of Biotechnology
  • April 2001

Quantitative Two-Color Fluorescence Cross-Correlation Spectroscopy in the Analysis of P...

  • Biological Chemistry
  • January 2001

Fluorescence Correlation Spectroscopy in Nucleic Acid Analysis

  • January 2001

Characterization of Pteridines: a New Approach by Fluorescence Correlation Spectroscopy...

  • Pteridines
  • January 2001

Fluorescence Correlation Spectroscopy in Single-Molecule Analysis: Enzymatic Catalysis ...

  • January 2001

Földes-Papp et al. (2001) Hematology 6: 423-428.

  • Hematology
  • January 2001

Single Molecule Detection and Bead Trapping in Microstructures for Molecule Selection a...

  • January 2000

The individual horseradish peroxidase molecule immobilized on an artifical structure (c...

  • Chemical Physics
  • August 1999

The Incipient Stage in Thrombin-Induced Fibrin Polymerization Detected by FCS at the Si...

  • Biochemical and Biophysical Research Communications
  • June 1999

Fluorescence Correlation Spectroscopy of Enzymatic DNA Polymerization†

  • Biochemistry
  • September 1998

Fluorescence cross-correlation: A new concept for polymerase chain reaction

  • Journal of Biotechnology
  • August 1998

The analysis of oligonucleotide preparations by fractal measures

  • Biopolymers
  • April 1998

The analysis of oligonucleotide preparations by fractal measures

  • Biopolymers
  • April 1998

Defining the fractal dimension of multicyclic syntheses and degradations in biological ...

  • January 1998

Exonuclease Degradation of DNA Studied by Fluorescence Correlation Spectroscopy

  • Nucleosides and Nucleotides
  • May 1997

Fractals for multicyclic synthesis conditions of biopolymers examples of oligonucleotid...

  • Journal of Chromatography A
  • July 1996

Oligonucleotide Synthesis on Polystyrene-Grafted Poly(tetrafluoroethylene) Support

  • Helvetica Chimica Acta
  • February 1996

Surface reactive polymers for special applications in nucleic acid synthesis

  • Reactive and Functional Polymers
  • September 1995

Efficiency of chemical oligonucleotide synthesis evaluated by ion-exchange high-perform...

  • Journal of Chromatography A
  • July 1995

Individual molecules in chemical oligonucleotide synthesis on solid support and ss-DNA ...

  • Journal of Theoretical Biology
  • June 1995

A versatile support for the synthesis of oligonucleotides of extended length and scale

  • Nucleic Acids Research
  • January 1994

Detection of Radicals at the Photolysis of tert-Butyl Hydroperoxide in DMSO and water

  • January 1991

Regulation of Purine Nucleotide Metabolism in Hypoxic Liver and Intestine of Rats: Radi...

  • January 1989