What is it about?
The mathematical error of Rigler’s et al. intuitive approaches to equations of local concentration fluctuations in the behavior of few molecules is that they did not sum up over an infinite number of periods before making any averaging. That is the reason why their approaches do not work.
Why is it important?
It must be made crystal clear that the underlying physics and molecular biochemistry can be modified easily but things hardly get worse when there is any trouble with the mathematics which rules the physical and biological formulations. The paper of Földes-Papp et al. (2001) "Detection and identification of single molecules in immunology and immunohematology: single (solution)-phase single-molecule FCS" in Hematology 6: 423-428 equates to it.
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This page is a summary of: Detection and Identification of Single Molecules in Immunology and Immunohematology: Single (solution)-phase Single-molecule FCS, Hematology, January 2001, Taylor & Francis, DOI: 10.1080/10245332.2001.11746597.
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