All Stories

  1. Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome
  2. The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs
  3. Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression
  4. Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability
  5. Correction for Travesa et al., “Repression of G1/S Transcription Is Mediated via Interaction of the GTB Motifs of Nrm1 and Whi5 with Swi6”
  6. Analysis of Biphenyl-Type Inhibitors Targeting the Eg5 α4/α6 Allosteric Pocket
  7. Differential Response of Mouse Thymic Epithelial Cell Types to Ionizing Radiation-Induced DNA Damage
  8. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
  9. BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells
  10. Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells
  11. Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein
  12. Rational design and validation of a Tip60 histone acetyltransferase inhibitor
  13. The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins
  14. ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset
  15. Hypoxia enhances the radio-resistance of mouse mesenchymal stromal cells
  16. Binding Specificity of the G1/S Transcriptional Regulators in Budding Yeast
  17. Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1
  18. Repression of G1/S Transcription Is Mediated via Interaction of the GTB Motifs of Nrm1 and Whi5 with Swi6
  19. Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell Lines
  20. Mesenchymal stromal cells: radio‐resistant members of the bone marrow
  21. ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway
  22. Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity
  23. Eukaryotic DNA damage checkpoint activation in response to double-strand breaks
  24. Modification of Histones by Sugar β- N -Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated
  25. Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
  26. The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer
  27. Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity
  28. Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56
  29. MRN and the race to the break
  30. 53BP1: function and mechanisms of focal recruitment
  31. Enhanced Protein Detection Using a Trapping Mode on a Hybrid Quadrupole Linear Ion Trap (Q-Trap)
  32. Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes
  33. The MRN complex
  34. Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
  35. Autofluorescent Proteins
  36. Comparisons Between DT40 Wild Type and DT40-Cre1 Cells as Suitable Model Systems for Studying the DNA Damage Response
  37. Chaperoning the Cln3 Cyclin Prevents Promiscuous Activation of Start
  38. Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
  39. An early experimental study indicating anomalous subdiffusive behavior in live cells
  40. Docking onto chromatin via theSaccharomyces cerevisiae Rad9 Tudor domain
  41. Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation
  42. Chromatin modulation and the DNA damage response
  43. DNA repair: From molecular mechanism to human disease
  44. Genetic dissection of vertebrate 53BP1: A major role in non-homologous end joining of DNA double strand breaks
  45. Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation
  46. Multiple Approaches to Study S. cerevisiae Rad9, a Prototypical Checkpoint Protein
  47. DNA Repair: The Importance of Phosphorylating Histone H2AX
  48. The switch from survival responses to apoptosis after chromosomal breaks
  49. Remodelling the Rad9 Checkpoint Complex: Preparing Rad53 for Action
  50. The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function
  51. The MRN complex: coordinating and mediating the response to broken chromosomes
  52. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage
  53. Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint
  54. Transducing the DNA damage signal in yeast
  55. Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
  56. Budding Yeast Rad9 Is an ATP-Dependent Rad53 Activating Machine
  57. RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers from the transcribed and non-transcribed regions of the Saccharomyces cerevisiae MFA2 gene
  58. A role for Saccharomyces cerevisiae histone H2A in DNA repair
  59. DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae
  60. The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining
  61. Sensing and responding to DNA damage
  62. A novel Rad24 checkpoint protein complex closely related to replication factor C
  63. A novel Rad24 checkpoint protein complex closely related to replication factor C
  64. DNA damage-dependent checkpoints in yeasts and human cells
  65. The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9–Rad9 interaction after DNA damage
  66. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
  67. Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis
  68. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
  69. DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?
  70. SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast
  71. Parallel pathways of cell cycle-regulated gene expression
  72. Cell cycle control of DNA synthesis in budding yeast
  73. Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+
  74. Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor
  75. The yeast DNA ligase gene C DC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation
  76. A Cell-cycle-regulated trans-Factor, DSC1, Controls Expression of DNA Synthesis Genes in Yeast
  77. An Investigation into 53BP1 Complex Formation
  78. Purification and Analysis of Checkpoint Protein Complexes From <I>Saccharomyces cerevisiae</I>
  79. Abstract